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The map label for this gene is rsh [H]

Identifier: 154247800

GI number: 154247800

Start: 4295630

End: 4297858

Strand: Direct

Name: rsh [H]

Synonym: Xaut_3877

Alternate gene names: 154247800

Gene position: 4295630-4297858 (Clockwise)

Preceding gene: 154247798

Following gene: 154247801

Centisome position: 80.91

GC content: 67.29

Gene sequence:

>2229_bases
ATGATGCGCCAATACGAACTCGTCGAGCGCGTTCGACGGTATAATCCCAACACCGACGAGGCGCTGCTCGACCGCGCCTA
TGTGTATGCCATGCGCGCGCACGGCAGCCAGCTGCGCGCGTCCGGCGACCCCTATTTCTCCCATCCCCTGGAAGTCGCGG
CGATCCTCACCGATCTCAAGCTGGACGATGCCACCATCGTCTCGGCCCTGCTGCACGACACCATCGAGGATACGAGCGCC
ACCAAGGTGGAGATCGAGCGCCTGTTCGGTCACCAGATCGCGACGCTGGTGGAGGGCCTCACCAAGATCAAGAAGCTGGA
CCTCGTCTCCAAGCAGGCCAAGCAGGCGGAAAACCTGCGCAAGCTGCTCCTCGCCATCGCCGACGACGTGCGGGTGCTCC
TCGTCAAGCTCGCCGACCGTCTCCACAACATGCGTACCCTGAAGTGGGTGCCGCCGGAGAAGCGCGATCGCGTGGCGCAG
GAGACGCTGGACATCTACGCCCCGCTCGCCGCCCGCATGGGCATGCAGGACATGCGCGAGGAACTGGAGGACCTGTCCTT
CCGCCAGCTCTCGCCGGAGGCCTACGAATCCATCGCCGAGAGGGTCTCGGAACTGCGCCAGGGCAACGGCGCCGTGGTGC
AGGAGATCGAGCGCGAGCTGAAGGACGAGCTGGAACGGCGCGGCATCGCGGCCGAGGTGAAGGGGCGTGAGAAGCGGCCG
TATTCCATCTGGGGCAAGATGGAGCGCAAGGCCATCGGCTTCGAGCAATTGTCCGACCTCTACGGCTTCCGCGTCATCGT
CGGCTCGGTGGAGGACTGCTATCGCGCTCTGGGGGTGATCCACACCAAGTGGGCCATTGTGCCCGGCCGCTTCAAGGACT
ACATCTCCACCCCCAAGCCCAACGACTACCGCTCGCTCCACACCACGGTGGTGGGACCGCGCCGGCAGCGGGTCGAGATG
CAGATCCGCACCCGGGACATGGAGGAGATCGCCGAATACGGCATCGCCGCCCACGCCCTCTACAAGGATGCGTCCGGCGC
GCCGGGGGCCATGCTCTCCCACGAGAGCCGGGCCTACGCCTGGCTGCGCAAGACCATCGAGAACCTGTCGCAGGGCCTCT
CGCCGGAGGAGTTCCTGGAGCACACCAAGCTCGAGCTGTTCCACGACCAGGTGTTCTGCTTCACCCCCAAGGGGCGGCTG
ATCGCGCTGCCGCGCAAGGCGACGCCCATCGATTTCGCCTATGCCGTGCATACCGACGTGGGCAATACGGCGGTGGGCTG
CAAGATCAACGGCTCCATCGCGCCCCTGGTGTCGGAGCTGAAGAACGGCGACGAGGTGGAGATCATCACCTCCAAGGCGC
AGACGCCGCCCGGCGCGTGGGAGACCATCGCCGTCACCGGCAAGGCGCGGGCCGCCGTGCGCCGTGCGACCCGCACCGCC
GTTCGCGCCCAATATGCCGGCCTCGGCCGCAAGATCGCCGAGCGGGCTTTTGCCAAGGCCGGCAAGGTGTTCTCGGAGGA
TGCGGTGGCCAAGGGCACGCCGCGCCTCGCCCGCACCGCCGCCGAGGACGTGTTCGCCGCCGTGGGCCGGGGCGAGATCA
AGACCGAGGATCTCATCCGCGCCGTCTATCCCGACTGGCAGCCGCCGCGCGCGGAAGACCGCACCGACCGTCAGATCAAC
GGCGAGGGCTGGTTCGAGCTGAAGCGCGGCCACAACCTCAAGTTCAAGATCCCCGAGGGCGCCAAACCGCGGGATGGGGA
GGATGCCGAGCGTCTCGACGCCATTCCCATACGCGGCATCAACGGTGAGCTTCCGGTGCGATTCGCGCCGGAGGGCGGCG
CCGTGCCTGGCGACCGCATCGTCGGCATTCTCACGCCGGGGGAGGGGATCACCATCTACCCGATCCAGTCGCCGTCCCTG
CAGAGTTTCGAGGATGCGCCCGAGCGCTGGCTCGACGTGCGCTGGGACGTGGACGAGCTGTCGGATGGCCGCTTCCCGGC
CCGCATCATCGTGACCGCCCGCAACGCACCCGGCTCGCTGGCCCAGGTGGCCGGCGCCATCGGCGATCGCGGCGGCAATA
TCGACGGTCTCCAGATGCGCTCCCGCTCGGCGGATTTCCACGAGATGGTGATCGACATCGAGGTGTTCGACCTCAGGCAC
CTCAACACCATCATGGCGGACCTGAAGGCCCGCGAGGTGGTGGCCCAGGTGGAGCGCGTGAACGGCTGA

Upstream 100 bases:

>100_bases
TTGCGCGTGGCCCCCCTCGCCATGATATCAAGGGTCAAACAAGGATAGGGCGGGCGCGCTGAACCTGCCCCGCCCGTGCT
GCGACGGATCGTTCCCGGCC

Downstream 100 bases:

>100_bases
CCCGCTGCGAGCGGGGCGCGCCCATCCATAAGCCGCAGCGGAGCAGGGAGCAGGGACGATGGCGGTGCTGAAGCCGGTGC
GGCTCGGAGTGAACGTCGAT

Product: (p)ppGpp synthetase I SpoT/RelA

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase [H]

Number of amino acids: Translated: 742; Mature: 742

Protein sequence:

>742_residues
MMRQYELVERVRRYNPNTDEALLDRAYVYAMRAHGSQLRASGDPYFSHPLEVAAILTDLKLDDATIVSALLHDTIEDTSA
TKVEIERLFGHQIATLVEGLTKIKKLDLVSKQAKQAENLRKLLLAIADDVRVLLVKLADRLHNMRTLKWVPPEKRDRVAQ
ETLDIYAPLAARMGMQDMREELEDLSFRQLSPEAYESIAERVSELRQGNGAVVQEIERELKDELERRGIAAEVKGREKRP
YSIWGKMERKAIGFEQLSDLYGFRVIVGSVEDCYRALGVIHTKWAIVPGRFKDYISTPKPNDYRSLHTTVVGPRRQRVEM
QIRTRDMEEIAEYGIAAHALYKDASGAPGAMLSHESRAYAWLRKTIENLSQGLSPEEFLEHTKLELFHDQVFCFTPKGRL
IALPRKATPIDFAYAVHTDVGNTAVGCKINGSIAPLVSELKNGDEVEIITSKAQTPPGAWETIAVTGKARAAVRRATRTA
VRAQYAGLGRKIAERAFAKAGKVFSEDAVAKGTPRLARTAAEDVFAAVGRGEIKTEDLIRAVYPDWQPPRAEDRTDRQIN
GEGWFELKRGHNLKFKIPEGAKPRDGEDAERLDAIPIRGINGELPVRFAPEGGAVPGDRIVGILTPGEGITIYPIQSPSL
QSFEDAPERWLDVRWDVDELSDGRFPARIIVTARNAPGSLAQVAGAIGDRGGNIDGLQMRSRSADFHEMVIDIEVFDLRH
LNTIMADLKAREVVAQVERVNG

Sequences:

>Translated_742_residues
MMRQYELVERVRRYNPNTDEALLDRAYVYAMRAHGSQLRASGDPYFSHPLEVAAILTDLKLDDATIVSALLHDTIEDTSA
TKVEIERLFGHQIATLVEGLTKIKKLDLVSKQAKQAENLRKLLLAIADDVRVLLVKLADRLHNMRTLKWVPPEKRDRVAQ
ETLDIYAPLAARMGMQDMREELEDLSFRQLSPEAYESIAERVSELRQGNGAVVQEIERELKDELERRGIAAEVKGREKRP
YSIWGKMERKAIGFEQLSDLYGFRVIVGSVEDCYRALGVIHTKWAIVPGRFKDYISTPKPNDYRSLHTTVVGPRRQRVEM
QIRTRDMEEIAEYGIAAHALYKDASGAPGAMLSHESRAYAWLRKTIENLSQGLSPEEFLEHTKLELFHDQVFCFTPKGRL
IALPRKATPIDFAYAVHTDVGNTAVGCKINGSIAPLVSELKNGDEVEIITSKAQTPPGAWETIAVTGKARAAVRRATRTA
VRAQYAGLGRKIAERAFAKAGKVFSEDAVAKGTPRLARTAAEDVFAAVGRGEIKTEDLIRAVYPDWQPPRAEDRTDRQIN
GEGWFELKRGHNLKFKIPEGAKPRDGEDAERLDAIPIRGINGELPVRFAPEGGAVPGDRIVGILTPGEGITIYPIQSPSL
QSFEDAPERWLDVRWDVDELSDGRFPARIIVTARNAPGSLAQVAGAIGDRGGNIDGLQMRSRSADFHEMVIDIEVFDLRH
LNTIMADLKAREVVAQVERVNG
>Mature_742_residues
MMRQYELVERVRRYNPNTDEALLDRAYVYAMRAHGSQLRASGDPYFSHPLEVAAILTDLKLDDATIVSALLHDTIEDTSA
TKVEIERLFGHQIATLVEGLTKIKKLDLVSKQAKQAENLRKLLLAIADDVRVLLVKLADRLHNMRTLKWVPPEKRDRVAQ
ETLDIYAPLAARMGMQDMREELEDLSFRQLSPEAYESIAERVSELRQGNGAVVQEIERELKDELERRGIAAEVKGREKRP
YSIWGKMERKAIGFEQLSDLYGFRVIVGSVEDCYRALGVIHTKWAIVPGRFKDYISTPKPNDYRSLHTTVVGPRRQRVEM
QIRTRDMEEIAEYGIAAHALYKDASGAPGAMLSHESRAYAWLRKTIENLSQGLSPEEFLEHTKLELFHDQVFCFTPKGRL
IALPRKATPIDFAYAVHTDVGNTAVGCKINGSIAPLVSELKNGDEVEIITSKAQTPPGAWETIAVTGKARAAVRRATRTA
VRAQYAGLGRKIAERAFAKAGKVFSEDAVAKGTPRLARTAAEDVFAAVGRGEIKTEDLIRAVYPDWQPPRAEDRTDRQIN
GEGWFELKRGHNLKFKIPEGAKPRDGEDAERLDAIPIRGINGELPVRFAPEGGAVPGDRIVGILTPGEGITIYPIQSPSL
QSFEDAPERWLDVRWDVDELSDGRFPARIIVTARNAPGSLAQVAGAIGDRGGNIDGLQMRSRSADFHEMVIDIEVFDLRH
LNTIMADLKAREVVAQVERVNG

Specific function: Functions as a (p)ppGpp synthase. In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. Plays a role in ada

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Homo sapiens, GI38348360, Length=140, Percent_Identity=39.2857142857143, Blast_Score=73, Evalue=8e-13,
Organism=Escherichia coli, GI1790082, Length=736, Percent_Identity=36.820652173913, Blast_Score=482, Evalue=1e-137,
Organism=Escherichia coli, GI1789147, Length=705, Percent_Identity=32.0567375886525, Blast_Score=365, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI25143118, Length=137, Percent_Identity=35.036496350365, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24650996, Length=138, Percent_Identity=34.7826086956522, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 82883; Mature: 82883

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMRQYELVERVRRYNPNTDEALLDRAYVYAMRAHGSQLRASGDPYFSHPLEVAAILTDLK
CCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCHHHHHHHHHHCC
LDDATIVSALLHDTIEDTSATKVEIERLFGHQIATLVEGLTKIKKLDLVSKQAKQAENLR
CCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLLLAIADDVRVLLVKLADRLHNMRTLKWVPPEKRDRVAQETLDIYAPLAARMGMQDMRE
HHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCHHHHHH
ELEDLSFRQLSPEAYESIAERVSELRQGNGAVVQEIERELKDELERRGIAAEVKGREKRP
HHHHCHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEECCCCCCCC
YSIWGKMERKAIGFEQLSDLYGFRVIVGSVEDCYRALGVIHTKWAIVPGRFKDYISTPKP
HHHHHHHHHHHCCHHHHHHHHHHHHEECCHHHHHHHHHHHHHHEEECCCHHHHHCCCCCC
NDYRSLHTTVVGPRRQRVEMQIRTRDMEEIAEYGIAAHALYKDASGAPGAMLSHESRAYA
CCCHHHHHEECCCHHHHHHHHHHHCCHHHHHHHCHHHHHHHCCCCCCCCCHHCCCHHHHH
WLRKTIENLSQGLSPEEFLEHTKLELFHDQVFCFTPKGRLIALPRKATPIDFAYAVHTDV
HHHHHHHHHHCCCCHHHHHHHHHHHHHHCEEEEECCCCCEEECCCCCCCCEEEEEEECCC
GNTAVGCKINGSIAPLVSELKNGDEVEIITSKAQTPPGAWETIAVTGKARAAVRRATRTA
CCCEEEEEECCCHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEEECCHHHHHHHHHHHHH
VRAQYAGLGRKIAERAFAKAGKVFSEDAVAKGTPRLARTAAEDVFAAVGRGEIKTEDLIR
HHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHH
AVYPDWQPPRAEDRTDRQINGEGWFELKRGHNLKFKIPEGAKPRDGEDAERLDAIPIRGI
HHCCCCCCCCCCCCCCCEECCCCCEEEECCCCEEEECCCCCCCCCCCCHHHHCCCCCCCC
NGELPVRFAPEGGAVPGDRIVGILTPGEGITIYPIQSPSLQSFEDAPERWLDVRWDVDEL
CCCCCEEECCCCCCCCCCCEEEEEECCCCEEEEECCCCCCCHHHHCHHHHEECEECHHHC
SDGRFPARIIVTARNAPGSLAQVAGAIGDRGGNIDGLQMRSRSADFHEMVIDIEVFDLRH
CCCCCCEEEEEEECCCCCHHHHHHHHHCCCCCCCCCHHHHCCCCCHHHEEEEEEEHHHHH
LNTIMADLKAREVVAQVERVNG
HHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MMRQYELVERVRRYNPNTDEALLDRAYVYAMRAHGSQLRASGDPYFSHPLEVAAILTDLK
CCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCHHHHHHHHHHCC
LDDATIVSALLHDTIEDTSATKVEIERLFGHQIATLVEGLTKIKKLDLVSKQAKQAENLR
CCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLLLAIADDVRVLLVKLADRLHNMRTLKWVPPEKRDRVAQETLDIYAPLAARMGMQDMRE
HHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCHHHHHH
ELEDLSFRQLSPEAYESIAERVSELRQGNGAVVQEIERELKDELERRGIAAEVKGREKRP
HHHHCHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEECCCCCCCC
YSIWGKMERKAIGFEQLSDLYGFRVIVGSVEDCYRALGVIHTKWAIVPGRFKDYISTPKP
HHHHHHHHHHHCCHHHHHHHHHHHHEECCHHHHHHHHHHHHHHEEECCCHHHHHCCCCCC
NDYRSLHTTVVGPRRQRVEMQIRTRDMEEIAEYGIAAHALYKDASGAPGAMLSHESRAYA
CCCHHHHHEECCCHHHHHHHHHHHCCHHHHHHHCHHHHHHHCCCCCCCCCHHCCCHHHHH
WLRKTIENLSQGLSPEEFLEHTKLELFHDQVFCFTPKGRLIALPRKATPIDFAYAVHTDV
HHHHHHHHHHCCCCHHHHHHHHHHHHHHCEEEEECCCCCEEECCCCCCCCEEEEEEECCC
GNTAVGCKINGSIAPLVSELKNGDEVEIITSKAQTPPGAWETIAVTGKARAAVRRATRTA
CCCEEEEEECCCHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEEECCHHHHHHHHHHHHH
VRAQYAGLGRKIAERAFAKAGKVFSEDAVAKGTPRLARTAAEDVFAAVGRGEIKTEDLIR
HHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHH
AVYPDWQPPRAEDRTDRQINGEGWFELKRGHNLKFKIPEGAKPRDGEDAERLDAIPIRGI
HHCCCCCCCCCCCCCCCEECCCCCEEEECCCCEEEECCCCCCCCCCCCHHHHCCCCCCCC
NGELPVRFAPEGGAVPGDRIVGILTPGEGITIYPIQSPSLQSFEDAPERWLDVRWDVDEL
CCCCCEEECCCCCCCCCCCEEEEEECCCCEEEEECCCCCCCHHHHCHHHHEECEECHHHC
SDGRFPARIIVTARNAPGSLAQVAGAIGDRGGNIDGLQMRSRSADFHEMVIDIEVFDLRH
CCCCCCEEEEEEECCCCCHHHHHHHHHCCCCCCCCCHHHHCCCCCHHHEEEEEEEHHHHH
LNTIMADLKAREVVAQVERVNG
HHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA