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The map label for this gene is mutL [H]

Identifier: 157163633

GI number: 157163633

Start: 4422148

End: 4423995

Strand: Direct

Name: mutL [H]

Synonym: EcHS_A4412

Alternate gene names: 157163633

Gene position: 4422148-4423995 (Clockwise)

Preceding gene: 157163632

Following gene: 157163634

Centisome position: 95.23

GC content: 56.49

Gene sequence:

>1848_bases
ATGCCAATTCAGGTCTTACCGCCACAACTGGCGAACCAGATTGCCGCAGGTGAGGTGGTCGAGCGACCTGCGTCGGTAGT
CAAAGAACTGGTGGAAAACAGCCTCGATGCAGGTGCGACACGTATCGATATTGATATCGAACGCGGTGGGGCGAAACTTA
TCCGCATTCGTGATAACGGCTGCGGTATCAAAAAAGACGAGCTGGCGCTGGCGCTGGCGCGTCATGCCACCAGTAAAATC
GCCTCTCTGGACGATCTCGAAGCCATTATCAGCCTGGGCTTTCGCGGTGAGGCGCTGGCGAGTATCAGTTCGGTTTCCCG
CCTGACGCTCACTTCACGCACCGCAGAACAGCAGGAAGCCTGGCAGGCCTATGCCGAAGGGCGCGATATGAACGTGACGG
TAAAACCGGCGGCGCATCCTGTGGGGACGACGCTGGAGGTGCTGGATCTGTTCTACAACACCCCGGCGCGGCGCAAATTC
CTGCGCACCGAGAAAACCGAATTTAACCACATTGATGAGATCATCCGCCGCATTGCGCTGGCGCGTTTCGACGTCACGAT
CAACCTGTCGCATAACGGTAAAATTGTGCGTCAGTACCGCGCAGTGCCGGAAGGCGGGCAAAAAGAACGGCGCTTAGGCG
CGATTTGCGGCACCGCTTTTCTTGAACAAGCGCTGGCGATTGAATGGCAACACGGCGATCTCACGCTACGCGGCTGGGTG
GCCGATCCAAATCACACCACGCCCGCACTGGCAGAAATTCAGTATTGCTACGTGAACGGTCGCATGATGCGCGATCGCCT
GATCAATCACGCGATCCGCCAGGCCTGCGAAGACAAACTGGGGGCCGATCAGCAACCGGCATTTGTGCTGTATCTGGAGA
TCGATCCGCATCAGGTGGACGTCAACGTGCACCCCGCCAAACACGAAGTGCGTTTCCATCAGTCGCGTCTGGTGCATGAT
TTTATCTATCAGGGCGTGCTGAGCGTGCTACAACAGCAACTGGAAACGCCGCTACCGCTGGACGATGAACCCCAACCTGC
ACCGCGTTCCATTCCGGAAAACCGCGTGGCGGCGGGGCGCAATCACTTTGCAGAACCGGCAGCTCGTGAGCCGGTAGCTC
CGCGCTACACTCCTGCGCCAGCATCAGGCAGTCGTCCGGCTGCCCCCTGGCCGAATGCGCAGCCAGGCTACCAGAAACAG
CAAGGTGAAGTGTATCGCCAGCTTTTGCAAACGCCCGCGCCGATGCAAAAACCAAAAGCGCCGGAACCGCAGGAACCTGC
ACTTGCGGCGAACAGTCAGAGTTTTGGTCGGGTACTGACTATCGTCCATTCCGACTGTGCGTTGCTGGAGCGCGATGGCA
ACATTTCACTTTTATCCTTGCCAGTGGCAGAACGTTGGCTACGTCAGGCACAATTGACGCCGGGTGAAGCGCCCGTTTGC
GCCCAGCCGCTGCTGATTCCGTTGCGGCTAAAAGTTTCTGCCGAAGAAAAATCGGCATTAGAAAAAGCGCAGTCTGCCCT
GGCGGAATTGGGTATTGATTTCCAGTCAGATGCACAGCATGTGACCATCAGGGCCGTGCCTTTACCCTTACGCCAACAAA
ATTTACAAATCTTGATTCCTGAACTGATAGGCTACCTGGCGAAGCAGTCCGTATTCGAACCTGGCAATATTGCGCAGTGG
ATTGCACGAAATCTGATGAGCGAACATGCGCAGTGGTCAATGGCACAGGCCATAACCCTGCTGGCGGACGTGGAACGGTT
ATGTCCGCAACTTGTGAAAACGCCGCCGGGTGGTCTGTTACAATCTGTTGATTTACATCCGGCGATAAAAGCCCTGAAAG
ATGAGTGA

Upstream 100 bases:

>100_bases
CCTTGCGCATCCGATGCAATCTGCGCCGCAGGGGGCAACGGCACAAACGGCCAGTACGGTGACGACGCCAGATCGCACGC
TGCCAAACTAAGGACGATTG

Downstream 100 bases:

>100_bases
TATCAGTAAGGCGAGCCTGCCTAAGGCGATTTTTTTGATGGGGCCGACGGCCTCCGGTAAAACGGCGTTAGCCATTGAGC
TGCGTAAAATTTTACCAGTA

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 615; Mature: 614

Protein sequence:

>615_residues
MPIQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDIERGGAKLIRIRDNGCGIKKDELALALARHATSKI
ASLDDLEAIISLGFRGEALASISSVSRLTLTSRTAEQQEAWQAYAEGRDMNVTVKPAAHPVGTTLEVLDLFYNTPARRKF
LRTEKTEFNHIDEIIRRIALARFDVTINLSHNGKIVRQYRAVPEGGQKERRLGAICGTAFLEQALAIEWQHGDLTLRGWV
ADPNHTTPALAEIQYCYVNGRMMRDRLINHAIRQACEDKLGADQQPAFVLYLEIDPHQVDVNVHPAKHEVRFHQSRLVHD
FIYQGVLSVLQQQLETPLPLDDEPQPAPRSIPENRVAAGRNHFAEPAAREPVAPRYTPAPASGSRPAAPWPNAQPGYQKQ
QGEVYRQLLQTPAPMQKPKAPEPQEPALAANSQSFGRVLTIVHSDCALLERDGNISLLSLPVAERWLRQAQLTPGEAPVC
AQPLLIPLRLKVSAEEKSALEKAQSALAELGIDFQSDAQHVTIRAVPLPLRQQNLQILIPELIGYLAKQSVFEPGNIAQW
IARNLMSEHAQWSMAQAITLLADVERLCPQLVKTPPGGLLQSVDLHPAIKALKDE

Sequences:

>Translated_615_residues
MPIQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDIERGGAKLIRIRDNGCGIKKDELALALARHATSKI
ASLDDLEAIISLGFRGEALASISSVSRLTLTSRTAEQQEAWQAYAEGRDMNVTVKPAAHPVGTTLEVLDLFYNTPARRKF
LRTEKTEFNHIDEIIRRIALARFDVTINLSHNGKIVRQYRAVPEGGQKERRLGAICGTAFLEQALAIEWQHGDLTLRGWV
ADPNHTTPALAEIQYCYVNGRMMRDRLINHAIRQACEDKLGADQQPAFVLYLEIDPHQVDVNVHPAKHEVRFHQSRLVHD
FIYQGVLSVLQQQLETPLPLDDEPQPAPRSIPENRVAAGRNHFAEPAAREPVAPRYTPAPASGSRPAAPWPNAQPGYQKQ
QGEVYRQLLQTPAPMQKPKAPEPQEPALAANSQSFGRVLTIVHSDCALLERDGNISLLSLPVAERWLRQAQLTPGEAPVC
AQPLLIPLRLKVSAEEKSALEKAQSALAELGIDFQSDAQHVTIRAVPLPLRQQNLQILIPELIGYLAKQSVFEPGNIAQW
IARNLMSEHAQWSMAQAITLLADVERLCPQLVKTPPGGLLQSVDLHPAIKALKDE
>Mature_614_residues
PIQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDIERGGAKLIRIRDNGCGIKKDELALALARHATSKIA
SLDDLEAIISLGFRGEALASISSVSRLTLTSRTAEQQEAWQAYAEGRDMNVTVKPAAHPVGTTLEVLDLFYNTPARRKFL
RTEKTEFNHIDEIIRRIALARFDVTINLSHNGKIVRQYRAVPEGGQKERRLGAICGTAFLEQALAIEWQHGDLTLRGWVA
DPNHTTPALAEIQYCYVNGRMMRDRLINHAIRQACEDKLGADQQPAFVLYLEIDPHQVDVNVHPAKHEVRFHQSRLVHDF
IYQGVLSVLQQQLETPLPLDDEPQPAPRSIPENRVAAGRNHFAEPAAREPVAPRYTPAPASGSRPAAPWPNAQPGYQKQQ
GEVYRQLLQTPAPMQKPKAPEPQEPALAANSQSFGRVLTIVHSDCALLERDGNISLLSLPVAERWLRQAQLTPGEAPVCA
QPLLIPLRLKVSAEEKSALEKAQSALAELGIDFQSDAQHVTIRAVPLPLRQQNLQILIPELIGYLAKQSVFEPGNIAQWI
ARNLMSEHAQWSMAQAITLLADVERLCPQLVKTPPGGLLQSVDLHPAIKALKDE

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=339, Percent_Identity=35.9882005899705, Blast_Score=214, Evalue=2e-55,
Organism=Homo sapiens, GI4505911, Length=318, Percent_Identity=31.7610062893082, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI189458898, Length=364, Percent_Identity=29.9450549450549, Blast_Score=155, Evalue=2e-37,
Organism=Homo sapiens, GI189458896, Length=313, Percent_Identity=30.6709265175719, Blast_Score=135, Evalue=9e-32,
Organism=Homo sapiens, GI4505913, Length=333, Percent_Identity=26.7267267267267, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI310128478, Length=333, Percent_Identity=27.027027027027, Blast_Score=128, Evalue=2e-29,
Organism=Homo sapiens, GI263191589, Length=245, Percent_Identity=31.0204081632653, Blast_Score=117, Evalue=4e-26,
Organism=Homo sapiens, GI91992160, Length=358, Percent_Identity=23.7430167597765, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI91992162, Length=358, Percent_Identity=23.7430167597765, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI310128480, Length=295, Percent_Identity=23.3898305084746, Blast_Score=89, Evalue=1e-17,
Organism=Escherichia coli, GI1790612, Length=615, Percent_Identity=99.8373983739837, Blast_Score=1247, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71991825, Length=326, Percent_Identity=36.8098159509202, Blast_Score=191, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17562796, Length=344, Percent_Identity=25.8720930232558, Blast_Score=122, Evalue=7e-28,
Organism=Saccharomyces cerevisiae, GI6323819, Length=340, Percent_Identity=35, Blast_Score=186, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6324247, Length=361, Percent_Identity=29.0858725761773, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6325093, Length=290, Percent_Identity=25.1724137931034, Blast_Score=97, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6323063, Length=215, Percent_Identity=30.6976744186047, Blast_Score=87, Evalue=9e-18,
Organism=Drosophila melanogaster, GI17136968, Length=329, Percent_Identity=34.6504559270517, Blast_Score=188, Evalue=9e-48,
Organism=Drosophila melanogaster, GI17136970, Length=357, Percent_Identity=26.3305322128852, Blast_Score=107, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 67908; Mature: 67777

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDIERGGAKLIRIRDNG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCEEEEEEECCC
CGIKKDELALALARHATSKIASLDDLEAIISLGFRGEALASISSVSRLTLTSRTAEQQEA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
WQAYAEGRDMNVTVKPAAHPVGTTLEVLDLFYNTPARRKFLRTEKTEFNHIDEIIRRIAL
HHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHH
ARFDVTINLSHNGKIVRQYRAVPEGGQKERRLGAICGTAFLEQALAIEWQHGDLTLRGWV
HHEEEEEEECCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHEEEEECCCEEEEEEE
ADPNHTTPALAEIQYCYVNGRMMRDRLINHAIRQACEDKLGADQQPAFVLYLEIDPHQVD
CCCCCCCCHHHHEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEE
VNVHPAKHEVRFHQSRLVHDFIYQGVLSVLQQQLETPLPLDDEPQPAPRSIPENRVAAGR
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHCCC
NHFAEPAAREPVAPRYTPAPASGSRPAAPWPNAQPGYQKQQGEVYRQLLQTPAPMQKPKA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCC
PEPQEPALAANSQSFGRVLTIVHSDCALLERDGNISLLSLPVAERWLRQAQLTPGEAPVC
CCCCCCCCCCCCCCHHHEEEHHCCCHHEEECCCCEEEEECHHHHHHHHHHCCCCCCCCCC
AQPLLIPLRLKVSAEEKSALEKAQSALAELGIDFQSDAQHVTIRAVPLPLRQQNLQILIP
CCCCEEEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCEEEHH
ELIGYLAKQSVFEPGNIAQWIARNLMSEHAQWSMAQAITLLADVERLCPQLVKTPPGGLL
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
QSVDLHPAIKALKDE
HCCCCCHHHHHHCCC
>Mature Secondary Structure 
PIQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDIERGGAKLIRIRDNG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCEEEEEEECCC
CGIKKDELALALARHATSKIASLDDLEAIISLGFRGEALASISSVSRLTLTSRTAEQQEA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
WQAYAEGRDMNVTVKPAAHPVGTTLEVLDLFYNTPARRKFLRTEKTEFNHIDEIIRRIAL
HHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHH
ARFDVTINLSHNGKIVRQYRAVPEGGQKERRLGAICGTAFLEQALAIEWQHGDLTLRGWV
HHEEEEEEECCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHEEEEECCCEEEEEEE
ADPNHTTPALAEIQYCYVNGRMMRDRLINHAIRQACEDKLGADQQPAFVLYLEIDPHQVD
CCCCCCCCHHHHEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEE
VNVHPAKHEVRFHQSRLVHDFIYQGVLSVLQQQLETPLPLDDEPQPAPRSIPENRVAAGR
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHCCC
NHFAEPAAREPVAPRYTPAPASGSRPAAPWPNAQPGYQKQQGEVYRQLLQTPAPMQKPKA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCC
PEPQEPALAANSQSFGRVLTIVHSDCALLERDGNISLLSLPVAERWLRQAQLTPGEAPVC
CCCCCCCCCCCCCCHHHEEEHHCCCHHEEECCCCEEEEECHHHHHHHHHHCCCCCCCCCC
AQPLLIPLRLKVSAEEKSALEKAQSALAELGIDFQSDAQHVTIRAVPLPLRQQNLQILIP
CCCCEEEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCEEEHH
ELIGYLAKQSVFEPGNIAQWIARNLMSEHAQWSMAQAITLLADVERLCPQLVKTPPGGLL
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
QSVDLHPAIKALKDE
HCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA