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The map label for this gene is oxc

Identifier: 157161846

GI number: 157161846

Start: 2521661

End: 2523355

Strand: Reverse

Name: oxc

Synonym: EcHS_A2510

Alternate gene names: 157161846

Gene position: 2523355-2521661 (Counterclockwise)

Preceding gene: 157161847

Following gene: 157161845

Centisome position: 54.34

GC content: 46.61

Gene sequence:

>1695_bases
ATGTCAGATCAACTTCAAATGACAGATGGTATGCATATCATCGTTGAAGCATTAAAACAGAATAATATTGACACTATTTA
TGGTGTTGTAGGTATTCCTGTGACGGATATGGCACGCCATGCCCAGGCGGAAGGCATTCGTTATATTGGTTTTCGTCATG
AGCAGTCGGCAGGCTATGCCGCTGCGGCAAGCGGTTTTCTTACCCAAAAACCGGGGATCTGCCTGACAGTTTCTGCGCCA
GGATTCCTCAATGGTTTGACCGCATTGGCCAACGCAACGGTAAATGGTTTTCCGATGATCATGATTAGCGGCTCCAGCGA
CCGCGCGATCGTCGACCTACAGCAAGGTGATTATGAAGAGCTGGACCAAATGAATGCGGCAAAACCGTATGCCAAAGCAG
CATTTCGCGTTAATCAGCCGCAGGATCTTGGCATTGCATTGGCACGCGCTATCCGGGTCTCTGTATCGGGTCGCCCTGGC
GGAGTTTATCTTGATTTGCCAGCAAATGTCCTGGCCGCGACGATGGAAAAAGACGAAGCGTTAACCACGATTGTTAAAGT
TGAAAATCCGTCGCCAGCATTATTGCCATGCCCGAAGTCAGTCACTAGCGCAATTTCGCTTTTAGCAAAAGCTGAACGGC
CATTAATTATCCTTGGCAAAGGCGCGGCGTATTCACAAGCTGATGAACAGCTTCGTGAATTTATTGAAAGTGCTCAGATT
CCATTCCTGCCAATGTCTATGGCGAAAGGGATCCTTGAAGATACGCATCCACTTTCTGCGGCAGCTGCGCGTTCGTTTGC
CCTGGCAAATGCTGACGTTGTCATGCTTGTTGGTGCACGACTGAATTGGTTATTGGCACACGGTAAAAAAGGATGGGCGG
CAGATACACAGTTTATTCAACTGGATATTGAACCGCAGGAAATTGACAGCAACCGCCCCATTGCTGTGCCAGTCGTTGGT
GATATTGCATCCAGTATGCAAGGTATGCTGGCAGAACTGAAACAAAACACATTTACGACTCCACTGGTATGGCGCGATAT
TTTAAATATCCACAAGCAGCAAAATGCACAAAAAATGCATGAAAAATTAAGTACAGATACTCAACCATTAAATTACTTTA
ATGCATTAAGTGCTGTGCGCGACGTATTGCGCGAGAACCAGGATATTTATTTAGTTAATGAAGGTGCAAATACCCTGGAT
AATGCACGAAATATTATTGATATGTATAAACCACGTCGTCGTCTGGATTGTGGTACCTGGGGTGTCATGGGCATCGGTAT
GGGCTATGCCATCGGTGCTAGCGTGACTTCTGGTTCTCCGGTTGTCGCCATTGAAGGTGATAGTGCTTTTGGTTTCAGTG
GGATGGAAATTGAAACGATTTGTCGATATAACCTGCCGGTGACGATCGTTATTTTTAATAATGGCGGCATCTACAGAGGA
GACGGTGTTGATCTCAGTGGCGCTGGTGCACCATCACCAACGGATCTGTTGCACCATGCAAGGTATGACAAATTAATGGA
TGCGTTTCGTGGCGTTGGCTATAACGTCACCACGACAGATGAACTTCGTCATGCTTTAACCACCGGTATTCAGTCGCGCA
AACCGACCATTATTAATGTGGTCATCGACCCTGCAGCAGGAACTGAAAGTGGCCATATTACCAAACTTAACCCAAAACAA
GTCGCTGGTAATTAA

Upstream 100 bases:

>100_bases
ATAGCGACGATGAAATTGCTGCAATGAAGCAAAACCACGCCATCTGATATTAACGGGGGCTTCTGGCTCCCAATTTATAA
AAATTTCGAGGTTATTAATC

Downstream 100 bases:

>100_bases
ATACTGACATCGTCTCCTCTTGCCAACTCATTATGCGATGGTGAGGGGACCCTTATCGGAAATACTATTATGCTAACATT
TTTTATTGGCGATTTATTGC

Product: putative oxalyl-CoA decarboxylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 564; Mature: 563

Protein sequence:

>564_residues
MSDQLQMTDGMHIIVEALKQNNIDTIYGVVGIPVTDMARHAQAEGIRYIGFRHEQSAGYAAAASGFLTQKPGICLTVSAP
GFLNGLTALANATVNGFPMIMISGSSDRAIVDLQQGDYEELDQMNAAKPYAKAAFRVNQPQDLGIALARAIRVSVSGRPG
GVYLDLPANVLAATMEKDEALTTIVKVENPSPALLPCPKSVTSAISLLAKAERPLIILGKGAAYSQADEQLREFIESAQI
PFLPMSMAKGILEDTHPLSAAAARSFALANADVVMLVGARLNWLLAHGKKGWAADTQFIQLDIEPQEIDSNRPIAVPVVG
DIASSMQGMLAELKQNTFTTPLVWRDILNIHKQQNAQKMHEKLSTDTQPLNYFNALSAVRDVLRENQDIYLVNEGANTLD
NARNIIDMYKPRRRLDCGTWGVMGIGMGYAIGASVTSGSPVVAIEGDSAFGFSGMEIETICRYNLPVTIVIFNNGGIYRG
DGVDLSGAGAPSPTDLLHHARYDKLMDAFRGVGYNVTTTDELRHALTTGIQSRKPTIINVVIDPAAGTESGHITKLNPKQ
VAGN

Sequences:

>Translated_564_residues
MSDQLQMTDGMHIIVEALKQNNIDTIYGVVGIPVTDMARHAQAEGIRYIGFRHEQSAGYAAAASGFLTQKPGICLTVSAP
GFLNGLTALANATVNGFPMIMISGSSDRAIVDLQQGDYEELDQMNAAKPYAKAAFRVNQPQDLGIALARAIRVSVSGRPG
GVYLDLPANVLAATMEKDEALTTIVKVENPSPALLPCPKSVTSAISLLAKAERPLIILGKGAAYSQADEQLREFIESAQI
PFLPMSMAKGILEDTHPLSAAAARSFALANADVVMLVGARLNWLLAHGKKGWAADTQFIQLDIEPQEIDSNRPIAVPVVG
DIASSMQGMLAELKQNTFTTPLVWRDILNIHKQQNAQKMHEKLSTDTQPLNYFNALSAVRDVLRENQDIYLVNEGANTLD
NARNIIDMYKPRRRLDCGTWGVMGIGMGYAIGASVTSGSPVVAIEGDSAFGFSGMEIETICRYNLPVTIVIFNNGGIYRG
DGVDLSGAGAPSPTDLLHHARYDKLMDAFRGVGYNVTTTDELRHALTTGIQSRKPTIINVVIDPAAGTESGHITKLNPKQ
VAGN
>Mature_563_residues
SDQLQMTDGMHIIVEALKQNNIDTIYGVVGIPVTDMARHAQAEGIRYIGFRHEQSAGYAAAASGFLTQKPGICLTVSAPG
FLNGLTALANATVNGFPMIMISGSSDRAIVDLQQGDYEELDQMNAAKPYAKAAFRVNQPQDLGIALARAIRVSVSGRPGG
VYLDLPANVLAATMEKDEALTTIVKVENPSPALLPCPKSVTSAISLLAKAERPLIILGKGAAYSQADEQLREFIESAQIP
FLPMSMAKGILEDTHPLSAAAARSFALANADVVMLVGARLNWLLAHGKKGWAADTQFIQLDIEPQEIDSNRPIAVPVVGD
IASSMQGMLAELKQNTFTTPLVWRDILNIHKQQNAQKMHEKLSTDTQPLNYFNALSAVRDVLRENQDIYLVNEGANTLDN
ARNIIDMYKPRRRLDCGTWGVMGIGMGYAIGASVTSGSPVVAIEGDSAFGFSGMEIETICRYNLPVTIVIFNNGGIYRGD
GVDLSGAGAPSPTDLLHHARYDKLMDAFRGVGYNVTTTDELRHALTTGIQSRKPTIINVVIDPAAGTESGHITKLNPKQV
AGN

Specific function: Oxalic acid catabolism; second step. [C]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family

Homologues:

Organism=Homo sapiens, GI93004078, Length=558, Percent_Identity=39.0681003584229, Blast_Score=420, Evalue=1e-117,
Organism=Homo sapiens, GI21361361, Length=511, Percent_Identity=26.4187866927593, Blast_Score=176, Evalue=5e-44,
Organism=Escherichia coli, GI1788716, Length=564, Percent_Identity=100, Blast_Score=1160, Evalue=0.0,
Organism=Escherichia coli, GI87081685, Length=556, Percent_Identity=24.6402877697842, Blast_Score=178, Evalue=9e-46,
Organism=Escherichia coli, GI1790104, Length=479, Percent_Identity=27.5574112734864, Blast_Score=156, Evalue=3e-39,
Organism=Escherichia coli, GI1786717, Length=478, Percent_Identity=26.5690376569038, Blast_Score=146, Evalue=4e-36,
Organism=Escherichia coli, GI1787096, Length=540, Percent_Identity=22.5925925925926, Blast_Score=100, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17531301, Length=549, Percent_Identity=38.0692167577413, Blast_Score=364, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI17531299, Length=549, Percent_Identity=38.0692167577413, Blast_Score=364, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI17542570, Length=514, Percent_Identity=27.2373540856031, Blast_Score=179, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6320816, Length=548, Percent_Identity=35.2189781021898, Blast_Score=301, Evalue=2e-82,
Organism=Saccharomyces cerevisiae, GI6323755, Length=583, Percent_Identity=24.1852487135506, Blast_Score=138, Evalue=3e-33,
Organism=Drosophila melanogaster, GI19922626, Length=561, Percent_Identity=39.7504456327986, Blast_Score=398, Evalue=1e-111,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OXC_ECO57 (P0AFI1)

Other databases:

- EMBL:   AE005174
- EMBL:   BA000007
- PIR:   E91035
- PIR:   G85879
- RefSeq:   NP_288943.1
- RefSeq:   NP_311280.1
- ProteinModelPortal:   P0AFI1
- SMR:   P0AFI1
- EnsemblBacteria:   EBESCT00000026658
- EnsemblBacteria:   EBESCT00000057724
- GeneID:   915646
- GeneID:   956741
- GenomeReviews:   AE005174_GR
- GenomeReviews:   BA000007_GR
- KEGG:   ece:Z3637
- KEGG:   ecs:ECs3253
- GeneTree:   EBGT00050000008286
- HOGENOM:   HBG316485
- OMA:   ARYDKMM
- ProtClustDB:   PRK09259
- BioCyc:   ECOL83334:ECS3253-MONOMER
- InterPro:   IPR017660
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR011766
- TIGRFAMs:   TIGR03254

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N

EC number: =4.1.1.8

Molecular weight: Translated: 60582; Mature: 60451

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS00187 TPP_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDQLQMTDGMHIIVEALKQNNIDTIYGVVGIPVTDMARHAQAEGIRYIGFRHEQSAGYA
CCCCEECCCCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCEEEEEEEECCCCCCH
AAASGFLTQKPGICLTVSAPGFLNGLTALANATVNGFPMIMISGSSDRAIVDLQQGDYEE
HHHCCCEECCCCEEEEECCCHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEECCCCHHH
LDQMNAAKPYAKAAFRVNQPQDLGIALARAIRVSVSGRPGGVYLDLPANVLAATMEKDEA
HHHCCCCCCHHHHHEECCCCHHHHHHHHHEEEEEECCCCCCEEEECCHHHHHHHHHHCCC
LTTIVKVENPSPALLPCPKSVTSAISLLAKAERPLIILGKGAAYSQADEQLREFIESAQI
EEEEEEECCCCCCEEECCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCC
PFLPMSMAKGILEDTHPLSAAAARSFALANADVVMLVGARLNWLLAHGKKGWAADTQFIQ
CEECHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEECCCEEEEEECCCCCCCCCCEEEE
LDIEPQEIDSNRPIAVPVVGDIASSMQGMLAELKQNTFTTPLVWRDILNIHKQQNAQKMH
EECCHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
EKLSTDTQPLNYFNALSAVRDVLRENQDIYLVNEGANTLDNARNIIDMYKPRRRLDCGTW
HHHCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCHHHCCCCCC
GVMGIGMGYAIGASVTSGSPVVAIEGDSAFGFSGMEIETICRYNLPVTIVIFNNGGIYRG
CHHHHCCCHHCCCEECCCCCEEEEECCCCCCCCCCEEEEEEECCCCEEEEEECCCCEEEC
DGVDLSGAGAPSPTDLLHHARYDKLMDAFRGVGYNVTTTDELRHALTTGIQSRKPTIINV
CCCEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCEEEEE
VIDPAAGTESGHITKLNPKQVAGN
EEECCCCCCCCCEEECCHHHCCCC
>Mature Secondary Structure 
SDQLQMTDGMHIIVEALKQNNIDTIYGVVGIPVTDMARHAQAEGIRYIGFRHEQSAGYA
CCCEECCCCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCEEEEEEEECCCCCCH
AAASGFLTQKPGICLTVSAPGFLNGLTALANATVNGFPMIMISGSSDRAIVDLQQGDYEE
HHHCCCEECCCCEEEEECCCHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEECCCCHHH
LDQMNAAKPYAKAAFRVNQPQDLGIALARAIRVSVSGRPGGVYLDLPANVLAATMEKDEA
HHHCCCCCCHHHHHEECCCCHHHHHHHHHEEEEEECCCCCCEEEECCHHHHHHHHHHCCC
LTTIVKVENPSPALLPCPKSVTSAISLLAKAERPLIILGKGAAYSQADEQLREFIESAQI
EEEEEEECCCCCCEEECCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCC
PFLPMSMAKGILEDTHPLSAAAARSFALANADVVMLVGARLNWLLAHGKKGWAADTQFIQ
CEECHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEECCCEEEEEECCCCCCCCCCEEEE
LDIEPQEIDSNRPIAVPVVGDIASSMQGMLAELKQNTFTTPLVWRDILNIHKQQNAQKMH
EECCHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
EKLSTDTQPLNYFNALSAVRDVLRENQDIYLVNEGANTLDNARNIIDMYKPRRRLDCGTW
HHHCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCHHHCCCCCC
GVMGIGMGYAIGASVTSGSPVVAIEGDSAFGFSGMEIETICRYNLPVTIVIFNNGGIYRG
CHHHHCCCHHCCCEECCCCCEEEEECCCCCCCCCCEEEEEEECCCCEEEEEECCCCEEEC
DGVDLSGAGAPSPTDLLHHARYDKLMDAFRGVGYNVTTTDELRHALTTGIQSRKPTIINV
CCCEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCEEEEE
VIDPAAGTESGHITKLNPKQVAGN
EEECCCCCCCCCEEECCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796