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The map label for this gene is serA [H]

Identifier: 156937177

GI number: 156937177

Start: 336829

End: 337755

Strand: Reverse

Name: serA [H]

Synonym: Igni_0383

Alternate gene names: 156937177

Gene position: 337755-336829 (Counterclockwise)

Preceding gene: 156937178

Following gene: 156937176

Centisome position: 26.03

GC content: 57.71

Gene sequence:

>927_bases
ATGTATAGGGCTCTCGTAACGGACAAGGTGCACCCCGCGGGCCTCGAGCTCTTGAGGGAAAAGGGAATAGAAGTAGTGGA
GGACTTGGAGGCCTACAAGCCGGAGGTCCTCAAGGAGAGGATAAAGGGGTTTGACGTGTTGATAGTAAGGAGCAGGACTA
AGGTTAGGAGAGAAGTTATAGAGGCGGCGGACAAGCTCAAGGTAATCGCCAGAGCGGGGAGCGGGCTGGACAACATAGAC
CTAGAGGCCGCGAAGGAAAAAGGAATAAAGGTCGTGAACGCGCCCGACGCTTTGAAGAACGCGGTGGCAGAGCTGGTAAT
AGGAATGATGGTTGTTCTAGCCCGCAGGGCGCACTACAGCTACCGTAAGCTCTTGGAGGGCGAGTGGGAGAAGGTGATGG
GCTTTGAGCTCGCCGGCAAGACCTTGGGCGTGGTCGGCTTCGGCAGGATAGGCCGGGAGGTTGCGAAGAAGGCCAAGGCG
TTGGGAATGAACGTAATCGCCTACGACGTTGTAGACTTGAGCGAGACCGCGAAGGAGATGGGCGTAGAGTTCACCCAAGA
CTTGGAGGAGCTCTTGAGGAAGTCCGACGTGGTCAGCTTACACGTCCCCTTAACGGAGCAGACCAGAAACATGATAAATA
GGGACCGGATCAAGATAATGAAGGACGGGGCCATATTGATCAACGCGGCCAGGGGGGAAGTGGCAGACTACTCCGCGTTG
CTCGAGGCCTTGGAGAGCGGCAAGCTGTGGGGGGTAGGGCTGGACGTCTACCCGGAGGAGCCCCCGAAGAGCGAGGAGCT
ACTCAAGCTGATTAGACACCCGAGGACGTTCGCTACCGCCCACATAGGAGCCCAGACGGAGGAGGCCCAGAGGAGGACCT
CCTTGGAGGTCGCCCAGAGGATCTTAGAGGCCTTAGGGCTCCAGTGA

Upstream 100 bases:

>100_bases
GCGAGGTTGGAGGGAATGAAGTACCACGCTAAGGCAATAGAGTACAAGCTCTCTAAGATCCTTTAAGCCCCTTTTTGCGG
GGGGTCAGCGGCGTCCCCAG

Downstream 100 bases:

>100_bases
GGTGGACGCCTTGGAGGAGAGGCTGTTCTGGGTAAAGGTCCACGAAGTGGAGGGCCACGTCATCGTTGCGGTGGTTGACG
AGGAGCTGATGGGCAAGGAG

Product: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MYRALVTDKVHPAGLELLREKGIEVVEDLEAYKPEVLKERIKGFDVLIVRSRTKVRREVIEAADKLKVIARAGSGLDNID
LEAAKEKGIKVVNAPDALKNAVAELVIGMMVVLARRAHYSYRKLLEGEWEKVMGFELAGKTLGVVGFGRIGREVAKKAKA
LGMNVIAYDVVDLSETAKEMGVEFTQDLEELLRKSDVVSLHVPLTEQTRNMINRDRIKIMKDGAILINAARGEVADYSAL
LEALESGKLWGVGLDVYPEEPPKSEELLKLIRHPRTFATAHIGAQTEEAQRRTSLEVAQRILEALGLQ

Sequences:

>Translated_308_residues
MYRALVTDKVHPAGLELLREKGIEVVEDLEAYKPEVLKERIKGFDVLIVRSRTKVRREVIEAADKLKVIARAGSGLDNID
LEAAKEKGIKVVNAPDALKNAVAELVIGMMVVLARRAHYSYRKLLEGEWEKVMGFELAGKTLGVVGFGRIGREVAKKAKA
LGMNVIAYDVVDLSETAKEMGVEFTQDLEELLRKSDVVSLHVPLTEQTRNMINRDRIKIMKDGAILINAARGEVADYSAL
LEALESGKLWGVGLDVYPEEPPKSEELLKLIRHPRTFATAHIGAQTEEAQRRTSLEVAQRILEALGLQ
>Mature_308_residues
MYRALVTDKVHPAGLELLREKGIEVVEDLEAYKPEVLKERIKGFDVLIVRSRTKVRREVIEAADKLKVIARAGSGLDNID
LEAAKEKGIKVVNAPDALKNAVAELVIGMMVVLARRAHYSYRKLLEGEWEKVMGFELAGKTLGVVGFGRIGREVAKKAKA
LGMNVIAYDVVDLSETAKEMGVEFTQDLEELLRKSDVVSLHVPLTEQTRNMINRDRIKIMKDGAILINAARGEVADYSAL
LEALESGKLWGVGLDVYPEEPPKSEELLKLIRHPRTFATAHIGAQTEEAQRRTSLEVAQRILEALGLQ

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=305, Percent_Identity=40.655737704918, Blast_Score=236, Evalue=2e-62,
Organism=Homo sapiens, GI145580578, Length=244, Percent_Identity=39.7540983606557, Blast_Score=155, Evalue=4e-38,
Organism=Homo sapiens, GI4557499, Length=244, Percent_Identity=39.7540983606557, Blast_Score=155, Evalue=4e-38,
Organism=Homo sapiens, GI145580575, Length=260, Percent_Identity=38.0769230769231, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI4557497, Length=260, Percent_Identity=35.7692307692308, Blast_Score=148, Evalue=6e-36,
Organism=Homo sapiens, GI61743967, Length=260, Percent_Identity=35.7692307692308, Blast_Score=148, Evalue=6e-36,
Organism=Homo sapiens, GI6912396, Length=317, Percent_Identity=30.5993690851735, Blast_Score=131, Evalue=9e-31,
Organism=Escherichia coli, GI1789279, Length=306, Percent_Identity=39.5424836601307, Blast_Score=191, Evalue=6e-50,
Organism=Escherichia coli, GI1787645, Length=223, Percent_Identity=39.0134529147982, Blast_Score=152, Evalue=2e-38,
Organism=Escherichia coli, GI87082289, Length=261, Percent_Identity=32.183908045977, Blast_Score=131, Evalue=6e-32,
Organism=Escherichia coli, GI1788660, Length=266, Percent_Identity=31.9548872180451, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI87081824, Length=240, Percent_Identity=29.1666666666667, Blast_Score=71, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17532191, Length=306, Percent_Identity=37.5816993464052, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI25147481, Length=262, Percent_Identity=31.2977099236641, Blast_Score=126, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6322116, Length=308, Percent_Identity=36.3636363636364, Blast_Score=196, Evalue=6e-51,
Organism=Saccharomyces cerevisiae, GI6320925, Length=314, Percent_Identity=36.9426751592357, Blast_Score=195, Evalue=8e-51,
Organism=Saccharomyces cerevisiae, GI6324055, Length=231, Percent_Identity=35.0649350649351, Blast_Score=155, Evalue=9e-39,
Organism=Saccharomyces cerevisiae, GI6324964, Length=304, Percent_Identity=29.9342105263158, Blast_Score=121, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6324980, Length=177, Percent_Identity=31.0734463276836, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6325144, Length=328, Percent_Identity=25.609756097561, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6321253, Length=289, Percent_Identity=24.9134948096886, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI19921140, Length=303, Percent_Identity=42.5742574257426, Blast_Score=231, Evalue=6e-61,
Organism=Drosophila melanogaster, GI28574286, Length=300, Percent_Identity=32, Blast_Score=145, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24585516, Length=317, Percent_Identity=29.0220820189274, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI62472511, Length=216, Percent_Identity=39.8148148148148, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24646446, Length=216, Percent_Identity=39.8148148148148, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24646448, Length=216, Percent_Identity=39.8148148148148, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24646452, Length=216, Percent_Identity=39.8148148148148, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24646450, Length=216, Percent_Identity=39.8148148148148, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI28574284, Length=315, Percent_Identity=29.5238095238095, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24585514, Length=315, Percent_Identity=29.5238095238095, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI28574282, Length=315, Percent_Identity=29.5238095238095, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI45551003, Length=315, Percent_Identity=29.5238095238095, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI45552429, Length=316, Percent_Identity=29.4303797468354, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI28571528, Length=305, Percent_Identity=33.1147540983607, Blast_Score=131, Evalue=6e-31,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 34199; Mature: 34199

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYRALVTDKVHPAGLELLREKGIEVVEDLEAYKPEVLKERIKGFDVLIVRSRTKVRREVI
CCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHCCCEEEEECCHHHHHHHHH
EAADKLKVIARAGSGLDNIDLEAAKEKGIKVVNAPDALKNAVAELVIGMMVVLARRAHYS
HHHHHHHHHHHCCCCCCCCCHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHH
YRKLLEGEWEKVMGFELAGKTLGVVGFGRIGREVAKKAKALGMNVIAYDVVDLSETAKEM
HHHHHCCHHHHHHHHHHCCCHHCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
GVEFTQDLEELLRKSDVVSLHVPLTEQTRNMINRDRIKIMKDGAILINAARGEVADYSAL
CCHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHEEEECCEEEEECCCCCHHHHHHH
LEALESGKLWGVGLDVYPEEPPKSEELLKLIRHPRTFATAHIGAQTEEAQRRTSLEVAQR
HHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHH
ILEALGLQ
HHHHHCCC
>Mature Secondary Structure
MYRALVTDKVHPAGLELLREKGIEVVEDLEAYKPEVLKERIKGFDVLIVRSRTKVRREVI
CCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHCCCEEEEECCHHHHHHHHH
EAADKLKVIARAGSGLDNIDLEAAKEKGIKVVNAPDALKNAVAELVIGMMVVLARRAHYS
HHHHHHHHHHHCCCCCCCCCHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHH
YRKLLEGEWEKVMGFELAGKTLGVVGFGRIGREVAKKAKALGMNVIAYDVVDLSETAKEM
HHHHHCCHHHHHHHHHHCCCHHCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
GVEFTQDLEELLRKSDVVSLHVPLTEQTRNMINRDRIKIMKDGAILINAARGEVADYSAL
CCHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHEEEECCEEEEECCCCCHHHHHHH
LEALESGKLWGVGLDVYPEEPPKSEELLKLIRHPRTFATAHIGAQTEEAQRRTSLEVAQR
HHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHH
ILEALGLQ
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]