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The map label for this gene is creC [H]

Identifier: 157163847

GI number: 157163847

Start: 4638582

End: 4640006

Strand: Direct

Name: creC [H]

Synonym: EcHS_A4635

Alternate gene names: 157163847

Gene position: 4638582-4640006 (Clockwise)

Preceding gene: 157163846

Following gene: 157163848

Centisome position: 99.89

GC content: 54.25

Gene sequence:

>1425_bases
ATGCGTATCGGCATGCGGTTGCTGCTGGGCTATTTTTTACTGGTGGCGGTGGCGGCCTGGTTCGTACTGGCTATTTTTGT
CAAAGAAGTTAAACCGGGCGTGCGAAGAGCAACGGAGGGGACGTTGATCGACACCGCAACGTTGCTGGCGGAGCTGGCGC
GTCCCGATTTGCTCTCTGGGGACCCAACGCATGGGCAACTGGCGCAGGCGTTTAATCAGCTACAACATCGCCCGTTTCGC
GCCAATATCGGTGGCATTAACAAAGTGCGCAATGAATATCATGTCTATATGACCGATTCGCAGGGTAAAGTATTGTTCGA
TTCGGCAAATAAAGCCGTTGGGCAGGATTATTCGCGCTGGAATGACGTCTGGCTAACGTTGCGTGGTCAGTATGGTGCGC
GCAGCACGTTGCAAAATCCTGCCGATCCCGAAAGTTCGGTGATGTATGTTGCCGCGCCGATTATGGACGGCTCGCGGCTT
ATTGGCGTTTTGAGCGTAGGCAAACCGAACGCGGCGATGGCTCCGGTCATTAAACGCAGCGAGCGGCGAATTTTATGGGC
CAGCGCCATTTTGTTGGGGATCGCACTGGTGATTGGCGCAGGCATGGTTTGGTGGATCAACCGCTCCATTGCCCGGCTCA
CTCGCTATGCTGATTCCGTCACTGACAATAAGCCCGTTCCTCTTCCCGATCTCGGTAGTAGCGAGCTGCGTAAACTCGCG
CAGGCGCTGGAAAGTATGCGCGTGAAGCTGGAAGGGAAAAACTATATTGAGCAGTATGTTTATGCGTTAACCCATGAGCT
AAAAAGCCCACTGGCGGCGATTCGTGGCGCGGCGGAAATTTTACGCGAAGGTCCGCCGCCTGAAGTAGTGGCTCGTTTTA
CTGACAACATTCTGACGCAAAATGCGCGAATGCAGGCACTGGTGGAAACGTTACTACGCCAGGCAAGACTGGAGAATCGT
CAGGAAGTCGTTTTGACTGCTGTTGATGTGGCGGCATTATTCCGCCGCGTCAGCGAAGCGCGCACCGTGCAGTTGGCAGA
AAAAAACATCACTCTACATGTTACGCCCACCGAGGTTAATGTTGCTGCTGAACCGGCGTTACTGGATCAGGCGCTGGGGA
ATTTACTGGATAACGCCATCGATTTTACCCCCGAGAGCGGTCGTATAACGCTAAGCGCCGAAGTGGATCAGGAACACGTC
ACGCTTAAGGTGCTGGATACCGGTAGTGGTATTCCTGACTACGCGCTGTCACGTATTTTTGAACGCTTTTACTCTTTGCC
GCGTGCAAATGGGCAAAAAAGCAGCGGTCTGGGGTTGGCGTTCGTCAGTGAGGTCGCCCGTTTGTTTAACGGCGAAGTCA
CGCTGCGCAACGTGCAGGAAGGTGGCGTGCTGGCCTCGCTTCGACTTCACCGTCACTTCACATAG

Upstream 100 bases:

>100_bases
CCCACATTAAAACGTTGCGTGCCAAGCTGCGCGCCATCAACCCCGATCTTTCACCGATTAATACTCATCGCGGCATGGGA
TATAGCCTGAGGGGCCTGTA

Downstream 100 bases:

>100_bases
CTTCAAATTCTTCCCACATAGCCTTCGTATCCTGCTGCCATTGCAAAGGAGAAGACTATGTTGAAATCCCCCCTGTTCTG
GAAAATGACCACCCTGTTTG

Product: sensory histidine kinase CreC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 474; Mature: 474

Protein sequence:

>474_residues
MRIGMRLLLGYFLLVAVAAWFVLAIFVKEVKPGVRRATEGTLIDTATLLAELARPDLLSGDPTHGQLAQAFNQLQHRPFR
ANIGGINKVRNEYHVYMTDSQGKVLFDSANKAVGQDYSRWNDVWLTLRGQYGARSTLQNPADPESSVMYVAAPIMDGSRL
IGVLSVGKPNAAMAPVIKRSERRILWASAILLGIALVIGAGMVWWINRSIARLTRYADSVTDNKPVPLPDLGSSELRKLA
QALESMRVKLEGKNYIEQYVYALTHELKSPLAAIRGAAEILREGPPPEVVARFTDNILTQNARMQALVETLLRQARLENR
QEVVLTAVDVAALFRRVSEARTVQLAEKNITLHVTPTEVNVAAEPALLDQALGNLLDNAIDFTPESGRITLSAEVDQEHV
TLKVLDTGSGIPDYALSRIFERFYSLPRANGQKSSGLGLAFVSEVARLFNGEVTLRNVQEGGVLASLRLHRHFT

Sequences:

>Translated_474_residues
MRIGMRLLLGYFLLVAVAAWFVLAIFVKEVKPGVRRATEGTLIDTATLLAELARPDLLSGDPTHGQLAQAFNQLQHRPFR
ANIGGINKVRNEYHVYMTDSQGKVLFDSANKAVGQDYSRWNDVWLTLRGQYGARSTLQNPADPESSVMYVAAPIMDGSRL
IGVLSVGKPNAAMAPVIKRSERRILWASAILLGIALVIGAGMVWWINRSIARLTRYADSVTDNKPVPLPDLGSSELRKLA
QALESMRVKLEGKNYIEQYVYALTHELKSPLAAIRGAAEILREGPPPEVVARFTDNILTQNARMQALVETLLRQARLENR
QEVVLTAVDVAALFRRVSEARTVQLAEKNITLHVTPTEVNVAAEPALLDQALGNLLDNAIDFTPESGRITLSAEVDQEHV
TLKVLDTGSGIPDYALSRIFERFYSLPRANGQKSSGLGLAFVSEVARLFNGEVTLRNVQEGGVLASLRLHRHFT
>Mature_474_residues
MRIGMRLLLGYFLLVAVAAWFVLAIFVKEVKPGVRRATEGTLIDTATLLAELARPDLLSGDPTHGQLAQAFNQLQHRPFR
ANIGGINKVRNEYHVYMTDSQGKVLFDSANKAVGQDYSRWNDVWLTLRGQYGARSTLQNPADPESSVMYVAAPIMDGSRL
IGVLSVGKPNAAMAPVIKRSERRILWASAILLGIALVIGAGMVWWINRSIARLTRYADSVTDNKPVPLPDLGSSELRKLA
QALESMRVKLEGKNYIEQYVYALTHELKSPLAAIRGAAEILREGPPPEVVARFTDNILTQNARMQALVETLLRQARLENR
QEVVLTAVDVAALFRRVSEARTVQLAEKNITLHVTPTEVNVAAEPALLDQALGNLLDNAIDFTPESGRITLSAEVDQEHV
TLKVLDTGSGIPDYALSRIFERFYSLPRANGQKSSGLGLAFVSEVARLFNGEVTLRNVQEGGVLASLRLHRHFT

Specific function: Member of the two-component regulatory system CreC/CreB involved in catabolic regulation. CreC may function as a membrane- associated protein kinase that phosphorylates CreB in response to environmental signals. CreC can also phosphorylate PhoB [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790861, Length=474, Percent_Identity=99.1561181434599, Blast_Score=952, Evalue=0.0,
Organism=Escherichia coli, GI87082128, Length=302, Percent_Identity=31.7880794701987, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI1788393, Length=250, Percent_Identity=29.6, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1786600, Length=201, Percent_Identity=30.3482587064677, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI48994928, Length=220, Percent_Identity=24.5454545454545, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI145693157, Length=228, Percent_Identity=23.6842105263158, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1788713, Length=234, Percent_Identity=26.0683760683761, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1789403, Length=477, Percent_Identity=24.7379454926625, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786912, Length=240, Percent_Identity=28.3333333333333, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1786783, Length=400, Percent_Identity=23, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790346, Length=261, Percent_Identity=24.5210727969349, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1789808, Length=240, Percent_Identity=25, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1790436, Length=203, Percent_Identity=28.5714285714286, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1788279, Length=268, Percent_Identity=25.3731343283582, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1787374, Length=287, Percent_Identity=26.4808362369338, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52218; Mature: 52218

Theoretical pI: Translated: 9.64; Mature: 9.64

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIGMRLLLGYFLLVAVAAWFVLAIFVKEVKPGVRRATEGTLIDTATLLAELARPDLLSG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCHHHHHHHHHHHHCCCCCCC
DPTHGQLAQAFNQLQHRPFRANIGGINKVRNEYHVYMTDSQGKVLFDSANKAVGQDYSRW
CCCCHHHHHHHHHHHCCCCCCCCCCHHHHCCCEEEEEECCCCCEEEECCCHHHCCCHHCC
NDVWLTLRGQYGARSTLQNPADPESSVMYVAAPIMDGSRLIGVLSVGKPNAAMAPVIKRS
CCEEEEEECCCCCHHCCCCCCCCCCCEEEEEEECCCCCCEEEEEECCCCCCHHHHHHHHC
ERRILWASAILLGIALVIGAGMVWWINRSIARLTRYADSVTDNKPVPLPDLGSSELRKLA
CCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
QALESMRVKLEGKNYIEQYVYALTHELKSPLAAIRGAAEILREGPPPEVVARFTDNILTQ
HHHHHHEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCC
NARMQALVETLLRQARLENRQEVVLTAVDVAALFRRVSEARTVQLAEKNITLHVTPTEVN
CHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHEEEECCEEEEEECCEEC
VAAEPALLDQALGNLLDNAIDFTPESGRITLSAEVDQEHVTLKVLDTGSGIPDYALSRIF
CCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEEEECCCCCHHHHHHHHH
ERFYSLPRANGQKSSGLGLAFVSEVARLFNGEVTLRNVQEGGVLASLRLHRHFT
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCEEEEEHHHHCCC
>Mature Secondary Structure
MRIGMRLLLGYFLLVAVAAWFVLAIFVKEVKPGVRRATEGTLIDTATLLAELARPDLLSG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCHHHHHHHHHHHHCCCCCCC
DPTHGQLAQAFNQLQHRPFRANIGGINKVRNEYHVYMTDSQGKVLFDSANKAVGQDYSRW
CCCCHHHHHHHHHHHCCCCCCCCCCHHHHCCCEEEEEECCCCCEEEECCCHHHCCCHHCC
NDVWLTLRGQYGARSTLQNPADPESSVMYVAAPIMDGSRLIGVLSVGKPNAAMAPVIKRS
CCEEEEEECCCCCHHCCCCCCCCCCCEEEEEEECCCCCCEEEEEECCCCCCHHHHHHHHC
ERRILWASAILLGIALVIGAGMVWWINRSIARLTRYADSVTDNKPVPLPDLGSSELRKLA
CCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
QALESMRVKLEGKNYIEQYVYALTHELKSPLAAIRGAAEILREGPPPEVVARFTDNILTQ
HHHHHHEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCC
NARMQALVETLLRQARLENRQEVVLTAVDVAALFRRVSEARTVQLAEKNITLHVTPTEVN
CHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHEEEECCEEEEEECCEEC
VAAEPALLDQALGNLLDNAIDFTPESGRITLSAEVDQEHVTLKVLDTGSGIPDYALSRIF
CCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEEEECCCCCHHHHHHHHH
ERFYSLPRANGQKSSGLGLAFVSEVARLFNGEVTLRNVQEGGVLASLRLHRHFT
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCEEEEEHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3531171; 7610040; 9278503; 2835585; 2228961 [H]