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The map label for this gene is ubiA [H]

Identifier: 157163509

GI number: 157163509

Start: 4284760

End: 4285632

Strand: Direct

Name: ubiA [H]

Synonym: EcHS_A4280

Alternate gene names: 157163509

Gene position: 4284760-4285632 (Clockwise)

Preceding gene: 157163508

Following gene: 157163511

Centisome position: 92.27

GC content: 50.97

Gene sequence:

>873_bases
ATGGAGTGGAGTCTGACGCAGAATAAGCTGCTGGCGTTTCATCGCTTAATGCGTACGGATAAGCCAATTGGCGCGTTACT
GCTGCTCTGGCCAACATTATGGGCGTTGTGGGTGGCGACACCGGGCGTTCCTCAGCTCTGGATCCTGGCGGTATTTGTCG
CGGGTGTCTGGCTGATGCGCGCTGCTGGATGTGTGGTGAATGATTATGCTGACCGAAAGTTTGATGGTCATGTTAAGCGC
ACGGCGAACCGACCACTTCCCAGCGGCGCGGTAACAGAGAAAGAGGCGCGCGCACTGTTTGTAGTGCTGGTACTGATTTC
GTTTTTACTGGTACTGACGCTGAATACGATGACCATTCTGTTGTCGATTGCCGCTCTGGCGTTGGCGTGGGTGTACCCGT
TTATGAAGCGGTATACCCATCTCCCGCAAGTGGTGCTGGGCGCGGCGTTTGGCTGGTCGATTCCAATGGCTTTTGCCGCT
GTGAGTGAGTCGGTGCCATTGAGTTGCTGGTTAATGTTCCTCGCCAATATTCTCTGGGCGGTGGCTTACGACACGCAGTA
TGCGATGGTTGACCGCGATGATGATGTGAAGATTGGCATTAAATCCACGGCAATCCTGTTCGGCCAATACGATAAATTGA
TTATTGGTATTTTGCAGATTGGCGTACTGGCACTGATGGCGATCATCGGTGAGTTAAATGGCTTAGGCTGGGGATATTAC
TGGTCAATTGTGGTGGCTGGCGCGCTGTTTGTTTATCAACAAAAACTGATTGCCAACCGCGAGCGTGAAGCCTGCTTTAA
AGCATTTATGAATAATAACTATGTTGGTCTGGTACTATTTTTAGGGCTGGCAATGAGTTACTGGCATTTCTGA

Upstream 100 bases:

>100_bases
ACTGTGGGGGCGACGTTCCCGCCTGCGATTAAGCGGTAAACCGCTGTTGCTAACAGAACTGTTTTTACCGGCGTCACCGT
TGTACTAAGAGGAAAAAAAT

Downstream 100 bases:

>100_bases
TGATGTAAAAAAGCCGGATGATCATCCGGCTTTCTTCTGGGTTGCCTGATGCGCGGCGCTTCTCAGGCCTACACAACACA
TCGCAATTTATTGAATTTGC

Product: 4-hydroxybenzoate octaprenyltransferase

Products: NA

Alternate protein names: 4-HB polyprenyltransferase [H]

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MEWSLTQNKLLAFHRLMRTDKPIGALLLLWPTLWALWVATPGVPQLWILAVFVAGVWLMRAAGCVVNDYADRKFDGHVKR
TANRPLPSGAVTEKEARALFVVLVLISFLLVLTLNTMTILLSIAALALAWVYPFMKRYTHLPQVVLGAAFGWSIPMAFAA
VSESVPLSCWLMFLANILWAVAYDTQYAMVDRDDDVKIGIKSTAILFGQYDKLIIGILQIGVLALMAIIGELNGLGWGYY
WSIVVAGALFVYQQKLIANREREACFKAFMNNNYVGLVLFLGLAMSYWHF

Sequences:

>Translated_290_residues
MEWSLTQNKLLAFHRLMRTDKPIGALLLLWPTLWALWVATPGVPQLWILAVFVAGVWLMRAAGCVVNDYADRKFDGHVKR
TANRPLPSGAVTEKEARALFVVLVLISFLLVLTLNTMTILLSIAALALAWVYPFMKRYTHLPQVVLGAAFGWSIPMAFAA
VSESVPLSCWLMFLANILWAVAYDTQYAMVDRDDDVKIGIKSTAILFGQYDKLIIGILQIGVLALMAIIGELNGLGWGYY
WSIVVAGALFVYQQKLIANREREACFKAFMNNNYVGLVLFLGLAMSYWHF
>Mature_290_residues
MEWSLTQNKLLAFHRLMRTDKPIGALLLLWPTLWALWVATPGVPQLWILAVFVAGVWLMRAAGCVVNDYADRKFDGHVKR
TANRPLPSGAVTEKEARALFVVLVLISFLLVLTLNTMTILLSIAALALAWVYPFMKRYTHLPQVVLGAAFGWSIPMAFAA
VSESVPLSCWLMFLANILWAVAYDTQYAMVDRDDDVKIGIKSTAILFGQYDKLIIGILQIGVLALMAIIGELNGLGWGYY
WSIVVAGALFVYQQKLIANREREACFKAFMNNNYVGLVLFLGLAMSYWHF

Specific function: Synthesis of 3-octaprenyl-4-hydroxybenzoate [H]

COG id: COG0382

COG function: function code H; 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI260656052, Length=282, Percent_Identity=34.3971631205674, Blast_Score=175, Evalue=4e-44,
Organism=Escherichia coli, GI1790473, Length=290, Percent_Identity=99.6551724137931, Blast_Score=583, Evalue=1e-168,
Organism=Caenorhabditis elegans, GI32565247, Length=281, Percent_Identity=37.0106761565836, Blast_Score=177, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI17553718, Length=284, Percent_Identity=36.9718309859155, Blast_Score=176, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17553720, Length=183, Percent_Identity=42.0765027322404, Blast_Score=130, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI32565245, Length=141, Percent_Identity=44.6808510638298, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI32565243, Length=140, Percent_Identity=44.2857142857143, Blast_Score=110, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6324370, Length=300, Percent_Identity=32, Blast_Score=144, Evalue=2e-35,
Organism=Drosophila melanogaster, GI21355567, Length=276, Percent_Identity=37.3188405797101, Blast_Score=181, Evalue=7e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006370
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: 2.5.1.-

Molecular weight: Translated: 32498; Mature: 32498

Theoretical pI: Translated: 9.24; Mature: 9.24

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEWSLTQNKLLAFHRLMRTDKPIGALLLLWPTLWALWVATPGVPQLWILAVFVAGVWLMR
CCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
AAGCVVNDYADRKFDGHVKRTANRPLPSGAVTEKEARALFVVLVLISFLLVLTLNTMTIL
HCCHHHHHHHCCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSIAALALAWVYPFMKRYTHLPQVVLGAAFGWSIPMAFAAVSESVPLSCWLMFLANILWA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
VAYDTQYAMVDRDDDVKIGIKSTAILFGQYDKLIIGILQIGVLALMAIIGELNGLGWGYY
HHHCCEEEEECCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
WSIVVAGALFVYQQKLIANREREACFKAFMNNNYVGLVLFLGLAMSYWHF
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEWSLTQNKLLAFHRLMRTDKPIGALLLLWPTLWALWVATPGVPQLWILAVFVAGVWLMR
CCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
AAGCVVNDYADRKFDGHVKRTANRPLPSGAVTEKEARALFVVLVLISFLLVLTLNTMTIL
HCCHHHHHHHCCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSIAALALAWVYPFMKRYTHLPQVVLGAAFGWSIPMAFAAVSESVPLSCWLMFLANILWA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
VAYDTQYAMVDRDDDVKIGIKSTAILFGQYDKLIIGILQIGVLALMAIIGELNGLGWGYY
HHHCCEEEEECCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
WSIVVAGALFVYQQKLIANREREACFKAFMNNNYVGLVLFLGLAMSYWHF
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA