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The map label for this gene is aroE

Identifier: 156937010

GI number: 156937010

Start: 189454

End: 190242

Strand: Reverse

Name: aroE

Synonym: Igni_0215

Alternate gene names: 156937010

Gene position: 190242-189454 (Counterclockwise)

Preceding gene: 156937012

Following gene: 156937009

Centisome position: 14.66

GC content: 51.84

Gene sequence:

>789_bases
ATGCTCTTCGCAGTCATAGGCCACCCCATAGAACACTCGTTGTCACCCTTGCTACACAAGATATCTTTTGAGCTGATGAA
GGTAGAAGCCGAATACGTGAAGGTGGACGTACCCCCTCACAGGTTAGGGGATTTCATGTCTTCCGTAGACATGATTTTTA
ATGGTATAAATGTGACCATTCCTCATAAGGTCGAAGTATTGAAGTACGTAGACGTGGCCGACGACCTCGTAAACGAGGTG
GGAGCTGCAAACACCTTGAAGATAAAGGACGGAAAGATATATGCGTTCAATACTGACGTTGAAGGCGTTAGAGGCAGTAT
AAAGGACGCCGTAGATCCGAAGGGCTTGAAGGTGGCCGTCTTGGGTGCCGGCGGGGCCGCGAGGGCGGCCGTGGTAGCTC
TGAGAGACGAGGCCCAAGTGACCGTTTTCAACAGGACGTTGGAGAAGGCCAAGAGGCTCGCGGAAGAGTTGGGCGTCGAT
TACGCGGGCCTCAACGAGGTCGACAAGATAAAGAAGCACGATATCATAATAAACGCGACTCCTGTCGGCATGGACGGCGT
TTCTATGCCTATACCTCCAGACGTGATAGAAAGTAGACACGTGTTAATGGATATGGTCTACAGACCTCTGTACACTCCCT
TCCTAAAGGTAGGGCTCGCGAAGGGTGCGAAGACAGTAAACGGCTTGAAGATGTTGGTTATCCAAGGGATGGAGAGCGAA
AAGGTGTGGCTGGGAGCCTCCCCTTACTGGAGGGACGTATACGAGCGACTTCTGGCCTCGCTCGCGTAA

Upstream 100 bases:

>100_bases
CTACCCCATCCCTTGCCAAACACCGCTTACACCACGTTAGACGCTCCTAACTCAGTGTAAATAAGTGTTACCGAGGGGCG
CCTTAAGGTAAAGGGCGGGG

Downstream 100 bases:

>100_bases
CTTTTAGGAACACGAACAACCCTTAAGTTGCCTTTTGGTCTCCCTAAATAGGGGTAGAGAGCTTGAAGAGGCTCCGCTTC
AGGTTTACCAAAGCGAAGTG

Product: shikimate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 262; Mature: 262

Protein sequence:

>262_residues
MLFAVIGHPIEHSLSPLLHKISFELMKVEAEYVKVDVPPHRLGDFMSSVDMIFNGINVTIPHKVEVLKYVDVADDLVNEV
GAANTLKIKDGKIYAFNTDVEGVRGSIKDAVDPKGLKVAVLGAGGAARAAVVALRDEAQVTVFNRTLEKAKRLAEELGVD
YAGLNEVDKIKKHDIIINATPVGMDGVSMPIPPDVIESRHVLMDMVYRPLYTPFLKVGLAKGAKTVNGLKMLVIQGMESE
KVWLGASPYWRDVYERLLASLA

Sequences:

>Translated_262_residues
MLFAVIGHPIEHSLSPLLHKISFELMKVEAEYVKVDVPPHRLGDFMSSVDMIFNGINVTIPHKVEVLKYVDVADDLVNEV
GAANTLKIKDGKIYAFNTDVEGVRGSIKDAVDPKGLKVAVLGAGGAARAAVVALRDEAQVTVFNRTLEKAKRLAEELGVD
YAGLNEVDKIKKHDIIINATPVGMDGVSMPIPPDVIESRHVLMDMVYRPLYTPFLKVGLAKGAKTVNGLKMLVIQGMESE
KVWLGASPYWRDVYERLLASLA
>Mature_262_residues
MLFAVIGHPIEHSLSPLLHKISFELMKVEAEYVKVDVPPHRLGDFMSSVDMIFNGINVTIPHKVEVLKYVDVADDLVNEV
GAANTLKIKDGKIYAFNTDVEGVRGSIKDAVDPKGLKVAVLGAGGAARAAVVALRDEAQVTVFNRTLEKAKRLAEELGVD
YAGLNEVDKIKKHDIIINATPVGMDGVSMPIPPDVIESRHVLMDMVYRPLYTPFLKVGLAKGAKTVNGLKMLVIQGMESE
KVWLGASPYWRDVYERLLASLA

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1789675, Length=273, Percent_Identity=32.6007326007326, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1787983, Length=264, Percent_Identity=28.4090909090909, Blast_Score=92, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6320332, Length=276, Percent_Identity=27.536231884058, Blast_Score=90, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROE_IGNH4 (A8A8Z7)

Other databases:

- EMBL:   CP000816
- RefSeq:   YP_001434806.1
- ProteinModelPortal:   A8A8Z7
- SMR:   A8A8Z7
- STRING:   A8A8Z7
- GeneID:   5562108
- GenomeReviews:   CP000816_GR
- KEGG:   iho:Igni_0215
- eggNOG:   arNOG05588
- HOGENOM:   HBG553408
- OMA:   ESVPPEG
- BioCyc:   IHOS453591:IGNI_0215-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00222
- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR00507

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N

EC number: =1.1.1.25

Molecular weight: Translated: 28672; Mature: 28672

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: NA

Important sites: ACT_SITE 63-63

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFAVIGHPIEHSLSPLLHKISFELMKVEAEYVKVDVPPHRLGDFMSSVDMIFNGINVTI
CEEEEECCCHHHHHHHHHHHHHHHHHEEEEEEEEEECCHHHHHHHHHHHHHHHCCCEEEE
PHKVEVLKYVDVADDLVNEVGAANTLKIKDGKIYAFNTDVEGVRGSIKDAVDPKGLKVAV
CCHHHHHHHHHHHHHHHHHHCCCCEEEEECCEEEEEECCCHHHHCCHHHCCCCCCCEEEE
LGAGGAARAAVVALRDEAQVTVFNRTLEKAKRLAEELGVDYAGLNEVDKIKKHDIIINAT
EECCCCHHEEEEEECCCCEEEHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCEEEEEC
PVGMDGVSMPIPPDVIESRHVLMDMVYRPLYTPFLKVGLAKGAKTVNGLKMLVIQGMESE
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCEEEEEEECCCCC
KVWLGASPYWRDVYERLLASLA
EEEECCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLFAVIGHPIEHSLSPLLHKISFELMKVEAEYVKVDVPPHRLGDFMSSVDMIFNGINVTI
CEEEEECCCHHHHHHHHHHHHHHHHHEEEEEEEEEECCHHHHHHHHHHHHHHHCCCEEEE
PHKVEVLKYVDVADDLVNEVGAANTLKIKDGKIYAFNTDVEGVRGSIKDAVDPKGLKVAV
CCHHHHHHHHHHHHHHHHHHCCCCEEEEECCEEEEEECCCHHHHCCHHHCCCCCCCEEEE
LGAGGAARAAVVALRDEAQVTVFNRTLEKAKRLAEELGVDYAGLNEVDKIKKHDIIINAT
EECCCCHHEEEEEECCCCEEEHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCEEEEEC
PVGMDGVSMPIPPDVIESRHVLMDMVYRPLYTPFLKVGLAKGAKTVNGLKMLVIQGMESE
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCEEEEEEECCCCC
KVWLGASPYWRDVYERLLASLA
EEEECCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA