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The map label for this gene is tpm

Identifier: 154246665

GI number: 154246665

Start: 3020861

End: 3021502

Strand: Reverse

Name: tpm

Synonym: Xaut_2726

Alternate gene names: 154246665

Gene position: 3021502-3020861 (Counterclockwise)

Preceding gene: 154246668

Following gene: 154246661

Centisome position: 56.91

GC content: 69.16

Gene sequence:

>642_bases
ATGGAACCGGATTTCTGGCACGCGAGATGGCAGACCAAGCAGATTCAGGGCTTCCATGAAGGCAAGGCCAACGCCTTCCT
GGTGAAGCATTTTCCCCGCCTGCCGGTGGCGCCGGGCGCGCGCGTGTTCGTGCCCTTGTGCGGCAAGACGCGGGACATCG
CCTGGCTGCTGGGTGAAGGATTTCGGGTGGCCGGCGCGGAGCTGAGCCGCATCGCGGTGGAGGAGCTGTTCGCGGAACTG
GGCGTTGTGCCTGAGGTGACGACGCAAGGCGCGCACACGCGCTTCAGCGCCCCCGGCCTCGACATTTTCCAGGGCGACAT
CTTCGCGCTCACCCCCGACACCCTCGGGCCGGTGGATGCGGTGTGGGACCGCGCCGCCCTCGTCGCCCTGCCGAAGGACA
TGCGCGCCCGCTACGCCCCGCACCTCGTGGCGCTGACCGACACCGCCCCGCAATTGCTGGTGTGCTTCGAGTATGACCAG
CCGCTGCTGGCGGGCCCGCCCTTCAGCGTCCCACCGGAGGAGACCCGCACGCTCTATGGCGCCGACTACGTGGTTGCGGC
GATAGACACAGCGCCGGTGCCCGGCGGCCTCAAGGGCCAGTGCGAGGCGGTGGAGCACGTCTGGCTGCTGGAGCGGGCGT
GA

Upstream 100 bases:

>100_bases
GAAAGTCATATCGCGAAAGCCGGGCCGCGCCCATATGTGCTGAACACCGGTGCGGGCGCACCGGTCGACGATGTGACGGG
ATGAAGCAAGGGAGGCGCGG

Downstream 100 bases:

>100_bases
AGGGGGGCGCGGGATTGTCCCAACCACTCGACATTGGCGAGGCGCTTAGGACCCCCATAACCGTCATGGCCGGGCTTGAC
CCGGGCATGACGGTTATGGT

Product: thiopurine S-methyltransferase

Products: NA

Alternate protein names: Thiopurine methyltransferase

Number of amino acids: Translated: 213; Mature: 213

Protein sequence:

>213_residues
MEPDFWHARWQTKQIQGFHEGKANAFLVKHFPRLPVAPGARVFVPLCGKTRDIAWLLGEGFRVAGAELSRIAVEELFAEL
GVVPEVTTQGAHTRFSAPGLDIFQGDIFALTPDTLGPVDAVWDRAALVALPKDMRARYAPHLVALTDTAPQLLVCFEYDQ
PLLAGPPFSVPPEETRTLYGADYVVAAIDTAPVPGGLKGQCEAVEHVWLLERA

Sequences:

>Translated_213_residues
MEPDFWHARWQTKQIQGFHEGKANAFLVKHFPRLPVAPGARVFVPLCGKTRDIAWLLGEGFRVAGAELSRIAVEELFAEL
GVVPEVTTQGAHTRFSAPGLDIFQGDIFALTPDTLGPVDAVWDRAALVALPKDMRARYAPHLVALTDTAPQLLVCFEYDQ
PLLAGPPFSVPPEETRTLYGADYVVAAIDTAPVPGGLKGQCEAVEHVWLLERA
>Mature_213_residues
MEPDFWHARWQTKQIQGFHEGKANAFLVKHFPRLPVAPGARVFVPLCGKTRDIAWLLGEGFRVAGAELSRIAVEELFAEL
GVVPEVTTQGAHTRFSAPGLDIFQGDIFALTPDTLGPVDAVWDRAALVALPKDMRARYAPHLVALTDTAPQLLVCFEYDQ
PLLAGPPFSVPPEETRTLYGADYVVAAIDTAPVPGGLKGQCEAVEHVWLLERA

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. TPMT family

Homologues:

Organism=Homo sapiens, GI4507653, Length=182, Percent_Identity=34.6153846153846, Blast_Score=100, Evalue=9e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TPMT_XANP2 (A7IIX3)

Other databases:

- EMBL:   CP000781
- RefSeq:   YP_001417623.1
- ProteinModelPortal:   A7IIX3
- SMR:   A7IIX3
- STRING:   A7IIX3
- GeneID:   5424104
- GenomeReviews:   CP000781_GR
- KEGG:   xau:Xaut_2726
- eggNOG:   COG0500
- HOGENOM:   HBG444929
- OMA:   PPFAVSP
- BioCyc:   XAUT78245:XAUT_2726-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00812
- InterPro:   IPR022474
- InterPro:   IPR008854
- InterPro:   IPR016822
- PIRSF:   PIRSF023956
- TIGRFAMs:   TIGR03840

Pfam domain/function: PF05724 TPMT

EC number: =2.1.1.67

Molecular weight: Translated: 23278; Mature: 23278

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: NA

Important sites: BINDING 10-10 BINDING 46-46 BINDING 67-67 BINDING 124-124

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPDFWHARWQTKQIQGFHEGKANAFLVKHFPRLPVAPGARVFVPLCGKTRDIAWLLGEG
CCCCCCCCCCCCHHHCCCCCCCCCEEEEECCCCCCCCCCCEEEEECCCCCCCEEEEECCC
FRVAGAELSRIAVEELFAELGVVPEVTTQGAHTRFSAPGLDIFQGDIFALTPDTLGPVDA
CEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCEEECCCEEEECCCCCCCHHH
VWDRAALVALPKDMRARYAPHLVALTDTAPQLLVCFEYDQPLLAGPPFSVPPEETRTLYG
HHCCEEEEECCHHHHHHCCCEEEEEECCCCEEEEEEECCCCCCCCCCCCCCCHHHEEEEC
ADYVVAAIDTAPVPGGLKGQCEAVEHVWLLERA
CCEEEEEEECCCCCCCCCCCHHHHHEEEEEECC
>Mature Secondary Structure
MEPDFWHARWQTKQIQGFHEGKANAFLVKHFPRLPVAPGARVFVPLCGKTRDIAWLLGEG
CCCCCCCCCCCCHHHCCCCCCCCCEEEEECCCCCCCCCCCEEEEECCCCCCCEEEEECCC
FRVAGAELSRIAVEELFAELGVVPEVTTQGAHTRFSAPGLDIFQGDIFALTPDTLGPVDA
CEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCEEECCCEEEECCCCCCCHHH
VWDRAALVALPKDMRARYAPHLVALTDTAPQLLVCFEYDQPLLAGPPFSVPPEETRTLYG
HHCCEEEEECCHHHHHHCCCEEEEEECCCCEEEEEEECCCCCCCCCCCCCCCHHHEEEEC
ADYVVAAIDTAPVPGGLKGQCEAVEHVWLLERA
CCEEEEEEECCCCCCCCCCCHHHHHEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA