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The map label for this gene is lhgO [H]

Identifier: 154246738

GI number: 154246738

Start: 3118511

End: 3119653

Strand: Reverse

Name: lhgO [H]

Synonym: Xaut_2799

Alternate gene names: 154246738

Gene position: 3119653-3118511 (Counterclockwise)

Preceding gene: 154246743

Following gene: 154246736

Centisome position: 58.76

GC content: 70.34

Gene sequence:

>1143_bases
ATGGATCAGGTGGAAGCCATCGTCATCGGCGCCGGCGTGGTGGGTCTTGCCATCGCCCGCGCGCTGACCTGCGCCGGCCG
CGAGGTGGTGCTGATCGAAGCGGCGGGGGCCATCGGAACCGGCATCTCGGCGCGCAGTTCCGAGGTCATCCATGCCGGCA
TCTATTACGAACCGGGAAGCCTGAAGGCCGAGCTGTGCGTGAGGGGCCGCGACGCCCTCTATGCCTTCTGCGCCAGCCAT
GGGGTCGGCCACACCCGCATCGGCAAGCTCATCGTCGCCGCCAGCTCAGACGAGGTGGCCTATCTGAAAAAGCTCGCCGC
CCATGGCGCCGCCAACGGGGTGGGCGACCTCGAGATGCTGGGCGGCGCCGAAGCGCGGGCGCTGGAGCCGGCGCTGGATG
TGCATGCCGCCCTGTTCTCGCCCTCCACCGGCATCGTGGAGTCCCGCGGCCTGATGCTGGCGCTGCAGGGCGACATGGAG
GCCGCCGGCGGCGTGCTGGCCCTCGGCGCGCCCTTCGTCGGTGCCGAGCCGGGGCCAAACGGGCTCATCGTGTGCACGGG
GGGCGATGCCCCGATGGTGCTGGGTTGTCGCCTGCTGGTGAATGCCGCCGGCCTCGATGCCCCGGACCTCGCCCGCCGGA
TCGCCGGCATGCCGGCCCACCTCGTGCCCGAGCAGACGCTGGCCAAGGGCAACTACTTCACCTGCGGGCGCAAGGTGCCG
TTCAGCCGCCTGATCTATCCGGTTCCGGAGCCGGGCGGGCTCGGCACCCACCTCACCCTCGACCTCGGCGGCCAGGGCCG
GTTCGGGCCGGATGTGGAATGGGTGAGCGAGCGGGACTATCAGGTGGACCCGGCCCGCAAGGCCACCATGATGGCCTCCA
TCCGCCGCTACTGGCCGGACGTGCGGGAGGAGGACCTTTCCCCCGGCTATGCCGGCATTCGCCCCAAGATCCCGGGGCCA
AACGGCGGACCGCAGGATTTCGTCATCCAGGGGCCGGAGGTCCACGGCATCGCCGGGCTGGTGAACCTGTTCGGCATCGA
ATCGCCCGGCCTCACCAGCTGCCTTGCCATCGCCGACAGGGTGCTGGAGGAGGCCAAAAAGAACACCCATGGCGGGCGCG
CTTCACGCAGCGGCCATGGGTGA

Upstream 100 bases:

>100_bases
CTGGAGCACTTCCAGGGAGCGCGGCGCGCGGCACCTCAAGGTCCTGCCCACCGGCCGCGCCTGCGCTATGGTGACCGCCG
CAGCAATGGGCGACTCCGTC

Downstream 100 bases:

>100_bases
AGCCCGCGCGGCGCCTGAGCGTGCCCACTTGGCCTCGGTCGAAGGCCGAGGCCAATGGCAAAAGGGCCGCCCCGAAGGAC
GGCCCTCAAAATCAGCAGCG

Product: FAD dependent oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MDQVEAIVIGAGVVGLAIARALTCAGREVVLIEAAGAIGTGISARSSEVIHAGIYYEPGSLKAELCVRGRDALYAFCASH
GVGHTRIGKLIVAASSDEVAYLKKLAAHGAANGVGDLEMLGGAEARALEPALDVHAALFSPSTGIVESRGLMLALQGDME
AAGGVLALGAPFVGAEPGPNGLIVCTGGDAPMVLGCRLLVNAAGLDAPDLARRIAGMPAHLVPEQTLAKGNYFTCGRKVP
FSRLIYPVPEPGGLGTHLTLDLGGQGRFGPDVEWVSERDYQVDPARKATMMASIRRYWPDVREEDLSPGYAGIRPKIPGP
NGGPQDFVIQGPEVHGIAGLVNLFGIESPGLTSCLAIADRVLEEAKKNTHGGRASRSGHG

Sequences:

>Translated_380_residues
MDQVEAIVIGAGVVGLAIARALTCAGREVVLIEAAGAIGTGISARSSEVIHAGIYYEPGSLKAELCVRGRDALYAFCASH
GVGHTRIGKLIVAASSDEVAYLKKLAAHGAANGVGDLEMLGGAEARALEPALDVHAALFSPSTGIVESRGLMLALQGDME
AAGGVLALGAPFVGAEPGPNGLIVCTGGDAPMVLGCRLLVNAAGLDAPDLARRIAGMPAHLVPEQTLAKGNYFTCGRKVP
FSRLIYPVPEPGGLGTHLTLDLGGQGRFGPDVEWVSERDYQVDPARKATMMASIRRYWPDVREEDLSPGYAGIRPKIPGP
NGGPQDFVIQGPEVHGIAGLVNLFGIESPGLTSCLAIADRVLEEAKKNTHGGRASRSGHG
>Mature_380_residues
MDQVEAIVIGAGVVGLAIARALTCAGREVVLIEAAGAIGTGISARSSEVIHAGIYYEPGSLKAELCVRGRDALYAFCASH
GVGHTRIGKLIVAASSDEVAYLKKLAAHGAANGVGDLEMLGGAEARALEPALDVHAALFSPSTGIVESRGLMLALQGDME
AAGGVLALGAPFVGAEPGPNGLIVCTGGDAPMVLGCRLLVNAAGLDAPDLARRIAGMPAHLVPEQTLAKGNYFTCGRKVP
FSRLIYPVPEPGGLGTHLTLDLGGQGRFGPDVEWVSERDYQVDPARKATMMASIRRYWPDVREEDLSPGYAGIRPKIPGP
NGGPQDFVIQGPEVHGIAGLVNLFGIESPGLTSCLAIADRVLEEAKKNTHGGRASRSGHG

Specific function: Oxidizes L-2-hydroxyglutarate, probably to recover alpha-ketoglutarate mistakenly reduced by other enzymes or formed during growth on propionate [H]

COG id: COG0579

COG function: function code R; Predicted dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the L2HGDH family [H]

Homologues:

Organism=Homo sapiens, GI13376331, Length=414, Percent_Identity=26.5700483091787, Blast_Score=110, Evalue=2e-24,
Organism=Escherichia coli, GI87082148, Length=382, Percent_Identity=27.7486910994764, Blast_Score=124, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17565764, Length=408, Percent_Identity=29.1666666666667, Blast_Score=137, Evalue=9e-33,
Organism=Drosophila melanogaster, GI24585081, Length=391, Percent_Identity=29.4117647058824, Blast_Score=123, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015657
- InterPro:   IPR006076 [H]

Pfam domain/function: PF01266 DAO [H]

EC number: =1.1.3.15 [H]

Molecular weight: Translated: 39200; Mature: 39200

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQVEAIVIGAGVVGLAIARALTCAGREVVLIEAAGAIGTGISARSSEVIHAGIYYEPGS
CCCCEEEEEECCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCEEEEEEEECCCC
LKAELCVRGRDALYAFCASHGVGHTRIGKLIVAASSDEVAYLKKLAAHGAANGVGDLEML
CEEEEEECCCHHHHHHHHHCCCCHHHHCEEEEEECCCHHHHHHHHHHHCCCCCCCCHHHH
GGAEARALEPALDVHAALFSPSTGIVESRGLMLALQGDMEAAGGVLALGAPFVGAEPGPN
CCCCHHHCCHHHHHHHHHCCCCCCCEECCCEEEEEECCCCCCCCEEEECCCCCCCCCCCC
GLIVCTGGDAPMVLGCRLLVNAAGLDAPDLARRIAGMPAHLVPEQTLAKGNYFTCGRKVP
CEEEEECCCCCHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCHHHHCCCCEEECCCCCC
FSRLIYPVPEPGGLGTHLTLDLGGQGRFGPDVEWVSERDYQVDPARKATMMASIRRYWPD
HHHEEEECCCCCCCCEEEEEEECCCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHCCC
VREEDLSPGYAGIRPKIPGPNGGPQDFVIQGPEVHGIAGLVNLFGIESPGLTSCLAIADR
CCHHCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHCCCCCCHHHHHHHHHH
VLEEAKKNTHGGRASRSGHG
HHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MDQVEAIVIGAGVVGLAIARALTCAGREVVLIEAAGAIGTGISARSSEVIHAGIYYEPGS
CCCCEEEEEECCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCEEEEEEEECCCC
LKAELCVRGRDALYAFCASHGVGHTRIGKLIVAASSDEVAYLKKLAAHGAANGVGDLEML
CEEEEEECCCHHHHHHHHHCCCCHHHHCEEEEEECCCHHHHHHHHHHHCCCCCCCCHHHH
GGAEARALEPALDVHAALFSPSTGIVESRGLMLALQGDMEAAGGVLALGAPFVGAEPGPN
CCCCHHHCCHHHHHHHHHCCCCCCCEECCCEEEEEECCCCCCCCEEEECCCCCCCCCCCC
GLIVCTGGDAPMVLGCRLLVNAAGLDAPDLARRIAGMPAHLVPEQTLAKGNYFTCGRKVP
CEEEEECCCCCHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCHHHHCCCCEEECCCCCC
FSRLIYPVPEPGGLGTHLTLDLGGQGRFGPDVEWVSERDYQVDPARKATMMASIRRYWPD
HHHEEEECCCCCCCCEEEEEEECCCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHCCC
VREEDLSPGYAGIRPKIPGPNGGPQDFVIQGPEVHGIAGLVNLFGIESPGLTSCLAIADR
CCHHCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHCCCCCCHHHHHHHHHH
VLEEAKKNTHGGRASRSGHG
HHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 8297211; 7984428 [H]