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The map label for this gene is ltaE [H]

Identifier: 157160393

GI number: 157160393

Start: 968528

End: 969529

Strand: Reverse

Name: ltaE [H]

Synonym: EcHS_A0974

Alternate gene names: 157160393

Gene position: 969529-968528 (Counterclockwise)

Preceding gene: 157160394

Following gene: 157160392

Centisome position: 20.88

GC content: 56.29

Gene sequence:

>1002_bases
ATGATTGATTTACGCAGTGATACCGTTACCCGACCGAGCCGCGCCATGCTCGAAGCGATGATGGCCGCCCCGGTTGGGGA
CGACGTTTACGGAGACGACCCTACCGTTAATGCTCTGCAGGACTATGCAGCAGAGCTTTCCGGTAAAGAAGCCGCCATTT
TTCTGCCTACCGGCACTCAGGCCAACCTGGTCGCTCTGCTCAGTCACTGCGAACGTGGCGAAGAGTATATTGTCGGTCAG
GCCGCGCATAACTATCTGTTTGAAGCCGGTGGCGCAGCGGTGCTGGGCAGTATTCAGCCGCAACCCATCGACGCGGCTGC
CGACGGCACGCTACCGCTGGATAAAGTGGCGATGAAAATCAAACCCGACGATATCCATTTCGCCCGCACCAAATTACTCA
GTCTGGAAAACACCCACAACGGCAAAGTGCTGCCGCGTGAATACTTGAAAGAAGCATGGGAATTTACCCGCGAGCGCAAT
CTGGCGCTGCATGTTGACGGTGCGCGCATCTTTAATGCCGTGGTGGCTTACGGCTGCGAACTGAAAGAGATCACGCAATA
TTGTGATTCGTTCACCATTTGCCTGTCGAAAGGTCTTGGGACGCCAGTCGGTTCATTACTCGTCGGTAATCGTGATTACA
TTAAACGTGCCATCCGCTGGCGGAAAATGGCCGGTGGCGGGATGCGTCAGTCCGGGATTCTGGCTGCCGCCGGGATGTAT
GCCCTGAAAAATAACGTCGCACGGTTGCAGGAAGATCACGACAACGCCGCCTGGATGGCGGAGCAACTGCGTGAAGCAGG
CGCGGATGTGATGCGTCAGGACACTAATATGCTGTTTGTTCGCGTCGGGGAAGAAAATGCTGCCGCGTTAGGCGAATACA
TGAAAGCGAGAAACGTGCTGATTAACGCCTCGCCGATTGTCCGCCTGGTGACGCATCTTGACGTCTCGCGCGAACAACTG
GCGGAAGTCGCCGCCCACTGGCGCGCATTCCTGGCGCGTTAA

Upstream 100 bases:

>100_bases
CGCAATCATCAGCGGACGCGGCGATGAAGTGATCGAACTGGCGAAAACGAACTGGCTAAGGTAAAAAGGGTGGCATTTCC
CGTCATAATAAGGACATGCC

Downstream 100 bases:

>100_bases
GGAGAGAGACGTGCCGCAACGCATTTTAGTTCTCGGTGCCAGTGGCTACATTGGTCAGCATCTGGTGCGCACACTCAGCC
AGCAAGGGCATCAGATCCTG

Product: L-threonine aldolase

Products: NA

Alternate protein names: Low-specificity L-TA [H]

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MIDLRSDTVTRPSRAMLEAMMAAPVGDDVYGDDPTVNALQDYAAELSGKEAAIFLPTGTQANLVALLSHCERGEEYIVGQ
AAHNYLFEAGGAAVLGSIQPQPIDAAADGTLPLDKVAMKIKPDDIHFARTKLLSLENTHNGKVLPREYLKEAWEFTRERN
LALHVDGARIFNAVVAYGCELKEITQYCDSFTICLSKGLGTPVGSLLVGNRDYIKRAIRWRKMAGGGMRQSGILAAAGMY
ALKNNVARLQEDHDNAAWMAEQLREAGADVMRQDTNMLFVRVGEENAAALGEYMKARNVLINASPIVRLVTHLDVSREQL
AEVAAHWRAFLAR

Sequences:

>Translated_333_residues
MIDLRSDTVTRPSRAMLEAMMAAPVGDDVYGDDPTVNALQDYAAELSGKEAAIFLPTGTQANLVALLSHCERGEEYIVGQ
AAHNYLFEAGGAAVLGSIQPQPIDAAADGTLPLDKVAMKIKPDDIHFARTKLLSLENTHNGKVLPREYLKEAWEFTRERN
LALHVDGARIFNAVVAYGCELKEITQYCDSFTICLSKGLGTPVGSLLVGNRDYIKRAIRWRKMAGGGMRQSGILAAAGMY
ALKNNVARLQEDHDNAAWMAEQLREAGADVMRQDTNMLFVRVGEENAAALGEYMKARNVLINASPIVRLVTHLDVSREQL
AEVAAHWRAFLAR
>Mature_333_residues
MIDLRSDTVTRPSRAMLEAMMAAPVGDDVYGDDPTVNALQDYAAELSGKEAAIFLPTGTQANLVALLSHCERGEEYIVGQ
AAHNYLFEAGGAAVLGSIQPQPIDAAADGTLPLDKVAMKIKPDDIHFARTKLLSLENTHNGKVLPREYLKEAWEFTRERN
LALHVDGARIFNAVVAYGCELKEITQYCDSFTICLSKGLGTPVGSLLVGNRDYIKRAIRWRKMAGGGMRQSGILAAAGMY
ALKNNVARLQEDHDNAAWMAEQLREAGADVMRQDTNMLFVRVGEENAAALGEYMKARNVLINASPIVRLVTHLDVSREQL
AEVAAHWRAFLAR

Specific function: Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde. L-threo-phenylserine and L- erythro-phenylserine are also good substrates [H]

COG id: COG2008

COG function: function code E; Threonine aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1787095, Length=333, Percent_Identity=99.3993993993994, Blast_Score=683, Evalue=0.0,
Organism=Caenorhabditis elegans, GI193206522, Length=347, Percent_Identity=40.9221902017291, Blast_Score=245, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI193206520, Length=347, Percent_Identity=40.9221902017291, Blast_Score=245, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI193206524, Length=346, Percent_Identity=40.4624277456647, Blast_Score=244, Evalue=3e-65,
Organism=Saccharomyces cerevisiae, GI6320789, Length=285, Percent_Identity=39.2982456140351, Blast_Score=190, Evalue=3e-49,
Organism=Drosophila melanogaster, GI21355439, Length=305, Percent_Identity=42.6229508196721, Blast_Score=236, Evalue=1e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001597
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01212 Beta_elim_lyase [H]

EC number: =4.1.2.5 [H]

Molecular weight: Translated: 36483; Mature: 36483

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDLRSDTVTRPSRAMLEAMMAAPVGDDVYGDDPTVNALQDYAAELSGKEAAIFLPTGTQ
CCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCC
ANLVALLSHCERGEEYIVGQAAHNYLFEAGGAAVLGSIQPQPIDAAADGTLPLDKVAMKI
HHHHHHHHHHHCCCCEEEHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCHHHHEEEE
KPDDIHFARTKLLSLENTHNGKVLPREYLKEAWEFTRERNLALHVDGARIFNAVVAYGCE
CCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHCCC
LKEITQYCDSFTICLSKGLGTPVGSLLVGNRDYIKRAIRWRKMAGGGMRQSGILAAAGMY
HHHHHHHHHHHHHHHHCCCCCCHHHHEECCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
ALKNNVARLQEDHDNAAWMAEQLREAGADVMRQDTNMLFVRVGEENAAALGEYMKARNVL
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHEE
INASPIVRLVTHLDVSREQLAEVAAHWRAFLAR
ECCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIDLRSDTVTRPSRAMLEAMMAAPVGDDVYGDDPTVNALQDYAAELSGKEAAIFLPTGTQ
CCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCC
ANLVALLSHCERGEEYIVGQAAHNYLFEAGGAAVLGSIQPQPIDAAADGTLPLDKVAMKI
HHHHHHHHHHHCCCCEEEHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCHHHHEEEE
KPDDIHFARTKLLSLENTHNGKVLPREYLKEAWEFTRERNLALHVDGARIFNAVVAYGCE
CCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHCCC
LKEITQYCDSFTICLSKGLGTPVGSLLVGNRDYIKRAIRWRKMAGGGMRQSGILAAAGMY
HHHHHHHHHHHHHHHHCCCCCCHHHHEECCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
ALKNNVARLQEDHDNAAWMAEQLREAGADVMRQDTNMLFVRVGEENAAALGEYMKARNVL
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHEE
INASPIVRLVTHLDVSREQLAEVAAHWRAFLAR
ECCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]