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The map label for this gene is ttdT [H]

Identifier: 157162539

GI number: 157162539

Start: 3251470

End: 3252933

Strand: Direct

Name: ttdT [H]

Synonym: EcHS_A3243

Alternate gene names: 157162539

Gene position: 3251470-3252933 (Clockwise)

Preceding gene: 157162538

Following gene: 157162541

Centisome position: 70.02

GC content: 54.71

Gene sequence:

>1464_bases
ATGAAACCTTCCACTGAATGGTGGCGATACCTTGCGCCGCTGGCGGTCATCGCCATTATTGCTCTAATTCCGGTTCCCGC
AGGGCTGGAGAGTCATACCTGGCTTTACTTTGCCGTTTTTACTGGCGTGATCGTTGGACTGATCCTCGAACCCGTGCCGG
GTGCCGTGGTGGCGATGGTGGGTATATCCATCATCGCCATACTCTCTCCCTGGCTGCTGTTCAGCCCGGAGCAGCTCGCT
CAGCCAGGCTTTAAATTCACTGCAAAATCCCTCTCGTGGGCCGTTTCCGGTTTTTCTAATTCGGTTATCTGGCTGATTTT
CGCCGCCTTTATGTTTGGCACAGGCTATGAAAAAACCGGGCTTGGACGCCGCATTGCGCTGATTCTGGTGAAAAAGATGG
GGCATCGTACGCTGTTTCTCGGCTATGCGGTGATGTTCTCCGAGCTGATCCTGGCACCTGTAACACCGTCCAACTCGGCG
CGTGGTGCGGGGATTATCTATCCCATCATCCGTAACCTGCCACCGCTCTATCAATCACAACCAAACGACAGCAGTTCACG
CAGCATTGGCTCGTACATCATGTGGATGGGGATTGTTGCCGACTGCGTGACCAGCGCCATTTTCCTGACGGCGATGGCAC
CAAACTTGCTGTTAATTGGACTGATGAAAAGTGCATCTCACGCCACGCTGAGTTGGGGCGACTGGTTCCTCGGGATGTTG
CCGCTCAGCATTTTACTGGTTCTGCTGGTTCCCTGGATGGCTTACGTGCTGTACCCACCGGTACTGAAGTCTGGTGATCA
GGTGCCGCGCTGGGCAGAGACGGAACTGCAGGCAATGGGCCCGCTCTGTTCTCGTGAAAAACGGATGCTGGGGCTGATGG
TAGGCGCGCTGGTGCTGTGGATTTTCGGCGGTGATTATATTGATGCTGCGATGGTTGGTTACAGCGTAGTGGCACTGATG
CTGCTTCTGCGCATTATCTGCTGGGACGACATTGTCAGTAATAAAGCGGCGTGGAACGTTTTCTTCTGGCTGGCCTCGCT
TATCACCCTCGCTACCGGACTCAACAACACCGGTTTTATTAGCTGGTTTGGCAAACTGTTAGCAGGCAGCTTAAGTGGTT
ATTCGCCGACGATGGTGATGGTGGCATTGATTGTGGTGTTTTATCTACTGCGCTACTTTTTCGCCAGCGCCACGGCGTAT
ACCTCCGCCCTCGCACCGATGATGATCGCCGCCGCGCTGGCGATGCCGGAAATCCCGCTGCCGGTGTTCTGCCTGATGGT
TGGCGCGGCAATTGGTCTGGGGAGCATTCTTACACCATACGCCACCGGACCCAGTCCGATTTACTACGGTAGTGGTTATC
TGCCAACGGCGGATTACTGGCGACTGGGGGCGATTTTTGGGCTGATATTCCTCGTATTGCTGGTGATTACCGGCTTACTG
TGGATGCCCGTGGTGTTGCTTTAA

Upstream 100 bases:

>100_bases
CCGCGATCCCATCGTGGAAGAGATCTGCGAGCACGTCCATTACATCAAATAACCCTCCCGGAGAGGCTCACCCCCTCTCC
TTTTTCGCAGGCATAACACG

Downstream 100 bases:

>100_bases
GTAAGGACGGTGCCGGAAATTGCTCTCCGGCACCCGATAGTTTTACGCGGCCGGTAACTCCGCCAGCGGCCAGCGCGGAC
GCACGCTAACGCCGAGATCC

Product: anion transporter

Products: tartrate [Cytoplasm]; succinate [Periplasm] [C]

Alternate protein names: Tartrate carrier; Tartrate transporter [H]

Number of amino acids: Translated: 487; Mature: 487

Protein sequence:

>487_residues
MKPSTEWWRYLAPLAVIAIIALIPVPAGLESHTWLYFAVFTGVIVGLILEPVPGAVVAMVGISIIAILSPWLLFSPEQLA
QPGFKFTAKSLSWAVSGFSNSVIWLIFAAFMFGTGYEKTGLGRRIALILVKKMGHRTLFLGYAVMFSELILAPVTPSNSA
RGAGIIYPIIRNLPPLYQSQPNDSSSRSIGSYIMWMGIVADCVTSAIFLTAMAPNLLLIGLMKSASHATLSWGDWFLGML
PLSILLVLLVPWMAYVLYPPVLKSGDQVPRWAETELQAMGPLCSREKRMLGLMVGALVLWIFGGDYIDAAMVGYSVVALM
LLLRIICWDDIVSNKAAWNVFFWLASLITLATGLNNTGFISWFGKLLAGSLSGYSPTMVMVALIVVFYLLRYFFASATAY
TSALAPMMIAAALAMPEIPLPVFCLMVGAAIGLGSILTPYATGPSPIYYGSGYLPTADYWRLGAIFGLIFLVLLVITGLL
WMPVVLL

Sequences:

>Translated_487_residues
MKPSTEWWRYLAPLAVIAIIALIPVPAGLESHTWLYFAVFTGVIVGLILEPVPGAVVAMVGISIIAILSPWLLFSPEQLA
QPGFKFTAKSLSWAVSGFSNSVIWLIFAAFMFGTGYEKTGLGRRIALILVKKMGHRTLFLGYAVMFSELILAPVTPSNSA
RGAGIIYPIIRNLPPLYQSQPNDSSSRSIGSYIMWMGIVADCVTSAIFLTAMAPNLLLIGLMKSASHATLSWGDWFLGML
PLSILLVLLVPWMAYVLYPPVLKSGDQVPRWAETELQAMGPLCSREKRMLGLMVGALVLWIFGGDYIDAAMVGYSVVALM
LLLRIICWDDIVSNKAAWNVFFWLASLITLATGLNNTGFISWFGKLLAGSLSGYSPTMVMVALIVVFYLLRYFFASATAY
TSALAPMMIAAALAMPEIPLPVFCLMVGAAIGLGSILTPYATGPSPIYYGSGYLPTADYWRLGAIFGLIFLVLLVITGLL
WMPVVLL
>Mature_487_residues
MKPSTEWWRYLAPLAVIAIIALIPVPAGLESHTWLYFAVFTGVIVGLILEPVPGAVVAMVGISIIAILSPWLLFSPEQLA
QPGFKFTAKSLSWAVSGFSNSVIWLIFAAFMFGTGYEKTGLGRRIALILVKKMGHRTLFLGYAVMFSELILAPVTPSNSA
RGAGIIYPIIRNLPPLYQSQPNDSSSRSIGSYIMWMGIVADCVTSAIFLTAMAPNLLLIGLMKSASHATLSWGDWFLGML
PLSILLVLLVPWMAYVLYPPVLKSGDQVPRWAETELQAMGPLCSREKRMLGLMVGALVLWIFGGDYIDAAMVGYSVVALM
LLLRIICWDDIVSNKAAWNVFFWLASLITLATGLNNTGFISWFGKLLAGSLSGYSPTMVMVALIVVFYLLRYFFASATAY
TSALAPMMIAAALAMPEIPLPVFCLMVGAAIGLGSILTPYATGPSPIYYGSGYLPTADYWRLGAIFGLIFLVLLVITGLL
WMPVVLL

Specific function: Catalyzes the uptake of tartrate in exchange for intracellular succinate. Essential for anaerobic L-tartrate fermentation [H]

COG id: COG0471

COG function: function code P; Di- and tricarboxylate transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SLC13A transporter (TC 2.A.47) family. SODIT1 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789444, Length=487, Percent_Identity=99.1786447638604, Blast_Score=946, Evalue=0.0,
Organism=Escherichia coli, GI1786829, Length=471, Percent_Identity=44.7983014861996, Blast_Score=453, Evalue=1e-128,
Organism=Escherichia coli, GI1786986, Length=480, Percent_Identity=34.1666666666667, Blast_Score=265, Evalue=6e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001898 [H]

Pfam domain/function: PF00939 Na_sulph_symp [H]

EC number: NA

Molecular weight: Translated: 52914; Mature: 52914

Theoretical pI: Translated: 8.93; Mature: 8.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPSTEWWRYLAPLAVIAIIALIPVPAGLESHTWLYFAVFTGVIVGLILEPVPGAVVAMV
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHH
GISIIAILSPWLLFSPEQLAQPGFKFTAKSLSWAVSGFSNSVIWLIFAAFMFGTGYEKTG
HHHHHHHHHHHHHCCCHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCC
LGRRIALILVKKMGHRTLFLGYAVMFSELILAPVTPSNSARGAGIIYPIIRNLPPLYQSQ
CCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCCCCCC
PNDSSSRSIGSYIMWMGIVADCVTSAIFLTAMAPNLLLIGLMKSASHATLSWGDWFLGML
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECHHHHHHHHH
PLSILLVLLVPWMAYVLYPPVLKSGDQVPRWAETELQAMGPLCSREKRMLGLMVGALVLW
HHHHHHHHHHHHHHHHHCCHHHCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
IFGGDYIDAAMVGYSVVALMLLLRIICWDDIVSNKAAWNVFFWLASLITLATGLNNTGFI
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHH
SWFGKLLAGSLSGYSPTMVMVALIVVFYLLRYFFASATAYTSALAPMMIAAALAMPEIPL
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
PVFCLMVGAAIGLGSILTPYATGPSPIYYGSGYLPTADYWRLGAIFGLIFLVLLVITGLL
HHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
WMPVVLL
HHHHHHC
>Mature Secondary Structure
MKPSTEWWRYLAPLAVIAIIALIPVPAGLESHTWLYFAVFTGVIVGLILEPVPGAVVAMV
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHH
GISIIAILSPWLLFSPEQLAQPGFKFTAKSLSWAVSGFSNSVIWLIFAAFMFGTGYEKTG
HHHHHHHHHHHHHCCCHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCC
LGRRIALILVKKMGHRTLFLGYAVMFSELILAPVTPSNSARGAGIIYPIIRNLPPLYQSQ
CCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCCCCCC
PNDSSSRSIGSYIMWMGIVADCVTSAIFLTAMAPNLLLIGLMKSASHATLSWGDWFLGML
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECHHHHHHHHH
PLSILLVLLVPWMAYVLYPPVLKSGDQVPRWAETELQAMGPLCSREKRMLGLMVGALVLW
HHHHHHHHHHHHHHHHHCCHHHCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
IFGGDYIDAAMVGYSVVALMLLLRIICWDDIVSNKAAWNVFFWLASLITLATGLNNTGFI
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHH
SWFGKLLAGSLSGYSPTMVMVALIVVFYLLRYFFASATAYTSALAPMMIAAALAMPEIPL
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
PVFCLMVGAAIGLGSILTPYATGPSPIYYGSGYLPTADYWRLGAIFGLIFLVLLVITGLL
HHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
WMPVVLL
HHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: tartrate [Periplasm]; succinate [Cytoplasm] [C]

Specific reaction: tartrate [Periplasm] + succinate [Cytoplasm] = tartrate [Cytoplasm] + succinate [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]