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The map label for this gene is pth

Identifier: 154246547

GI number: 154246547

Start: 2892823

End: 2893431

Strand: Reverse

Name: pth

Synonym: Xaut_2606

Alternate gene names: 154246547

Gene position: 2893431-2892823 (Counterclockwise)

Preceding gene: 154246548

Following gene: 154246546

Centisome position: 54.5

GC content: 66.17

Gene sequence:

>609_bases
ATGTTCCTGTTCGCAGGGCTCGGCAATCCCGGCCCGAAATATGCCGGCAACCGGCATAATATCGGCTTCATGGCGCTCGA
GGCGATCTGCCGCCGCCACCGCCTCGGCCCGCTGCGCCGCCGCTTCCAGTCCTTGGCGGCAGAAGGCGAGATCGCCGGCG
AGAAGGTGATCGCGCTGTTCCCCGAGACCTACATGAACGAGAGCGGGCGCGCCGTTTCCGAGGCGCAGCGCTTCTACAAG
ATCCCCCTCGACCACATCTTCGTCTTCCACGACGAGTTGGACCTGCCTCCGGCCAAGCTGCGCATCAAGAAGGGTGGCGG
CAACGCCGGCCACAACGGCCTGCGGTCCATCACCGCCCAGTGTGGCAACGACTATTTCCGCGTCCGTCTCGGCATCGGCC
ATCCCGGCGACAAGGCGCTGGTGCATGCCTACGTGCTCAACGACTTCGCCAAGAGCGAGAAGCCGTGGCTCGACGCCGTC
TGCGACGCCTGCGCCGATTTTGCCGACCTGCTCGCTCAGAAGCGGCCGGAGGAGTTCCAGAACCGCGCGCACCTGTTCCT
CGACGCCCAGGGCTTCGGCGAGCAGAAGCGGGTGGGCGAGAAGGGCTGA

Upstream 100 bases:

>100_bases
GAGGACGCCGCCGAAGCCGCCAAGGCCTGAGTTCGCAATCTCCATCCTGCTGTCACACCGACAGCAGGATGGTCCAGAAC
GTTCGGGCCGGAGGCGCCAC

Downstream 100 bases:

>100_bases
GGCGCAGGCCTTCGCGGACCGATGCGGCCCGGCGTGATGGTCCGGCGGGTTGCGGAGCCACGCCGTGAGGGGATATGCGG
AGGGCAAGAGCTGTCCCCGC

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 202; Mature: 202

Protein sequence:

>202_residues
MFLFAGLGNPGPKYAGNRHNIGFMALEAICRRHRLGPLRRRFQSLAAEGEIAGEKVIALFPETYMNESGRAVSEAQRFYK
IPLDHIFVFHDELDLPPAKLRIKKGGGNAGHNGLRSITAQCGNDYFRVRLGIGHPGDKALVHAYVLNDFAKSEKPWLDAV
CDACADFADLLAQKRPEEFQNRAHLFLDAQGFGEQKRVGEKG

Sequences:

>Translated_202_residues
MFLFAGLGNPGPKYAGNRHNIGFMALEAICRRHRLGPLRRRFQSLAAEGEIAGEKVIALFPETYMNESGRAVSEAQRFYK
IPLDHIFVFHDELDLPPAKLRIKKGGGNAGHNGLRSITAQCGNDYFRVRLGIGHPGDKALVHAYVLNDFAKSEKPWLDAV
CDACADFADLLAQKRPEEFQNRAHLFLDAQGFGEQKRVGEKG
>Mature_202_residues
MFLFAGLGNPGPKYAGNRHNIGFMALEAICRRHRLGPLRRRFQSLAAEGEIAGEKVIALFPETYMNESGRAVSEAQRFYK
IPLDHIFVFHDELDLPPAKLRIKKGGGNAGHNGLRSITAQCGNDYFRVRLGIGHPGDKALVHAYVLNDFAKSEKPWLDAV
CDACADFADLLAQKRPEEFQNRAHLFLDAQGFGEQKRVGEKG

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=170, Percent_Identity=34.7058823529412, Blast_Score=99, Evalue=3e-21,
Organism=Escherichia coli, GI1787455, Length=188, Percent_Identity=40.9574468085106, Blast_Score=117, Evalue=6e-28,
Organism=Saccharomyces cerevisiae, GI6321983, Length=166, Percent_Identity=34.3373493975904, Blast_Score=70, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_XANP2 (A7IIK5)

Other databases:

- EMBL:   CP000781
- RefSeq:   YP_001417505.1
- ProteinModelPortal:   A7IIK5
- SMR:   A7IIK5
- STRING:   A7IIK5
- GeneID:   5420705
- GenomeReviews:   CP000781_GR
- KEGG:   xau:Xaut_2606
- eggNOG:   COG0193
- HOGENOM:   HBG610927
- OMA:   AMHRLHS
- ProtClustDB:   PRK05426
- BioCyc:   XAUT78245:XAUT_2606-MONOMER
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 22463; Mature: 22463

Theoretical pI: Translated: 8.92; Mature: 8.92

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLFAGLGNPGPKYAGNRHNIGFMALEAICRRHRLGPLRRRFQSLAAEGEIAGEKVIALF
CEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCEEEEEC
PETYMNESGRAVSEAQRFYKIPLDHIFVFHDELDLPPAKLRIKKGGGNAGHNGLRSITAQ
CHHHHCCCCCHHHHHHHHHCCCHHHEEEEECCCCCCHHHEEEECCCCCCCCHHHHHHHHH
CGNDYFRVRLGIGHPGDKALVHAYVLNDFAKSEKPWLDAVCDACADFADLLAQKRPEEFQ
HCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHH
NRAHLFLDAQGFGEQKRVGEKG
CCEEEEEECCCCCHHHCCCCCC
>Mature Secondary Structure
MFLFAGLGNPGPKYAGNRHNIGFMALEAICRRHRLGPLRRRFQSLAAEGEIAGEKVIALF
CEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCEEEEEC
PETYMNESGRAVSEAQRFYKIPLDHIFVFHDELDLPPAKLRIKKGGGNAGHNGLRSITAQ
CHHHHCCCCCHHHHHHHHHCCCHHHEEEEECCCCCCHHHEEEECCCCCCCCHHHHHHHHH
CGNDYFRVRLGIGHPGDKALVHAYVLNDFAKSEKPWLDAVCDACADFADLLAQKRPEEFQ
HCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHH
NRAHLFLDAQGFGEQKRVGEKG
CCEEEEEECCCCCHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA