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The map label for this gene is pdhA [H]

Identifier: 154247811

GI number: 154247811

Start: 4307962

End: 4308969

Strand: Direct

Name: pdhA [H]

Synonym: Xaut_3888

Alternate gene names: 154247811

Gene position: 4307962-4308969 (Clockwise)

Preceding gene: 154247810

Following gene: 154247812

Centisome position: 81.15

GC content: 65.58

Gene sequence:

>1008_bases
ATGGCCAAAAAGTCTATTGCCCGCGTTGCCGATGCCTCGGCCCCGGCCCCCTTCACCAAAGACCAGGATCTTCTCGCCTA
CCGCGAGATGCTGCTCATCCGCCGCTTCGAGGAGAAGGCCGGCCAGATGTACGGCATGGGCCTCATCGGCGGCTTCTGCC
ATCTCTACATCGGCCAGGAGGCCGTGGTGGTGGGCATGCAGATGGCCATGAAGCCGGGTGACCAGGTCATCACCGGCTAT
CGCGACCACGGCCACATGCTGTCCACCGGCATGGCCGCCCGCGGCGTCATGGCCGAGCTGACGGGCCGCCGCGGCGGCCT
GTCCAAGGGCAAGGGCGGCTCGATGCACATGTTCAGCATCGAGAAGCAGTTCTTCGGCGGCCACGGTATCGTCGGCGCCC
AGGTCTCGCTCGGCACCGGCCTCGCCTTCGCCGATCGCTACCGCAACAATGGCGCCGTCTCGGTCACCTATTTCGGCGAC
GGCGCGGCCAACCAGGGCCAAGTCTACGAGAGCTTCAACATGGCCGAGCTGTGGAAGCTCCCGGTCGTGTATGTGATCGA
GAACAACAAGTATGCCATGGGCACCTCGGTGTCCCGCGCCTCGGCGCAGCAGGACTTCTCCAAGCGCGGCACCTCCTTCA
ACATCCCCGGCGAGCAGGTGGATGGCATGGACGTGCAGGCGGTGAAGGCCGCCGGCGAGCGGGCGCTCGCCTTCGCCCGC
GAGGGCAACGGTCCCTACATCCTGGAAATGCAGACCTACCGCTATCGCGGTCACTCCATGTCGGACCCGGCCAAGTACCG
GTCCAAGGAGGAGGTCCAGAAGATGCGCACCGAGCACGATCCCATCGAGCAGGTCCGCAACCGTCTGCTGGAAACCCACG
GCGCGACCGAGGACGAGCTGAAGAAGTTCGACGCCGAGGTCCGCGAGATCGTCAACGAGGCGACGGACTTCGCCACCAAC
GATCCCGAGCCCGACGCGTCGGAGCTGTACACGGACATCCTGCGCTGA

Upstream 100 bases:

>100_bases
GTTTGCAACGTGTTGCAGTGCACAACACGAAAATTGGCGCTTTGAGGGCACAGGGAGCTGAGTTAGGAAGGCGCAGTTCC
AGCGCTTCCTGAGGATGCCG

Downstream 100 bases:

>100_bases
GCGGCGGGCCGTGGCCGCGCTGTTCCATATCCTCGCCGGCCTCGCGCTTGTCGCGGCGCTGATTGCTTGGGCCGTCGCGG
TGCGCGGAGGCCTGAAGGCC

Product: pyruvate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 335; Mature: 334

Protein sequence:

>335_residues
MAKKSIARVADASAPAPFTKDQDLLAYREMLLIRRFEEKAGQMYGMGLIGGFCHLYIGQEAVVVGMQMAMKPGDQVITGY
RDHGHMLSTGMAARGVMAELTGRRGGLSKGKGGSMHMFSIEKQFFGGHGIVGAQVSLGTGLAFADRYRNNGAVSVTYFGD
GAANQGQVYESFNMAELWKLPVVYVIENNKYAMGTSVSRASAQQDFSKRGTSFNIPGEQVDGMDVQAVKAAGERALAFAR
EGNGPYILEMQTYRYRGHSMSDPAKYRSKEEVQKMRTEHDPIEQVRNRLLETHGATEDELKKFDAEVREIVNEATDFATN
DPEPDASELYTDILR

Sequences:

>Translated_335_residues
MAKKSIARVADASAPAPFTKDQDLLAYREMLLIRRFEEKAGQMYGMGLIGGFCHLYIGQEAVVVGMQMAMKPGDQVITGY
RDHGHMLSTGMAARGVMAELTGRRGGLSKGKGGSMHMFSIEKQFFGGHGIVGAQVSLGTGLAFADRYRNNGAVSVTYFGD
GAANQGQVYESFNMAELWKLPVVYVIENNKYAMGTSVSRASAQQDFSKRGTSFNIPGEQVDGMDVQAVKAAGERALAFAR
EGNGPYILEMQTYRYRGHSMSDPAKYRSKEEVQKMRTEHDPIEQVRNRLLETHGATEDELKKFDAEVREIVNEATDFATN
DPEPDASELYTDILR
>Mature_334_residues
AKKSIARVADASAPAPFTKDQDLLAYREMLLIRRFEEKAGQMYGMGLIGGFCHLYIGQEAVVVGMQMAMKPGDQVITGYR
DHGHMLSTGMAARGVMAELTGRRGGLSKGKGGSMHMFSIEKQFFGGHGIVGAQVSLGTGLAFADRYRNNGAVSVTYFGDG
AANQGQVYESFNMAELWKLPVVYVIENNKYAMGTSVSRASAQQDFSKRGTSFNIPGEQVDGMDVQAVKAAGERALAFARE
GNGPYILEMQTYRYRGHSMSDPAKYRSKEEVQKMRTEHDPIEQVRNRLLETHGATEDELKKFDAEVREIVNEATDFATND
PEPDASELYTDILR

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=313, Percent_Identity=52.7156549520767, Blast_Score=346, Evalue=2e-95,
Organism=Homo sapiens, GI291084742, Length=313, Percent_Identity=51.4376996805112, Blast_Score=322, Evalue=3e-88,
Organism=Homo sapiens, GI4505685, Length=313, Percent_Identity=51.4376996805112, Blast_Score=321, Evalue=5e-88,
Organism=Homo sapiens, GI291084744, Length=320, Percent_Identity=50.3125, Blast_Score=314, Evalue=6e-86,
Organism=Homo sapiens, GI291084757, Length=313, Percent_Identity=46.3258785942492, Blast_Score=273, Evalue=2e-73,
Organism=Homo sapiens, GI11386135, Length=327, Percent_Identity=29.0519877675841, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI258645172, Length=327, Percent_Identity=29.3577981651376, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI32564172, Length=317, Percent_Identity=50.4731861198738, Blast_Score=313, Evalue=1e-85,
Organism=Caenorhabditis elegans, GI17536047, Length=317, Percent_Identity=50.4731861198738, Blast_Score=312, Evalue=1e-85,
Organism=Caenorhabditis elegans, GI86563357, Length=333, Percent_Identity=28.5285285285285, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI86563355, Length=333, Percent_Identity=28.5285285285285, Blast_Score=125, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6321026, Length=318, Percent_Identity=49.3710691823899, Blast_Score=313, Evalue=3e-86,
Organism=Drosophila melanogaster, GI24639744, Length=317, Percent_Identity=51.1041009463722, Blast_Score=327, Evalue=6e-90,
Organism=Drosophila melanogaster, GI28571106, Length=317, Percent_Identity=51.1041009463722, Blast_Score=327, Evalue=6e-90,
Organism=Drosophila melanogaster, GI24639740, Length=317, Percent_Identity=51.1041009463722, Blast_Score=327, Evalue=8e-90,
Organism=Drosophila melanogaster, GI24639746, Length=305, Percent_Identity=51.1475409836066, Blast_Score=315, Evalue=2e-86,
Organism=Drosophila melanogaster, GI24639748, Length=317, Percent_Identity=51.1041009463722, Blast_Score=306, Evalue=1e-83,
Organism=Drosophila melanogaster, GI21355903, Length=307, Percent_Identity=26.0586319218241, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017597 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 36900; Mature: 36769

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKKSIARVADASAPAPFTKDQDLLAYREMLLIRRFEEKAGQMYGMGLIGGFCHLYIGQE
CCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEECHHHHHHHHHHHCCCH
AVVVGMQMAMKPGDQVITGYRDHGHMLSTGMAARGVMAELTGRRGGLSKGKGGSMHMFSI
HHHHHHHHHCCCCCCEEECCCCCCCCHHCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEE
EKQFFGGHGIVGAQVSLGTGLAFADRYRNNGAVSVTYFGDGAANQGQVYESFNMAELWKL
HHHHCCCCCEEEEEEECCCCHHHHHHHCCCCCEEEEEECCCCCCCCCHHHCCCHHHHHCC
PVVYVIENNKYAMGTSVSRASAQQDFSKRGTSFNIPGEQVDGMDVQAVKAAGERALAFAR
CEEEEEECCCEEECCCHHHHHHHHHHHHCCCEECCCCCCCCCCCHHHHHHCCHHHEEEEE
EGNGPYILEMQTYRYRGHSMSDPAKYRSKEEVQKMRTEHDPIEQVRNRLLETHGATEDEL
CCCCCEEEEEEEEEECCCCCCCHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHH
KKFDAEVREIVNEATDFATNDPEPDASELYTDILR
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHC
>Mature Secondary Structure 
AKKSIARVADASAPAPFTKDQDLLAYREMLLIRRFEEKAGQMYGMGLIGGFCHLYIGQE
CHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEECHHHHHHHHHHHCCCH
AVVVGMQMAMKPGDQVITGYRDHGHMLSTGMAARGVMAELTGRRGGLSKGKGGSMHMFSI
HHHHHHHHHCCCCCCEEECCCCCCCCHHCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEE
EKQFFGGHGIVGAQVSLGTGLAFADRYRNNGAVSVTYFGDGAANQGQVYESFNMAELWKL
HHHHCCCCCEEEEEEECCCCHHHHHHHCCCCCEEEEEECCCCCCCCCHHHCCCHHHHHCC
PVVYVIENNKYAMGTSVSRASAQQDFSKRGTSFNIPGEQVDGMDVQAVKAAGERALAFAR
CEEEEEECCCEEECCCHHHHHHHHHHHHCCCEECCCCCCCCCCCHHHHHHCCHHHEEEEE
EGNGPYILEMQTYRYRGHSMSDPAKYRSKEEVQKMRTEHDPIEQVRNRLLETHGATEDEL
CCCCCEEEEEEEEEECCCCCCCHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHH
KKFDAEVREIVNEATDFATNDPEPDASELYTDILR
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10796014; 11481430 [H]