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The map label for this gene is flu [H]

Identifier: 157161493

GI number: 157161493

Start: 2120165

End: 2121916

Strand: Direct

Name: flu [H]

Synonym: EcHS_A2139

Alternate gene names: 157161493

Gene position: 2120165-2121916 (Clockwise)

Preceding gene: 157161492

Following gene: 157161494

Centisome position: 45.66

GC content: 56.45

Gene sequence:

>1752_bases
ATGAAACGACATCTGAACACCAGCTACAGGCTGGTATGGAATCACATTACGGGCACCCTGGTGGTGGCCTCCGAACTGGC
CCGCTCACGGGGAAAACGCGCCGGTGTGGCGGTTGCACTGTCTCTTGCTGCTGTCACATCAGTCCCGGCACTGGCTGCTG
ACACGGTTGTACAGGCGGGAGAAACCGTGAACGACGGAACACTGACAAATCATGACAACCAGATTGTCCTCGGTACTGCC
AACGGAATGACCATCAGTACCGGGCTGGAGTATGGGCCGGATAACGAAGCCAATACCGGCGGACAATGGATACAAAATGG
CGGTATCGCCAACAACACTACTGTCACCGGTGGTGGTCTTCAGAGAGTGAATGCCGGAGGAAGCGTTTCAGACACGGTTA
TCAGTGCCGGAGGAGGACAGAGCCTTCAGGGGCAGGCAGTGAACACCACTCTGAACGGCGGTGAGCAGTGGGTACATGAA
GGCGGGATTGCAACGGGTACCGTCATTAATGAGAAGGGCTGGCAGGCCGTCAAATCCGGCGCAATGGCAACCGACACGGT
TGTGAATACCGGCGCGGAAGGGGGACCGGATGCAGAAAATGGTGATACCGGGCAGTTTGTTCGCGGAAATGCCGTACGTA
CCACTATCAATGAGAATGGTCGTCAGATTGTGGCTGCTGAAGGAACGGCAAATACCACTGTGGTTTATGCCGGCGGCGAC
CAGACTGTACATGGCTACGCGCTGGATACCACACTGAACGGCGGTAACCAGTATGTGCACAACGGCGGTACAGCGTCTGG
CACTGTTGTGAACAGTGACGGCTGGCAGATTGTCAAGGAAGGTGGTCTGGCGGATTTCACCATCGTTAACCAGAAAGGCA
AACTGCAGGTGAACGCCGGTGGTACAGCCACGAATGTCACCCTGAAGCAGGGAGGCGCACTGGTCACCAGTACGGCGGCA
ACCGTCACCGGCAGCAACCGTCTGGGCAATTTCACAGTGGAAAACGGTAATGCTGACGGTGTTGTTCTGGAGTCCGGTGG
TCGCCTGGATGTACTGGAGGGCCATTCAGCCTGGAAAACACTGGTGGATGACGGCGGTACCCTGGCAGTGTCTGCCGGTG
GTAAGGCAACAGATGTCACCATGACATCCGGTGGTGCCCTGATAGCAGACAGTGGTGCCACTGTTGAGGGGACCAATGCC
AGCGGTAAGTTCAGTATTGATGGCATATCCGGTCAGGCCAGCGGCCTGCTACTGGAAAATGGCGGCAGCTTTACGGTTAA
TGCCGGGGGACAGGCAGGCAACACCACTGTCGGACATCGTGGAACACTGACGCTGGCTGCCGGGGGAAGTCTGAGTGGCA
GAACACAGCTCAGTAAAGGCGCCAGTATGGTACTGAATGGTGATGTGGTCAGTACCGGCGATATTGTTAACGCAGGAGAG
ATTCACTTTGATAATCAGACGACACAGGATGCCGTGCTGAGCCGTGCTGTTGCAAAAGGCGACTCCCCGGTAACGTTCCA
TAAACTGACCACCACCAACCTCACTGGTCAGGGCGGCACCATCAATATGCGTGTTCGCCTTGATGGCAGCAATACCTCTG
ACCAGCTGGTGATTAATGGTGGTCAGGCAACCGGCAAAACCTGGCTTGCGTTTACAAATGTCGGAAACAGTAACCTCGGG
GTGGCAACCTCCGGACAGGGTACCCTGCACAGTGACGCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAA

Upstream 100 bases:

>100_bases
CCGGGAAAAACCACTTTATCTGACCATGCTGTTTTGTACCTGCCGGTATCCACATTTGTGGGTACCGGCTTTTTTATTCA
CCCTCTGTAAGGAAAAGCTG

Downstream 100 bases:

>100_bases
CCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGTTCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCT
TTCCGCTGCTGATGAAACAA

Product: antigen 43, truncation

Products: NA

Alternate protein names: AG43; Fluffing protein [H]

Number of amino acids: Translated: 583; Mature: 583

Protein sequence:

>583_residues
MKRHLNTSYRLVWNHITGTLVVASELARSRGKRAGVAVALSLAAVTSVPALAADTVVQAGETVNDGTLTNHDNQIVLGTA
NGMTISTGLEYGPDNEANTGGQWIQNGGIANNTTVTGGGLQRVNAGGSVSDTVISAGGGQSLQGQAVNTTLNGGEQWVHE
GGIATGTVINEKGWQAVKSGAMATDTVVNTGAEGGPDAENGDTGQFVRGNAVRTTINENGRQIVAAEGTANTTVVYAGGD
QTVHGYALDTTLNGGNQYVHNGGTASGTVVNSDGWQIVKEGGLADFTIVNQKGKLQVNAGGTATNVTLKQGGALVTSTAA
TVTGSNRLGNFTVENGNADGVVLESGGRLDVLEGHSAWKTLVDDGGTLAVSAGGKATDVTMTSGGALIADSGATVEGTNA
SGKFSIDGISGQASGLLLENGGSFTVNAGGQAGNTTVGHRGTLTLAAGGSLSGRTQLSKGASMVLNGDVVSTGDIVNAGE
IHFDNQTTQDAVLSRAVAKGDSPVTFHKLTTTNLTGQGGTINMRVRLDGSNTSDQLVINGGQATGKTWLAFTNVGNSNLG
VATSGQGTLHSDALFRRPSGAGG

Sequences:

>Translated_583_residues
MKRHLNTSYRLVWNHITGTLVVASELARSRGKRAGVAVALSLAAVTSVPALAADTVVQAGETVNDGTLTNHDNQIVLGTA
NGMTISTGLEYGPDNEANTGGQWIQNGGIANNTTVTGGGLQRVNAGGSVSDTVISAGGGQSLQGQAVNTTLNGGEQWVHE
GGIATGTVINEKGWQAVKSGAMATDTVVNTGAEGGPDAENGDTGQFVRGNAVRTTINENGRQIVAAEGTANTTVVYAGGD
QTVHGYALDTTLNGGNQYVHNGGTASGTVVNSDGWQIVKEGGLADFTIVNQKGKLQVNAGGTATNVTLKQGGALVTSTAA
TVTGSNRLGNFTVENGNADGVVLESGGRLDVLEGHSAWKTLVDDGGTLAVSAGGKATDVTMTSGGALIADSGATVEGTNA
SGKFSIDGISGQASGLLLENGGSFTVNAGGQAGNTTVGHRGTLTLAAGGSLSGRTQLSKGASMVLNGDVVSTGDIVNAGE
IHFDNQTTQDAVLSRAVAKGDSPVTFHKLTTTNLTGQGGTINMRVRLDGSNTSDQLVINGGQATGKTWLAFTNVGNSNLG
VATSGQGTLHSDALFRRPSGAGG
>Mature_583_residues
MKRHLNTSYRLVWNHITGTLVVASELARSRGKRAGVAVALSLAAVTSVPALAADTVVQAGETVNDGTLTNHDNQIVLGTA
NGMTISTGLEYGPDNEANTGGQWIQNGGIANNTTVTGGGLQRVNAGGSVSDTVISAGGGQSLQGQAVNTTLNGGEQWVHE
GGIATGTVINEKGWQAVKSGAMATDTVVNTGAEGGPDAENGDTGQFVRGNAVRTTINENGRQIVAAEGTANTTVVYAGGD
QTVHGYALDTTLNGGNQYVHNGGTASGTVVNSDGWQIVKEGGLADFTIVNQKGKLQVNAGGTATNVTLKQGGALVTSTAA
TVTGSNRLGNFTVENGNADGVVLESGGRLDVLEGHSAWKTLVDDGGTLAVSAGGKATDVTMTSGGALIADSGATVEGTNA
SGKFSIDGISGQASGLLLENGGSFTVNAGGQAGNTTVGHRGTLTLAAGGSLSGRTQLSKGASMVLNGDVVSTGDIVNAGE
IHFDNQTTQDAVLSRAVAKGDSPVTFHKLTTTNLTGQGGTINMRVRLDGSNTSDQLVINGGQATGKTWLAFTNVGNSNLG
VATSGQGTLHSDALFRRPSGAGG

Specific function: Controls colony form variation and autoaggregation. May function as an adhesin [H]

COG id: COG3468

COG function: function code MU; Type V secretory pathway, adhesin AidA

Gene ontology:

Cell location: Antigen 43 beta chain:Cell outer membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 autotransporter (TC 1.B.12) domain [H]

Homologues:

Organism=Escherichia coli, GI48994897, Length=471, Percent_Identity=78.1316348195329, Blast_Score=681, Evalue=0.0,
Organism=Escherichia coli, GI87082145, Length=418, Percent_Identity=34.688995215311, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI1787954, Length=190, Percent_Identity=40, Blast_Score=92, Evalue=8e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005546
- InterPro:   IPR006315
- InterPro:   IPR012332
- InterPro:   IPR011050 [H]

Pfam domain/function: PF03797 Autotransporter [H]

EC number: NA

Molecular weight: Translated: 58299; Mature: 58299

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRHLNTSYRLVWNHITGTLVVASELARSRGKRAGVAVALSLAAVTSVPALAADTVVQAG
CCCCCCCCEEEEEECCCEEEEEHHHHHHHCCCCCCEEEEEEHHHHHCCCHHHHHHHHHCC
ETVNDGTLTNHDNQIVLGTANGMTISTGLEYGPDNEANTGGQWIQNGGIANNTTVTGGGL
CCCCCCEEECCCCEEEEECCCCEEEECCCCCCCCCCCCCCCHHHCCCCCCCCCEEECCCE
QRVNAGGSVSDTVISAGGGQSLQGQAVNTTLNGGEQWVHEGGIATGTVINEKGWQAVKSG
EEECCCCCCCCEEEECCCCCCCCCEEEEEEECCCHHHHHCCCCEEEEEECCCCHHHHHCC
AMATDTVVNTGAEGGPDAENGDTGQFVRGNAVRTTINENGRQIVAAEGTANTTVVYAGGD
CCEECCEEECCCCCCCCCCCCCCCCEEECCEEEEEECCCCCEEEEECCCCCEEEEEECCC
QTVHGYALDTTLNGGNQYVHNGGTASGTVVNSDGWQIVKEGGLADFTIVNQKGKLQVNAG
CEEEEEEEEEEECCCCEEEECCCCCCCEEECCCCCEEEECCCCEEEEEECCCCEEEEECC
GTATNVTLKQGGALVTSTAATVTGSNRLGNFTVENGNADGVVLESGGRLDVLEGHSAWKT
CCEEEEEEECCCEEEEEEEEEEECCCCCCEEEEECCCCCEEEECCCCCEEEEECCCHHHH
LVDDGGTLAVSAGGKATDVTMTSGGALIADSGATVEGTNASGKFSIDGISGQASGLLLEN
HHCCCCEEEEECCCCEEEEEEECCCEEEECCCCEEECCCCCCEEEEECCCCCCCEEEEEC
GGSFTVNAGGQAGNTTVGHRGTLTLAAGGSLSGRTQLSKGASMVLNGDVVSTGDIVNAGE
CCCEEEECCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCEEEEECCEEECCCEEECCE
IHFDNQTTQDAVLSRAVAKGDSPVTFHKLTTTNLTGQGGTINMRVRLDGSNTSDQLVING
EEECCCCHHHHHHHHHHHCCCCCEEEEEEEEEEECCCCCEEEEEEEECCCCCCCEEEEEC
GQATGKTWLAFTNVGNSNLGVATSGQGTLHSDALFRRPSGAGG
CCCCCCEEEEEEECCCCCCCEEECCCCCCCCCHHEECCCCCCC
>Mature Secondary Structure
MKRHLNTSYRLVWNHITGTLVVASELARSRGKRAGVAVALSLAAVTSVPALAADTVVQAG
CCCCCCCCEEEEEECCCEEEEEHHHHHHHCCCCCCEEEEEEHHHHHCCCHHHHHHHHHCC
ETVNDGTLTNHDNQIVLGTANGMTISTGLEYGPDNEANTGGQWIQNGGIANNTTVTGGGL
CCCCCCEEECCCCEEEEECCCCEEEECCCCCCCCCCCCCCCHHHCCCCCCCCCEEECCCE
QRVNAGGSVSDTVISAGGGQSLQGQAVNTTLNGGEQWVHEGGIATGTVINEKGWQAVKSG
EEECCCCCCCCEEEECCCCCCCCCEEEEEEECCCHHHHHCCCCEEEEEECCCCHHHHHCC
AMATDTVVNTGAEGGPDAENGDTGQFVRGNAVRTTINENGRQIVAAEGTANTTVVYAGGD
CCEECCEEECCCCCCCCCCCCCCCCEEECCEEEEEECCCCCEEEEECCCCCEEEEEECCC
QTVHGYALDTTLNGGNQYVHNGGTASGTVVNSDGWQIVKEGGLADFTIVNQKGKLQVNAG
CEEEEEEEEEEECCCCEEEECCCCCCCEEECCCCCEEEECCCCEEEEEECCCCEEEEECC
GTATNVTLKQGGALVTSTAATVTGSNRLGNFTVENGNADGVVLESGGRLDVLEGHSAWKT
CCEEEEEEECCCEEEEEEEEEEECCCCCCEEEEECCCCCEEEECCCCCEEEEECCCHHHH
LVDDGGTLAVSAGGKATDVTMTSGGALIADSGATVEGTNASGKFSIDGISGQASGLLLEN
HHCCCCEEEEECCCCEEEEEEECCCEEEECCCCEEECCCCCCEEEEECCCCCCCEEEEEC
GGSFTVNAGGQAGNTTVGHRGTLTLAAGGSLSGRTQLSKGASMVLNGDVVSTGDIVNAGE
CCCEEEECCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCEEEEECCEEECCCEEECCE
IHFDNQTTQDAVLSRAVAKGDSPVTFHKLTTTNLTGQGGTINMRVRLDGSNTSDQLVING
EEECCCCHHHHHHHHHHHCCCCCEEEEEEEEEEECCCCCEEEEEEEECCCCCCCEEEEEC
GQATGKTWLAFTNVGNSNLGVATSGQGTLHSDALFRRPSGAGG
CCCCCCEEEEEEECCCCCCCEEECCCCCCCCCHHEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 2661530; 9298646; 9103983 [H]