| Definition | Escherichia coli HS, complete genome. |
|---|---|
| Accession | NC_009800 |
| Length | 4,643,538 |
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The map label for this gene is dkgB [H]
Identifier: 157159668
GI number: 157159668
Start: 228545
End: 229348
Strand: Direct
Name: dkgB [H]
Synonym: EcHS_A0211
Alternate gene names: 157159668
Gene position: 228545-229348 (Clockwise)
Preceding gene: 157159667
Following gene: 157159670
Centisome position: 4.92
GC content: 46.27
Gene sequence:
>804_bases ATGGCTATCCCTGCATTTGGTTTAGGTACTTTCCGTCTGAAAGACGACGTTGTTATTTCATCTGTGAAAACGGCGCTTGA ACTTGGTTATCGCGCAATTGATACCGCACAAATCTATGATAACGAAGCCGCAGTAGGTCAGGCGATTGCAGAAAGTGGCG TGCCACGTCATGAACTCTACATCACCACTAAAATCTGGATTGAAAATCTCAGCAAAGACAAATTGATCCCAAGTCTGAAA GAGAGCCTGCAAAAATTGCGTACCGATTATGTTGATCTGACGCTAATCCACTGGCCGTCACCAAACGATGAAGTCTCTGT TGAAGAGTTTATGCAGGCGCTGCTGAAAGCCAAAAAACAAGGGCTGACGCGTGAGATCGGTATTTCCAACTTCACGATCC CATTGATGGAAAAGGCGATTGCTGCTGTTGGCGCTGAAAACATCGCTACTAACCAGATTGAACTCTCTCCTTATCTGCAA AACCGTAAAGTGGTTGCCTGGGCTAAACAGCACGGCATCCATATTACTTCCTATATGACGCTGGCGTATGGTAAGGCCCT GAAAGATGAGGTTATTGCTCGTATCGCAGCTAAACACAATGCGACTCCGGCACAAGTGATTCTGGCGTGGGCTATGGGGG AAGGTTACTCAGTAATTCCTTCTTCTACTAAACGTAAAAACCTGGAAAGTAATCTTAAGGCACAAAATTTACAGCTCGAT GCCAAAGATAAAAAAGCGATCGCCGCCCTGGATTGCAACGACCGCCTGGTTAGCCCGAAAGGTCTGGCTCCTGAATGGGA TTAA
Upstream 100 bases:
>100_bases AGAATCGCAAAAATCCTCTGCATTTTACGCTCTTTTTCCTCAACAGTCTGAAGCCCATAATCACCTCAGTTAACGAAAAT AGCATTAAAAGAGGCATATT
Downstream 100 bases:
>100_bases GCCTCTCTGACAGCTCCTCCGGGAGCTGTTTTTACATGCTCGCTAAGGAAATCGATAAAAGCCCGGATGCGCGTACTTAC CGCACGGTCGCTGTAATAGA
Product: 2,5-diketo-D-gluconate reductase B
Products: NA
Alternate protein names: 2,5-DKG reductase B; 2,5-DKGR B; 25DKGR-B; AKR5D [H]
Number of amino acids: Translated: 267; Mature: 266
Protein sequence:
>267_residues MAIPAFGLGTFRLKDDVVISSVKTALELGYRAIDTAQIYDNEAAVGQAIAESGVPRHELYITTKIWIENLSKDKLIPSLK ESLQKLRTDYVDLTLIHWPSPNDEVSVEEFMQALLKAKKQGLTREIGISNFTIPLMEKAIAAVGAENIATNQIELSPYLQ NRKVVAWAKQHGIHITSYMTLAYGKALKDEVIARIAAKHNATPAQVILAWAMGEGYSVIPSSTKRKNLESNLKAQNLQLD AKDKKAIAALDCNDRLVSPKGLAPEWD
Sequences:
>Translated_267_residues MAIPAFGLGTFRLKDDVVISSVKTALELGYRAIDTAQIYDNEAAVGQAIAESGVPRHELYITTKIWIENLSKDKLIPSLK ESLQKLRTDYVDLTLIHWPSPNDEVSVEEFMQALLKAKKQGLTREIGISNFTIPLMEKAIAAVGAENIATNQIELSPYLQ NRKVVAWAKQHGIHITSYMTLAYGKALKDEVIARIAAKHNATPAQVILAWAMGEGYSVIPSSTKRKNLESNLKAQNLQLD AKDKKAIAALDCNDRLVSPKGLAPEWD >Mature_266_residues AIPAFGLGTFRLKDDVVISSVKTALELGYRAIDTAQIYDNEAAVGQAIAESGVPRHELYITTKIWIENLSKDKLIPSLKE SLQKLRTDYVDLTLIHWPSPNDEVSVEEFMQALLKAKKQGLTREIGISNFTIPLMEKAIAAVGAENIATNQIELSPYLQN RKVVAWAKQHGIHITSYMTLAYGKALKDEVIARIAAKHNATPAQVILAWAMGEGYSVIPSSTKRKNLESNLKAQNLQLDA KDKKAIAALDCNDRLVSPKGLAPEWD
Specific function: Catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG) [H]
COG id: COG0656
COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: Unknown [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the aldo/keto reductase family [H]
Homologues:
Organism=Homo sapiens, GI310109922, Length=275, Percent_Identity=32, Blast_Score=143, Evalue=2e-34, Organism=Homo sapiens, GI310109920, Length=292, Percent_Identity=30.4794520547945, Blast_Score=139, Evalue=2e-33, Organism=Homo sapiens, GI45446745, Length=292, Percent_Identity=30.4794520547945, Blast_Score=139, Evalue=3e-33, Organism=Homo sapiens, GI4503285, Length=292, Percent_Identity=30.4794520547945, Blast_Score=139, Evalue=3e-33, Organism=Homo sapiens, GI5453543, Length=292, Percent_Identity=30.1369863013699, Blast_Score=137, Evalue=8e-33, Organism=Homo sapiens, GI24497577, Length=289, Percent_Identity=29.757785467128, Blast_Score=137, Evalue=1e-32, Organism=Homo sapiens, GI5174391, Length=289, Percent_Identity=29.757785467128, Blast_Score=137, Evalue=1e-32, Organism=Homo sapiens, GI24497585, Length=291, Percent_Identity=29.553264604811, Blast_Score=135, Evalue=4e-32, Organism=Homo sapiens, GI5174695, Length=293, Percent_Identity=30.7167235494881, Blast_Score=135, Evalue=5e-32, Organism=Homo sapiens, GI24497583, Length=287, Percent_Identity=31.3588850174216, Blast_Score=134, Evalue=7e-32, Organism=Homo sapiens, GI93277124, Length=299, Percent_Identity=30.1003344481605, Blast_Score=130, Evalue=1e-30, Organism=Homo sapiens, GI223468663, Length=285, Percent_Identity=29.8245614035088, Blast_Score=127, Evalue=8e-30, Organism=Homo sapiens, GI300116273, Length=269, Percent_Identity=30.4832713754647, Blast_Score=124, Evalue=7e-29, Organism=Homo sapiens, GI4502049, Length=288, Percent_Identity=32.9861111111111, Blast_Score=124, Evalue=9e-29, Organism=Homo sapiens, GI291291012, Length=273, Percent_Identity=28.9377289377289, Blast_Score=115, Evalue=4e-26, Organism=Homo sapiens, GI300116271, Length=278, Percent_Identity=30.2158273381295, Blast_Score=115, Evalue=4e-26, Organism=Homo sapiens, GI310109926, Length=114, Percent_Identity=37.719298245614, Blast_Score=79, Evalue=5e-15, Organism=Homo sapiens, GI207028673, Length=114, Percent_Identity=37.719298245614, Blast_Score=79, Evalue=6e-15, Organism=Homo sapiens, GI310109924, Length=155, Percent_Identity=29.0322580645161, Blast_Score=75, Evalue=8e-14, Organism=Escherichia coli, GI1786400, Length=267, Percent_Identity=98.501872659176, Blast_Score=538, Evalue=1e-154, Organism=Escherichia coli, GI87082198, Length=256, Percent_Identity=38.28125, Blast_Score=180, Evalue=9e-47, Organism=Escherichia coli, GI1788081, Length=279, Percent_Identity=29.3906810035842, Blast_Score=108, Evalue=2e-25, Organism=Escherichia coli, GI48994888, Length=271, Percent_Identity=29.1512915129151, Blast_Score=77, Evalue=1e-15, Organism=Escherichia coli, GI1787674, Length=270, Percent_Identity=26.6666666666667, Blast_Score=70, Evalue=2e-13, Organism=Caenorhabditis elegans, GI17550248, Length=271, Percent_Identity=35.4243542435424, Blast_Score=152, Evalue=1e-37, Organism=Caenorhabditis elegans, GI17537075, Length=290, Percent_Identity=35.5172413793103, Blast_Score=143, Evalue=1e-34, Organism=Caenorhabditis elegans, GI17537077, Length=288, Percent_Identity=35.4166666666667, Blast_Score=141, Evalue=4e-34, Organism=Caenorhabditis elegans, GI71998625, Length=262, Percent_Identity=30.9160305343511, Blast_Score=137, Evalue=6e-33, Organism=Caenorhabditis elegans, GI17561298, Length=276, Percent_Identity=30.4347826086957, Blast_Score=131, Evalue=3e-31, Organism=Caenorhabditis elegans, GI17552492, Length=267, Percent_Identity=30.3370786516854, Blast_Score=130, Evalue=5e-31, Organism=Caenorhabditis elegans, GI17538386, Length=281, Percent_Identity=31.3167259786477, Blast_Score=126, Evalue=1e-29, Organism=Caenorhabditis elegans, GI17561300, Length=277, Percent_Identity=30.6859205776173, Blast_Score=125, Evalue=2e-29, Organism=Caenorhabditis elegans, GI17566692, Length=262, Percent_Identity=32.0610687022901, Blast_Score=121, Evalue=4e-28, Organism=Caenorhabditis elegans, GI17537079, Length=294, Percent_Identity=27.2108843537415, Blast_Score=119, Evalue=2e-27, Organism=Caenorhabditis elegans, GI17564128, Length=292, Percent_Identity=27.0547945205479, Blast_Score=116, Evalue=1e-26, Organism=Caenorhabditis elegans, GI17562292, Length=268, Percent_Identity=29.4776119402985, Blast_Score=114, Evalue=5e-26, Organism=Caenorhabditis elegans, GI212645785, Length=140, Percent_Identity=30.7142857142857, Blast_Score=64, Evalue=7e-11, Organism=Saccharomyces cerevisiae, GI6324694, Length=276, Percent_Identity=35.8695652173913, Blast_Score=158, Evalue=7e-40, Organism=Saccharomyces cerevisiae, GI6320576, Length=282, Percent_Identity=36.5248226950355, Blast_Score=155, Evalue=7e-39, Organism=Saccharomyces cerevisiae, GI6321896, Length=306, Percent_Identity=29.0849673202614, Blast_Score=126, Evalue=4e-30, Organism=Saccharomyces cerevisiae, GI6322556, Length=259, Percent_Identity=26.2548262548263, Blast_Score=115, Evalue=6e-27, Organism=Saccharomyces cerevisiae, GI6319625, Length=275, Percent_Identity=30.5454545454545, Blast_Score=108, Evalue=6e-25, Organism=Saccharomyces cerevisiae, GI6320079, Length=258, Percent_Identity=30.2325581395349, Blast_Score=94, Evalue=2e-20, Organism=Drosophila melanogaster, GI24662789, Length=293, Percent_Identity=31.0580204778157, Blast_Score=141, Evalue=4e-34, Organism=Drosophila melanogaster, GI24644950, Length=294, Percent_Identity=31.9727891156463, Blast_Score=139, Evalue=2e-33, Organism=Drosophila melanogaster, GI24657054, Length=288, Percent_Identity=31.25, Blast_Score=135, Evalue=4e-32, Organism=Drosophila melanogaster, GI221378297, Length=314, Percent_Identity=30.5732484076433, Blast_Score=133, Evalue=1e-31, Organism=Drosophila melanogaster, GI20129731, Length=286, Percent_Identity=31.1188811188811, Blast_Score=128, Evalue=4e-30, Organism=Drosophila melanogaster, GI24663317, Length=285, Percent_Identity=29.8245614035088, Blast_Score=128, Evalue=5e-30, Organism=Drosophila melanogaster, GI21356425, Length=286, Percent_Identity=30.7692307692308, Blast_Score=125, Evalue=3e-29, Organism=Drosophila melanogaster, GI24662785, Length=289, Percent_Identity=33.5640138408304, Blast_Score=123, Evalue=1e-28, Organism=Drosophila melanogaster, GI24662781, Length=290, Percent_Identity=33.1034482758621, Blast_Score=119, Evalue=3e-27, Organism=Drosophila melanogaster, GI45553081, Length=284, Percent_Identity=28.169014084507, Blast_Score=113, Evalue=1e-25, Organism=Drosophila melanogaster, GI281366140, Length=259, Percent_Identity=26.6409266409266, Blast_Score=94, Evalue=1e-19,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR001395 - InterPro: IPR018170 - InterPro: IPR020471 - InterPro: IPR023210 [H]
Pfam domain/function: PF00248 Aldo_ket_red [H]
EC number: =1.1.1.274 [H]
Molecular weight: Translated: 29449; Mature: 29318
Theoretical pI: Translated: 8.39; Mature: 8.39
Prosite motif: PS00798 ALDOKETO_REDUCTASE_1 ; PS00062 ALDOKETO_REDUCTASE_2
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.4 %Cys (Translated Protein) 1.9 %Met (Translated Protein) 2.2 %Cys+Met (Translated Protein) 0.4 %Cys (Mature Protein) 1.5 %Met (Mature Protein) 1.9 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MAIPAFGLGTFRLKDDVVISSVKTALELGYRAIDTAQIYDNEAAVGQAIAESGVPRHELY CCCCCCCCCEEEECCHHHHHHHHHHHHHCHHHCCHHHHCCCHHHHHHHHHHCCCCCCEEE ITTKIWIENLSKDKLIPSLKESLQKLRTDYVDLTLIHWPSPNDEVSVEEFMQALLKAKKQ EEEEHHHHCCCCCCCCHHHHHHHHHHHHCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHC GLTREIGISNFTIPLMEKAIAAVGAENIATNQIELSPYLQNRKVVAWAKQHGIHITSYMT CCCEECCCCCCCHHHHHHHHHHHCCCCCCCCEEEECHHHCCCEEEEEHHHCCEEEEHHHH LAYGKALKDEVIARIAAKHNATPAQVILAWAMGEGYSVIPSSTKRKNLESNLKAQNLQLD HHHHHHHHHHHHHHHHHHCCCCHHHEEEEEECCCCCEECCCCHHHHHHHHCCCCCCEEEC AKDKKAIAALDCNDRLVSPKGLAPEWD CCCCCEEEEECCCCCEECCCCCCCCCC >Mature Secondary Structure AIPAFGLGTFRLKDDVVISSVKTALELGYRAIDTAQIYDNEAAVGQAIAESGVPRHELY CCCCCCCCEEEECCHHHHHHHHHHHHHCHHHCCHHHHCCCHHHHHHHHHHCCCCCCEEE ITTKIWIENLSKDKLIPSLKESLQKLRTDYVDLTLIHWPSPNDEVSVEEFMQALLKAKKQ EEEEHHHHCCCCCCCCHHHHHHHHHHHHCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHC GLTREIGISNFTIPLMEKAIAAVGAENIATNQIELSPYLQNRKVVAWAKQHGIHITSYMT CCCEECCCCCCCHHHHHHHHHHHCCCCCCCCEEEECHHHCCCEEEEEHHHCCEEEEHHHH LAYGKALKDEVIARIAAKHNATPAQVILAWAMGEGYSVIPSSTKRKNLESNLKAQNLQLD HHHHHHHHHHHHHHHHHHCCCCHHHEEEEEECCCCCEECCCCHHHHHHHHCCCCCCEEEC AKDKKAIAALDCNDRLVSPKGLAPEWD CCCCCEEEEECCCCCEECCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 11206551; 11258796; 11108008 [H]