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The map label for this gene is hisD [H]

Identifier: 156937178

GI number: 156937178

Start: 337790

End: 339004

Strand: Reverse

Name: hisD [H]

Synonym: Igni_0384

Alternate gene names: 156937178

Gene position: 339004-337790 (Counterclockwise)

Preceding gene: 156937179

Following gene: 156937177

Centisome position: 26.13

GC content: 62.96

Gene sequence:

>1215_bases
TTGAAGGGGCCCGCGAGGGCCTCCGGGAGGGGTTCCTTGCTGAAGTTCGTCCCGCCGGAGGAAGTGAAGAACGTGAGGGG
GTCCTTGGACCTTTGGGAATACGTGGAGAAGGTGATGCCCGTAGTTAAGGAAGTTAAGGCCAGAGGGCTGGAGGCCGTAA
AGAAGTACAACAAGGCGTTCGATAACTACGAAGGTTGCGTCTCCCTCTCGCAGGAGGACTTCGCCTCCTACTCGAAGGAG
AGCTTGGTAAGCTTGTTCGAGGAGGTTTTGGAGCAACTTTCCGCGTTCCACAAGCAAACCGCCCCCAAGGACAGCGCCTT
CTCGTCCAAGGGGGTTAGGGCAGTAACCTTGTGGAGGCCCGTGGAGCGCTTGGGGGCTTACGTACCCGGGGGCCTTTACC
CCTACCCCTCCACGGCCTTGATGACCGCCGGAGTTGCGAAGGCCTTAGGGGTGAAGGAGGTAACTGTCGCCACCCCGCCC
AAGTTCGCCACGAGCGAAGTCATGGCTTCAGCGTTCCTCGCCTCCAAGGTGGACTCCGTCTTGGCCGCCGGCGGGGCCCA
CGGGGTCTCGGCCCTAGCCTACGTGGCCGGGGCTCACAAGGTCGTGGGCCCCGGGGGGCCCTACGTTCAAGCCGCCAAGC
TCTTAGTTTCCGTCGACGTCCCCATCGACATGATAGCCGGTCCTACGGAGCTCGCCGTGATAGCTGACTCCTCCGCGGAC
CCGGAGGAGGTAGCTTACGACATGTTGGCCCAAGCGGAGCACGGCCCCACCAGCTTCGCCTTGCTGGTCTCCACGGACGA
GGGCCTGGTGCTTGAAGTAGAGAAGAGGGTAAAGGGGGAGGAAGTGGAAGGGGGGCTCTACGCCACGGTCGTGAGGGACC
TAGAGGAGGCGAAGAGGTTGGTGAGCGAGCTGGCGCCGGAGCACGTCTCCGTTTACGCGGAAACCTACGAGCCCCCGGTC
GCGGGGGCGGCCTCCTTCAAGGCCCCGAGCCCGTTCTTGGACTACTCCGCCGGCCCCAACCACGTGCTCCCCACCTCCGG
GTGGGCCAAGGCGAGGGGCCCGCTGGGGCCCGTAGACTTCATGAGGTGGACCACGCTGGTGGAGGTCTTCCCGGAGGCTG
CCGACCTACTGAAGTTGGCAGCGGAGCTGGCGAGGTTGGAGGGAATGAAGTACCACGCTAAGGCAATAGAGTACAAGCTC
TCTAAGATCCTTTAA

Upstream 100 bases:

>100_bases
TTCGGAATACAAGGTGTTTGAAGTAAACCCCTTAATAGTTTCCGAGAGGGGCTGCTGGGCGGTGGACGTCAAGGTCTGGG
TCTAAAGGTCATAACAGCCT

Downstream 100 bases:

>100_bases
GCCCCTTTTTGCGGGGGGTCAGCGGCGTCCCCAGATGTATAGGGCTCTCGTAACGGACAAGGTGCACCCCGCGGGCCTCG
AGCTCTTGAGGGAAAAGGGA

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MKGPARASGRGSLLKFVPPEEVKNVRGSLDLWEYVEKVMPVVKEVKARGLEAVKKYNKAFDNYEGCVSLSQEDFASYSKE
SLVSLFEEVLEQLSAFHKQTAPKDSAFSSKGVRAVTLWRPVERLGAYVPGGLYPYPSTALMTAGVAKALGVKEVTVATPP
KFATSEVMASAFLASKVDSVLAAGGAHGVSALAYVAGAHKVVGPGGPYVQAAKLLVSVDVPIDMIAGPTELAVIADSSAD
PEEVAYDMLAQAEHGPTSFALLVSTDEGLVLEVEKRVKGEEVEGGLYATVVRDLEEAKRLVSELAPEHVSVYAETYEPPV
AGAASFKAPSPFLDYSAGPNHVLPTSGWAKARGPLGPVDFMRWTTLVEVFPEAADLLKLAAELARLEGMKYHAKAIEYKL
SKIL

Sequences:

>Translated_404_residues
MKGPARASGRGSLLKFVPPEEVKNVRGSLDLWEYVEKVMPVVKEVKARGLEAVKKYNKAFDNYEGCVSLSQEDFASYSKE
SLVSLFEEVLEQLSAFHKQTAPKDSAFSSKGVRAVTLWRPVERLGAYVPGGLYPYPSTALMTAGVAKALGVKEVTVATPP
KFATSEVMASAFLASKVDSVLAAGGAHGVSALAYVAGAHKVVGPGGPYVQAAKLLVSVDVPIDMIAGPTELAVIADSSAD
PEEVAYDMLAQAEHGPTSFALLVSTDEGLVLEVEKRVKGEEVEGGLYATVVRDLEEAKRLVSELAPEHVSVYAETYEPPV
AGAASFKAPSPFLDYSAGPNHVLPTSGWAKARGPLGPVDFMRWTTLVEVFPEAADLLKLAAELARLEGMKYHAKAIEYKL
SKIL
>Mature_404_residues
MKGPARASGRGSLLKFVPPEEVKNVRGSLDLWEYVEKVMPVVKEVKARGLEAVKKYNKAFDNYEGCVSLSQEDFASYSKE
SLVSLFEEVLEQLSAFHKQTAPKDSAFSSKGVRAVTLWRPVERLGAYVPGGLYPYPSTALMTAGVAKALGVKEVTVATPP
KFATSEVMASAFLASKVDSVLAAGGAHGVSALAYVAGAHKVVGPGGPYVQAAKLLVSVDVPIDMIAGPTELAVIADSSAD
PEEVAYDMLAQAEHGPTSFALLVSTDEGLVLEVEKRVKGEEVEGGLYATVVRDLEEAKRLVSELAPEHVSVYAETYEPPV
AGAASFKAPSPFLDYSAGPNHVLPTSGWAKARGPLGPVDFMRWTTLVEVFPEAADLLKLAAELARLEGMKYHAKAIEYKL
SKIL

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=399, Percent_Identity=33.0827067669173, Blast_Score=167, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6319819, Length=413, Percent_Identity=31.7191283292978, Blast_Score=166, Evalue=6e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 43099; Mature: 43099

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGPARASGRGSLLKFVPPEEVKNVRGSLDLWEYVEKVMPVVKEVKARGLEAVKKYNKAF
CCCCCCCCCCCCEEECCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DNYEGCVSLSQEDFASYSKESLVSLFEEVLEQLSAFHKQTAPKDSAFSSKGVRAVTLWRP
CCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEHHHH
VERLGAYVPGGLYPYPSTALMTAGVAKALGVKEVTVATPPKFATSEVMASAFLASKVDSV
HHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHH
LAAGGAHGVSALAYVAGAHKVVGPGGPYVQAAKLLVSVDVPIDMIAGPTELAVIADSSAD
HHCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHEECCCHHHHCCCCEEEEEECCCCC
PEEVAYDMLAQAEHGPTSFALLVSTDEGLVLEVEKRVKGEEVEGGLYATVVRDLEEAKRL
HHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEHHHCCCCCCCCCHHHHHHHHHHHHHHH
VSELAPEHVSVYAETYEPPVAGAASFKAPSPFLDYSAGPNHVLPTSGWAKARGPLGPVDF
HHHHCCHHHEEHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
MRWTTLVEVFPEAADLLKLAAELARLEGMKYHAKAIEYKLSKIL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKGPARASGRGSLLKFVPPEEVKNVRGSLDLWEYVEKVMPVVKEVKARGLEAVKKYNKAF
CCCCCCCCCCCCEEECCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DNYEGCVSLSQEDFASYSKESLVSLFEEVLEQLSAFHKQTAPKDSAFSSKGVRAVTLWRP
CCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEHHHH
VERLGAYVPGGLYPYPSTALMTAGVAKALGVKEVTVATPPKFATSEVMASAFLASKVDSV
HHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHH
LAAGGAHGVSALAYVAGAHKVVGPGGPYVQAAKLLVSVDVPIDMIAGPTELAVIADSSAD
HHCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHEECCCHHHHCCCCEEEEEECCCCC
PEEVAYDMLAQAEHGPTSFALLVSTDEGLVLEVEKRVKGEEVEGGLYATVVRDLEEAKRL
HHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEHHHCCCCCCCCCHHHHHHHHHHHHHHH
VSELAPEHVSVYAETYEPPVAGAASFKAPSPFLDYSAGPNHVLPTSGWAKARGPLGPVDF
HHHHCCHHHEEHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
MRWTTLVEVFPEAADLLKLAAELARLEGMKYHAKAIEYKLSKIL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA