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The map label for this gene is yfdZ

Identifier: 157161852

GI number: 157161852

Start: 2528459

End: 2529697

Strand: Reverse

Name: yfdZ

Synonym: EcHS_A2516

Alternate gene names: 157161852

Gene position: 2529697-2528459 (Counterclockwise)

Preceding gene: 157161856

Following gene: 157161849

Centisome position: 54.48

GC content: 54.96

Gene sequence:

>1239_bases
ATGGCTGACACTCGCCCTGAACGTCGCTTTACGCGCATTGATCGTCTCCCGCCCTACGTTTTTAACATCACCGCTGAACT
GAAAATGGCTGCGCGTCGGCGCGGCGAAGATATTATCGATTTCAGCATGGGTAACCCGGACGGTGCGACTCCGCCGCATA
TCGTCGAAAAATTATGTACTGTGGCCCAGCGCCCGGACACGCATGGTTACTCCACTTCACGCGGCATTCCGCGGTTACGT
CGCGCCATTTCCCGCTGGTATCAGGATCGCTACGACGTTGAAATCGACCCGGAATCAGAAGCCATCGTCACTATTGGTTC
GAAAGAGGGCCTGGCGCATCTGATGCTGGCGACGCTGGATCATGGTGACACGGTGCTGGTGCCGAATCCAAGTTACCCGA
TCCATATTTATGGCGCGGTGATTGCCGGGGCGCAGGTACGCTCAGTGCCGCTGGTGGAAGGTGTCGATTTCTTCAACGAA
CTGGAGCGAGCCATTCGTGAAAGTTATCCGAAACCGAAGATGATGATCCTCGGCTTCCCGTCAAACCCAACCGCGCAATG
CGTGGAACTGGAGTTCTTCGAAAAAGTAGTGGCGCTGGCGAAACGCTACGATGTGCTGGTGGTCCATGACCTGGCCTATG
CCGATATCGTCTACGATGGCTGGAAAGCGCCGTCAATTATGCAGGTACCGGGTGCACGCGATGTGGCAGTCGAGTTCTTT
ACGCTGTCGAAAAGCTACAACATGGCGGGCTGGCGTATCGGCTTTATGGTTGGCAACAAAACGCTGGTCAGCGCCCTGGC
TCGTATTAAAAGCTATCACGATTACGGCACCTTTACGCCGTTGCAGGTGGCGGCGATTGCGGCGCTGGAGGGCGATCAAC
AGTGCGTGCGCGACATTGCCGAACAGTACAAACGCCGCCGTGATGTATTGGTTAAAGGGCTGCATGAAGCGGGCTGGATG
GTTGAAATGCCGAAGGCTTCGATGTATGTCTGGGCGAAAATCCCGGAACCATATGCGGCCATGGGATCGCTGGAATTTGC
CAAGAAGCTCCTTAACGAAGCGAAGGTTTGTGTCTCGCCGGGGATTGGCTTTGGCGACTATGGTGATACGCATGTTCGCT
TTGCACTGATTGAAAACCGCGACCGTATTCGTCAGGCCATCAGAGGGATTAAAGCGATGTTCCGTGCCGACGGTTTACTA
CCCGCCAGCAGCAAACATATTCACGAAAACGCGGAATAA

Upstream 100 bases:

>100_bases
CGCTGGACAGACAGAAATTAATCAGGCTATTTTCAAAACAGCCACCATCGTGGCAGCGTCGCTCGGACGGTCCGGGCGCT
AACGTTAATCTGAGGAAATT

Downstream 100 bases:

>100_bases
ACACCGTCGTCAGAAATGCAAACAGGAGCCTGATGGCTCCTGTTTTTCATTGCACAGTTTGCTTTTAGATCATCAGGGCA
AAAGTACCGGCCCAAACGAT

Product: aminotransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 412; Mature: 411

Protein sequence:

>412_residues
MADTRPERRFTRIDRLPPYVFNITAELKMAARRRGEDIIDFSMGNPDGATPPHIVEKLCTVAQRPDTHGYSTSRGIPRLR
RAISRWYQDRYDVEIDPESEAIVTIGSKEGLAHLMLATLDHGDTVLVPNPSYPIHIYGAVIAGAQVRSVPLVEGVDFFNE
LERAIRESYPKPKMMILGFPSNPTAQCVELEFFEKVVALAKRYDVLVVHDLAYADIVYDGWKAPSIMQVPGARDVAVEFF
TLSKSYNMAGWRIGFMVGNKTLVSALARIKSYHDYGTFTPLQVAAIAALEGDQQCVRDIAEQYKRRRDVLVKGLHEAGWM
VEMPKASMYVWAKIPEPYAAMGSLEFAKKLLNEAKVCVSPGIGFGDYGDTHVRFALIENRDRIRQAIRGIKAMFRADGLL
PASSKHIHENAE

Sequences:

>Translated_412_residues
MADTRPERRFTRIDRLPPYVFNITAELKMAARRRGEDIIDFSMGNPDGATPPHIVEKLCTVAQRPDTHGYSTSRGIPRLR
RAISRWYQDRYDVEIDPESEAIVTIGSKEGLAHLMLATLDHGDTVLVPNPSYPIHIYGAVIAGAQVRSVPLVEGVDFFNE
LERAIRESYPKPKMMILGFPSNPTAQCVELEFFEKVVALAKRYDVLVVHDLAYADIVYDGWKAPSIMQVPGARDVAVEFF
TLSKSYNMAGWRIGFMVGNKTLVSALARIKSYHDYGTFTPLQVAAIAALEGDQQCVRDIAEQYKRRRDVLVKGLHEAGWM
VEMPKASMYVWAKIPEPYAAMGSLEFAKKLLNEAKVCVSPGIGFGDYGDTHVRFALIENRDRIRQAIRGIKAMFRADGLL
PASSKHIHENAE
>Mature_411_residues
ADTRPERRFTRIDRLPPYVFNITAELKMAARRRGEDIIDFSMGNPDGATPPHIVEKLCTVAQRPDTHGYSTSRGIPRLRR
AISRWYQDRYDVEIDPESEAIVTIGSKEGLAHLMLATLDHGDTVLVPNPSYPIHIYGAVIAGAQVRSVPLVEGVDFFNEL
ERAIRESYPKPKMMILGFPSNPTAQCVELEFFEKVVALAKRYDVLVVHDLAYADIVYDGWKAPSIMQVPGARDVAVEFFT
LSKSYNMAGWRIGFMVGNKTLVSALARIKSYHDYGTFTPLQVAAIAALEGDQQCVRDIAEQYKRRRDVLVKGLHEAGWMV
EMPKASMYVWAKIPEPYAAMGSLEFAKKLLNEAKVCVSPGIGFGDYGDTHVRFALIENRDRIRQAIRGIKAMFRADGLLP
ASSKHIHENAE

Specific function: Unknown

COG id: COG0436

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family

Homologues:

Organism=Homo sapiens, GI56713254, Length=421, Percent_Identity=25.41567695962, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI56713256, Length=421, Percent_Identity=25.41567695962, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI95147551, Length=417, Percent_Identity=22.5419664268585, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI169881279, Length=417, Percent_Identity=22.5419664268585, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI169881281, Length=236, Percent_Identity=21.6101694915254, Blast_Score=72, Evalue=7e-13,
Organism=Escherichia coli, GI1788722, Length=412, Percent_Identity=100, Blast_Score=852, Evalue=0.0,
Organism=Escherichia coli, GI1786816, Length=337, Percent_Identity=25.2225519287834, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI1788627, Length=376, Percent_Identity=26.063829787234, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1787710, Length=312, Percent_Identity=26.2820512820513, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1788332, Length=226, Percent_Identity=28.3185840707965, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17567369, Length=398, Percent_Identity=24.1206030150754, Blast_Score=118, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI71994472, Length=367, Percent_Identity=24.5231607629428, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI71994476, Length=365, Percent_Identity=24.3835616438356, Blast_Score=117, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6322401, Length=393, Percent_Identity=21.1195928753181, Blast_Score=88, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6320317, Length=349, Percent_Identity=24.0687679083095, Blast_Score=86, Evalue=9e-18,
Organism=Drosophila melanogaster, GI28573069, Length=340, Percent_Identity=27.0588235294118, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24646114, Length=340, Percent_Identity=27.0588235294118, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI28573067, Length=340, Percent_Identity=27.0588235294118, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI28573065, Length=340, Percent_Identity=27.0588235294118, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI45551451, Length=387, Percent_Identity=25.0645994832041, Blast_Score=78, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24641770, Length=379, Percent_Identity=25.065963060686, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24641760, Length=379, Percent_Identity=25.065963060686, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24641768, Length=379, Percent_Identity=25.065963060686, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24641766, Length=379, Percent_Identity=25.065963060686, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24641764, Length=379, Percent_Identity=25.065963060686, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): YFDZ_ECOLI (P77434)

Other databases:

- EMBL:   U00096
- EMBL:   AP009048
- PIR:   H65011
- RefSeq:   AP_002979.1
- RefSeq:   NP_416880.1
- ProteinModelPortal:   P77434
- SMR:   P77434
- DIP:   DIP-12010N
- STRING:   P77434
- EnsemblBacteria:   EBESCT00000004526
- EnsemblBacteria:   EBESCT00000014961
- GeneID:   946850
- GenomeReviews:   AP009048_GR
- GenomeReviews:   U00096_GR
- KEGG:   ecj:JW2376
- KEGG:   eco:b2379
- EchoBASE:   EB3950
- EcoGene:   EG14198
- eggNOG:   COG0436
- GeneTree:   EBGT00050000008899
- HOGENOM:   HBG645860
- OMA:   YVRFALI
- ProtClustDB:   PRK08175
- BioCyc:   EcoCyc:G7242-MONOMER
- Genevestigator:   P77434
- GO:   GO:0005737
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: 2.6.1.- [C]

Molecular weight: Translated: 46217; Mature: 46086

Theoretical pI: Translated: 8.00; Mature: 8.00

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADTRPERRFTRIDRLPPYVFNITAELKMAARRRGEDIIDFSMGNPDGATPPHIVEKLCT
CCCCCCHHHHHHHHCCCCEEEEHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHH
VAQRPDTHGYSTSRGIPRLRRAISRWYQDRYDVEIDPESEAIVTIGSKEGLAHLMLATLD
HHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCEEEEECCCCCHHHHHHHEEC
HGDTVLVPNPSYPIHIYGAVIAGAQVRSVPLVEGVDFFNELERAIRESYPKPKMMILGFP
CCCEEEECCCCCCEEEEEEECCCCHHCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECC
SNPTAQCVELEFFEKVVALAKRYDVLVVHDLAYADIVYDGWKAPSIMQVPGARDVAVEFF
CCCCHHHHHHHHHHHHHHHHHHCCEEEEECHHHHHHEECCCCCCCEEECCCCCHHEEEEE
TLSKSYNMAGWRIGFMVGNKTLVSALARIKSYHDYGTFTPLQVAAIAALEGDQQCVRDIA
EECCCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHH
EQYKRRRDVLVKGLHEAGWMVEMPKASMYVWAKIPEPYAAMGSLEFAKKLLNEAKVCVSP
HHHHHHHHHHHHHHHHCCCEEECCCCCEEEEEECCCCHHHHCCHHHHHHHHHCCCEEECC
GIGFGDYGDTHVRFALIENRDRIRQAIRGIKAMFRADGLLPASSKHIHENAE
CCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
ADTRPERRFTRIDRLPPYVFNITAELKMAARRRGEDIIDFSMGNPDGATPPHIVEKLCT
CCCCCHHHHHHHHCCCCEEEEHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHH
VAQRPDTHGYSTSRGIPRLRRAISRWYQDRYDVEIDPESEAIVTIGSKEGLAHLMLATLD
HHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCEEEEECCCCCHHHHHHHEEC
HGDTVLVPNPSYPIHIYGAVIAGAQVRSVPLVEGVDFFNELERAIRESYPKPKMMILGFP
CCCEEEECCCCCCEEEEEEECCCCHHCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECC
SNPTAQCVELEFFEKVVALAKRYDVLVVHDLAYADIVYDGWKAPSIMQVPGARDVAVEFF
CCCCHHHHHHHHHHHHHHHHHHCCEEEEECHHHHHHEECCCCCCCEEECCCCCHHEEEEE
TLSKSYNMAGWRIGFMVGNKTLVSALARIKSYHDYGTFTPLQVAAIAALEGDQQCVRDIA
EECCCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHH
EQYKRRRDVLVKGLHEAGWMVEMPKASMYVWAKIPEPYAAMGSLEFAKKLLNEAKVCVSP
HHHHHHHHHHHHHHHHCCCEEECCCCCEEEEEECCCCHHHHCCHHHHHHHHHCCCEEECC
GIGFGDYGDTHVRFALIENRDRIRQAIRGIKAMFRADGLLPASSKHIHENAE
CCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Pyridoxal Phosphate. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503