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The map label for this gene is nuoC [H]

Identifier: 157161774

GI number: 157161774

Start: 2443626

End: 2445428

Strand: Reverse

Name: nuoC [H]

Synonym: EcHS_A2435

Alternate gene names: 157161774

Gene position: 2445428-2443626 (Counterclockwise)

Preceding gene: 157161775

Following gene: 157161773

Centisome position: 52.66

GC content: 56.02

Gene sequence:

>1803_bases
ATGGTGAACAATATGACCGACTTAACCGCGCAAGAACCCGCCTGGCAGACCCGCGATCATCTTGATGATCCGGTGATTGG
CGAACTGCGCAACCGTTTTGGGCCGGATGCCTTTACTGTTCAGGCGACTCGCACCGGGGTTCCCGTTGTGTGGATCAAGC
GTGAACAATTACTGGAAGTTGGCGATTTCTTAAAGAAACTGCCGAAACCTTACGTCATGCTGTTTGACTTACACGGCATG
GACGAACGTCTGCGCACACACCGCGAAGGGTTACCTGCCGCGGATTTTTCCGTTTTCTACCATCTGATTTCTATCGATCG
TAACCGCGACATCATGCTGAAGGTGGCGCTGGCAGAAAACGACCTGCACGTACCGACCTTCACCAAACTGTTCCCGAACG
CTAACTGGTATGAGCGTGAAACCTGGGATCTGTTTGGCATTACTTTCGACGGTCACCCGAACCTGCGCCGCATCATGATG
CCGCAAACCTGGAAAGGTCACCCGCTGCGTAAAGATTACCCGGCGCGCGCTACCGAATTCTCGCCGTTTGAGCTGACCAA
AGCCAAACAGGATCTGGAGATGGAAGCCCTGACCTTCAAACCGGAAGAGTGGGGGATGAAGCGCGGCACCGAAAACGAGG
ACTTCATGTTCCTCAACCTCGGTCCGAACCACCCGTCGGCGCACGGGGCTTTCCGTATCGTTTTACAACTCGACGGCGAA
GAGATTGTCGACTGCGTACCAGACATCGGCTACCACCACCGTGGTGCGGAGAAAATGGGCGAGCGCCAGTCCTGGCACAG
CTACATTCCGTATACCGACCGTATTGAATACCTCGGCGGCTGCGTTAACGAAATGCCTTACGTGCTGGCGGTAGAGAAAC
TGGCCGGGATCACCGTGCCGGATCGCGTTAACGTCATTCGCGTTATGCTCTCCGAACTGTTCCGTATCAACAGCCACCTG
CTGTACATCTCGACCTTTATTCAGGACGTCGGCGCAATGACGCCCGTGTTCTTCGCCTTTACCGATCGTCAGAAAATTTA
CGATCTGGTGGAAGCGATCACGGGTTTCCGTATGCACCCGGCGTGGTTCCGTATTGGCGGCGTAGCGCACGACCTGCCGC
GCGGCTGGGATCGCCTGCTGCGTGAGTTCCTCGACTGGATGCCGAAACGTCTGGCGTCTTACGAGAAAGCGGCGCTGCAA
AATACCATTCTGAAAGGTCGTTCCCAGGGCGTTGCCGCCTATGGCGCGAAAGAGGCGCTGGAGTGGGGCACCACTGGCGC
GGGCCTGCGTGCTACCGGGATCGACTTCGACGTGCGTAAGGCGCGTCCTTATTCTGGCTATGAAAACTTCGACTTTGAAA
TCCCGGTTGGTGGTGGTGTTTCTGACTGCTACACCCGCGTAATGCTGAAAGTGGAAGAGCTGCGCCAGAGTCTGCGCATT
CTTGAGCAGTGCCTCAACAACATGCCGGAAGGCCCGTTCAAAGCGGATCACCCGCTGACCACGCCGCCGCCGAAAGAGCG
CACGCTGCAACATATCGAAACCCTGATCACCCACTTCCTGCAAGTGTCGTGGGGGCCGGTGATGCCTGCCAATGAATCTT
TCCAGATGATTGAGGCGACCAAGGGGATCAACAGTTACTACCTGACCAGCGACGGTAGCACCATGAGTTATCGCACTCGT
ATCCGCACGCCGAGTTATGCGCATTTGCAGCAAATTCCGGCGGCGATCCGCGGCAGCCTGGTGTCTGACCTGATTGTTTA
TCTGGGCAGTATCGATTTTGTTATGTCAGATGTGGACCGCTAA

Upstream 100 bases:

>100_bases
GATTTAATTTGCGCCTGTCGGCAAAGGGATTTTTCTTCGCTTATTCCTAAATCTATTTCGCGAAGCTTACTGCGCCGACA
GTCACCACGGACCATTTGCA

Downstream 100 bases:

>100_bases
TTATGCACGAGAATCAACAACCACAAACCGAGGCTTTTGAGCTGAGTGCGGCAGAGCGTGAAGCGATTGAGCACGAGATG
CACCACTACGAAGACCCGCG

Product: bifunctional NADH:ubiquinone oxidoreductase subunit C/D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit C/D; NDH-1 subunit C/D [H]

Number of amino acids: Translated: 600; Mature: 600

Protein sequence:

>600_residues
MVNNMTDLTAQEPAWQTRDHLDDPVIGELRNRFGPDAFTVQATRTGVPVVWIKREQLLEVGDFLKKLPKPYVMLFDLHGM
DERLRTHREGLPAADFSVFYHLISIDRNRDIMLKVALAENDLHVPTFTKLFPNANWYERETWDLFGITFDGHPNLRRIMM
PQTWKGHPLRKDYPARATEFSPFELTKAKQDLEMEALTFKPEEWGMKRGTENEDFMFLNLGPNHPSAHGAFRIVLQLDGE
EIVDCVPDIGYHHRGAEKMGERQSWHSYIPYTDRIEYLGGCVNEMPYVLAVEKLAGITVPDRVNVIRVMLSELFRINSHL
LYISTFIQDVGAMTPVFFAFTDRQKIYDLVEAITGFRMHPAWFRIGGVAHDLPRGWDRLLREFLDWMPKRLASYEKAALQ
NTILKGRSQGVAAYGAKEALEWGTTGAGLRATGIDFDVRKARPYSGYENFDFEIPVGGGVSDCYTRVMLKVEELRQSLRI
LEQCLNNMPEGPFKADHPLTTPPPKERTLQHIETLITHFLQVSWGPVMPANESFQMIEATKGINSYYLTSDGSTMSYRTR
IRTPSYAHLQQIPAAIRGSLVSDLIVYLGSIDFVMSDVDR

Sequences:

>Translated_600_residues
MVNNMTDLTAQEPAWQTRDHLDDPVIGELRNRFGPDAFTVQATRTGVPVVWIKREQLLEVGDFLKKLPKPYVMLFDLHGM
DERLRTHREGLPAADFSVFYHLISIDRNRDIMLKVALAENDLHVPTFTKLFPNANWYERETWDLFGITFDGHPNLRRIMM
PQTWKGHPLRKDYPARATEFSPFELTKAKQDLEMEALTFKPEEWGMKRGTENEDFMFLNLGPNHPSAHGAFRIVLQLDGE
EIVDCVPDIGYHHRGAEKMGERQSWHSYIPYTDRIEYLGGCVNEMPYVLAVEKLAGITVPDRVNVIRVMLSELFRINSHL
LYISTFIQDVGAMTPVFFAFTDRQKIYDLVEAITGFRMHPAWFRIGGVAHDLPRGWDRLLREFLDWMPKRLASYEKAALQ
NTILKGRSQGVAAYGAKEALEWGTTGAGLRATGIDFDVRKARPYSGYENFDFEIPVGGGVSDCYTRVMLKVEELRQSLRI
LEQCLNNMPEGPFKADHPLTTPPPKERTLQHIETLITHFLQVSWGPVMPANESFQMIEATKGINSYYLTSDGSTMSYRTR
IRTPSYAHLQQIPAAIRGSLVSDLIVYLGSIDFVMSDVDR
>Mature_600_residues
MVNNMTDLTAQEPAWQTRDHLDDPVIGELRNRFGPDAFTVQATRTGVPVVWIKREQLLEVGDFLKKLPKPYVMLFDLHGM
DERLRTHREGLPAADFSVFYHLISIDRNRDIMLKVALAENDLHVPTFTKLFPNANWYERETWDLFGITFDGHPNLRRIMM
PQTWKGHPLRKDYPARATEFSPFELTKAKQDLEMEALTFKPEEWGMKRGTENEDFMFLNLGPNHPSAHGAFRIVLQLDGE
EIVDCVPDIGYHHRGAEKMGERQSWHSYIPYTDRIEYLGGCVNEMPYVLAVEKLAGITVPDRVNVIRVMLSELFRINSHL
LYISTFIQDVGAMTPVFFAFTDRQKIYDLVEAITGFRMHPAWFRIGGVAHDLPRGWDRLLREFLDWMPKRLASYEKAALQ
NTILKGRSQGVAAYGAKEALEWGTTGAGLRATGIDFDVRKARPYSGYENFDFEIPVGGGVSDCYTRVMLKVEELRQSLRI
LEQCLNNMPEGPFKADHPLTTPPPKERTLQHIETLITHFLQVSWGPVMPANESFQMIEATKGINSYYLTSDGSTMSYRTR
IRTPSYAHLQQIPAAIRGSLVSDLIVYLGSIDFVMSDVDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the complex I 49 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI4758786, Length=383, Percent_Identity=40.7310704960835, Blast_Score=309, Evalue=5e-84,
Organism=Homo sapiens, GI260898743, Length=373, Percent_Identity=40.4825737265416, Blast_Score=299, Evalue=4e-81,
Organism=Homo sapiens, GI4758788, Length=101, Percent_Identity=39.6039603960396, Blast_Score=77, Evalue=6e-14,
Organism=Escherichia coli, GI145693162, Length=596, Percent_Identity=99.6644295302013, Blast_Score=1238, Evalue=0.0,
Organism=Escherichia coli, GI1789076, Length=563, Percent_Identity=25.9325044404973, Blast_Score=160, Evalue=3e-40,
Organism=Escherichia coli, GI1788832, Length=493, Percent_Identity=28.6004056795132, Blast_Score=150, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17555284, Length=397, Percent_Identity=41.3098236775819, Blast_Score=329, Evalue=2e-90,
Organism=Caenorhabditis elegans, GI17568379, Length=402, Percent_Identity=40.547263681592, Blast_Score=328, Evalue=7e-90,
Organism=Caenorhabditis elegans, GI71990788, Length=127, Percent_Identity=30.7086614173228, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI32563621, Length=127, Percent_Identity=30.7086614173228, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI221459469, Length=384, Percent_Identity=39.0625, Blast_Score=318, Evalue=5e-87,
Organism=Drosophila melanogaster, GI24638644, Length=383, Percent_Identity=40.4699738903394, Blast_Score=316, Evalue=4e-86,
Organism=Drosophila melanogaster, GI24656494, Length=169, Percent_Identity=32.5443786982249, Blast_Score=77, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010219
- InterPro:   IPR010218
- InterPro:   IPR023062
- InterPro:   IPR001135
- InterPro:   IPR001268
- InterPro:   IPR014029
- InterPro:   IPR020396
- InterPro:   IPR022885
- ProDom:   PD001581 [H]

Pfam domain/function: PF00329 Complex1_30kDa; PF00346 Complex1_49kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 68726; Mature: 68726

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS00542 COMPLEX1_30K ; PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVNNMTDLTAQEPAWQTRDHLDDPVIGELRNRFGPDAFTVQATRTGVPVVWIKREQLLEV
CCCCCCCCCCCCCCCCHHHCCCCCHHHHHHHHCCCCCEEEEEECCCCCEEEECHHHHHHH
GDFLKKLPKPYVMLFDLHGMDERLRTHREGLPAADFSVFYHLISIDRNRDIMLKVALAEN
HHHHHHCCCCEEEEEECCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEEEEEEECC
DLHVPTFTKLFPNANWYERETWDLFGITFDGHPNLRRIMMPQTWKGHPLRKDYPARATEF
CCCCCHHHHHCCCCCCCCCCCEEEEEEEECCCCCCEEEECCCCCCCCCCCCCCCCCCCCC
SPFELTKAKQDLEMEALTFKPEEWGMKRGTENEDFMFLNLGPNHPSAHGAFRIVLQLDGE
CCHHHHHHHHCCCCHHEEECCHHHHCCCCCCCCCEEEEEECCCCCCCCCEEEEEEEECCH
EIVDCVPDIGYHHRGAEKMGERQSWHSYIPYTDRIEYLGGCVNEMPYVLAVEKLAGITVP
HHHHHHCCCCCCCCCHHHHCCHHHHCCCCCCHHHHHHHHHHHHHCCHHEEHHHHHCCCCC
DRVNVIRVMLSELFRINSHLLYISTFIQDVGAMTPVFFAFTDRQKIYDLVEAITGFRMHP
CHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHCCCCCC
AWFRIGGVAHDLPRGWDRLLREFLDWMPKRLASYEKAALQNTILKGRSQGVAAYGAKEAL
HHHEECCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHCHHHHH
EWGTTGAGLRATGIDFDVRKARPYSGYENFDFEIPVGGGVSDCYTRVMLKVEELRQSLRI
HCCCCCCCCEECCCCCCHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
LEQCLNNMPEGPFKADHPLTTPPPKERTLQHIETLITHFLQVSWGPVMPANESFQMIEAT
HHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
KGINSYYLTSDGSTMSYRTRIRTPSYAHLQQIPAAIRGSLVSDLIVYLGSIDFVMSDVDR
CCCCEEEEECCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVNNMTDLTAQEPAWQTRDHLDDPVIGELRNRFGPDAFTVQATRTGVPVVWIKREQLLEV
CCCCCCCCCCCCCCCCHHHCCCCCHHHHHHHHCCCCCEEEEEECCCCCEEEECHHHHHHH
GDFLKKLPKPYVMLFDLHGMDERLRTHREGLPAADFSVFYHLISIDRNRDIMLKVALAEN
HHHHHHCCCCEEEEEECCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEEEEEEECC
DLHVPTFTKLFPNANWYERETWDLFGITFDGHPNLRRIMMPQTWKGHPLRKDYPARATEF
CCCCCHHHHHCCCCCCCCCCCEEEEEEEECCCCCCEEEECCCCCCCCCCCCCCCCCCCCC
SPFELTKAKQDLEMEALTFKPEEWGMKRGTENEDFMFLNLGPNHPSAHGAFRIVLQLDGE
CCHHHHHHHHCCCCHHEEECCHHHHCCCCCCCCCEEEEEECCCCCCCCCEEEEEEEECCH
EIVDCVPDIGYHHRGAEKMGERQSWHSYIPYTDRIEYLGGCVNEMPYVLAVEKLAGITVP
HHHHHHCCCCCCCCCHHHHCCHHHHCCCCCCHHHHHHHHHHHHHCCHHEEHHHHHCCCCC
DRVNVIRVMLSELFRINSHLLYISTFIQDVGAMTPVFFAFTDRQKIYDLVEAITGFRMHP
CHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHCCCCCC
AWFRIGGVAHDLPRGWDRLLREFLDWMPKRLASYEKAALQNTILKGRSQGVAAYGAKEAL
HHHEECCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHCHHHHH
EWGTTGAGLRATGIDFDVRKARPYSGYENFDFEIPVGGGVSDCYTRVMLKVEELRQSLRI
HCCCCCCCCEECCCCCCHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
LEQCLNNMPEGPFKADHPLTTPPPKERTLQHIETLITHFLQVSWGPVMPANESFQMIEAT
HHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
KGINSYYLTSDGSTMSYRTRIRTPSYAHLQQIPAAIRGSLVSDLIVYLGSIDFVMSDVDR
CCCCEEEEECCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA