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The map label for this gene is upp [H]

Identifier: 157161959

GI number: 157161959

Start: 2642183

End: 2642809

Strand: Reverse

Name: upp [H]

Synonym: EcHS_A2633

Alternate gene names: 157161959

Gene position: 2642809-2642183 (Counterclockwise)

Preceding gene: 157161964

Following gene: 157161958

Centisome position: 56.91

GC content: 53.11

Gene sequence:

>627_bases
ATGAAGATCGTGGAAGTCAAACACCCACTCGTCAAACACAAGCTGGGACTGATGCGTGAGCAAGATATCAGCACCAAGCG
CTTTCGCGAACTCGCTTCCGAAGTGGGTAGCCTGCTGACTTACGAAGCGACCGCCGACCTCGAAACGGAAAAAGTAACTA
TCGAAGGCTGGAACGGCCCGGTAGAAATCGACCAGATCAAAGGTAAGAAAATTACCGTTGTGCCAATTCTGCGTGCGGGT
CTTGGTATGATGGACGGTGTGCTGGAAAACGTTCCGAGCGCGCGCATCAGCGTTGTCGGTATGTACCGTAATGAAGAAAC
GCTGGAGCCGGTACCGTACTTCCAGAAACTGGTTTCTAACATCGATGAGCGTATGGCGCTGATCGTTGACCCAATGCTGG
CAACCGGTGGTTCCGTTATCGCGACCATCGACCTGCTGAAAAAAGCGGGCTGCAGCAGCATCAAAGTTCTGGTGCTGGTC
GCTGCGCCAGAAGGTATCGCTGCGCTGGAAAAAGCGCACCCGGACGTCGAACTGTATACCGCATCGATTGATCAGGGACT
GAACGAGCACGGATACATTATTCCGGGCCTCGGCGATGCCGGTGACAAAATCTTTGGTACGAAATAA

Upstream 100 bases:

>100_bases
TCATTTTGACTAAAGTCAACGAAAAGAATATTGCCGCCTTGAAGAAAGGAGGTATAATCCGTCGATTTTTTTTGTGGCTG
CCCCTCAAAGGAGAAAGAGT

Downstream 100 bases:

>100_bases
AGAATAAAAATAATTAAAGCCGACTTTAAGAGTCGGCTTTTTTTTGAGTAAAGCGCCTATAACACATAATACAGAGGATA
ATACTATGACGCGCCGTGCT

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MKIVEVKHPLVKHKLGLMREQDISTKRFRELASEVGSLLTYEATADLETEKVTIEGWNGPVEIDQIKGKKITVVPILRAG
LGMMDGVLENVPSARISVVGMYRNEETLEPVPYFQKLVSNIDERMALIVDPMLATGGSVIATIDLLKKAGCSSIKVLVLV
AAPEGIAALEKAHPDVELYTASIDQGLNEHGYIIPGLGDAGDKIFGTK

Sequences:

>Translated_208_residues
MKIVEVKHPLVKHKLGLMREQDISTKRFRELASEVGSLLTYEATADLETEKVTIEGWNGPVEIDQIKGKKITVVPILRAG
LGMMDGVLENVPSARISVVGMYRNEETLEPVPYFQKLVSNIDERMALIVDPMLATGGSVIATIDLLKKAGCSSIKVLVLV
AAPEGIAALEKAHPDVELYTASIDQGLNEHGYIIPGLGDAGDKIFGTK
>Mature_208_residues
MKIVEVKHPLVKHKLGLMREQDISTKRFRELASEVGSLLTYEATADLETEKVTIEGWNGPVEIDQIKGKKITVVPILRAG
LGMMDGVLENVPSARISVVGMYRNEETLEPVPYFQKLVSNIDERMALIVDPMLATGGSVIATIDLLKKAGCSSIKVLVLV
AAPEGIAALEKAHPDVELYTASIDQGLNEHGYIIPGLGDAGDKIFGTK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Homo sapiens, GI301129207, Length=202, Percent_Identity=26.7326732673267, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI57863312, Length=202, Percent_Identity=26.7326732673267, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI87082118, Length=208, Percent_Identity=100, Blast_Score=419, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI17539892, Length=201, Percent_Identity=27.363184079602, Blast_Score=80, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17539894, Length=201, Percent_Identity=27.363184079602, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6321920, Length=203, Percent_Identity=35.4679802955665, Blast_Score=109, Evalue=3e-25,
Organism=Drosophila melanogaster, GI45550449, Length=203, Percent_Identity=27.5862068965517, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28573516, Length=203, Percent_Identity=27.5862068965517, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28573514, Length=203, Percent_Identity=27.5862068965517, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28573512, Length=203, Percent_Identity=27.5862068965517, Blast_Score=79, Evalue=2e-15,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR005765 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 22534; Mature: 22534

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIVEVKHPLVKHKLGLMREQDISTKRFRELASEVGSLLTYEATADLETEKVTIEGWNGP
CEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHEEEECCCCCCCCEEEEECCCCC
VEIDQIKGKKITVVPILRAGLGMMDGVLENVPSARISVVGMYRNEETLEPVPYFQKLVSN
EEEEEECCCEEEEEHHHHHCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCHHHHHHHHH
IDERMALIVDPMLATGGSVIATIDLLKKAGCSSIKVLVLVAAPEGIAALEKAHPDVELYT
HHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHCCCCEEEEE
ASIDQGLNEHGYIIPGLGDAGDKIFGTK
ECHHCCCCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MKIVEVKHPLVKHKLGLMREQDISTKRFRELASEVGSLLTYEATADLETEKVTIEGWNGP
CEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHEEEECCCCCCCCEEEEECCCCC
VEIDQIKGKKITVVPILRAGLGMMDGVLENVPSARISVVGMYRNEETLEPVPYFQKLVSN
EEEEEECCCEEEEEHHHHHCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCHHHHHHHHH
IDERMALIVDPMLATGGSVIATIDLLKKAGCSSIKVLVLVAAPEGIAALEKAHPDVELYT
HHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHCCCCEEEEE
ASIDQGLNEHGYIIPGLGDAGDKIFGTK
ECHHCCCCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA