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The map label for this gene is yeaE [H]

Identifier: 154248175

GI number: 154248175

Start: 4722248

End: 4723084

Strand: Direct

Name: yeaE [H]

Synonym: Xaut_4255

Alternate gene names: 154248175

Gene position: 4722248-4723084 (Clockwise)

Preceding gene: 154248173

Following gene: 154248176

Centisome position: 88.95

GC content: 68.34

Gene sequence:

>837_bases
ATGCCAAAGATCGTCACGCTCCCCAATGGCGAAACCGTGCCGGCCCTCGGCCAGGGCACCTGGTACATGGGCGAGAGCGC
ATCGGCGCGGGCAGGGGAGGTGGCCGCCCTTCGCGCGGGGCTGGACCTCGGCCTCACCCTCATCGACACCGCCGAGATGT
ATGCGGACGGCGGCGCGGAAGAGGTGGTGGGCGAGGCTATATCCGGCCGGCGGAATGAGGTGTTCCTGGTCAGCAAGGTC
TATCCCCACAATGCCAGCCGGGCCGGGGTCCAGGCCGCCTGCGAGCGTAGCCTCAAGCGGCTGAAGACCGATGTGATCGA
CCTGTATCTCCTGCACTGGCGCGGCAGCCATCCGCTCAAGGAGACCATCGCTGGATTCGAAGCGCTGCAAGCGGCCGGCA
AGATCCGCCTGTGGGGCGTCAGCAATCTCGACACCGACGACATGGAGGAACTGCTGGCGGCCCCGGGCGGGCGGGCCTGC
GCCGCCAACCAGGTGCTCTACAATCCCAGCCGCAGGGGGCCGGAATTCGACCTGCTGCCCTTCCTCGCCGAAACCGGCAT
TCCGGCTATGGCCTACAGCCCCATCGAGCAGGCTCGCCTGCCGCGCGGCGGGGCGCTGGGCGCGGTGGCGAAGAAACACG
GCGTGGATCCGTTCCAGGTGGCACTGGCCTGGGTGATGCGGGCCGGCGACGTGATCGCCATACCCAAGGCGAGCCGTATC
GCCCATGTGCAGATGAACGCAGCGGCCCGCGACCTCGTGCTTGATGCGGACGACCTCGCTGCCATCGACCGTGCCTTCCC
CGCGCCACGCCGCAAGGTGGGGCTGGAGATGCTTTAG

Upstream 100 bases:

>100_bases
AAAATCAAGGCCACGGCCGAGTGGACACAACGGGTTATGCTCTTCCACCGACCGTGCGCAGGTCTTATGGTCGCCGCGAT
CTTCAATTCTGGAATACCGT

Downstream 100 bases:

>100_bases
GGAGAAGTGGATCCCGGTTCGCGTGAGGAAAATACGTCCATCGAATTTCGAGTGCTTTCTGTGAGCCGGTGCGAACGCAA
AGCACTCCGAGTCCCCGGGA

Product: aldo/keto reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 278; Mature: 277

Protein sequence:

>278_residues
MPKIVTLPNGETVPALGQGTWYMGESASARAGEVAALRAGLDLGLTLIDTAEMYADGGAEEVVGEAISGRRNEVFLVSKV
YPHNASRAGVQAACERSLKRLKTDVIDLYLLHWRGSHPLKETIAGFEALQAAGKIRLWGVSNLDTDDMEELLAAPGGRAC
AANQVLYNPSRRGPEFDLLPFLAETGIPAMAYSPIEQARLPRGGALGAVAKKHGVDPFQVALAWVMRAGDVIAIPKASRI
AHVQMNAAARDLVLDADDLAAIDRAFPAPRRKVGLEML

Sequences:

>Translated_278_residues
MPKIVTLPNGETVPALGQGTWYMGESASARAGEVAALRAGLDLGLTLIDTAEMYADGGAEEVVGEAISGRRNEVFLVSKV
YPHNASRAGVQAACERSLKRLKTDVIDLYLLHWRGSHPLKETIAGFEALQAAGKIRLWGVSNLDTDDMEELLAAPGGRAC
AANQVLYNPSRRGPEFDLLPFLAETGIPAMAYSPIEQARLPRGGALGAVAKKHGVDPFQVALAWVMRAGDVIAIPKASRI
AHVQMNAAARDLVLDADDLAAIDRAFPAPRRKVGLEML
>Mature_277_residues
PKIVTLPNGETVPALGQGTWYMGESASARAGEVAALRAGLDLGLTLIDTAEMYADGGAEEVVGEAISGRRNEVFLVSKVY
PHNASRAGVQAACERSLKRLKTDVIDLYLLHWRGSHPLKETIAGFEALQAAGKIRLWGVSNLDTDDMEELLAAPGGRACA
ANQVLYNPSRRGPEFDLLPFLAETGIPAMAYSPIEQARLPRGGALGAVAKKHGVDPFQVALAWVMRAGDVIAIPKASRIA
HVQMNAAARDLVLDADDLAAIDRAFPAPRRKVGLEML

Specific function: Unknown

COG id: COG0656

COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI310109922, Length=280, Percent_Identity=30, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI5453543, Length=300, Percent_Identity=29.6666666666667, Blast_Score=95, Evalue=8e-20,
Organism=Homo sapiens, GI45446745, Length=300, Percent_Identity=29.6666666666667, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI4503285, Length=300, Percent_Identity=29.6666666666667, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI310109920, Length=300, Percent_Identity=29.6666666666667, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI24497577, Length=298, Percent_Identity=27.5167785234899, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI5174391, Length=298, Percent_Identity=27.5167785234899, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI24497585, Length=298, Percent_Identity=29.5302013422819, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI223468663, Length=300, Percent_Identity=28, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI24497583, Length=300, Percent_Identity=29.3333333333333, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI291291012, Length=265, Percent_Identity=27.5471698113208, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI4502049, Length=295, Percent_Identity=28.8135593220339, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI223718702, Length=176, Percent_Identity=30.1136363636364, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1788081, Length=281, Percent_Identity=56.5836298932384, Blast_Score=316, Evalue=1e-87,
Organism=Escherichia coli, GI1786400, Length=256, Percent_Identity=28.515625, Blast_Score=111, Evalue=7e-26,
Organism=Escherichia coli, GI87082198, Length=268, Percent_Identity=28.7313432835821, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI87081735, Length=299, Percent_Identity=26.4214046822742, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1788070, Length=316, Percent_Identity=27.2151898734177, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1787674, Length=247, Percent_Identity=25.9109311740891, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1789375, Length=315, Percent_Identity=25.3968253968254, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI48994888, Length=252, Percent_Identity=28.968253968254, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71998625, Length=284, Percent_Identity=28.5211267605634, Blast_Score=98, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17561298, Length=284, Percent_Identity=30.6338028169014, Blast_Score=94, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17552492, Length=271, Percent_Identity=28.4132841328413, Blast_Score=91, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17537077, Length=303, Percent_Identity=29.042904290429, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17537075, Length=303, Percent_Identity=29.042904290429, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17550248, Length=305, Percent_Identity=26.2295081967213, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17561300, Length=276, Percent_Identity=27.536231884058, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17564128, Length=300, Percent_Identity=26, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17566692, Length=310, Percent_Identity=24.8387096774194, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17538386, Length=282, Percent_Identity=25.886524822695, Blast_Score=73, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320576, Length=292, Percent_Identity=30.8219178082192, Blast_Score=107, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6320079, Length=282, Percent_Identity=28.3687943262411, Blast_Score=79, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6322556, Length=277, Percent_Identity=24.9097472924188, Blast_Score=72, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24644950, Length=305, Percent_Identity=29.8360655737705, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24657054, Length=298, Percent_Identity=26.1744966442953, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24663317, Length=297, Percent_Identity=27.9461279461279, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI45553081, Length=303, Percent_Identity=28.7128712871287, Blast_Score=88, Evalue=5e-18,
Organism=Drosophila melanogaster, GI20129731, Length=297, Percent_Identity=28.6195286195286, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI21356425, Length=291, Percent_Identity=25.085910652921, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24662789, Length=298, Percent_Identity=26.510067114094, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: NA

Molecular weight: Translated: 29656; Mature: 29525

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKIVTLPNGETVPALGQGTWYMGESASARAGEVAALRAGLDLGLTLIDTAEMYADGGAE
CCEEEECCCCCCCCCCCCCCEECCCCCCCCCCHHHHHHHCCCCCEEEEEHHHHHHCCCHH
EVVGEAISGRRNEVFLVSKVYPHNASRAGVQAACERSLKRLKTDVIDLYLLHWRGSHPLK
HHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHH
ETIAGFEALQAAGKIRLWGVSNLDTDDMEELLAAPGGRACAANQVLYNPSRRGPEFDLLP
HHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCCCEECCCEEECCCCCCCCCCHHH
FLAETGIPAMAYSPIEQARLPRGGALGAVAKKHGVDPFQVALAWVMRAGDVIAIPKASRI
HHHHCCCCHHEECCHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHHHCCCEEEECCCCCE
AHVQMNAAARDLVLDADDLAAIDRAFPAPRRKVGLEML
EEEEECCHHHHEEECCHHHHHHHHHCCCCHHHCCCCCC
>Mature Secondary Structure 
PKIVTLPNGETVPALGQGTWYMGESASARAGEVAALRAGLDLGLTLIDTAEMYADGGAE
CEEEECCCCCCCCCCCCCCEECCCCCCCCCCHHHHHHHCCCCCEEEEEHHHHHHCCCHH
EVVGEAISGRRNEVFLVSKVYPHNASRAGVQAACERSLKRLKTDVIDLYLLHWRGSHPLK
HHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHH
ETIAGFEALQAAGKIRLWGVSNLDTDDMEELLAAPGGRACAANQVLYNPSRRGPEFDLLP
HHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCCCEECCCEEECCCCCCCCCCHHH
FLAETGIPAMAYSPIEQARLPRGGALGAVAKKHGVDPFQVALAWVMRAGDVIAIPKASRI
HHHHCCCCHHEECCHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHHHCCCEEEECCCCCE
AHVQMNAAARDLVLDADDLAAIDRAFPAPRRKVGLEML
EEEEECCHHHHEEECCHHHHHHHHHCCCCHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]