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The map label for this gene is mdtA [H]

Identifier: 154248086

GI number: 154248086

Start: 4608130

End: 4609413

Strand: Direct

Name: mdtA [H]

Synonym: Xaut_4166

Alternate gene names: 154248086

Gene position: 4608130-4609413 (Clockwise)

Preceding gene: 154248085

Following gene: 154248087

Centisome position: 86.8

GC content: 69.55

Gene sequence:

>1284_bases
ATGGACAAACAGGTATCCGGCCGTGCCGAATCGCCTCCGGCAGCCGTACGTCGCAGCTGGCGTTCAACGGTGATTCTCAC
CGTCGTTGCGCTGGCGGCCATTGGTGGCCTCGGCGCCCTGTATTGGCGCGGGCCGGGCTCCGCCCCGGCAGGTCCGGGGG
GCCGGATGCCGCCGCCGCAGGCCAGCGTTTCCGTAGGAACGGTGGAGCGCGGTGACATCACGGTCACGGTCCAGGCGCTG
GGCACGGTCACCTCCACGTCCACCGTGACGGTGCGGCCGCAGGTCAGCGGGCAGCTGCTGAGCGTGAATTTCAAGGAAGG
CCAGAGCGTCAAGCGCGGCGACCTCATCGCCCAGATCGATCCGCGGCCGTTCCAGGCCACCCTTGACCAGGCCAAGGCCC
AGGTGGACCGCGACCAGGCCCTGCTGGAAGGCGCCAAGGTGGATCTCCAGCGCTACCAGGGCCTATCGGCGCAGAACGCG
GTGCCGCGCCAGACCCTCGACACCCAGAAGGCGCTCGTGGCGCAGTACACGGCGACCATCGAGGCGGACAAGGCGCAGCT
CCAGACCGCCGCCATCAACCTCGATTTCACGCAGATCCGCGCCCCGGTGGACGGGCGGGCCGGATTGCGCCTCGTGGACC
AGGGCAATTACGTCACACCCGGCGACACCAGCGGCATCACCGTGCTGACCCAGCTCCAGCCCATCAGCGTGGTGTTTTCC
GTGCCGGAGGACCGGTTGGCGGAGATTTCCCGGCGCCTCAAGGCCGGCGCGAAACTGGCGGTGCATGCTTTCGACCGCAC
CGGTCAGAACAGGATCGCCGAAGGGGTGCTGGAGACCTTCGACAGCCAGATCGACCAGACCACGGGCACCATCAAGCTGC
GCGCCAGCTTCCCCAACGAGGACCAGCGGCTCTACCCGAACCAGTTCGTCAACGTGACGCTGGATGTGGACACCCATTCG
GGCGTCGCCATCGCCCCGACATCCGGGATTCAGCGCGGCGTGCCGGGGACTTTCGCCTATCTGCTCAATGCGGACCAGAC
GGTGTCGGTGCGGCCCATCACCCTCGGCGTCACCACGGGCGAGAAGGTGGAGATCCTCTCCGGCCTCGCGCCCGGCGACC
AGATCGTGGTGGAGGGGGCCGACCGGTTGCGCGACGGGGCCCATGTGACGGTGCGCCCGGGAGCGGCTCGATCGCCGCCC
GCCGCCGGTGCCCCGCCGGCGCGGCCGGGTGGCCAACCTGAGGCGCATCAGGGCCGCCAGCCGGACCGCGCGGCAGCGCA
ATGA

Upstream 100 bases:

>100_bases
CGCCGCATTTTCAACAGGGGCGAATGGCGGGGAGGGGTCCGGTGGGCCGGCATGCTGCCGGTTCAGGAGCGGGAAGGTTC
TGTCGGGAGACGCCGGCTCA

Downstream 100 bases:

>100_bases
ACCCGTCGCGTCCGTTCATCCTGCGGCCGGTGGCCACCACGCTGGCGATGGTGGCGATCCTGCTCTCGGGTGCCATCGCG
CTGTTGTTCCTGCCGGTGTC

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: Multidrug transporter mdtA [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MDKQVSGRAESPPAAVRRSWRSTVILTVVALAAIGGLGALYWRGPGSAPAGPGGRMPPPQASVSVGTVERGDITVTVQAL
GTVTSTSTVTVRPQVSGQLLSVNFKEGQSVKRGDLIAQIDPRPFQATLDQAKAQVDRDQALLEGAKVDLQRYQGLSAQNA
VPRQTLDTQKALVAQYTATIEADKAQLQTAAINLDFTQIRAPVDGRAGLRLVDQGNYVTPGDTSGITVLTQLQPISVVFS
VPEDRLAEISRRLKAGAKLAVHAFDRTGQNRIAEGVLETFDSQIDQTTGTIKLRASFPNEDQRLYPNQFVNVTLDVDTHS
GVAIAPTSGIQRGVPGTFAYLLNADQTVSVRPITLGVTTGEKVEILSGLAPGDQIVVEGADRLRDGAHVTVRPGAARSPP
AAGAPPARPGGQPEAHQGRQPDRAAAQ

Sequences:

>Translated_427_residues
MDKQVSGRAESPPAAVRRSWRSTVILTVVALAAIGGLGALYWRGPGSAPAGPGGRMPPPQASVSVGTVERGDITVTVQAL
GTVTSTSTVTVRPQVSGQLLSVNFKEGQSVKRGDLIAQIDPRPFQATLDQAKAQVDRDQALLEGAKVDLQRYQGLSAQNA
VPRQTLDTQKALVAQYTATIEADKAQLQTAAINLDFTQIRAPVDGRAGLRLVDQGNYVTPGDTSGITVLTQLQPISVVFS
VPEDRLAEISRRLKAGAKLAVHAFDRTGQNRIAEGVLETFDSQIDQTTGTIKLRASFPNEDQRLYPNQFVNVTLDVDTHS
GVAIAPTSGIQRGVPGTFAYLLNADQTVSVRPITLGVTTGEKVEILSGLAPGDQIVVEGADRLRDGAHVTVRPGAARSPP
AAGAPPARPGGQPEAHQGRQPDRAAAQ
>Mature_427_residues
MDKQVSGRAESPPAAVRRSWRSTVILTVVALAAIGGLGALYWRGPGSAPAGPGGRMPPPQASVSVGTVERGDITVTVQAL
GTVTSTSTVTVRPQVSGQLLSVNFKEGQSVKRGDLIAQIDPRPFQATLDQAKAQVDRDQALLEGAKVDLQRYQGLSAQNA
VPRQTLDTQKALVAQYTATIEADKAQLQTAAINLDFTQIRAPVDGRAGLRLVDQGNYVTPGDTSGITVLTQLQPISVVFS
VPEDRLAEISRRLKAGAKLAVHAFDRTGQNRIAEGVLETFDSQIDQTTGTIKLRASFPNEDQRLYPNQFVNVTLDVDTHS
GVAIAPTSGIQRGVPGTFAYLLNADQTVSVRPITLGVTTGEKVEILSGLAPGDQIVVEGADRLRDGAHVTVRPGAARSPP
AAGAPPARPGGQPEAHQGRQPDRAAAQ

Specific function: The mdtABC tripartite complex confers resistance against novobiocin and deoxycholate [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87082036, Length=380, Percent_Identity=42.8947368421053, Blast_Score=307, Evalue=1e-84,
Organism=Escherichia coli, GI1786668, Length=384, Percent_Identity=33.0729166666667, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI1789665, Length=334, Percent_Identity=32.0359281437126, Blast_Score=148, Evalue=6e-37,
Organism=Escherichia coli, GI1789929, Length=331, Percent_Identity=29.0030211480363, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI87081951, Length=270, Percent_Identity=27.037037037037, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI87081796, Length=364, Percent_Identity=28.5714285714286, Blast_Score=76, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022824
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 44963; Mature: 44963

Theoretical pI: Translated: 9.59; Mature: 9.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
0.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKQVSGRAESPPAAVRRSWRSTVILTVVALAAIGGLGALYWRGPGSAPAGPGGRMPPPQ
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCC
ASVSVGTVERGDITVTVQALGTVTSTSTVTVRPQVSGQLLSVNFKEGQSVKRGDLIAQID
CCEEECEEECCCEEEEEEEECCEECCCEEEEEECCCCEEEEEECCCCCCCCCCCEEEEEC
PRPFQATLDQAKAQVDRDQALLEGAKVDLQRYQGLSAQNAVPRQTLDTQKALVAQYTATI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHEE
EADKAQLQTAAINLDFTQIRAPVDGRAGLRLVDQGNYVTPGDTSGITVLTQLQPISVVFS
ECCHHEEEEEEEECCHHHEECCCCCCCCEEEEECCCEECCCCCCCEEEEEECCEEEEEEE
VPEDRLAEISRRLKAGAKLAVHAFDRTGQNRIAEGVLETFDSQIDQTTGTIKLRASFPNE
CCHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCC
DQRLYPNQFVNVTLDVDTHSGVAIAPTSGIQRGVPGTFAYLLNADQTVSVRPITLGVTTG
CCEECCCEEEEEEEEEECCCCEEEECCCCCCCCCCCEEEEEECCCCEEEEEEEEEEECCC
EKVEILSGLAPGDQIVVEGADRLRDGAHVTVRPGAARSPPAAGAPPARPGGQPEAHQGRQ
CHHHHHHCCCCCCEEEEECHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PDRAAAQ
CCHHCCC
>Mature Secondary Structure
MDKQVSGRAESPPAAVRRSWRSTVILTVVALAAIGGLGALYWRGPGSAPAGPGGRMPPPQ
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCC
ASVSVGTVERGDITVTVQALGTVTSTSTVTVRPQVSGQLLSVNFKEGQSVKRGDLIAQID
CCEEECEEECCCEEEEEEEECCEECCCEEEEEECCCCEEEEEECCCCCCCCCCCEEEEEC
PRPFQATLDQAKAQVDRDQALLEGAKVDLQRYQGLSAQNAVPRQTLDTQKALVAQYTATI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHEE
EADKAQLQTAAINLDFTQIRAPVDGRAGLRLVDQGNYVTPGDTSGITVLTQLQPISVVFS
ECCHHEEEEEEEECCHHHEECCCCCCCCEEEEECCCEECCCCCCCEEEEEECCEEEEEEE
VPEDRLAEISRRLKAGAKLAVHAFDRTGQNRIAEGVLETFDSQIDQTTGTIKLRASFPNE
CCHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCC
DQRLYPNQFVNVTLDVDTHSGVAIAPTSGIQRGVPGTFAYLLNADQTVSVRPITLGVTTG
CCEECCCEEEEEEEEEECCCCEEEECCCCCCCCCCCEEEEEECCCCEEEEEEEEEEECCC
EKVEILSGLAPGDQIVVEGADRLRDGAHVTVRPGAARSPPAAGAPPARPGGQPEAHQGRQ
CHHHHHHCCCCCCEEEEECHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PDRAAAQ
CCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA