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The map label for this gene is fdrA [H]

Identifier: 157160041

GI number: 157160041

Start: 606257

End: 607924

Strand: Direct

Name: fdrA [H]

Synonym: EcHS_A0592

Alternate gene names: 157160041

Gene position: 606257-607924 (Clockwise)

Preceding gene: 157160037

Following gene: 157160042

Centisome position: 13.06

GC content: 56.06

Gene sequence:

>1668_bases
ATGATCCACGCCTTTATTAAAAAAGGGTGTTTTCAGGATTCGGTCAGTTTAATGATTATTTCACGAAAACTCAGCGAATC
AGAAAATGTTGATGATGTTTCCGTAATGATGGGTACGCCCGCCAATAAAGCGTTATTAGATACCACAGGTTTCTGGCATG
ACGATTTTAATAACGCCACGCCGAACGATATTTGCGTGGCAATTCGTAGCGAAGCGGCGGATGCGGGGATCGCGCAGGCG
ATTATGCAGCAGCTTGAAGAGGCGCTAAAACAACTGGCGCAGGGGGCAGGCAGCAGCCAGGCGTTGACGCAGGTGCGTCG
CTGGGACAGTGCCTGTCAGAAATTACCCGACGCCAGTCTGGCGCTGATTTCAGTGGCTGGTGAGTATGCGGCGGAGCTGG
CGAACCAGGCGCTGGATCGCAACCTCAACGTGATGATGTTCTCCGATAACGTCACGCTGGAAGATGAAATCCAACTTAAA
ACCCGCGCGCGGGAAAAAGGCTTGCTGGTGATGGGGCCGGACTGCGGTACATCGATGATTGCCGGCACGCCGCTGGCTTT
TGCTAACGTGATGCCGGAAGGCAACATTGGCGTCATTGGCGCTTCCGGTACCGGGATTCAGGAGCTGTGCTCGCAGATTG
CGCTGGCAGGGGAGGGAATTACTCACGCGATTGGCCTTGGCGGGCGCGACCTCAGCCGTGAAGTAGGCGGCATCAGTGCG
CTGACGGCGCTGGAAATGCTCAGTGCAGACGAGAAAAGCGAAGTGCTGGCATTTGTTTCAAAACCGCCTGCCGAAGCTGT
GCGTCTGAAAATTGTTAATGCCATGAAAGCAACCGGCAAACCGACGGTGGCGCTGTTTTTAGGTTATACCCCGGCGGTGG
CCCGCGACGAGAATGTCTGGTTTGCCTCCTCGCTGGATGAGGCCGCACGCCTGGCTTGCCTGCTTTCACGTGTCACGGCG
CGACGTAACGCAATAGCGCCTGTCAGCAGCGGATTTATTTGCGGTTTGTATACCGGCGGTACGCTGGCTGCCGAAGCGGC
GGGATTACTTGCTGGACACCTTGGCGTGGAAGCCGACGATACCCATCATCACGGCATGATGCTCGACGCCGATGGTCACC
AGATTATTGACCTCGGCGATGATTTCTACACCGTCGGGCGTCCCCATCCGATGATCGACCCAGCCTTACGCAACCAGTTA
ATTGCCGATCTCGGCGCTAAACCGCAAGTGCGCGTATTGCTGCTTGATGTCGTGATTGGCTTCGGTGCGACCGCCGATCC
TGCCGCCTCGCTGGTAAGCGCCTGGCAAAAAGCATGTGCCGCGCGTTCAGACAATCAACCACTGTATGCCATTGCCACGG
TGACAGGCACTGAACGTGACCCGCAATGCCGCTCGCAGCAAATCGCCACGCTGGAAGATGCAGGGATCGCGGTAGTGAGT
TCGCTGCCGGAAGCCACCTTGCTGGCGGCGGCACTGATTCGTCCGCTTTCGCCTGCCACTCAGCAACACACACCGTCATT
ACTGGAAAACGTCGCCGTGATTAACATCGGATTACGCAGCTTTGCGCTGGAGCTACAAAGCGCCAGCAAACCGGTTGTGC
ATTACCAATGGTCGCCAGTCGCCGGCGGCAATAAAAAACTGGCTCGTTTATTAGAACGTTTGCAATAA

Upstream 100 bases:

>100_bases
TGATATTCATCACCTTATTTACCCGTTGTCATCGATACCGTAATCGCCACATTAACACTGCTCGTGCAATTGCCATGGGT
GCAATTTTTAAGGAGTTGTT

Downstream 100 bases:

>100_bases
GGGGTTCCCATGTTTACATCAGTAGCGCAAGCCAATGCTGCGGTTATCGAACAAATTCGTCGCGCTCGTCCACACTGGCT
GGATGTGCAACCGGCTTCTT

Product: membrane protein FdrA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 555; Mature: 555

Protein sequence:

>555_residues
MIHAFIKKGCFQDSVSLMIISRKLSESENVDDVSVMMGTPANKALLDTTGFWHDDFNNATPNDICVAIRSEAADAGIAQA
IMQQLEEALKQLAQGAGSSQALTQVRRWDSACQKLPDASLALISVAGEYAAELANQALDRNLNVMMFSDNVTLEDEIQLK
TRAREKGLLVMGPDCGTSMIAGTPLAFANVMPEGNIGVIGASGTGIQELCSQIALAGEGITHAIGLGGRDLSREVGGISA
LTALEMLSADEKSEVLAFVSKPPAEAVRLKIVNAMKATGKPTVALFLGYTPAVARDENVWFASSLDEAARLACLLSRVTA
RRNAIAPVSSGFICGLYTGGTLAAEAAGLLAGHLGVEADDTHHHGMMLDADGHQIIDLGDDFYTVGRPHPMIDPALRNQL
IADLGAKPQVRVLLLDVVIGFGATADPAASLVSAWQKACAARSDNQPLYAIATVTGTERDPQCRSQQIATLEDAGIAVVS
SLPEATLLAAALIRPLSPATQQHTPSLLENVAVINIGLRSFALELQSASKPVVHYQWSPVAGGNKKLARLLERLQ

Sequences:

>Translated_555_residues
MIHAFIKKGCFQDSVSLMIISRKLSESENVDDVSVMMGTPANKALLDTTGFWHDDFNNATPNDICVAIRSEAADAGIAQA
IMQQLEEALKQLAQGAGSSQALTQVRRWDSACQKLPDASLALISVAGEYAAELANQALDRNLNVMMFSDNVTLEDEIQLK
TRAREKGLLVMGPDCGTSMIAGTPLAFANVMPEGNIGVIGASGTGIQELCSQIALAGEGITHAIGLGGRDLSREVGGISA
LTALEMLSADEKSEVLAFVSKPPAEAVRLKIVNAMKATGKPTVALFLGYTPAVARDENVWFASSLDEAARLACLLSRVTA
RRNAIAPVSSGFICGLYTGGTLAAEAAGLLAGHLGVEADDTHHHGMMLDADGHQIIDLGDDFYTVGRPHPMIDPALRNQL
IADLGAKPQVRVLLLDVVIGFGATADPAASLVSAWQKACAARSDNQPLYAIATVTGTERDPQCRSQQIATLEDAGIAVVS
SLPEATLLAAALIRPLSPATQQHTPSLLENVAVINIGLRSFALELQSASKPVVHYQWSPVAGGNKKLARLLERLQ
>Mature_555_residues
MIHAFIKKGCFQDSVSLMIISRKLSESENVDDVSVMMGTPANKALLDTTGFWHDDFNNATPNDICVAIRSEAADAGIAQA
IMQQLEEALKQLAQGAGSSQALTQVRRWDSACQKLPDASLALISVAGEYAAELANQALDRNLNVMMFSDNVTLEDEIQLK
TRAREKGLLVMGPDCGTSMIAGTPLAFANVMPEGNIGVIGASGTGIQELCSQIALAGEGITHAIGLGGRDLSREVGGISA
LTALEMLSADEKSEVLAFVSKPPAEAVRLKIVNAMKATGKPTVALFLGYTPAVARDENVWFASSLDEAARLACLLSRVTA
RRNAIAPVSSGFICGLYTGGTLAAEAAGLLAGHLGVEADDTHHHGMMLDADGHQIIDLGDDFYTVGRPHPMIDPALRNQL
IADLGAKPQVRVLLLDVVIGFGATADPAASLVSAWQKACAARSDNQPLYAIATVTGTERDPQCRSQQIATLEDAGIAVVS
SLPEATLLAAALIRPLSPATQQHTPSLLENVAVINIGLRSFALELQSASKPVVHYQWSPVAGGNKKLARLLERLQ

Specific function: Not known; multicopy suppressor of dominant negative ftsH mutations [H]

COG id: COG0074

COG function: function code C; Succinyl-CoA synthetase, alpha subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To E.coli yahF and some, to bacterial sucD [H]

Homologues:

Organism=Escherichia coli, GI1786729, Length=555, Percent_Identity=98.5585585585586, Blast_Score=1113, Evalue=0.0,
Organism=Escherichia coli, GI1786513, Length=513, Percent_Identity=37.4269005847953, Blast_Score=295, Evalue=4e-81,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003781
- InterPro:   IPR005811
- InterPro:   IPR016102 [H]

Pfam domain/function: PF02629 CoA_binding; PF00549 Ligase_CoA [H]

EC number: NA

Molecular weight: Translated: 58526; Mature: 58526

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIHAFIKKGCFQDSVSLMIISRKLSESENVDDVSVMMGTPANKALLDTTGFWHDDFNNAT
CCCHHHHCCCCCCCCEEEEEEHHHCCCCCCCCEEEEECCCCCCEEEECCCCCCCCCCCCC
PNDICVAIRSEAADAGIAQAIMQQLEEALKQLAQGAGSSQALTQVRRWDSACQKLPDASL
CCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCE
ALISVAGEYAAELANQALDRNLNVMMFSDNVTLEDEIQLKTRAREKGLLVMGPDCGTSMI
EHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHCCEEEECCCCCCHHH
AGTPLAFANVMPEGNIGVIGASGTGIQELCSQIALAGEGITHAIGLGGRDLSREVGGISA
CCCCHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCHHEECCCCCHHHHHHCCHHH
LTALEMLSADEKSEVLAFVSKPPAEAVRLKIVNAMKATGKPTVALFLGYTPAVARDENVW
HHHHHHHCCCCHHHEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCEE
FASSLDEAARLACLLSRVTARRNAIAPVSSGFICGLYTGGTLAAEAAGLLAGHLGVEADD
EECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCC
THHHGMMLDADGHQIIDLGDDFYTVGRPHPMIDPALRNQLIADLGAKPQVRVLLLDVVIG
CCCCCEEEECCCCEEEECCCCEEECCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHH
FGATADPAASLVSAWQKACAARSDNQPLYAIATVTGTERDPQCRSQQIATLEDAGIAVVS
CCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCHHHHHHCCHHCCCCHHHH
SLPEATLLAAALIRPLSPATQQHTPSLLENVAVINIGLRSFALELQSASKPVVHYQWSPV
CCCHHHHHHHHHHHCCCCCCHHCCHHHHHCEEEEEECHHHHHHHHHCCCCCEEEEECCCC
AGGNKKLARLLERLQ
CCCCHHHHHHHHHCC
>Mature Secondary Structure
MIHAFIKKGCFQDSVSLMIISRKLSESENVDDVSVMMGTPANKALLDTTGFWHDDFNNAT
CCCHHHHCCCCCCCCEEEEEEHHHCCCCCCCCEEEEECCCCCCEEEECCCCCCCCCCCCC
PNDICVAIRSEAADAGIAQAIMQQLEEALKQLAQGAGSSQALTQVRRWDSACQKLPDASL
CCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCE
ALISVAGEYAAELANQALDRNLNVMMFSDNVTLEDEIQLKTRAREKGLLVMGPDCGTSMI
EHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHCCEEEECCCCCCHHH
AGTPLAFANVMPEGNIGVIGASGTGIQELCSQIALAGEGITHAIGLGGRDLSREVGGISA
CCCCHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCHHEECCCCCHHHHHHCCHHH
LTALEMLSADEKSEVLAFVSKPPAEAVRLKIVNAMKATGKPTVALFLGYTPAVARDENVW
HHHHHHHCCCCHHHEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCEE
FASSLDEAARLACLLSRVTARRNAIAPVSSGFICGLYTGGTLAAEAAGLLAGHLGVEADD
EECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCC
THHHGMMLDADGHQIIDLGDDFYTVGRPHPMIDPALRNQLIADLGAKPQVRVLLLDVVIG
CCCCCEEEECCCCEEEECCCCEEECCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHH
FGATADPAASLVSAWQKACAARSDNQPLYAIATVTGTERDPQCRSQQIATLEDAGIAVVS
CCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCHHHHHHCCHHCCCCHHHH
SLPEATLLAAALIRPLSPATQQHTPSLLENVAVINIGLRSFALELQSASKPVVHYQWSPV
CCCHHHHHHHHHHHCCCCCCHHCCHHHHHCEEEEEECHHHHHHHHHCCCCCEEEEECCCC
AGGNKKLARLLERLQ
CCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7500942; 9278503; 3309887 [H]