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The map label for this gene is mdh [H]

Identifier: 156936927

GI number: 156936927

Start: 119157

End: 120401

Strand: Reverse

Name: mdh [H]

Synonym: Igni_0132

Alternate gene names: 156936927

Gene position: 120401-119157 (Counterclockwise)

Preceding gene: 156936934

Following gene: 156936926

Centisome position: 9.28

GC content: 62.49

Gene sequence:

>1245_bases
GTGTACAACCCCTTCGGCGACTACGTCTGGGAGTTCCGCTCCCCCCGCAGCAAGTTCGGGCCGGGGGCGCTAAACGAGCT
CAAGGTAGACCTTGAGAGGCTCAGGGTGGAGAAGCCCTTCCTAATAACCACCAAGGGGTGGGTAAAGAGGGGTATAGTCG
ACAGGCTTAGGGAAATACTAGGAAAGGACGTGCCCTACTGGGACGGGGTGGAGCCAGAGCCCTCCGCCGAGAGCGTCGAG
GAGGCCGCCAAGGCTTTAGCAGAGAGCGGGGCCGACTCGGTAATCGCCATTGGCGGGGGCTCTGCCTTGGACACCGCCAA
GATAGCGAACTTGCTCGCAACCTACGGCGGGAGGGTTAGGGACTACGTCGCCCCGCCCTACGGTGAAGGCAAGCCCGTCC
CGGGCCCGGTCAAGCCAATGGTAGCGGTGCCCACCACCGCCGGCACCGGCAGCGAAGTCACTAGCGTGGCCGTGGTGACC
CTAAAGGACGTCGGAGTTAAGGTGGGCATAAGCTCGGACTTCCTAAGGCCCAGCTTGGCCCTGTTGGACCCCGAGCTGAC
CATGACTGTGCCCCCCAAGGTCACCGCCGACACCGGGATGGACGCCCTCACGCACGCGGTAGAGTCTTACATAGCCAAGC
CGTACTGGGCTAGGGAGAGGCCAGAGGACCCGGCCAAGAGGCCGGTCTACGTGGGCTCCTTCACCGTGACGGACGCGTTG
GCCGAAAGGGCGATAGAACTCATAGGTAAGTACTTGAGGAGGGCAGTGTACCAAGGTAGAACGGACTTAGAGGCTAGATC
GGGCATGTTGATAGCCAGCTACTTGGCGGGCCTCGCCTTCGGCAACGCGGGCGTCGGACTGGCCCACGCCGCCTCTTACC
CGCTCGGGGGCCGCTACAAGGTGACCCACGGCGAGGCAGTAGGCATCTTACTCCCGGCGGTCTTGGAGTTCAACGCTCCG
GCGAACTACGAGAAGGCCAAGAGGGTCGGGGAGCTGTTGACCGGCGAGAAGTGTCCGGAGAGGGACCCCGCTAAGTGCGC
GGAGTGGGCGGCCAACGCGATCAGGGAGCTCCAGCGCGACATAAAGTTCACGCCGGGCCTCGAGGCGGTAGGGGTCAAGG
AAGAGGACTTGATGGAAATGGCCAAGGAGACCTTGAACCAGAAGAGGCTCCTAGCGACCAACCCGAGGCCCGTAACTGAG
GAGGACGTGTATTGGGTCTACAAGAGGAGCATGAGAAACTACTAA

Upstream 100 bases:

>100_bases
TCCTCACAACTATACGCATCATTAGCCTTCGGCGCCTCAAGTGCGCTCTCTGCCTTAAAAACTAAATACTTGTCGTGAGC
TCCCGGGCGCGGTGACGACG

Downstream 100 bases:

>100_bases
ACCTTAGGGGATTGGACCGTCATGAAGTTAAAGGACGTTTTAGAGGCGGCCGCCTCCTTAGTTAGGACGGGGTGGATGCA
GAGGGGGGTGCCCCCTCAGC

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: MEDH [H]

Number of amino acids: Translated: 414; Mature: 414

Protein sequence:

>414_residues
MYNPFGDYVWEFRSPRSKFGPGALNELKVDLERLRVEKPFLITTKGWVKRGIVDRLREILGKDVPYWDGVEPEPSAESVE
EAAKALAESGADSVIAIGGGSALDTAKIANLLATYGGRVRDYVAPPYGEGKPVPGPVKPMVAVPTTAGTGSEVTSVAVVT
LKDVGVKVGISSDFLRPSLALLDPELTMTVPPKVTADTGMDALTHAVESYIAKPYWARERPEDPAKRPVYVGSFTVTDAL
AERAIELIGKYLRRAVYQGRTDLEARSGMLIASYLAGLAFGNAGVGLAHAASYPLGGRYKVTHGEAVGILLPAVLEFNAP
ANYEKAKRVGELLTGEKCPERDPAKCAEWAANAIRELQRDIKFTPGLEAVGVKEEDLMEMAKETLNQKRLLATNPRPVTE
EDVYWVYKRSMRNY

Sequences:

>Translated_414_residues
MYNPFGDYVWEFRSPRSKFGPGALNELKVDLERLRVEKPFLITTKGWVKRGIVDRLREILGKDVPYWDGVEPEPSAESVE
EAAKALAESGADSVIAIGGGSALDTAKIANLLATYGGRVRDYVAPPYGEGKPVPGPVKPMVAVPTTAGTGSEVTSVAVVT
LKDVGVKVGISSDFLRPSLALLDPELTMTVPPKVTADTGMDALTHAVESYIAKPYWARERPEDPAKRPVYVGSFTVTDAL
AERAIELIGKYLRRAVYQGRTDLEARSGMLIASYLAGLAFGNAGVGLAHAASYPLGGRYKVTHGEAVGILLPAVLEFNAP
ANYEKAKRVGELLTGEKCPERDPAKCAEWAANAIRELQRDIKFTPGLEAVGVKEEDLMEMAKETLNQKRLLATNPRPVTE
EDVYWVYKRSMRNY
>Mature_414_residues
MYNPFGDYVWEFRSPRSKFGPGALNELKVDLERLRVEKPFLITTKGWVKRGIVDRLREILGKDVPYWDGVEPEPSAESVE
EAAKALAESGADSVIAIGGGSALDTAKIANLLATYGGRVRDYVAPPYGEGKPVPGPVKPMVAVPTTAGTGSEVTSVAVVT
LKDVGVKVGISSDFLRPSLALLDPELTMTVPPKVTADTGMDALTHAVESYIAKPYWARERPEDPAKRPVYVGSFTVTDAL
AERAIELIGKYLRRAVYQGRTDLEARSGMLIASYLAGLAFGNAGVGLAHAASYPLGGRYKVTHGEAVGILLPAVLEFNAP
ANYEKAKRVGELLTGEKCPERDPAKCAEWAANAIRELQRDIKFTPGLEAVGVKEEDLMEMAKETLNQKRLLATNPRPVTE
EDVYWVYKRSMRNY

Specific function: Unknown

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=426, Percent_Identity=37.5586854460094, Blast_Score=244, Evalue=1e-64,
Organism=Escherichia coli, GI48994951, Length=378, Percent_Identity=33.8624338624339, Blast_Score=200, Evalue=1e-52,
Organism=Escherichia coli, GI1789163, Length=401, Percent_Identity=32.9177057356608, Blast_Score=191, Evalue=1e-49,
Organism=Escherichia coli, GI87082107, Length=396, Percent_Identity=35.3535353535354, Blast_Score=185, Evalue=5e-48,
Organism=Escherichia coli, GI1787493, Length=311, Percent_Identity=29.903536977492, Blast_Score=131, Evalue=8e-32,
Organism=Escherichia coli, GI1789386, Length=325, Percent_Identity=28.6153846153846, Blast_Score=100, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17537053, Length=431, Percent_Identity=32.4825986078886, Blast_Score=217, Evalue=7e-57,
Organism=Saccharomyces cerevisiae, GI6321181, Length=399, Percent_Identity=33.8345864661654, Blast_Score=204, Evalue=2e-53,
Organism=Drosophila melanogaster, GI24657991, Length=428, Percent_Identity=37.6168224299065, Blast_Score=230, Evalue=1e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.244 [H]

Molecular weight: Translated: 45040; Mature: 45040

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS00913 ADH_IRON_1 ; PS00060 ADH_IRON_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYNPFGDYVWEFRSPRSKFGPGALNELKVDLERLRVEKPFLITTKGWVKRGIVDRLREIL
CCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHH
GKDVPYWDGVEPEPSAESVEEAAKALAESGADSVIAIGGGSALDTAKIANLLATYGGRVR
CCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHCCCHH
DYVAPPYGEGKPVPGPVKPMVAVPTTAGTGSEVTSVAVVTLKDVGVKVGISSDFLRPSLA
HCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCHHHEEEEEEECCCEEECCCHHHHCCHHH
LLDPELTMTVPPKVTADTGMDALTHAVESYIAKPYWARERPEDPAKRPVYVGSFTVTDAL
HCCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECHHHHHHH
AERAIELIGKYLRRAVYQGRTDLEARSGMLIASYLAGLAFGNAGVGLAHAASYPLGGRYK
HHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHHHHHCCCCCCCHHHHCCCCCCCEEE
VTHGEAVGILLPAVLEFNAPANYEKAKRVGELLTGEKCPERDPAKCAEWAANAIRELQRD
EECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
IKFTPGLEAVGVKEEDLMEMAKETLNQKRLLATNPRPVTEEDVYWVYKRSMRNY
CCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MYNPFGDYVWEFRSPRSKFGPGALNELKVDLERLRVEKPFLITTKGWVKRGIVDRLREIL
CCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHH
GKDVPYWDGVEPEPSAESVEEAAKALAESGADSVIAIGGGSALDTAKIANLLATYGGRVR
CCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHCCCHH
DYVAPPYGEGKPVPGPVKPMVAVPTTAGTGSEVTSVAVVTLKDVGVKVGISSDFLRPSLA
HCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCHHHEEEEEEECCCEEECCCHHHHCCHHH
LLDPELTMTVPPKVTADTGMDALTHAVESYIAKPYWARERPEDPAKRPVYVGSFTVTDAL
HCCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECHHHHHHH
AERAIELIGKYLRRAVYQGRTDLEARSGMLIASYLAGLAFGNAGVGLAHAASYPLGGRYK
HHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHHHHHCCCCCCCHHHHCCCCCCCEEE
VTHGEAVGILLPAVLEFNAPANYEKAKRVGELLTGEKCPERDPAKCAEWAANAIRELQRD
EECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
IKFTPGLEAVGVKEEDLMEMAKETLNQKRLLATNPRPVTEEDVYWVYKRSMRNY
CCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1644761; 1995642 [H]