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The map label for this gene is glcC

Identifier: 157162453

GI number: 157162453

Start: 3165906

End: 3166670

Strand: Direct

Name: glcC

Synonym: EcHS_A3153

Alternate gene names: 157162453

Gene position: 3165906-3166670 (Clockwise)

Preceding gene: 157162445

Following gene: 157162455

Centisome position: 68.18

GC content: 55.03

Gene sequence:

>765_bases
ATGAAAGATGAACGTCGCCCTATTTGCGAAGTGGTTGCAGAGAGTATCGAACGGTTAATTATCGACGGCGTACTGAAGGT
CGGTCAGCCGCTTCCCTCGGAACGTCGACTGTGTGAAAAGCTCGGCTTCTCACGCTCCGCACTGCGTGAAGGGCTGACCG
TGCTGCGCGGGCGCGGGATTATTGAAACGGCGCAGGGTCGCGATTCTCGTGTCGCACGGCTTAATCGGGTGCAGGACACC
AGCCCGCTGATCCATCTGTTCAGTACGCAGCCGCGAACGCTGTACGATCTGCTCGACGTTCGCGCATTACTGGAGGGCGA
ATCGGCAAGGCTGGCGGCAACGCTGGGAACGCAGGCTGATTTTGTTGTGATAACCCGCTGTTATGAAAAAATGCTCGCCG
CCAGTGAGAACAACAAAGAGATTTCGCTGATCGAACATGCGCAGTTGGATCACGCTTTCCATCTCGCCATTTGTCAGGCT
TCTCACAATCAGGTGCTGGTGTTTACGCTGCAATCATTGACCGATCTGATGTTTAATTCAGTGTTTGCCAGCGTAAATAA
TCTCTACCATCGACCACAGCAAAAAAAGCAGATCGATCGCCAGCATGCGCGGATCTACAACGCGGTGTTGCAGCGGCTGC
CGCACGTCGCCCAGCGCGCAGCACGCGATCATGTGCGGACCGTGAAAAAGAATCTCCACGATATCGAGCTGGAAGGCCAC
CATTTGATTCGCTCGGCGGTGCCGCTGGAGATGAACCTGAGTTAG

Upstream 100 bases:

>100_bases
ACTAAATGTTAAATTGATGTAACATAATCACTTACGTGATGTGCGTGTTTTGCGAGTTAAGAACAGAAAAATTGGTCCTA
CCTGTGCACGAGGTCCGGGA

Downstream 100 bases:

>100_bases
CTGGTATTAAATCTGCTTTTCATACAATCGGTAACGCTTGTACGGCTCCGCCCCAATGCGTTCCAGCATGTTATTCATGC
CTGTATTGGTTTCGAGGATC

Product: DNA-binding transcriptional regulator GlcC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 254; Mature: 254

Protein sequence:

>254_residues
MKDERRPICEVVAESIERLIIDGVLKVGQPLPSERRLCEKLGFSRSALREGLTVLRGRGIIETAQGRDSRVARLNRVQDT
SPLIHLFSTQPRTLYDLLDVRALLEGESARLAATLGTQADFVVITRCYEKMLAASENNKEISLIEHAQLDHAFHLAICQA
SHNQVLVFTLQSLTDLMFNSVFASVNNLYHRPQQKKQIDRQHARIYNAVLQRLPHVAQRAARDHVRTVKKNLHDIELEGH
HLIRSAVPLEMNLS

Sequences:

>Translated_254_residues
MKDERRPICEVVAESIERLIIDGVLKVGQPLPSERRLCEKLGFSRSALREGLTVLRGRGIIETAQGRDSRVARLNRVQDT
SPLIHLFSTQPRTLYDLLDVRALLEGESARLAATLGTQADFVVITRCYEKMLAASENNKEISLIEHAQLDHAFHLAICQA
SHNQVLVFTLQSLTDLMFNSVFASVNNLYHRPQQKKQIDRQHARIYNAVLQRLPHVAQRAARDHVRTVKKNLHDIELEGH
HLIRSAVPLEMNLS
>Mature_254_residues
MKDERRPICEVVAESIERLIIDGVLKVGQPLPSERRLCEKLGFSRSALREGLTVLRGRGIIETAQGRDSRVARLNRVQDT
SPLIHLFSTQPRTLYDLLDVRALLEGESARLAATLGTQADFVVITRCYEKMLAASENNKEISLIEHAQLDHAFHLAICQA
SHNQVLVFTLQSLTDLMFNSVFASVNNLYHRPQQKKQIDRQHARIYNAVLQRLPHVAQRAARDHVRTVKKNLHDIELEGH
HLIRSAVPLEMNLS

Specific function: Activator for the glycolate oxidation locus

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain

Homologues:

Organism=Escherichia coli, GI1789353, Length=254, Percent_Identity=100, Blast_Score=518, Evalue=1e-148,
Organism=Escherichia coli, GI1790032, Length=234, Percent_Identity=31.1965811965812, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1786303, Length=231, Percent_Identity=28.5714285714286, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1790780, Length=247, Percent_Identity=29.5546558704453, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI48994955, Length=228, Percent_Identity=27.1929824561404, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI87082208, Length=244, Percent_Identity=24.1803278688525, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1789621, Length=232, Percent_Identity=22.8448275862069, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLCC_ECOL6 (P0ACL6)

Other databases:

- EMBL:   AE014075
- RefSeq:   NP_755581.1
- ProteinModelPortal:   P0ACL6
- SMR:   P0ACL6
- EnsemblBacteria:   EBESCT00000042780
- GeneID:   1039754
- GenomeReviews:   AE014075_GR
- KEGG:   ecc:c3710
- GeneTree:   EBGT00050000009602
- HOGENOM:   HBG700007
- OMA:   NLYHREP
- ProtClustDB:   PRK09990
- GO:   GO:0005622
- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PRINTS:   PR00035
- SMART:   SM00895
- SMART:   SM00345

Pfam domain/function: PF07729 FCD; PF00392 GntR

EC number: NA

Molecular weight: Translated: 28827; Mature: 28827

Theoretical pI: Translated: 9.27; Mature: 9.27

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDERRPICEVVAESIERLIIDGVLKVGQPLPSERRLCEKLGFSRSALREGLTVLRGRGI
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCC
IETAQGRDSRVARLNRVQDTSPLIHLFSTQPRTLYDLLDVRALLEGESARLAATLGTQAD
EECCCCCHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHCCCCHHEEEECCCCCC
FVVITRCYEKMLAASENNKEISLIEHAQLDHAFHLAICQASHNQVLVFTLQSLTDLMFNS
HHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHEEECCCCEEEEEEHHHHHHHHHHH
VFASVNNLYHRPQQKKQIDRQHARIYNAVLQRLPHVAQRAARDHVRTVKKNLHDIELEGH
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCH
HLIRSAVPLEMNLS
HHHHHCCCEEECCC
>Mature Secondary Structure
MKDERRPICEVVAESIERLIIDGVLKVGQPLPSERRLCEKLGFSRSALREGLTVLRGRGI
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCC
IETAQGRDSRVARLNRVQDTSPLIHLFSTQPRTLYDLLDVRALLEGESARLAATLGTQAD
EECCCCCHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHCCCCHHEEEECCCCCC
FVVITRCYEKMLAASENNKEISLIEHAQLDHAFHLAICQASHNQVLVFTLQSLTDLMFNS
HHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHEEECCCCEEEEEEHHHHHHHHHHH
VFASVNNLYHRPQQKKQIDRQHARIYNAVLQRLPHVAQRAARDHVRTVKKNLHDIELEGH
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCH
HLIRSAVPLEMNLS
HHHHHCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157