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The map label for this gene is allB [H]

Identifier: 157160034

GI number: 157160034

Start: 598724

End: 600085

Strand: Direct

Name: allB [H]

Synonym: EcHS_A0585

Alternate gene names: 157160034

Gene position: 598724-600085 (Clockwise)

Preceding gene: 157160033

Following gene: 157160035

Centisome position: 12.89

GC content: 51.03

Gene sequence:

>1362_bases
ATGTCTTTTGATTTAATCATTAAAAACGGCACCGTTATTTTAGAAAACGAAGCTCGCGTTGTAGATATCGCCGTTAAAGG
CGGAAAAATTGCTGCTATCGGTCAGGATCTGGGCGATGCAAAAGAAGTTATGGATGCGTCTGGTCTGGTGGTTTCGCCGG
GCATGGTTGATGCGCACACCCATATTTCTGAACCGGGTCGTAGCCACTGGGAAGGTTATGAAACCGGTACTCGCGCAGCG
GCAAAAGGTGGTATCACCACCATGATCGAAATGCCGCTCAACCAGCTGCCTGCAACGGTTGACCGTGCTTCAATTGAACT
GAAGTTCGATGCCGCTAAAGGCAAGCTGACTATCGATGCGGCACAACTCGGTGGCCTGGTGTCTTACAACATTGATCGTC
TGCATGAGTTGGATGAAGTGGGCGTTGTCGGCTTCAAATGCTTCGTTGCGACCTGTGGCGATCGCGGTATCGACAACGAC
TTCCGTGATGTAAACGACTGGCAGTTCTTCAAAGGTGCGCAGAAGCTGGGCGAACTGGGGCAGCCGGTGCTGGTGCACTG
CGAAAACGCGCTGATCTGTGATGCACTGGGCGAAGAAGCGAAAAGTGAAGGTCGCGTAACTGCCCATGACTATGTGGCTT
CGCGTCCGGTATTTACCGAAGTGGAAGCGATTCGCCGCGTACTGTACCTGGCGAAAGTTGCCGGTTGCCGTCTGCACATT
TGCCATATCAGCAGCCCAGAAGGTGTTGAAGAAGTGACTCGTGCACGTCAGGAAGGTCAGGATGTTACTTGTGAATCCTG
CCCGCATTACTTTGTACTGGATACCGATCAGTTCGAAGAAATCGGTACTCTGGCGAAGTGTTCACCGCCGATCCGCGATC
TGGAAAACCAGAAAGGCATGTGGGAAAAACTGTTTAACGGTGAAATCGACTGCCTGGTTTCCGACCACTCACCATGCCCT
CCGGAAATGAAAGCCGGCAACATCATGGAAGCATGGGGCGGTATTGCCGGTCTGCAAAACTGTATGGACGTGATGTTCGA
TGAAGCGGTACAGAAACGCGGAATGTCTCTGCCAATGTTCGGCAAATTAATGGCGACTAACGCAGCAGATATTTTCGGTC
TGCAGCAAAAAGGCCGTATCGCCCCAGGAAAAGATGCCGAGTTCGTCTTCATTCAGCCGAATAGCAGCTATGTTCTTACC
AATGACGATCTGGAATATCGCCACAAAGTCAGCCCGTATGTTGGCCGTACCATTGGCGCGCGTATCACGAAAACCATCTT
ACGTGGTGATGTGATTTACGACATTGAACAGGGCTTCCCTGTTGCGCCGAAAGGTCAATTTATCCTTAAACATCAGCAGT
AA

Upstream 100 bases:

>100_bases
CAACAGCAGAAAAAACAGGAGAGCAAAAAACCATAGGTTAATTAATCCCGATATTGAACATTGAGTTAAAAACCAATCTG
TATTTTACAAGGAGTTTGTT

Downstream 100 bases:

>100_bases
TCTGGCCCCTGCAATGCCCGTCCTTGCGGCGGGCATTCTCCGGTTAAGGTGTGTTTATGTTCAATTTTGCAGTCAGCCGC
GAAAGCCTGTTATCAGGATT

Product: allantoinase

Products: NA

Alternate protein names: Allantoin-utilizing enzyme [H]

Number of amino acids: Translated: 453; Mature: 452

Protein sequence:

>453_residues
MSFDLIIKNGTVILENEARVVDIAVKGGKIAAIGQDLGDAKEVMDASGLVVSPGMVDAHTHISEPGRSHWEGYETGTRAA
AKGGITTMIEMPLNQLPATVDRASIELKFDAAKGKLTIDAAQLGGLVSYNIDRLHELDEVGVVGFKCFVATCGDRGIDND
FRDVNDWQFFKGAQKLGELGQPVLVHCENALICDALGEEAKSEGRVTAHDYVASRPVFTEVEAIRRVLYLAKVAGCRLHI
CHISSPEGVEEVTRARQEGQDVTCESCPHYFVLDTDQFEEIGTLAKCSPPIRDLENQKGMWEKLFNGEIDCLVSDHSPCP
PEMKAGNIMEAWGGIAGLQNCMDVMFDEAVQKRGMSLPMFGKLMATNAADIFGLQQKGRIAPGKDAEFVFIQPNSSYVLT
NDDLEYRHKVSPYVGRTIGARITKTILRGDVIYDIEQGFPVAPKGQFILKHQQ

Sequences:

>Translated_453_residues
MSFDLIIKNGTVILENEARVVDIAVKGGKIAAIGQDLGDAKEVMDASGLVVSPGMVDAHTHISEPGRSHWEGYETGTRAA
AKGGITTMIEMPLNQLPATVDRASIELKFDAAKGKLTIDAAQLGGLVSYNIDRLHELDEVGVVGFKCFVATCGDRGIDND
FRDVNDWQFFKGAQKLGELGQPVLVHCENALICDALGEEAKSEGRVTAHDYVASRPVFTEVEAIRRVLYLAKVAGCRLHI
CHISSPEGVEEVTRARQEGQDVTCESCPHYFVLDTDQFEEIGTLAKCSPPIRDLENQKGMWEKLFNGEIDCLVSDHSPCP
PEMKAGNIMEAWGGIAGLQNCMDVMFDEAVQKRGMSLPMFGKLMATNAADIFGLQQKGRIAPGKDAEFVFIQPNSSYVLT
NDDLEYRHKVSPYVGRTIGARITKTILRGDVIYDIEQGFPVAPKGQFILKHQQ
>Mature_452_residues
SFDLIIKNGTVILENEARVVDIAVKGGKIAAIGQDLGDAKEVMDASGLVVSPGMVDAHTHISEPGRSHWEGYETGTRAAA
KGGITTMIEMPLNQLPATVDRASIELKFDAAKGKLTIDAAQLGGLVSYNIDRLHELDEVGVVGFKCFVATCGDRGIDNDF
RDVNDWQFFKGAQKLGELGQPVLVHCENALICDALGEEAKSEGRVTAHDYVASRPVFTEVEAIRRVLYLAKVAGCRLHIC
HISSPEGVEEVTRARQEGQDVTCESCPHYFVLDTDQFEEIGTLAKCSPPIRDLENQKGMWEKLFNGEIDCLVSDHSPCPP
EMKAGNIMEAWGGIAGLQNCMDVMFDEAVQKRGMSLPMFGKLMATNAADIFGLQQKGRIAPGKDAEFVFIQPNSSYVLTN
DDLEYRHKVSPYVGRTIGARITKTILRGDVIYDIEQGFPVAPKGQFILKHQQ

Specific function: Catalyzes the conversion of allantoin (5- ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring [H]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Allantoinase subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503375, Length=469, Percent_Identity=27.2921108742004, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI4503379, Length=474, Percent_Identity=25.3164556962025, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI4503051, Length=418, Percent_Identity=28.2296650717703, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI18105007, Length=422, Percent_Identity=23.9336492890995, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI62422571, Length=420, Percent_Identity=27.8571428571429, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI19923821, Length=456, Percent_Identity=25.6578947368421, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI4503377, Length=430, Percent_Identity=26.7441860465116, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI190194363, Length=430, Percent_Identity=26.7441860465116, Blast_Score=102, Evalue=8e-22,
Organism=Escherichia coli, GI1786722, Length=453, Percent_Identity=98.4547461368653, Blast_Score=929, Evalue=0.0,
Organism=Escherichia coli, GI87082175, Length=444, Percent_Identity=29.954954954955, Blast_Score=172, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI71989490, Length=471, Percent_Identity=26.5392781316348, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17539558, Length=469, Percent_Identity=26.6524520255864, Blast_Score=128, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI193204318, Length=381, Percent_Identity=24.4094488188976, Blast_Score=124, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI86575075, Length=439, Percent_Identity=24.1457858769932, Blast_Score=96, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6322218, Length=416, Percent_Identity=34.375, Blast_Score=251, Evalue=1e-67,
Organism=Drosophila melanogaster, GI18859883, Length=430, Percent_Identity=33.4883720930233, Blast_Score=201, Evalue=7e-52,
Organism=Drosophila melanogaster, GI221377917, Length=470, Percent_Identity=26.1702127659574, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24642586, Length=399, Percent_Identity=23.8095238095238, Blast_Score=123, Evalue=3e-28,
Organism=Drosophila melanogaster, GI17137462, Length=465, Percent_Identity=25.8064516129032, Blast_Score=122, Evalue=6e-28,
Organism=Drosophila melanogaster, GI24644287, Length=304, Percent_Identity=26.6447368421053, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24644289, Length=263, Percent_Identity=26.615969581749, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017593
- InterPro:   IPR006680
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.5 [H]

Molecular weight: Translated: 49545; Mature: 49414

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFDLIIKNGTVILENEARVVDIAVKGGKIAAIGQDLGDAKEVMDASGLVVSPGMVDAHT
CCEEEEEECCEEEEECCCEEEEEEECCCEEEEECCCCCHHHHHHCCCCEEECCCCCCCCC
HISEPGRSHWEGYETGTRAAAKGGITTMIEMPLNQLPATVDRASIELKFDAAKGKLTIDA
CCCCCCCHHCCCCCCCCHHHHCCCCEEEEECCHHHCCCCCCCEEEEEEEECCCCEEEEEH
AQLGGLVSYNIDRLHELDEVGVVGFKCFVATCGDRGIDNDFRDVNDWQFFKGAQKLGELG
HHHCCEEEECHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCC
QPVLVHCENALICDALGEEAKSEGRVTAHDYVASRPVFTEVEAIRRVLYLAKVAGCRLHI
CCEEEEECCEEEEHHHHHHHHHCCCEEEHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEE
CHISSPEGVEEVTRARQEGQDVTCESCPHYFVLDTDQFEEIGTLAKCSPPIRDLENQKGM
EECCCCCCHHHHHHHHHCCCCCCHHCCCCEEEECCHHHHHHCCHHHCCCCHHHHHCCCCH
WEKLFNGEIDCLVSDHSPCPPEMKAGNIMEAWGGIAGLQNCMDVMFDEAVQKRGMSLPMF
HHHHHCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
GKLMATNAADIFGLQQKGRIAPGKDAEFVFIQPNSSYVLTNDDLEYRHKVSPYVGRTIGA
HHHHHCCCHHHCCCCCCCCCCCCCCCCEEEECCCCCEEEECCCCHHHHCCCHHHHHHHHH
RITKTILRGDVIYDIEQGFPVAPKGQFILKHQQ
HHHHHHHCCCEEEEECCCCCCCCCCCEEEECCC
>Mature Secondary Structure 
SFDLIIKNGTVILENEARVVDIAVKGGKIAAIGQDLGDAKEVMDASGLVVSPGMVDAHT
CEEEEEECCEEEEECCCEEEEEEECCCEEEEECCCCCHHHHHHCCCCEEECCCCCCCCC
HISEPGRSHWEGYETGTRAAAKGGITTMIEMPLNQLPATVDRASIELKFDAAKGKLTIDA
CCCCCCCHHCCCCCCCCHHHHCCCCEEEEECCHHHCCCCCCCEEEEEEEECCCCEEEEEH
AQLGGLVSYNIDRLHELDEVGVVGFKCFVATCGDRGIDNDFRDVNDWQFFKGAQKLGELG
HHHCCEEEECHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCC
QPVLVHCENALICDALGEEAKSEGRVTAHDYVASRPVFTEVEAIRRVLYLAKVAGCRLHI
CCEEEEECCEEEEHHHHHHHHHCCCEEEHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEE
CHISSPEGVEEVTRARQEGQDVTCESCPHYFVLDTDQFEEIGTLAKCSPPIRDLENQKGM
EECCCCCCHHHHHHHHHCCCCCCHHCCCCEEEECCHHHHHHCCHHHCCCCHHHHHCCCCH
WEKLFNGEIDCLVSDHSPCPPEMKAGNIMEAWGGIAGLQNCMDVMFDEAVQKRGMSLPMF
HHHHHCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
GKLMATNAADIFGLQQKGRIAPGKDAEFVFIQPNSSYVLTNDDLEYRHKVSPYVGRTIGA
HHHHHCCCHHHCCCCCCCCCCCCCCCCEEEECCCCCEEEECCCCHHHHCCCHHHHHHHHH
RITKTILRGDVIYDIEQGFPVAPKGQFILKHQQ
HHHHHHHCCCEEEEECCCCCCCCCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA