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The map label for this gene is iscR [H]

Identifier: 157162006

GI number: 157162006

Start: 2699291

End: 2699779

Strand: Reverse

Name: iscR [H]

Synonym: EcHS_A2682

Alternate gene names: 157162006

Gene position: 2699779-2699291 (Counterclockwise)

Preceding gene: 157162007

Following gene: 157162005

Centisome position: 58.14

GC content: 53.37

Gene sequence:

>489_bases
ATGAGACTGACATCTAAAGGGCGCTATGCCGTGACCGCAATGCTTGACGTTGCGCTCAACTCTGAAGCGGGCCCGGTACC
GTTGGCTGATATTTCCGAACGTCAGGGAATTTCCCTTTCTTATCTGGAACAACTGTTTTCCCGTCTGCGTAAAAATGGTC
TGGTTTCCAGCGTACGTGGACCAGGCGGTGGTTATCTGTTAGGCAAAGATGCCAGCAGCATCGCCGTTGGCGAAGTAATT
AGCGCCGTTGACGAATCTGTAGATGCCACCCGTTGTCAGGGTAAAGGCGGCTGCCAGGGCGGCGATAAATGCCTGACCCA
CGCGCTGTGGCGTGATTTGAGCGACCGTCTCACCGGTTTTCTCAACAACATTACTTTAGGCGAACTGGTTAATAACCAGG
AAGTGCTGGATGTGTCTGGTCGTCAGCATACTCACGACGCGCCACGCACCCGCATACAAGACGCGATCGACGTTAAGTTA
CGCGCTTAA

Upstream 100 bases:

>100_bases
CCAATTTACTCGGGAATGTCAGACTTGACCCTGCTATGCAATACCCCCACTTTTACAATAAAAAACCCCGGGCAGGGGCG
AGTTTGAGGTGAAGTAAGAC

Downstream 100 bases:

>100_bases
TTTAACCGTCCTGTTTCGTGTTGCATCTGCGTTGACTGCACATACTCACTCCGGTCACTTACTTATGTAAGCTCCCGGAG
ATTCGTAAGTTTGTCAACTT

Product: DNA-binding transcriptional regulator IscR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 162; Mature: 162

Protein sequence:

>162_residues
MRLTSKGRYAVTAMLDVALNSEAGPVPLADISERQGISLSYLEQLFSRLRKNGLVSSVRGPGGGYLLGKDASSIAVGEVI
SAVDESVDATRCQGKGGCQGGDKCLTHALWRDLSDRLTGFLNNITLGELVNNQEVLDVSGRQHTHDAPRTRIQDAIDVKL
RA

Sequences:

>Translated_162_residues
MRLTSKGRYAVTAMLDVALNSEAGPVPLADISERQGISLSYLEQLFSRLRKNGLVSSVRGPGGGYLLGKDASSIAVGEVI
SAVDESVDATRCQGKGGCQGGDKCLTHALWRDLSDRLTGFLNNITLGELVNNQEVLDVSGRQHTHDAPRTRIQDAIDVKL
RA
>Mature_162_residues
MRLTSKGRYAVTAMLDVALNSEAGPVPLADISERQGISLSYLEQLFSRLRKNGLVSSVRGPGGGYLLGKDASSIAVGEVI
SAVDESVDATRCQGKGGCQGGDKCLTHALWRDLSDRLTGFLNNITLGELVNNQEVLDVSGRQHTHDAPRTRIQDAIDVKL
RA

Specific function: Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins [H]

COG id: COG1959

COG function: function code K; Predicted transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH rrf2-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788880, Length=162, Percent_Identity=99.3827160493827, Blast_Score=327, Evalue=2e-91,
Organism=Escherichia coli, GI1790621, Length=137, Percent_Identity=30.6569343065693, Blast_Score=60, Evalue=8e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010242
- InterPro:   IPR000944
- InterPro:   IPR011991 [H]

Pfam domain/function: PF02082 Rrf2 [H]

EC number: NA

Molecular weight: Translated: 17349; Mature: 17349

Theoretical pI: Translated: 7.44; Mature: 7.44

Prosite motif: PS01332 UPF0074

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLTSKGRYAVTAMLDVALNSEAGPVPLADISERQGISLSYLEQLFSRLRKNGLVSSVRG
CCCCCCCCEEHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCC
PGGGYLLGKDASSIAVGEVISAVDESVDATRCQGKGGCQGGDKCLTHALWRDLSDRLTGF
CCCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
LNNITLGELVNNQEVLDVSGRQHTHDAPRTRIQDAIDVKLRA
HHCCHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHCEEECC
>Mature Secondary Structure
MRLTSKGRYAVTAMLDVALNSEAGPVPLADISERQGISLSYLEQLFSRLRKNGLVSSVRG
CCCCCCCCEEHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCC
PGGGYLLGKDASSIAVGEVISAVDESVDATRCQGKGGCQGGDKCLTHALWRDLSDRLTGF
CCCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
LNNITLGELVNNQEVLDVSGRQHTHDAPRTRIQDAIDVKLRA
HHCCHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA