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The map label for this gene is pdp [H]

Identifier: 156980451

GI number: 156980451

Start: 2265416

End: 2266756

Strand: Reverse

Name: pdp [H]

Synonym: SAHV_2120

Alternate gene names: 156980451

Gene position: 2266756-2265416 (Counterclockwise)

Preceding gene: 156980452

Following gene: 156980450

Centisome position: 78.7

GC content: 35.79

Gene sequence:

>1341_bases
ATGCTTTGTCCTAAGCTTTTTAAGAAAAGGATGATAAAAATGAGAATGATAGACATTATTGAGAAAAAGCGTGACGGTCA
TACACTAACAACGGAAGAAATTAATTTCTTTATTGACGGCTATGTTAAAGGGGATATTCCTGATTACCAAGCATCAAGTT
TAGCAATGGCGATTTATTTCCAAGATATGAATGATGATGAGCGTGCAGCATTAACGATGGCTATGGTTAATTCTGGTGAT
ATGATAGATTTGAGTGATATTAAAGGTGTCAAAGTAGATAAGCACTCAACAGGTGGTGTAGGAGATACAACTACATTGGT
TTTAGCACCATTAGTAGCAGCTGTAGATGTTCCTGTTGCAAAAATGAGTGGGCGTGGATTAGGTCATACAGGTGGTACGA
TTGATAAATTAGAAGCAATTGATGGTTTTCATGTTGAAATAGATGAAGCAACATTTGTGAAATTGGTTAATGAAAATAAA
GTGGCAGTTGTAGGACAATCAGGAAATTTAACTCCTGCAGACAAAAAATTATATGCCTTAAGGGATGTTACTGGTACTGT
CAATTCAATACCATTAATTGCCTCTTCAATTATGAGTAAAAAGATTGCTGCTGGTGCAGATGCAATTGTATTAGATGTAA
AAACTGGTAGCGGTGCATTTATGAAAACATTAGAAGATGCTGAAGCATTAGCGCACGCAATGGTACGTATTGGTAATAAT
GTGGGACGTAATACGATGGCGATTATTTCTGATATGAATCAGCCACTTGGACGTGCGATTGGCAATGCGCTTGAGTTACA
AGAAGCAATTGATACGTTGAAAGGACAAGGTCCGAAAGATTTAACAGAACTTGTATTAACATTAGGTTCTCAAATGGTTG
TACTTGCAAACAAAGCTGAAACGCTTGAAGAAGCGAGAGCGTTGCTAATTGAGGCAATTAATTCAGGTGCAGCATTAGAA
AAATTCAAAATATTTATTAAAAACCAAGGTGGCGACGAAACTGTTATTGACCATCCAGAGCGTTTGCCACAAGCTCAATA
TCAAATTGAATATAAAGCTAAAAAATCAGGTTATGTGACTGAATTAGTCTCTAACGATATAGGTGTCGCTTCGATGATGT
TAGGAGCGGGACGTTTAACAAAAGAGGATGATATTGATTTAGCGGTTGGTATTGTTTTAAATAAAAAAATTGGTGATAAA
GTAGAAGAAGGAGAATCATTATTAACGATTCACAGTAATCGCCAAGATGTAGACGATGTTGTTAAAAAATTAGATTCAAG
CATAACAATTGCTGATCATGTTGTATCGCCTACATTAATTCATAAAATCATTACAGAGTAG

Upstream 100 bases:

>100_bases
TAATAACATCGCATTGAAATTGTGATATTAAAAATGAAATCGATAGCTTGCTATAATAATTTTCGCTTGTGCTTTTAAAA
ATGGACTAGAGAAAGCGCAG

Downstream 100 bases:

>100_bases
GAGTTGAAGCTGATTGAACATACTAAGATATTTATTAGGAATAGGTTTTAGTGTAATAGGTGTATTGCATTTTACACGAG
AACGACAATTTAGAAATATC

Product: pyrimidine-nucleoside phosphorylase

Products: NA

Alternate protein names: PYNP [H]

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MLCPKLFKKRMIKMRMIDIIEKKRDGHTLTTEEINFFIDGYVKGDIPDYQASSLAMAIYFQDMNDDERAALTMAMVNSGD
MIDLSDIKGVKVDKHSTGGVGDTTTLVLAPLVAAVDVPVAKMSGRGLGHTGGTIDKLEAIDGFHVEIDEATFVKLVNENK
VAVVGQSGNLTPADKKLYALRDVTGTVNSIPLIASSIMSKKIAAGADAIVLDVKTGSGAFMKTLEDAEALAHAMVRIGNN
VGRNTMAIISDMNQPLGRAIGNALELQEAIDTLKGQGPKDLTELVLTLGSQMVVLANKAETLEEARALLIEAINSGAALE
KFKIFIKNQGGDETVIDHPERLPQAQYQIEYKAKKSGYVTELVSNDIGVASMMLGAGRLTKEDDIDLAVGIVLNKKIGDK
VEEGESLLTIHSNRQDVDDVVKKLDSSITIADHVVSPTLIHKIITE

Sequences:

>Translated_446_residues
MLCPKLFKKRMIKMRMIDIIEKKRDGHTLTTEEINFFIDGYVKGDIPDYQASSLAMAIYFQDMNDDERAALTMAMVNSGD
MIDLSDIKGVKVDKHSTGGVGDTTTLVLAPLVAAVDVPVAKMSGRGLGHTGGTIDKLEAIDGFHVEIDEATFVKLVNENK
VAVVGQSGNLTPADKKLYALRDVTGTVNSIPLIASSIMSKKIAAGADAIVLDVKTGSGAFMKTLEDAEALAHAMVRIGNN
VGRNTMAIISDMNQPLGRAIGNALELQEAIDTLKGQGPKDLTELVLTLGSQMVVLANKAETLEEARALLIEAINSGAALE
KFKIFIKNQGGDETVIDHPERLPQAQYQIEYKAKKSGYVTELVSNDIGVASMMLGAGRLTKEDDIDLAVGIVLNKKIGDK
VEEGESLLTIHSNRQDVDDVVKKLDSSITIADHVVSPTLIHKIITE
>Mature_446_residues
MLCPKLFKKRMIKMRMIDIIEKKRDGHTLTTEEINFFIDGYVKGDIPDYQASSLAMAIYFQDMNDDERAALTMAMVNSGD
MIDLSDIKGVKVDKHSTGGVGDTTTLVLAPLVAAVDVPVAKMSGRGLGHTGGTIDKLEAIDGFHVEIDEATFVKLVNENK
VAVVGQSGNLTPADKKLYALRDVTGTVNSIPLIASSIMSKKIAAGADAIVLDVKTGSGAFMKTLEDAEALAHAMVRIGNN
VGRNTMAIISDMNQPLGRAIGNALELQEAIDTLKGQGPKDLTELVLTLGSQMVVLANKAETLEEARALLIEAINSGAALE
KFKIFIKNQGGDETVIDHPERLPQAQYQIEYKAKKSGYVTELVSNDIGVASMMLGAGRLTKEDDIDLAVGIVLNKKIGDK
VEEGESLLTIHSNRQDVDDVVKKLDSSITIADHVVSPTLIHKIITE

Specific function: The Enzymes Which Catalyze The Reversible Phosphorolysis Of Pyrimidine Nucleosides Are Involved In The Degradation Of These Compounds And In Their Utilization As Carbon And Energy Sources, Or In The Rescue Of Pyrimidine Bases For Nucleotide Synthesis. [C

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI166158925, Length=409, Percent_Identity=38.1418092909535, Blast_Score=264, Evalue=1e-70,
Organism=Homo sapiens, GI4503445, Length=409, Percent_Identity=38.1418092909535, Blast_Score=264, Evalue=1e-70,
Organism=Homo sapiens, GI166158922, Length=409, Percent_Identity=38.1418092909535, Blast_Score=264, Evalue=1e-70,
Organism=Escherichia coli, GI1790842, Length=404, Percent_Identity=43.8118811881188, Blast_Score=324, Evalue=8e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872 [H]

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C [H]

EC number: =2.4.2.2 [H]

Molecular weight: Translated: 47997; Mature: 47997

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLCPKLFKKRMIKMRMIDIIEKKRDGHTLTTEEINFFIDGYVKGDIPDYQASSLAMAIYF
CCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCEEEEEEEEEECCCCCCCCCCEEEEEEE
QDMNDDERAALTMAMVNSGDMIDLSDIKGVKVDKHSTGGVGDTTTLVLAPLVAAVDVPVA
ECCCCCHHHEEEEEEECCCCEEECCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCHH
KMSGRGLGHTGGTIDKLEAIDGFHVEIDEATFVKLVNENKVAVVGQSGNLTPADKKLYAL
HHCCCCCCCCCCCHHHHHHCCCCEEEECCCEEEEEECCCEEEEEECCCCCCCCHHHEEEE
RDVTGTVNSIPLIASSIMSKKIAAGADAIVLDVKTGSGAFMKTLEDAEALAHAMVRIGNN
HHCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCC
VGRNTMAIISDMNQPLGRAIGNALELQEAIDTLKGQGPKDLTELVLTLGSQMVVLANKAE
CCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEECCHH
TLEEARALLIEAINSGAALEKFKIFIKNQGGDETVIDHPERLPQAQYQIEYKAKKSGYVT
HHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCCCHHHCCCCEEEEEEEECCCCCHH
ELVSNDIGVASMMLGAGRLTKEDDIDLAVGIVLNKKIGDKVEEGESLLTIHSNRQDVDDV
HHHHCCCCHHHHHHCCCCCCCCCCCCEEEEEEEECHHCCHHHCCCEEEEEECCCCCHHHH
VKKLDSSITIADHVVSPTLIHKIITE
HHHHCCCEEEHHHHCCHHHHHHHHCC
>Mature Secondary Structure
MLCPKLFKKRMIKMRMIDIIEKKRDGHTLTTEEINFFIDGYVKGDIPDYQASSLAMAIYF
CCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCEEEEEEEEEECCCCCCCCCCEEEEEEE
QDMNDDERAALTMAMVNSGDMIDLSDIKGVKVDKHSTGGVGDTTTLVLAPLVAAVDVPVA
ECCCCCHHHEEEEEEECCCCEEECCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCHH
KMSGRGLGHTGGTIDKLEAIDGFHVEIDEATFVKLVNENKVAVVGQSGNLTPADKKLYAL
HHCCCCCCCCCCCHHHHHHCCCCEEEECCCEEEEEECCCEEEEEECCCCCCCCHHHEEEE
RDVTGTVNSIPLIASSIMSKKIAAGADAIVLDVKTGSGAFMKTLEDAEALAHAMVRIGNN
HHCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCC
VGRNTMAIISDMNQPLGRAIGNALELQEAIDTLKGQGPKDLTELVLTLGSQMVVLANKAE
CCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEECCHH
TLEEARALLIEAINSGAALEKFKIFIKNQGGDETVIDHPERLPQAQYQIEYKAKKSGYVT
HHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCCCHHHCCCCEEEEEEEECCCCCHH
ELVSNDIGVASMMLGAGRLTKEDDIDLAVGIVLNKKIGDKVEEGESLLTIHSNRQDVDDV
HHHHCCCCHHHHHHCCCCCCCCCCCCEEEEEEEECHHCCHHHCCCEEEEEECCCCCHHHH
VKKLDSSITIADHVVSPTLIHKIITE
HHHHCCCEEEHHHHCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA