Click here to switch to the map view.

The map label for this gene is hmuU [H]

Identifier: 154248113

GI number: 154248113

Start: 4639246

End: 4640334

Strand: Direct

Name: hmuU [H]

Synonym: Xaut_4193

Alternate gene names: 154248113

Gene position: 4639246-4640334 (Clockwise)

Preceding gene: 154248112

Following gene: 154248114

Centisome position: 87.39

GC content: 74.2

Gene sequence:

>1089_bases
ATGAGCGTGGAGCACGTCACAATGGCCGCTCCGGCGGAAATCGCATCCGGCCGTCCGGTGAGGGCCGGCCTGATCCTGTT
CGCGCTGCTGGCCGGCGTGGCCTTGATCGGGGCGCTGGCTATCGGCCCCTTCACCATAGCGCCGGGGCGGGTGCTGACCA
TCCTGTGGGCGGCACTGACGGGCGATGCCACCCCCACCATCGCCCTGCGCGAGCGCATCGTGGTGATCGATGTGCGCTTT
CCCCGCGCCGTGCTGGGCGCGCTCACGGGGGCGGGCACGGCGGTGGCCGGGGCGGTGATGCAGGGCGTGTTCCGCAATCC
GCTGGCCGATCCCGGCCTCGTGGGCGTCGCCCCCGGCGCGGCGCTGGCGGCGGTGGCTTTCGTGGTGTTCGGCGCGCCGC
TGGCGATGCTGCTGCCGGTGCCGCTCCAGGCGCTGGGCCTGCCGCTGGCGGCGTTCGCCGGCGGGCTCGGCACAACGCTC
GTCATCGCCCGCCTCGCCGCGAAGGACGGGCGCACGCAAGTGGCGACTTTGCTCTTCGCCGGGCTCGCCCTCGGCGCGCT
GGCCAGTGCCGGAACCGGGGTGATGGTGTTCCTCGCCTCCGAGCAGCAGACCCGCGAATTCCTGTTCTGGACCCTCGGCA
GCCTCGGCGGCGCCACCTGGCAGAAGGCGGCCCTCGCCGCGCCGTTCGTGCTGGGCCTGCTGGCGGCGTCCGTCTTCCTC
GCCCGGGGGCTCGACGCGCTGGCGCTGGGGGAGGCGGAGGCGTTCCACGCCGGTGTTTCGGTGGAGCGGCTGAAGCGGGG
CGCGGTGATCGCGGTGGCCGCCGGGGTCGGGGCCTCGGTGGCGGCGGCGGGCGTGGTGGGTTTCATCGGGCTGGTGGTGC
CGCATCTGGCGCGGCTGGTGGTGGGGCCGTCCCATCGGGTGCTGCTGCCGGCCTCGGCGTTGCTGGGTGTCGCGGTGCTG
CTCGGTGCCGACATCCTGGCGCGGATGATCGCCGCACCGGCCGAGCTGCCGCTGGGCGTCGTGACCGCTCTGGTGGGCGC
ACCCTTCTTCCTGTGGCTGCTGCTGCGCCGGCGTGCGTTCGTCGGATGA

Upstream 100 bases:

>100_bases
CGCGTGCGCCACGGGCGGCGCGGGATCTTGCCGCGGCGCTCCATCCGGGCGCGCGCCTGCCGGAACTGCCGGCCCGTCCG
TGGAGTGCGGAGAAGGATCA

Downstream 100 bases:

>100_bases
TGGGGATGAACATGTATCAGGCCGAGAGCGTGAGCGTTGCGGCTGGCGGACGCCTGCTGGTGCACGGTGCCAGCCTTGCC
ATCCAGCCGGGGCGCGTGAC

Product: transport system permease

Products: ADP; phosphate; iron dicitrate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 362; Mature: 361

Protein sequence:

>362_residues
MSVEHVTMAAPAEIASGRPVRAGLILFALLAGVALIGALAIGPFTIAPGRVLTILWAALTGDATPTIALRERIVVIDVRF
PRAVLGALTGAGTAVAGAVMQGVFRNPLADPGLVGVAPGAALAAVAFVVFGAPLAMLLPVPLQALGLPLAAFAGGLGTTL
VIARLAAKDGRTQVATLLFAGLALGALASAGTGVMVFLASEQQTREFLFWTLGSLGGATWQKAALAAPFVLGLLAASVFL
ARGLDALALGEAEAFHAGVSVERLKRGAVIAVAAGVGASVAAAGVVGFIGLVVPHLARLVVGPSHRVLLPASALLGVAVL
LGADILARMIAAPAELPLGVVTALVGAPFFLWLLLRRRAFVG

Sequences:

>Translated_362_residues
MSVEHVTMAAPAEIASGRPVRAGLILFALLAGVALIGALAIGPFTIAPGRVLTILWAALTGDATPTIALRERIVVIDVRF
PRAVLGALTGAGTAVAGAVMQGVFRNPLADPGLVGVAPGAALAAVAFVVFGAPLAMLLPVPLQALGLPLAAFAGGLGTTL
VIARLAAKDGRTQVATLLFAGLALGALASAGTGVMVFLASEQQTREFLFWTLGSLGGATWQKAALAAPFVLGLLAASVFL
ARGLDALALGEAEAFHAGVSVERLKRGAVIAVAAGVGASVAAAGVVGFIGLVVPHLARLVVGPSHRVLLPASALLGVAVL
LGADILARMIAAPAELPLGVVTALVGAPFFLWLLLRRRAFVG
>Mature_361_residues
SVEHVTMAAPAEIASGRPVRAGLILFALLAGVALIGALAIGPFTIAPGRVLTILWAALTGDATPTIALRERIVVIDVRFP
RAVLGALTGAGTAVAGAVMQGVFRNPLADPGLVGVAPGAALAAVAFVVFGAPLAMLLPVPLQALGLPLAAFAGGLGTTLV
IARLAAKDGRTQVATLLFAGLALGALASAGTGVMVFLASEQQTREFLFWTLGSLGGATWQKAALAAPFVLGLLAASVFLA
RGLDALALGEAEAFHAGVSVERLKRGAVIAVAAGVGASVAAAGVVGFIGLVVPHLARLVVGPSHRVLLPASALLGVAVLL
GADILARMIAAPAELPLGVVTALVGAPFFLWLLLRRRAFVG

Specific function: Part of the binding-protein-dependent transport system for hemin; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790740, Length=329, Percent_Identity=40.1215805471125, Blast_Score=179, Evalue=2e-46,
Organism=Escherichia coli, GI1788004, Length=290, Percent_Identity=42.4137931034483, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI1790741, Length=295, Percent_Identity=37.2881355932203, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1786804, Length=326, Percent_Identity=33.7423312883436, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI1786805, Length=289, Percent_Identity=36.6782006920415, Blast_Score=111, Evalue=6e-26,
Organism=Escherichia coli, GI1786347, Length=284, Percent_Identity=31.3380281690141, Blast_Score=92, Evalue=7e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 36144; Mature: 36013

Theoretical pI: Translated: 11.93; Mature: 11.93

Prosite motif: PS00318 HMG_COA_REDUCTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVEHVTMAAPAEIASGRPVRAGLILFALLAGVALIGALAIGPFTIAPGRVLTILWAALT
CCCCCEEECCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEECCCHHHHHHHHHHHC
GDATPTIALRERIVVIDVRFPRAVLGALTGAGTAVAGAVMQGVFRNPLADPGLVGVAPGA
CCCCCCHHHHCEEEEEEECCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCEECCCHH
ALAAVAFVVFGAPLAMLLPVPLQALGLPLAAFAGGLGTTLVIARLAAKDGRTQVATLLFA
HHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHH
GLALGALASAGTGVMVFLASEQQTREFLFWTLGSLGGATWQKAALAAPFVLGLLAASVFL
HHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
ARGLDALALGEAEAFHAGVSVERLKRGAVIAVAAGVGASVAAAGVVGFIGLVVPHLARLV
HCCCCHHHCCCHHHHHCCCCHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
VGPSHRVLLPASALLGVAVLLGADILARMIAAPAELPLGVVTALVGAPFFLWLLLRRRAF
CCCCCCEEECHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
VG
CC
>Mature Secondary Structure 
SVEHVTMAAPAEIASGRPVRAGLILFALLAGVALIGALAIGPFTIAPGRVLTILWAALT
CCCCEEECCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEECCCHHHHHHHHHHHC
GDATPTIALRERIVVIDVRFPRAVLGALTGAGTAVAGAVMQGVFRNPLADPGLVGVAPGA
CCCCCCHHHHCEEEEEEECCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCEECCCHH
ALAAVAFVVFGAPLAMLLPVPLQALGLPLAAFAGGLGTTLVIARLAAKDGRTQVATLLFA
HHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHH
GLALGALASAGTGVMVFLASEQQTREFLFWTLGSLGGATWQKAALAAPFVLGLLAASVFL
HHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
ARGLDALALGEAEAFHAGVSVERLKRGAVIAVAAGVGASVAAAGVVGFIGLVVPHLARLV
HCCCCHHHCCCHHHHHCCCCHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
VGPSHRVLLPASALLGVAVLLGADILARMIAAPAELPLGVVTALVGAPFFLWLLLRRRAF
CCCCCCEEECHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
VG
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron dicitrate [Periplasm]; H2O [C]

Specific reaction: ATP + iron dicitrate [Periplasm] + H2O = ADP + phosphate + iron dicitrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9026634; 11586360; 12142430 [H]