Click here to switch to the map view.

The map label for this gene is gltP [H]

Identifier: 157368547

GI number: 157368547

Start: 352747

End: 354063

Strand: Direct

Name: gltP [H]

Synonym: Spro_0298

Alternate gene names: 157368547

Gene position: 352747-354063 (Clockwise)

Preceding gene: 157368543

Following gene: 157368549

Centisome position: 6.47

GC content: 53.15

Gene sequence:

>1317_bases
ATGAAGAGTGTAAAAATCAGTCTTGCCTGGCAAATTATGATTGCATTGGCGTTGGGCATTATTGTTGGGGCGGTGCTCCA
TAATCAAACTGAATCACGAGAGTGGTTAGTCAGTAATATTCTAAGCCCGGCCGGTGATATATTTATCCGCCTGATTAAGA
TGATTGTGGTACCTATCGTTATTTCTACGCTGGTGGTGGGGATTGCCGGCGTGGGGGATGCGAAGAAGTTAGGCCGTCTC
GGGTTGAAAACCATTATTTACTTCGAAGTGATCACCACTATCGCCATTGTGGTGGGGCTGACATTGGCTAATGTTTTTCA
ACCCGGCCACGGTATCGACATGTCGACGCTGACCGCGGTGGATATCTCGCAGTATGAAAAAACCACGGAGCAGGTGCAAA
GTGGCTCGCACAGCCTGGTTGCCACCATTCTGTCGTTGATCCCGTCGAACATCTTCGCCTCGATGGCGAAGGGCGACATG
TTGCCGATCATCTTCTTCTCGGTGCTGTTTGGCTTGGGCCTGTCGTCACTGCCGAAAGAAACCAAAGAGCCGCTGCTGAA
GGTATTTAAAGCCGTTTCCGAAAGCATGTTCAAAGTCACGCATATGATCATGCGCTATGCGCCGATTGGGGTGTTTGGTC
TGATTGCAGTGACGGTTGCCAACTTCGGCTTCGCCTCATTGCTGCCTCTGGCCAAACTGGTACTGCTGGTGTACTTCGCG
ATTGCCTTCTTTGCGTTGGTGGTGCTGGGGGCGGTCGCACGCATCTGTAACCTGCGTATCTGGACGCTGATCCGTATCCT
GAAGGATGAACTGATCCTGGCCTTTTCCACCGCCAGTTCGGAAACGGTGCTGCCGCGTATCATCGAAAAGATGGAGGCTT
ACGGCGCGCCGAAGGCGATCACCAGTTTTGTGGTACCGACCGGTTACTCCTTCAATCTGGACGGTTCAACGCTGTATCAG
AGCATTGCCGCCATCTTCATCGCGCAGTTGTATGGGATTGAACTGTCCCTGGGCCAGGAGATTGTGCTGGTGGTGACGCT
GATGCTTACCTCCAAGGGGATTGCCGGCGTGCCCGGAGTTTCCTTTGTGGTGCTGTTGGCGACGCTGGGTAGCGTGGGGA
TCCCGTTGGAAGGCCTGGCGTTTATCGCTGGTGTAGATCGCATCCTGGATATGGCGCGTACTGCACTGAACGTGGTGGGC
AATGCGCTGGCGGTGCTGGTGGTAGCTAAATGGGAACACCAGTTCGACAGTAAAAAGGCGCTCGCCTTTGAGAAAGAGTT
CTTGTCCGGCAAAGCCAGGCAGATAACAGACTCTTAA

Upstream 100 bases:

>100_bases
CTTCCTGGTCATTAACATAAGCCTGTATTAAATGATTAAGTATTCTTTTCGGCGCGTTATTATAAATGTGCCGAAAAGAG
TCTTTGAGGACTTTTTGGGT

Downstream 100 bases:

>100_bases
CCGTTTTTGGACGAGATTGATTTGACGACTAAACCCGCCTGATGGCGGGTTTAGTCGTCTTGGGATCAGCAGGAGGGGGC
AGAGCCCTGGGCTGGCAGGA

Product: sodium:dicarboxylate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MKSVKISLAWQIMIALALGIIVGAVLHNQTESREWLVSNILSPAGDIFIRLIKMIVVPIVISTLVVGIAGVGDAKKLGRL
GLKTIIYFEVITTIAIVVGLTLANVFQPGHGIDMSTLTAVDISQYEKTTEQVQSGSHSLVATILSLIPSNIFASMAKGDM
LPIIFFSVLFGLGLSSLPKETKEPLLKVFKAVSESMFKVTHMIMRYAPIGVFGLIAVTVANFGFASLLPLAKLVLLVYFA
IAFFALVVLGAVARICNLRIWTLIRILKDELILAFSTASSETVLPRIIEKMEAYGAPKAITSFVVPTGYSFNLDGSTLYQ
SIAAIFIAQLYGIELSLGQEIVLVVTLMLTSKGIAGVPGVSFVVLLATLGSVGIPLEGLAFIAGVDRILDMARTALNVVG
NALAVLVVAKWEHQFDSKKALAFEKEFLSGKARQITDS

Sequences:

>Translated_438_residues
MKSVKISLAWQIMIALALGIIVGAVLHNQTESREWLVSNILSPAGDIFIRLIKMIVVPIVISTLVVGIAGVGDAKKLGRL
GLKTIIYFEVITTIAIVVGLTLANVFQPGHGIDMSTLTAVDISQYEKTTEQVQSGSHSLVATILSLIPSNIFASMAKGDM
LPIIFFSVLFGLGLSSLPKETKEPLLKVFKAVSESMFKVTHMIMRYAPIGVFGLIAVTVANFGFASLLPLAKLVLLVYFA
IAFFALVVLGAVARICNLRIWTLIRILKDELILAFSTASSETVLPRIIEKMEAYGAPKAITSFVVPTGYSFNLDGSTLYQ
SIAAIFIAQLYGIELSLGQEIVLVVTLMLTSKGIAGVPGVSFVVLLATLGSVGIPLEGLAFIAGVDRILDMARTALNVVG
NALAVLVVAKWEHQFDSKKALAFEKEFLSGKARQITDS
>Mature_438_residues
MKSVKISLAWQIMIALALGIIVGAVLHNQTESREWLVSNILSPAGDIFIRLIKMIVVPIVISTLVVGIAGVGDAKKLGRL
GLKTIIYFEVITTIAIVVGLTLANVFQPGHGIDMSTLTAVDISQYEKTTEQVQSGSHSLVATILSLIPSNIFASMAKGDM
LPIIFFSVLFGLGLSSLPKETKEPLLKVFKAVSESMFKVTHMIMRYAPIGVFGLIAVTVANFGFASLLPLAKLVLLVYFA
IAFFALVVLGAVARICNLRIWTLIRILKDELILAFSTASSETVLPRIIEKMEAYGAPKAITSFVVPTGYSFNLDGSTLYQ
SIAAIFIAQLYGIELSLGQEIVLVVTLMLTSKGIAGVPGVSFVVLLATLGSVGIPLEGLAFIAGVDRILDMARTALNVVG
NALAVLVVAKWEHQFDSKKALAFEKEFLSGKARQITDS

Specific function: This carrier protein is part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI169790839, Length=425, Percent_Identity=28.7058823529412, Blast_Score=155, Evalue=6e-38,
Organism=Homo sapiens, GI40254478, Length=463, Percent_Identity=28.2937365010799, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI194239697, Length=479, Percent_Identity=28.6012526096033, Blast_Score=147, Evalue=3e-35,
Organism=Homo sapiens, GI66773030, Length=456, Percent_Identity=29.8245614035088, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI21314632, Length=438, Percent_Identity=27.1689497716895, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI4827012, Length=277, Percent_Identity=33.2129963898917, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI5032093, Length=398, Percent_Identity=27.6381909547739, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI262359914, Length=360, Percent_Identity=27.7777777777778, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI223468566, Length=287, Percent_Identity=30.3135888501742, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI223468564, Length=287, Percent_Identity=30.3135888501742, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI301601644, Length=156, Percent_Identity=33.974358974359, Blast_Score=93, Evalue=5e-19,
Organism=Escherichia coli, GI1790514, Length=438, Percent_Identity=79.4520547945205, Blast_Score=707, Evalue=0.0,
Organism=Escherichia coli, GI1789947, Length=416, Percent_Identity=40.3846153846154, Blast_Score=324, Evalue=8e-90,
Organism=Escherichia coli, GI1788024, Length=417, Percent_Identity=25.1798561151079, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1789473, Length=392, Percent_Identity=23.469387755102, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17537407, Length=424, Percent_Identity=29.4811320754717, Blast_Score=161, Evalue=8e-40,
Organism=Caenorhabditis elegans, GI71983106, Length=419, Percent_Identity=28.1622911694511, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI71983099, Length=419, Percent_Identity=28.1622911694511, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI71996953, Length=463, Percent_Identity=26.133909287257, Blast_Score=148, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI193206505, Length=471, Percent_Identity=27.3885350318471, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI193206654, Length=445, Percent_Identity=26.2921348314607, Blast_Score=125, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI17541374, Length=446, Percent_Identity=24.8878923766816, Blast_Score=111, Evalue=7e-25,
Organism=Drosophila melanogaster, GI24583025, Length=435, Percent_Identity=25.7471264367816, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI17137668, Length=435, Percent_Identity=25.7471264367816, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI24583023, Length=435, Percent_Identity=25.7471264367816, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI281360481, Length=428, Percent_Identity=25, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI281360483, Length=428, Percent_Identity=25.2336448598131, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17137666, Length=428, Percent_Identity=25.2336448598131, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 46957; Mature: 46957

Theoretical pI: Translated: 9.58; Mature: 9.58

Prosite motif: PS00713 NA_DICARBOXYL_SYMP_1 ; PS00714 NA_DICARBOXYL_SYMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSVKISLAWQIMIALALGIIVGAVLHNQTESREWLVSNILSPAGDIFIRLIKMIVVPIV
CCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
ISTLVVGIAGVGDAKKLGRLGLKTIIYFEVITTIAIVVGLTLANVFQPGHGIDMSTLTAV
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
DISQYEKTTEQVQSGSHSLVATILSLIPSNIFASMAKGDMLPIIFFSVLFGLGLSSLPKE
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHH
TKEPLLKVFKAVSESMFKVTHMIMRYAPIGVFGLIAVTVANFGFASLLPLAKLVLLVYFA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
IAFFALVVLGAVARICNLRIWTLIRILKDELILAFSTASSETVLPRIIEKMEAYGAPKAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHCCCHHH
TSFVVPTGYSFNLDGSTLYQSIAAIFIAQLYGIELSLGQEIVLVVTLMLTSKGIAGVPGV
HHHHCCCCCEECCCHHHHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHCCCCCCCCHH
SFVVLLATLGSVGIPLEGLAFIAGVDRILDMARTALNVVGNALAVLVVAKWEHQFDSKKA
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
LAFEKEFLSGKARQITDS
HHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MKSVKISLAWQIMIALALGIIVGAVLHNQTESREWLVSNILSPAGDIFIRLIKMIVVPIV
CCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
ISTLVVGIAGVGDAKKLGRLGLKTIIYFEVITTIAIVVGLTLANVFQPGHGIDMSTLTAV
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
DISQYEKTTEQVQSGSHSLVATILSLIPSNIFASMAKGDMLPIIFFSVLFGLGLSSLPKE
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHH
TKEPLLKVFKAVSESMFKVTHMIMRYAPIGVFGLIAVTVANFGFASLLPLAKLVLLVYFA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
IAFFALVVLGAVARICNLRIWTLIRILKDELILAFSTASSETVLPRIIEKMEAYGAPKAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHCCCHHH
TSFVVPTGYSFNLDGSTLYQSIAAIFIAQLYGIELSLGQEIVLVVTLMLTSKGIAGVPGV
HHHHCCCCCEECCCHHHHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHCCCCCCCCHH
SFVVLLATLGSVGIPLEGLAFIAGVDRILDMARTALNVVGNALAVLVVAKWEHQFDSKKA
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
LAFEKEFLSGKARQITDS
HHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1971622; 1551855; 8265357; 9278503 [H]