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The map label for this gene is tatD [H]

Identifier: 157368503

GI number: 157368503

Start: 283392

End: 284174

Strand: Direct

Name: tatD [H]

Synonym: Spro_0254

Alternate gene names: 157368503

Gene position: 283392-284174 (Clockwise)

Preceding gene: 157368502

Following gene: 157368504

Centisome position: 5.2

GC content: 59.9

Gene sequence:

>783_bases
ATGTTTGATATCGGCGTCAATCTCACCAGCTCACAATTTGCCAAAGACCGTCCGGCGGTGGTGGAGCGCGCCCGTGCTGC
AGGCGTAACAGGGCTGCTGATTACCGGTACCGATCTGCAGGAGAGCCGTGCAGCCAGTGAACTGGCGCAACAGCATGCGA
ATTTTTGCTGGTCCACCGCCGGTGTGCATCCTCACCATGCCAGCAGTTGGGACGAGCGAGTCGCAGAACAAATCTGCGAG
TTAGCCGCCCGGCCACGGGTCGCGGCTATTGGTGAATGTGGGCTGGATTTCAACCGCAACTTCTCTACTCCAGAGCAGCA
GGAGGCGGCATTCAGCGCACAACTGGCGCTGGCGGCAGAGTTGTCGATGCCGGTTTTTCTTCATTGTCGCGATGCACACG
CACGTTTTGCAGCGCTGCTGGCGCCGTGGTTGGATAAACTGCCCGCGGCCGTGGTGCACTGTTTTACCGGCACCGCCGAA
GAATTGGAAAGCTGCCTGTCGTTAGGCCTGTCGGTGGGTATTACCGGTTGGGTCTGCGATGAGCGGCGTGGCCTGGAACT
GCGCGCGTTGCTGCCGCAGATCCCGGCGGACCGTCTGTTGCTGGAAACCGACGCCCCCTATCTGTTGCCCCGGGATTTAC
TTCCGAAACCCACATCTCGCCGCAACGAACCCTGTTTTTTGCCTCATATCGTCCGGCAGGTGGCCGCCTGGCGACAAGAA
GATCCCGAATGGCTGGGGCAAAAAATCGATGAGAACGCCCGCCGGCTATTCCGGCTGGAATGA

Upstream 100 bases:

>100_bases
CCGCAGCCAGAAGAAGAAGACGAGGGTGACGAACCCCCGGCACCTTAATTTCTGTTTGTTTCTAAGCCGCCCGATGGGCG
GCTTTTACTTTGGGAACATC

Downstream 100 bases:

>100_bases
GTTAGGAGAAAACTATGAGCTATGCATTTCCGGGCACCTTCCCAGGTCGCCGTATGCGCCGCGTGCGCCGTCATGATTTC
AGTCGTCGCCTGGTGGCGGA

Product: DNase TatD

Products: NA

Alternate protein names: DNase tatD [H]

Number of amino acids: Translated: 260; Mature: 260

Protein sequence:

>260_residues
MFDIGVNLTSSQFAKDRPAVVERARAAGVTGLLITGTDLQESRAASELAQQHANFCWSTAGVHPHHASSWDERVAEQICE
LAARPRVAAIGECGLDFNRNFSTPEQQEAAFSAQLALAAELSMPVFLHCRDAHARFAALLAPWLDKLPAAVVHCFTGTAE
ELESCLSLGLSVGITGWVCDERRGLELRALLPQIPADRLLLETDAPYLLPRDLLPKPTSRRNEPCFLPHIVRQVAAWRQE
DPEWLGQKIDENARRLFRLE

Sequences:

>Translated_260_residues
MFDIGVNLTSSQFAKDRPAVVERARAAGVTGLLITGTDLQESRAASELAQQHANFCWSTAGVHPHHASSWDERVAEQICE
LAARPRVAAIGECGLDFNRNFSTPEQQEAAFSAQLALAAELSMPVFLHCRDAHARFAALLAPWLDKLPAAVVHCFTGTAE
ELESCLSLGLSVGITGWVCDERRGLELRALLPQIPADRLLLETDAPYLLPRDLLPKPTSRRNEPCFLPHIVRQVAAWRQE
DPEWLGQKIDENARRLFRLE
>Mature_260_residues
MFDIGVNLTSSQFAKDRPAVVERARAAGVTGLLITGTDLQESRAASELAQQHANFCWSTAGVHPHHASSWDERVAEQICE
LAARPRVAAIGECGLDFNRNFSTPEQQEAAFSAQLALAAELSMPVFLHCRDAHARFAALLAPWLDKLPAAVVHCFTGTAE
ELESCLSLGLSVGITGWVCDERRGLELRALLPQIPADRLLLETDAPYLLPRDLLPKPTSRRNEPCFLPHIVRQVAAWRQE
DPEWLGQKIDENARRLFRLE

Specific function: Shows DNase activity [H]

COG id: COG0084

COG function: function code L; Mg-dependent DNase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tatD DNase family [H]

Homologues:

Organism=Homo sapiens, GI14042943, Length=292, Percent_Identity=32.5342465753425, Blast_Score=146, Evalue=1e-35,
Organism=Homo sapiens, GI225903439, Length=250, Percent_Identity=32.8, Blast_Score=131, Evalue=8e-31,
Organism=Homo sapiens, GI225903424, Length=209, Percent_Identity=32.5358851674641, Blast_Score=109, Evalue=2e-24,
Organism=Escherichia coli, GI48994985, Length=259, Percent_Identity=68.3397683397683, Blast_Score=370, Evalue=1e-104,
Organism=Escherichia coli, GI1787342, Length=253, Percent_Identity=31.6205533596838, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI87082439, Length=250, Percent_Identity=28.8, Blast_Score=90, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17559024, Length=281, Percent_Identity=36.6548042704626, Blast_Score=203, Evalue=6e-53,
Organism=Caenorhabditis elegans, GI17565396, Length=168, Percent_Identity=33.9285714285714, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17543026, Length=169, Percent_Identity=32.5443786982249, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71980746, Length=274, Percent_Identity=24.0875912408759, Blast_Score=71, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6319416, Length=295, Percent_Identity=29.4915254237288, Blast_Score=84, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24648690, Length=283, Percent_Identity=35.3356890459364, Blast_Score=174, Evalue=4e-44,
Organism=Drosophila melanogaster, GI221330018, Length=297, Percent_Identity=31.3131313131313, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24586117, Length=273, Percent_Identity=31.5018315018315, Blast_Score=109, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015992
- InterPro:   IPR001130
- InterPro:   IPR018228
- InterPro:   IPR012278 [H]

Pfam domain/function: PF01026 TatD_DNase [H]

EC number: 3.1.21.-

Molecular weight: Translated: 28807; Mature: 28807

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS01091 TATD_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDIGVNLTSSQFAKDRPAVVERARAAGVTGLLITGTDLQESRAASELAQQHANFCWSTA
CEECCCCCCHHHHHCCCHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCC
GVHPHHASSWDERVAEQICELAARPRVAAIGECGLDFNRNFSTPEQQEAAFSAQLALAAE
CCCCCCCCCHHHHHHHHHHHHHCCCCEEEHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
LSMPVFLHCRDAHARFAALLAPWLDKLPAAVVHCFTGTAEELESCLSLGLSVGITGWVCD
CCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCEEEEEC
ERRGLELRALLPQIPADRLLLETDAPYLLPRDLLPKPTSRRNEPCFLPHIVRQVAAWRQE
CCCCCHHHHHHCCCCCCCEEEECCCCCCCCHHCCCCCCCCCCCCCHHHHHHHHHHHHCCC
DPEWLGQKIDENARRLFRLE
CHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MFDIGVNLTSSQFAKDRPAVVERARAAGVTGLLITGTDLQESRAASELAQQHANFCWSTA
CEECCCCCCHHHHHCCCHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCC
GVHPHHASSWDERVAEQICELAARPRVAAIGECGLDFNRNFSTPEQQEAAFSAQLALAAE
CCCCCCCCCHHHHHHHHHHHHHCCCCEEEHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
LSMPVFLHCRDAHARFAALLAPWLDKLPAAVVHCFTGTAEELESCLSLGLSVGITGWVCD
CCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCEEEEEC
ERRGLELRALLPQIPADRLLLETDAPYLLPRDLLPKPTSRRNEPCFLPHIVRQVAAWRQE
CCCCCHHHHHHCCCCCCCEEEECCCCCCCCHHCCCCCCCCCCCCCHHHHHHHHHHHHCCC
DPEWLGQKIDENARRLFRLE
CHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Mg [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1584020; 9649434; 1379743; 9278503; 10747959 [H]