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The map label for this gene is siaT [H]

Identifier: 154246456

GI number: 154246456

Start: 2809095

End: 2810360

Strand: Direct

Name: siaT [H]

Synonym: Xaut_2515

Alternate gene names: 154246456

Gene position: 2809095-2810360 (Clockwise)

Preceding gene: 154246455

Following gene: 154246457

Centisome position: 52.91

GC content: 64.61

Gene sequence:

>1266_bases
ATGGTCACCACCGCCGCATTCCTCATCACCATGCTGGTGGGCGTGCCCATCAGCCTGTGCCTGGCCCTGTCGGGGGTGGC
GTTCATCCTCGCCACCGGCAATCCGCTGCTGCTGCAGACCTTTCCCACCCAGCTGTTCGGCGGCGTGGACAGCTACGGCC
TCATCGCCATCCCGCTGTTCGTGCTGATCGGCGAGATCATGAACGGCGGCGGCATCACCCGCCGGCTCATCGACATGGCC
ATGGCGGTGGTGGGCCGCATGCGCGGCGGCCTCGCCTATGTGAACCTCATCGCCAACATGCTGGTCTCGTCCATCCTCGG
CTCGGCCACGGCGCAGGTGGCCATCATGGCGCAGATCCTGGTGCCGGAGATGGAGAAGAAGGGCTACGACAAGACCTTCG
CCGCCGGCCTCACCGCCTATGCGGGCATGCTGGGACCCATCATCCCGCCGTCCATCATGTTCGTGGTGTATTCAGTGCTG
GCGCAGGTCTCGGTGAGCGACATGCTCATCGCCGGCATCATCCCCGGCGTGCTTTTGACCGGGCTGTTCTGCCTGTGCGT
CTACATCATGGGCTTCTTCTACAATTACCCCCGCGGCGAAAGCATGACCTGGCGCCAGCGGGCGGACATCGTGCTGAATG
CCATCCCCACCCTGCTCATCCCCATCGTCATCGTCGGCTCCATCCTCACCGGCCTTGCCAATGCGACGGAATCGGCGGCG
GTGGGCGCGCTCGCGGCGCTGCTCATCGGCCGCTACTGGACCAAGGAATTGTCCTTCTCCCAGCTGCCGCAGATGCTGCT
GAAGGCCGGGCTGTATTCGTCCGTCATCCTGTTCCTGGTGGCGGTGGCGGCGGTGTTCTCCTGGGTGCTGGTCTACGGCA
AGGTCCCGCAGGCGGTGGCGGCCTGGGTGCAGACCGTGGCCCATGACCCCATCAGCTTCATGCTGCTGGTCAACGTGATC
CTGCTGGTCATCGGCACGGTGATCGACGGCGCGCCCGGCCTCATCATGACGGTGCCGATCCTTCTGCCCATCGCCGTGGA
TGTCTACCACATCGATCCCGTGCATTTCGGCGTGGTGGTGGTGATCAACCTTGTCCTCGGCTTCCTCTCCCCGCCGGTAG
GCCTGTGTTTCTTCGTCGCCTCCGCAGTTACGGGGGCGAAGGTGGGGCGGATGTTCTACGTCACCCTGCCGTTCTTCTTC
GCCGCCTGCGCGCTTCTGGTGCTGCTGTCGCTGGTGCCGTGGCTGTCGACCGTCCTCGTCAAATAA

Upstream 100 bases:

>100_bases
TCACTATTCACGGCCTCGCCAACCTGGTGGAAGACCTGGAATTCGTGCCGCGCCGCGTCTACCGCGGCTTCCCCATGGCC
AATGCGGAGGCGGCAAGCTG

Downstream 100 bases:

>100_bases
AACCAACCTTCCCGGAGCCCTGCCATGTCCCGCCCTGCCATGACTTTGTCCCGTCGTCATTTCCTCATGAGTGCCGCCGC
CGGCGCCGCCCTTCCGCTTG

Product: TRAP dicarboxylate transporter subunit DctM

Products: NA

Alternate protein names: N-acetylneuraminic acid permease; N-acetylneuraminic acid transporter; Neu5Ac permease [H]

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MVTTAAFLITMLVGVPISLCLALSGVAFILATGNPLLLQTFPTQLFGGVDSYGLIAIPLFVLIGEIMNGGGITRRLIDMA
MAVVGRMRGGLAYVNLIANMLVSSILGSATAQVAIMAQILVPEMEKKGYDKTFAAGLTAYAGMLGPIIPPSIMFVVYSVL
AQVSVSDMLIAGIIPGVLLTGLFCLCVYIMGFFYNYPRGESMTWRQRADIVLNAIPTLLIPIVIVGSILTGLANATESAA
VGALAALLIGRYWTKELSFSQLPQMLLKAGLYSSVILFLVAVAAVFSWVLVYGKVPQAVAAWVQTVAHDPISFMLLVNVI
LLVIGTVIDGAPGLIMTVPILLPIAVDVYHIDPVHFGVVVVINLVLGFLSPPVGLCFFVASAVTGAKVGRMFYVTLPFFF
AACALLVLLSLVPWLSTVLVK

Sequences:

>Translated_421_residues
MVTTAAFLITMLVGVPISLCLALSGVAFILATGNPLLLQTFPTQLFGGVDSYGLIAIPLFVLIGEIMNGGGITRRLIDMA
MAVVGRMRGGLAYVNLIANMLVSSILGSATAQVAIMAQILVPEMEKKGYDKTFAAGLTAYAGMLGPIIPPSIMFVVYSVL
AQVSVSDMLIAGIIPGVLLTGLFCLCVYIMGFFYNYPRGESMTWRQRADIVLNAIPTLLIPIVIVGSILTGLANATESAA
VGALAALLIGRYWTKELSFSQLPQMLLKAGLYSSVILFLVAVAAVFSWVLVYGKVPQAVAAWVQTVAHDPISFMLLVNVI
LLVIGTVIDGAPGLIMTVPILLPIAVDVYHIDPVHFGVVVVINLVLGFLSPPVGLCFFVASAVTGAKVGRMFYVTLPFFF
AACALLVLLSLVPWLSTVLVK
>Mature_421_residues
MVTTAAFLITMLVGVPISLCLALSGVAFILATGNPLLLQTFPTQLFGGVDSYGLIAIPLFVLIGEIMNGGGITRRLIDMA
MAVVGRMRGGLAYVNLIANMLVSSILGSATAQVAIMAQILVPEMEKKGYDKTFAAGLTAYAGMLGPIIPPSIMFVVYSVL
AQVSVSDMLIAGIIPGVLLTGLFCLCVYIMGFFYNYPRGESMTWRQRADIVLNAIPTLLIPIVIVGSILTGLANATESAA
VGALAALLIGRYWTKELSFSQLPQMLLKAGLYSSVILFLVAVAAVFSWVLVYGKVPQAVAAWVQTVAHDPISFMLLVNVI
LLVIGTVIDGAPGLIMTVPILLPIAVDVYHIDPVHFGVVVVINLVLGFLSPPVGLCFFVASAVTGAKVGRMFYVTLPFFF
AACALLVLLSLVPWLSTVLVK

Specific function: Part of the tripartite ATP-independent periplasmic (TRAP) transport system siaPT involved in the uptake of sialic acid [H]

COG id: COG1593

COG function: function code G; TRAP-type C4-dicarboxylate transport system, large permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the TRAP transporter large permease family [H]

Homologues:

Organism=Escherichia coli, GI48994950, Length=375, Percent_Identity=36, Blast_Score=204, Evalue=8e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010656
- InterPro:   IPR007387
- InterPro:   IPR004681 [H]

Pfam domain/function: PF06808 DctM; PF04290 DctQ [H]

EC number: NA

Molecular weight: Translated: 44573; Mature: 44573

Theoretical pI: Translated: 8.18; Mature: 8.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTTAAFLITMLVGVPISLCLALSGVAFILATGNPLLLQTFPTQLFGGVDSYGLIAIPLF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCEEEHHHHHHHHCCCCCCHHHHHHHH
VLIGEIMNGGGITRRLIDMAMAVVGRMRGGLAYVNLIANMLVSSILGSATAQVAIMAQIL
HHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VPEMEKKGYDKTFAAGLTAYAGMLGPIIPPSIMFVVYSVLAQVSVSDMLIAGIIPGVLLT
HHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLFCLCVYIMGFFYNYPRGESMTWRQRADIVLNAIPTLLIPIVIVGSILTGLANATESAA
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
VGALAALLIGRYWTKELSFSQLPQMLLKAGLYSSVILFLVAVAAVFSWVLVYGKVPQAVA
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
AWVQTVAHDPISFMLLVNVILLVIGTVIDGAPGLIMTVPILLPIAVDVYHIDPVHFGVVV
HHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHEEECHHHHHHHH
VINLVLGFLSPPVGLCFFVASAVTGAKVGRMFYVTLPFFFAACALLVLLSLVPWLSTVLV
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
K
C
>Mature Secondary Structure
MVTTAAFLITMLVGVPISLCLALSGVAFILATGNPLLLQTFPTQLFGGVDSYGLIAIPLF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCEEEHHHHHHHHCCCCCCHHHHHHHH
VLIGEIMNGGGITRRLIDMAMAVVGRMRGGLAYVNLIANMLVSSILGSATAQVAIMAQIL
HHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VPEMEKKGYDKTFAAGLTAYAGMLGPIIPPSIMFVVYSVLAQVSVSDMLIAGIIPGVLLT
HHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLFCLCVYIMGFFYNYPRGESMTWRQRADIVLNAIPTLLIPIVIVGSILTGLANATESAA
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
VGALAALLIGRYWTKELSFSQLPQMLLKAGLYSSVILFLVAVAAVFSWVLVYGKVPQAVA
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
AWVQTVAHDPISFMLLVNVILLVIGTVIDGAPGLIMTVPILLPIAVDVYHIDPVHFGVVV
HHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHEEECHHHHHHHH
VINLVLGFLSPPVGLCFFVASAVTGAKVGRMFYVTLPFFFAACALLVLLSLVPWLSTVLV
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
K
C

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]