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The map label for this gene is fixC [C]

Identifier: 156937896

GI number: 156937896

Start: 988278

End: 989612

Strand: Direct

Name: fixC [C]

Synonym: Igni_1108

Alternate gene names: 156937896

Gene position: 988278-989612 (Clockwise)

Preceding gene: 156937894

Following gene: 156937902

Centisome position: 76.17

GC content: 62.02

Gene sequence:

>1335_bases
TTGGAATACGACGCCGTCGTAGTGGGCGCGGGGACCACCGGGCTGGTGGCCGCCAAGTTCCTAGCCGAGGCCGGCTACAA
GGTCCTAGTGGTGGAGCTCAAGGCCGAGGAGGAGGTGGGCACCAAGGTCTGCGGGGACGCGATAAGCAAGGAGTACTTCG
AGAAGATTCCCATAGGCAACCCCCCGGAGGAGGCGGTGGACGGGAACATAGTGGGGGCCAAGATATACTCCCCGGACGAG
GAGACCGTGTGGACCGTCCCCGGAGAGGGCTACATGCTCAACAGGAAGAAGTTCGGAGAGTGGTTGTATAACATGGCTAA
GGAGGCGGGCGCGGAGTTCTCCTTCAAGACCCGCGCTCTAGGCCCCGTGGTGAAGGACAACAAAGTCGTCGGCTTGACCG
TTCGCAAGGACGGCAAGGTGGAGACTGTGAGGGCGAGGCTCGTGGTGGACGCCAGCGGGGTCGCCTACGTAGTGAGGAGG
GCCTTACCGAAGAGCTGGCCCGTGGCCGAGCCCTTGGACCCCAAGGACACCGCCGTGGCTTACAGAGAGATAAGGAGGAT
AACGACCCCCTTAGAGGACGACAAGTACATAAGGATATACGTCGGCCAGCAGAAGGCCCCGGGAGGCTACTGGTGGCTCT
TCCCCTACCGCGGGGGAGCTAGGGTCAACTTGGGCCTAGGGGTACAAGGCGGGGTGGGCCACAAGGACCCCATGTGGTAC
TTCCACGAGTACTTGGCCCCCAGGTTCCCCGGCGAGGTGGAGCACGCCGGCGGAGGCGTTGTGCCCACGAGGAGGCCCTT
GGACACCATGGTCGCCCACGGCTTCGCGACGGCCGGCGACGCGGCGTACCAAGTGAACCCCATCCACGGCGGCGGCATAG
GCTCCGGCATGCTGGGGGCCTACTTGCTGGCCAAGACCGCAGTGAAGGCCCTTGAGGAGGAGCCCACAGTCGAGAACTTG
TGGAAGTACAACAAGGACTTCATGGACGCTTACGGCGCGAAGCAAGCTGCCTTGGACGTCTTCCGCGTCTTCCTCCAGTC
CTTGACTGACGACGAGATAAACTACGGGATGAAAAACAGAATAATAAAGGAGGAGGACTTGCTCAAGGCCTCCCTGGAGG
GGGACTTGAGGGTCTCCGCGCTGGACAAGCTGGGCAGGGTGATAAGGGCCCTCGGGAAGCCTTCCTTGCTCCCCAAGCTC
AAGACCGTGGCGGAGTACATGAAGGAGGTCAAGCAGCTCTACAAGGACTACCCGGAGACCCCGGAGGGCTTCGAGGAGTG
GAGGGAAAGGGTCTCGGAGACCTTCGAGCGCTATAGGAAGGAGCTGAGCAAGTAG

Upstream 100 bases:

>100_bases
CATTTCCGCTCCTTGTGACGGCGTCCGGAGGAGGATTAATGAAGCGGGGACAACACGCTTCTAACCTTCCCCCGGCGCCG
CGCAGCCCGGGTCCGAGATT

Downstream 100 bases:

>100_bases
CGCGCCAACTCCTTGGCCCCCTCCGGGTAGGAGGGCTTGAGCACGCCCTTAGCCCTCTCGACCGCCTCCCTCAACCCTTT
CAAGTCACTCAAAACGGCCC

Product: geranylgeranyl reductase

Products: NA

Alternate protein names: DGGGPL reductase 1; 2,3-di-O-geranylgeranylglyceryl phosphate reductase 1; Geranylgeranyl reductase 1; GGR 1 [H]

Number of amino acids: Translated: 444; Mature: 444

Protein sequence:

>444_residues
MEYDAVVVGAGTTGLVAAKFLAEAGYKVLVVELKAEEEVGTKVCGDAISKEYFEKIPIGNPPEEAVDGNIVGAKIYSPDE
ETVWTVPGEGYMLNRKKFGEWLYNMAKEAGAEFSFKTRALGPVVKDNKVVGLTVRKDGKVETVRARLVVDASGVAYVVRR
ALPKSWPVAEPLDPKDTAVAYREIRRITTPLEDDKYIRIYVGQQKAPGGYWWLFPYRGGARVNLGLGVQGGVGHKDPMWY
FHEYLAPRFPGEVEHAGGGVVPTRRPLDTMVAHGFATAGDAAYQVNPIHGGGIGSGMLGAYLLAKTAVKALEEEPTVENL
WKYNKDFMDAYGAKQAALDVFRVFLQSLTDDEINYGMKNRIIKEEDLLKASLEGDLRVSALDKLGRVIRALGKPSLLPKL
KTVAEYMKEVKQLYKDYPETPEGFEEWRERVSETFERYRKELSK

Sequences:

>Translated_444_residues
MEYDAVVVGAGTTGLVAAKFLAEAGYKVLVVELKAEEEVGTKVCGDAISKEYFEKIPIGNPPEEAVDGNIVGAKIYSPDE
ETVWTVPGEGYMLNRKKFGEWLYNMAKEAGAEFSFKTRALGPVVKDNKVVGLTVRKDGKVETVRARLVVDASGVAYVVRR
ALPKSWPVAEPLDPKDTAVAYREIRRITTPLEDDKYIRIYVGQQKAPGGYWWLFPYRGGARVNLGLGVQGGVGHKDPMWY
FHEYLAPRFPGEVEHAGGGVVPTRRPLDTMVAHGFATAGDAAYQVNPIHGGGIGSGMLGAYLLAKTAVKALEEEPTVENL
WKYNKDFMDAYGAKQAALDVFRVFLQSLTDDEINYGMKNRIIKEEDLLKASLEGDLRVSALDKLGRVIRALGKPSLLPKL
KTVAEYMKEVKQLYKDYPETPEGFEEWRERVSETFERYRKELSK
>Mature_444_residues
MEYDAVVVGAGTTGLVAAKFLAEAGYKVLVVELKAEEEVGTKVCGDAISKEYFEKIPIGNPPEEAVDGNIVGAKIYSPDE
ETVWTVPGEGYMLNRKKFGEWLYNMAKEAGAEFSFKTRALGPVVKDNKVVGLTVRKDGKVETVRARLVVDASGVAYVVRR
ALPKSWPVAEPLDPKDTAVAYREIRRITTPLEDDKYIRIYVGQQKAPGGYWWLFPYRGGARVNLGLGVQGGVGHKDPMWY
FHEYLAPRFPGEVEHAGGGVVPTRRPLDTMVAHGFATAGDAAYQVNPIHGGGIGSGMLGAYLLAKTAVKALEEEPTVENL
WKYNKDFMDAYGAKQAALDVFRVFLQSLTDDEINYGMKNRIIKEEDLLKASLEGDLRVSALDKLGRVIRALGKPSLLPKL
KTVAEYMKEVKQLYKDYPETPEGFEEWRERVSETFERYRKELSK

Specific function: Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2

COG id: COG0644

COG function: function code C; Dehydrogenases (flavoproteins)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786227, Length=315, Percent_Identity=28.8888888888889, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1787991, Length=226, Percent_Identity=29.646017699115, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011777
- InterPro:   IPR002218
- InterPro:   IPR003042 [H]

Pfam domain/function: PF01134 GIDA [H]

EC number: NA

Molecular weight: Translated: 49327; Mature: 49327

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEYDAVVVGAGTTGLVAAKFLAEAGYKVLVVELKAEEEVGTKVCGDAISKEYFEKIPIGN
CCCCEEEEECCCHHHHHHHHHHHCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCC
PPEEAVDGNIVGAKIYSPDEETVWTVPGEGYMLNRKKFGEWLYNMAKEAGAEFSFKTRAL
CCHHHCCCCEEEEEEECCCCCEEEEECCCCEEECHHHHHHHHHHHHHHHCCCCEEEHHHC
GPVVKDNKVVGLTVRKDGKVETVRARLVVDASGVAYVVRRALPKSWPVAEPLDPKDTAVA
CCCCCCCEEEEEEEECCCCEEEEEEEEEEECCHHHHHHHHHCCCCCCCCCCCCCCHHHHH
YREIRRITTPLEDDKYIRIYVGQQKAPGGYWWLFPYRGGARVNLGLGVQGGVGHKDPMWY
HHHHHHHCCCCCCCCEEEEEECCCCCCCCEEEEEEECCCCEEEEECCCCCCCCCCCHHHH
FHEYLAPRFPGEVEHAGGGVVPTRRPLDTMVAHGFATAGDAAYQVNPIHGGGIGSGMLGA
HHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCEEEECCCCCCCCCHHHHHH
YLLAKTAVKALEEEPTVENLWKYNKDFMDAYGAKQAALDVFRVFLQSLTDDEINYGMKNR
HHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHCCCCHHCCCHHHC
IIKEEDLLKASLEGDLRVSALDKLGRVIRALGKPSLLPKLKTVAEYMKEVKQLYKDYPET
CCCHHHHHHHHCCCCEEHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
PEGFEEWRERVSETFERYRKELSK
CHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEYDAVVVGAGTTGLVAAKFLAEAGYKVLVVELKAEEEVGTKVCGDAISKEYFEKIPIGN
CCCCEEEEECCCHHHHHHHHHHHCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCC
PPEEAVDGNIVGAKIYSPDEETVWTVPGEGYMLNRKKFGEWLYNMAKEAGAEFSFKTRAL
CCHHHCCCCEEEEEEECCCCCEEEEECCCCEEECHHHHHHHHHHHHHHHCCCCEEEHHHC
GPVVKDNKVVGLTVRKDGKVETVRARLVVDASGVAYVVRRALPKSWPVAEPLDPKDTAVA
CCCCCCCEEEEEEEECCCCEEEEEEEEEEECCHHHHHHHHHCCCCCCCCCCCCCCHHHHH
YREIRRITTPLEDDKYIRIYVGQQKAPGGYWWLFPYRGGARVNLGLGVQGGVGHKDPMWY
HHHHHHHCCCCCCCCEEEEEECCCCCCCCEEEEEEECCCCEEEEECCCCCCCCCCCHHHH
FHEYLAPRFPGEVEHAGGGVVPTRRPLDTMVAHGFATAGDAAYQVNPIHGGGIGSGMLGA
HHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCEEEECCCCCCCCCHHHHHH
YLLAKTAVKALEEEPTVENLWKYNKDFMDAYGAKQAALDVFRVFLQSLTDDEINYGMKNR
HHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHCCCCHHCCCHHHC
IIKEEDLLKASLEGDLRVSALDKLGRVIRALGKPSLLPKLKTVAEYMKEVKQLYKDYPET
CCCHHHHHHHHCCCCEEHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
PEGFEEWRERVSETFERYRKELSK
CHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Oxidoreductases; Acting on NADH or NADPH; With a quinone or similar compound as acceptor [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA