BacMap

Definition	Xanthobacter autotrophicus Py2 chromosome, complete genome.
Accession	NC_009720
Length	5,308,934

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The map label for this gene is ppi [H]

Identifier: 154247712

GI number: 154247712

Start: 4195137

End: 4195697

Strand: Direct

Name: ppi [H]

Synonym: Xaut_3788

Alternate gene names: 154247712

Gene position: 4195137-4195697 (Clockwise)

Preceding gene: 154247711

Following gene: 154247713

Centisome position: 79.02

GC content: 66.49

Gene sequence:

>561_bases
ATGACGCGTCTTTTGGGCCGCTTCCTCGCCGCAGCCCTGCTCGCCTTCGCCGTCGCGCTGCCGGCGGCCGCGCAGACGAA
GCCCGATCCGCAGAACACCCTCTTTCTCGACACGCCCTATGGCCGCGTGGTGATCCAGCTGCGGCCGGACCTTGCGCCCA
AACATGTGGAGCGCATGAAGACCCTGACCCGCGAGGGCTTCTACAACAACGTGCCGTTCCACCGCGTCATCGACGGCTTC
ATGGCCCAGACCGGCGACGGCCAGTACGGCAACGGCACCGGCGGCTCCAAATATCCCAACCTGCCGGCGGAATTCTCCTC
GGTGCCGTTCAAGCGCGGCGTGGTGGGCATGGCGCGGGCCTCCTCGCCCGACAGCGCCAACTCGCAGTTCTTCATCATGT
TCGACGAGACCCCCAGCCTGAACAACCAGTACACCGTGGTGGGCCAGGTGGTGTCGGGCATGGAGTTCGTGGACAAGATC
AAGAAGGGCTCGGGCGCGGGTGGCGTGGTGTCCGGCCCCGACCGCATCGTGAAGATGCAGGTGGCGGCGGACGCCAAGTG
A

Upstream 100 bases:

>100_bases
GCCTTCGTGCCGGCCGAAGTGCTGGCGCGCCTCAAGGACAAGTTCCCGCGCTAGAGCACGCCCATCCGCCCCGAAACGGG
GCCGTTCGCAGGAGATCTTC

Downstream 100 bases:

>100_bases
TGCAGTTGACGTGATTGCGTGCCGTGCCGGTCGGCTCAGCCGATCGGTGCGGCTTTCTTGAGTCCCGGCACGGCCGGGCG
GACGCGGCGGCCGGCCCTCC

Product: cyclophilin type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 186; Mature: 185

Protein sequence:

>186_residues
MTRLLGRFLAAALLAFAVALPAAAQTKPDPQNTLFLDTPYGRVVIQLRPDLAPKHVERMKTLTREGFYNNVPFHRVIDGF
MAQTGDGQYGNGTGGSKYPNLPAEFSSVPFKRGVVGMARASSPDSANSQFFIMFDETPSLNNQYTVVGQVVSGMEFVDKI
KKGSGAGGVVSGPDRIVKMQVAADAK

Sequences:

>Translated_186_residues
MTRLLGRFLAAALLAFAVALPAAAQTKPDPQNTLFLDTPYGRVVIQLRPDLAPKHVERMKTLTREGFYNNVPFHRVIDGF
MAQTGDGQYGNGTGGSKYPNLPAEFSSVPFKRGVVGMARASSPDSANSQFFIMFDETPSLNNQYTVVGQVVSGMEFVDKI
KKGSGAGGVVSGPDRIVKMQVAADAK
>Mature_185_residues
TRLLGRFLAAALLAFAVALPAAAQTKPDPQNTLFLDTPYGRVVIQLRPDLAPKHVERMKTLTREGFYNNVPFHRVIDGFM
AQTGDGQYGNGTGGSKYPNLPAEFSSVPFKRGVVGMARASSPDSANSQFFIMFDETPSLNNQYTVVGQVVSGMEFVDKIK
KGSGAGGVVSGPDRIVKMQVAADAK

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI19557636, Length=131, Percent_Identity=38.1679389312977, Blast_Score=88, Evalue=4e-18,
Organism=Homo sapiens, GI5031987, Length=138, Percent_Identity=40.5797101449275, Blast_Score=84, Evalue=9e-17,
Organism=Homo sapiens, GI24308049, Length=136, Percent_Identity=38.9705882352941, Blast_Score=80, Evalue=8e-16,
Organism=Homo sapiens, GI4758950, Length=186, Percent_Identity=37.0967741935484, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI7706339, Length=146, Percent_Identity=32.8767123287671, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI10863927, Length=141, Percent_Identity=36.1702127659575, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI45439316, Length=153, Percent_Identity=32.0261437908497, Blast_Score=74, Evalue=7e-14,
Organism=Homo sapiens, GI27735045, Length=149, Percent_Identity=32.8859060402685, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI5174637, Length=159, Percent_Identity=32.0754716981132, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI303305009, Length=152, Percent_Identity=31.5789473684211, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI4505991, Length=131, Percent_Identity=40.4580152671756, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI64276486, Length=122, Percent_Identity=39.344262295082, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI42560244, Length=139, Percent_Identity=35.9712230215827, Blast_Score=71, Evalue=5e-13,
Organism=Homo sapiens, GI4826932, Length=151, Percent_Identity=33.7748344370861, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI310110104, Length=142, Percent_Identity=35.2112676056338, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI310129267, Length=140, Percent_Identity=33.5714285714286, Blast_Score=68, Evalue=5e-12,
Organism=Homo sapiens, GI310120620, Length=140, Percent_Identity=33.5714285714286, Blast_Score=68, Evalue=5e-12,
Organism=Homo sapiens, GI169163387, Length=140, Percent_Identity=33.5714285714286, Blast_Score=67, Evalue=8e-12,
Organism=Homo sapiens, GI169164185, Length=140, Percent_Identity=33.5714285714286, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI169163623, Length=140, Percent_Identity=33.5714285714286, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1786736, Length=132, Percent_Identity=40.1515151515151, Blast_Score=88, Evalue=4e-19,
Organism=Escherichia coli, GI1789763, Length=160, Percent_Identity=36.875, Blast_Score=83, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17506311, Length=136, Percent_Identity=38.9705882352941, Blast_Score=82, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71980594, Length=130, Percent_Identity=37.6923076923077, Blast_Score=78, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71980590, Length=130, Percent_Identity=37.6923076923077, Blast_Score=77, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17539498, Length=128, Percent_Identity=35.9375, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17552780, Length=174, Percent_Identity=33.9080459770115, Blast_Score=74, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17566266, Length=145, Percent_Identity=35.1724137931034, Blast_Score=73, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17532643, Length=136, Percent_Identity=36.7647058823529, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17551282, Length=135, Percent_Identity=34.0740740740741, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17551284, Length=135, Percent_Identity=34.0740740740741, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17565860, Length=142, Percent_Identity=37.3239436619718, Blast_Score=71, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17539496, Length=130, Percent_Identity=33.0769230769231, Blast_Score=71, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17506307, Length=131, Percent_Identity=39.6946564885496, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17532641, Length=131, Percent_Identity=36.6412213740458, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17552782, Length=167, Percent_Identity=30.5389221556886, Blast_Score=68, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI115533296, Length=133, Percent_Identity=31.5789473684211, Blast_Score=67, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17559074, Length=136, Percent_Identity=33.0882352941176, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320359, Length=131, Percent_Identity=40.4580152671756, Blast_Score=81, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6323562, Length=139, Percent_Identity=35.9712230215827, Blast_Score=72, Evalue=5e-14,
Organism=Drosophila melanogaster, GI45549139, Length=140, Percent_Identity=39.2857142857143, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24664125, Length=129, Percent_Identity=40.3100775193798, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21357783, Length=129, Percent_Identity=40.3100775193798, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17986117, Length=129, Percent_Identity=38.7596899224806, Blast_Score=80, Evalue=9e-16,
Organism=Drosophila melanogaster, GI17647301, Length=134, Percent_Identity=38.0597014925373, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21357249, Length=122, Percent_Identity=38.5245901639344, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24652460, Length=133, Percent_Identity=34.5864661654135, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI20130249, Length=170, Percent_Identity=34.1176470588235, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24650807, Length=135, Percent_Identity=37.037037037037, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI19922376, Length=135, Percent_Identity=32.5925925925926, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI17136360, Length=176, Percent_Identity=30.1136363636364, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI19922912, Length=149, Percent_Identity=36.9127516778523, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24661775, Length=146, Percent_Identity=31.5068493150685, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21355237, Length=146, Percent_Identity=31.5068493150685, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24661771, Length=146, Percent_Identity=31.5068493150685, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 19986; Mature: 19855

Theoretical pI: Translated: 10.07; Mature: 10.07

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRLLGRFLAAALLAFAVALPAAAQTKPDPQNTLFLDTPYGRVVIQLRPDLAPKHVERMK
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCEEEEEECCCCCHHHHHHHH
TLTREGFYNNVPFHRVIDGFMAQTGDGQYGNGTGGSKYPNLPAEFSSVPFKRGVVGMARA
HHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHCCCCHHHCCEEHHCC
SSPDSANSQFFIMFDETPSLNNQYTVVGQVVSGMEFVDKIKKGSGAGGVVSGPDRIVKMQ
CCCCCCCCEEEEEECCCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEE
VAADAK
ECCCCC
>Mature Secondary Structure 
TRLLGRFLAAALLAFAVALPAAAQTKPDPQNTLFLDTPYGRVVIQLRPDLAPKHVERMK
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCEEEEEECCCCCHHHHHHHH
TLTREGFYNNVPFHRVIDGFMAQTGDGQYGNGTGGSKYPNLPAEFSSVPFKRGVVGMARA
HHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHCCCCHHHCCEEHHCC
SSPDSANSQFFIMFDETPSLNNQYTVVGQVVSGMEFVDKIKKGSGAGGVVSGPDRIVKMQ
CCCCCCCCEEEEEECCCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEE
VAADAK
ECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA