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The map label for this gene is ppi [H]

Identifier: 154247713

GI number: 154247713

Start: 4195824

End: 4196282

Strand: Direct

Name: ppi [H]

Synonym: Xaut_3789

Alternate gene names: 154247713

Gene position: 4195824-4196282 (Clockwise)

Preceding gene: 154247712

Following gene: 154247718

Centisome position: 79.03

GC content: 66.01

Gene sequence:

>459_bases
ATGAGTGACGAAGTTCTGGTTCTGGAGACCACCAAGGGTCCGGTGACCATCGCGTTCCGCCCGGACCTCGCTCCCGGCCA
CGTGGCCCGCATCAAGGAGCTGGTGTCCACCGGCTTTTATGACGGCGTACCGTTCCATCGCGTCATCGACGGCTTCATGG
CCCAGACCGGCGATCCCACCGGCACCGGCATGGGCGGCTCGGGCAAGAAGCTGAAGGCCGAGTTCAACCGCCAGCCCCAC
GTGCGCGGCACCTGCTCCATGGCGCGCGCGCAGAACCCCGATTCCGGCGACAGCCAGTTCTTCATCTGCTTTGGCGACGC
CCGCTTCCTCGACGGCCAGTACACCGTGTGGGGCGAGGTGGTCTCGGGCATGGAGAATGTGGACCAGATCAAGCGCGGCG
AGCCGGTGAAGGATCCCGACAAGATCGTCTCCGCCAAGCTCGCCCCCAAGGCGGCGTGA

Upstream 100 bases:

>100_bases
CCGGTCGGCTCAGCCGATCGGTGCGGCTTTCTTGAGTCCCGGCACGGCCGGGCGGACGCGGCGGCCGGCCCTCCGGCGCC
GCCTCGAAAGGATGACACCC

Downstream 100 bases:

>100_bases
GCCGCTAGGCGCAATAAGGGTCGGCGTGAGCCGGTGCCGAGAAAAAGGAAGGGCGCCCTCAGGGGCGCCCTTCTTCGTTC
CGGGGTCCCCCGGATCGGAT

Product: cyclophilin type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 152; Mature: 151

Protein sequence:

>152_residues
MSDEVLVLETTKGPVTIAFRPDLAPGHVARIKELVSTGFYDGVPFHRVIDGFMAQTGDPTGTGMGGSGKKLKAEFNRQPH
VRGTCSMARAQNPDSGDSQFFICFGDARFLDGQYTVWGEVVSGMENVDQIKRGEPVKDPDKIVSAKLAPKAA

Sequences:

>Translated_152_residues
MSDEVLVLETTKGPVTIAFRPDLAPGHVARIKELVSTGFYDGVPFHRVIDGFMAQTGDPTGTGMGGSGKKLKAEFNRQPH
VRGTCSMARAQNPDSGDSQFFICFGDARFLDGQYTVWGEVVSGMENVDQIKRGEPVKDPDKIVSAKLAPKAA
>Mature_151_residues
SDEVLVLETTKGPVTIAFRPDLAPGHVARIKELVSTGFYDGVPFHRVIDGFMAQTGDPTGTGMGGSGKKLKAEFNRQPHV
RGTCSMARAQNPDSGDSQFFICFGDARFLDGQYTVWGEVVSGMENVDQIKRGEPVKDPDKIVSAKLAPKAA

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI19557636, Length=132, Percent_Identity=40.1515151515151, Blast_Score=99, Evalue=1e-21,
Organism=Homo sapiens, GI7706339, Length=129, Percent_Identity=36.4341085271318, Blast_Score=88, Evalue=3e-18,
Organism=Homo sapiens, GI24308049, Length=129, Percent_Identity=41.8604651162791, Blast_Score=84, Evalue=5e-17,
Organism=Homo sapiens, GI64276486, Length=120, Percent_Identity=39.1666666666667, Blast_Score=77, Evalue=8e-15,
Organism=Homo sapiens, GI22547212, Length=134, Percent_Identity=41.7910447761194, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI7657473, Length=134, Percent_Identity=41.7910447761194, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI22547215, Length=134, Percent_Identity=41.7910447761194, Blast_Score=69, Evalue=1e-12,
Organism=Homo sapiens, GI5031987, Length=127, Percent_Identity=38.5826771653543, Blast_Score=66, Evalue=9e-12,
Organism=Homo sapiens, GI10863927, Length=128, Percent_Identity=38.28125, Blast_Score=65, Evalue=2e-11,
Organism=Homo sapiens, GI20911035, Length=138, Percent_Identity=34.0579710144928, Blast_Score=64, Evalue=7e-11,
Organism=Escherichia coli, GI1789763, Length=164, Percent_Identity=37.1951219512195, Blast_Score=79, Evalue=1e-16,
Organism=Escherichia coli, GI1786736, Length=138, Percent_Identity=37.6811594202899, Blast_Score=78, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17539496, Length=132, Percent_Identity=37.8787878787879, Blast_Score=88, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71980594, Length=131, Percent_Identity=38.1679389312977, Blast_Score=87, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI71980590, Length=131, Percent_Identity=38.1679389312977, Blast_Score=86, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17506311, Length=133, Percent_Identity=39.0977443609023, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17532641, Length=132, Percent_Identity=35.6060606060606, Blast_Score=77, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17539498, Length=140, Percent_Identity=38.5714285714286, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71997782, Length=126, Percent_Identity=39.6825396825397, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17559074, Length=109, Percent_Identity=40.3669724770642, Blast_Score=66, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17552780, Length=127, Percent_Identity=37.007874015748, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17565860, Length=157, Percent_Identity=35.031847133758, Blast_Score=64, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6320359, Length=143, Percent_Identity=38.4615384615385, Blast_Score=67, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323562, Length=97, Percent_Identity=44.3298969072165, Blast_Score=62, Evalue=3e-11,
Organism=Drosophila melanogaster, GI17986117, Length=154, Percent_Identity=40.2597402597403, Blast_Score=97, Evalue=4e-21,
Organism=Drosophila melanogaster, GI19922376, Length=144, Percent_Identity=36.1111111111111, Blast_Score=90, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24652460, Length=132, Percent_Identity=35.6060606060606, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI17647301, Length=128, Percent_Identity=39.0625, Blast_Score=73, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24664125, Length=127, Percent_Identity=38.5826771653543, Blast_Score=69, Evalue=8e-13,
Organism=Drosophila melanogaster, GI21357783, Length=127, Percent_Identity=38.5826771653543, Blast_Score=69, Evalue=8e-13,
Organism=Drosophila melanogaster, GI20130249, Length=140, Percent_Identity=37.8571428571429, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI45549139, Length=144, Percent_Identity=36.1111111111111, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI19922912, Length=160, Percent_Identity=40.625, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI21357249, Length=120, Percent_Identity=33.3333333333333, Blast_Score=64, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 16373; Mature: 16242

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDEVLVLETTKGPVTIAFRPDLAPGHVARIKELVSTGFYDGVPFHRVIDGFMAQTGDPT
CCCCEEEEEECCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCC
GTGMGGSGKKLKAEFNRQPHVRGTCSMARAQNPDSGDSQFFICFGDARFLDGQYTVWGEV
CCCCCCCCCEEEEECCCCCCCCCCHHHHHCCCCCCCCCEEEEEECCCEEECCCEEEHHHH
VSGMENVDQIKRGEPVKDPDKIVSAKLAPKAA
HHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCC
>Mature Secondary Structure 
SDEVLVLETTKGPVTIAFRPDLAPGHVARIKELVSTGFYDGVPFHRVIDGFMAQTGDPT
CCCEEEEEECCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCC
GTGMGGSGKKLKAEFNRQPHVRGTCSMARAQNPDSGDSQFFICFGDARFLDGQYTVWGEV
CCCCCCCCCEEEEECCCCCCCCCCHHHHHCCCCCCCCCEEEEEECCCEEECCCEEEHHHH
VSGMENVDQIKRGEPVKDPDKIVSAKLAPKAA
HHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA