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The map label for this gene is aaeA [H]

Identifier: 157162719

GI number: 157162719

Start: 3431782

End: 3432714

Strand: Reverse

Name: aaeA [H]

Synonym: EcHS_A3430

Alternate gene names: 157162719

Gene position: 3432714-3431782 (Counterclockwise)

Preceding gene: 229220673

Following gene: 157162718

Centisome position: 73.92

GC content: 53.59

Gene sequence:

>933_bases
GTGAAAACACTAATAAGAAAATTCTCCCGTACGGCCATCACGGTCGTATTAGTCATTCTGGCCTTCATCGCAATTTTTAA
TGCCTGGGTCTATTACACCGAATCCCCGTGGACGCGTGACGCGCGCTTTAGCGCTGATGTCGTTGCGATCGCGCCGGACG
TTTCTGGACTCATTACCCAGGTGAATGTTCATGATAACCAGCTGGTGAAAAAAGGACAGGTACTGTTCACCATCGACCAG
CCGCGCTATCAAAAGGCGCTTGAGGAAGCGCAAGCCGATGTTGCTTATTATCAGGTACTGGCACAGGAGAAACGCCAGGA
GGCCGGACGTCGTAATCGTCTCGGTGTGCAGGCGATGTCTCGCGAAGAGATCGACCAGGCCAACAACGTACTACAAACGG
TTCTGCATCAGTTAGCGAAAGCGCAGGCGACCCGCGATCTGGCAAAACTGGATCTTGAACGCACGGTGATCCGCGCGCCA
GTGGATGGCTGGGTGACCAACCTCAACGTCTATACCGGTGAGTTTATTACTCGTGGATCAACGGCGGTTGCGCTGGTGAA
ACAGAACTCTTTCTATGTACTGGCCTATATGGAAGAAACTAAGCTGGAAGGGGTGCGCCCTGGGTATCGTGCAGAGATCA
CGCCGCTTGGCAGTAACAAAGTGCTGAAAGGGACTGTTGATAGTGTTGCCGCTGGGGTCACCAACGCCAGCAGCACGCGT
GACGACAAAGGGATGGCGACCATCGACTCTAACCTTGAATGGGTGCGTTTGGCGCAACGTGTTCCGGTTCGTATTCGTCT
CGACAACCAGCAAGAGAACATCTGGCCTGCGGGCACCACTGCTACAGTGGTGGTCACTGGCAAACAAGATCGCGACGAAA
GCCAGGATTCGTTCTTCCGTAAAATGGCCCATCGCCTGCGTGAGTTTGGTTAA

Upstream 100 bases:

>100_bases
ACAGGTATCTACGACTTTGTCTGGCATCCGGCGTTGTTCAACACCGCGCTCTATTGCTGCTTGTTTTATTTGATATCGCG
ACTGTTCGTTTGAGGTTGAA

Downstream 100 bases:

>100_bases
TCACGATGGGTATTTTCTCCATTGCTAACCAACATATTCGCTTTGCGGTAAAACTGGCGACCGCCATTGTACTGGCGCTG
TTTGTTGGCTTTCACTTCCA

Product: p-hydroxybenzoic acid efflux subunit AaeA

Products: NA

Alternate protein names: pHBA efflux pump protein A [H]

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MKTLIRKFSRTAITVVLVILAFIAIFNAWVYYTESPWTRDARFSADVVAIAPDVSGLITQVNVHDNQLVKKGQVLFTIDQ
PRYQKALEEAQADVAYYQVLAQEKRQEAGRRNRLGVQAMSREEIDQANNVLQTVLHQLAKAQATRDLAKLDLERTVIRAP
VDGWVTNLNVYTGEFITRGSTAVALVKQNSFYVLAYMEETKLEGVRPGYRAEITPLGSNKVLKGTVDSVAAGVTNASSTR
DDKGMATIDSNLEWVRLAQRVPVRIRLDNQQENIWPAGTTATVVVTGKQDRDESQDSFFRKMAHRLREFG

Sequences:

>Translated_310_residues
MKTLIRKFSRTAITVVLVILAFIAIFNAWVYYTESPWTRDARFSADVVAIAPDVSGLITQVNVHDNQLVKKGQVLFTIDQ
PRYQKALEEAQADVAYYQVLAQEKRQEAGRRNRLGVQAMSREEIDQANNVLQTVLHQLAKAQATRDLAKLDLERTVIRAP
VDGWVTNLNVYTGEFITRGSTAVALVKQNSFYVLAYMEETKLEGVRPGYRAEITPLGSNKVLKGTVDSVAAGVTNASSTR
DDKGMATIDSNLEWVRLAQRVPVRIRLDNQQENIWPAGTTATVVVTGKQDRDESQDSFFRKMAHRLREFG
>Mature_310_residues
MKTLIRKFSRTAITVVLVILAFIAIFNAWVYYTESPWTRDARFSADVVAIAPDVSGLITQVNVHDNQLVKKGQVLFTIDQ
PRYQKALEEAQADVAYYQVLAQEKRQEAGRRNRLGVQAMSREEIDQANNVLQTVLHQLAKAQATRDLAKLDLERTVIRAP
VDGWVTNLNVYTGEFITRGSTAVALVKQNSFYVLAYMEETKLEGVRPGYRAEITPLGSNKVLKGTVDSVAAGVTNASSTR
DDKGMATIDSNLEWVRLAQRVPVRIRLDNQQENIWPAGTTATVVVTGKQDRDESQDSFFRKMAHRLREFG

Specific function: Unknown

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789637, Length=310, Percent_Identity=99.3548387096774, Blast_Score=631, Evalue=0.0,
Organism=Escherichia coli, GI87081951, Length=282, Percent_Identity=41.1347517730496, Blast_Score=203, Evalue=1e-53,
Organism=Escherichia coli, GI1790519, Length=301, Percent_Identity=29.2358803986711, Blast_Score=110, Evalue=8e-26,
Organism=Escherichia coli, GI1788711, Length=310, Percent_Identity=26.1290322580645, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1789041, Length=288, Percent_Identity=26.3888888888889, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022871
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 34789; Mature: 34789

Theoretical pI: Translated: 9.75; Mature: 9.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTLIRKFSRTAITVVLVILAFIAIFNAWVYYTESPWTRDARFSADVVAIAPDVSGLITQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCEEEECCCCCCEEEE
VNVHDNQLVKKGQVLFTIDQPRYQKALEEAQADVAYYQVLAQEKRQEAGRRNRLGVQAMS
EECCCHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
REEIDQANNVLQTVLHQLAKAQATRDLAKLDLERTVIRAPVDGWVTNLNVYTGEFITRGS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEEEEECCEEECCC
TAVALVKQNSFYVLAYMEETKLEGVRPGYRAEITPLGSNKVLKGTVDSVAAGVTNASSTR
EEEEEEECCCEEEEEEEECCCCCCCCCCCCEEEEECCCCCEEECCHHHHHHCCCCCCCCC
DDKGMATIDSNLEWVRLAQRVPVRIRLDNQQENIWPAGTTATVVVTGKQDRDESQDSFFR
CCCCCEEECCCHHHHHHHHHCCEEEEECCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHH
KMAHRLREFG
HHHHHHHHCC
>Mature Secondary Structure
MKTLIRKFSRTAITVVLVILAFIAIFNAWVYYTESPWTRDARFSADVVAIAPDVSGLITQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCEEEECCCCCCEEEE
VNVHDNQLVKKGQVLFTIDQPRYQKALEEAQADVAYYQVLAQEKRQEAGRRNRLGVQAMS
EECCCHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
REEIDQANNVLQTVLHQLAKAQATRDLAKLDLERTVIRAPVDGWVTNLNVYTGEFITRGS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEEEEECCEEECCC
TAVALVKQNSFYVLAYMEETKLEGVRPGYRAEITPLGSNKVLKGTVDSVAAGVTNASSTR
EEEEEEECCCEEEEEEEECCCCCCCCCCCCEEEEECCCCCEEECCHHHHHHCCCCCCCCC
DDKGMATIDSNLEWVRLAQRVPVRIRLDNQQENIWPAGTTATVVVTGKQDRDESQDSFFR
CCCCCEEECCCHHHHHHHHHCCEEEEECCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHH
KMAHRLREFG
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA