Click here to switch to the map view.

The map label for this gene is cysJ [H]

Identifier: 154246439

GI number: 154246439

Start: 2791274

End: 2792902

Strand: Reverse

Name: cysJ [H]

Synonym: Xaut_2498

Alternate gene names: 154246439

Gene position: 2792902-2791274 (Counterclockwise)

Preceding gene: 154246440

Following gene: 154246438

Centisome position: 52.61

GC content: 71.09

Gene sequence:

>1629_bases
ATGAGCCTCCAGACCCGCATTCCCGTTGTGCCCGTCCTGCCCGACAGCGCGCCCTTCACCGGCGAGCAGCGGGCGTGGCT
GAACGGCTTCTTCGCCGCCATCCTCTCCGCCGATCAGGTCAGCGCCCCCACCGCCCTCTCGGCGGGCGACGCGGCGGCAC
TGATGCCGGGCATGCCCGTCCCCGCGGCAGCGCCGGAAGACGATGGCGCACCCTGGCACGACCCCGCCATGCCGCTGGCC
GAGCGCATGGCGCTGGCAGAGGGCAGGGCCCTGCCCCGGCGCATGATGGCGGCCATGGCCCAGCAGGATTGCGGCCAGTG
CGGCTATGTCTGCGAGACCTACGCCAAGGCACTGGCCGACGGCGCCGAAAGCAAGCTCAACCTCTGCGCCCCCGGCGGCA
AGGAGACCCTGCGCATGCTGAAGCAGCTGGCGGAAGAGACCTCCGCCCCCGCCGCCAAGCCGGCCGCCACGCCCGCCGCC
GCCGTCTCCTACGCCCACGAGCCCCACGCCCCGGCACCTTTGGGCACCCGCGAAAATCCCGGCGAGGTCACCTTCCTCGG
CCGCACCCGCCTCAACAAGGACGGCTCCGAGAAGGAGACCTGGCACATCGAGTTCGATCTTGCCGGCTCGGGCATCGACT
ATGTGGCCGGCGACAGCTTCGGCGTGTTCCCGGTGAACGATCCCGACCTCGTGGCGGCGGTACTCGCCGCGCTCCACGCT
CCGCCGGATTTCCCCATCGCCGACAAGACGCTGGGCGAGGTGCTCTCCCGCGAGGTGTGCCTGAAATCGGCCCCCGACGC
CCTGTTCACCCTCATCTCCTACATCACCGGCGGCGATCGCAAGGCCAAGGCCCGGGCGCTGGCCTCCGGCGCTGATCCGG
ACGGCGATGCCGCCACCCTCGACGTGCTGGCGGCGCTGGAGAAGTTCCCCGGCATCCGTCCCGATCCGGAGGCTCTGGTG
GAATGCCTGGAGCCGCTCCAGCCGCGGCTCTACTCCATCTCCTCCAGCCCCACCGCCACCCCCGGCAAGCTGACCCTGAC
GGTGGACGCGGTGCGCTACGAGCAGACCGGCCGCACCCGGCTCGGCGTTGCCTCCACCTTCCTCGGCGGCCGCATCGCGC
CGGGCACGCGCATGAAGGCCTATATCCAGAAGGCCCACGGCTTCGCCCTGCCGGCAGACCTCTCCAAGGATGTGATCATG
GTGGGGCCGGGCACCGGCATCGCCCCGTTCCGCTCGTTCCTGCACGAGCGCCTCGCCACCAAGGCCCCCGGCCGCAACTG
GCTGTTCTTCGGCCACCAGAAGCGCGACACGGACTTCTTCTACGAGGACGAGCTGAACGGCCTCCAGGCCTGCGGCACCC
TCACCCGGCTCGACACCGCATGGTCGCGGGACGGCGCCGCCAAGGTCTACGTGCAGGACAAGATCCGCGCGGCGGGGCCA
GAGCTATGGGCGTGGCTTCAGGCCGGCGCGCATTTCTACATCTGCGGCGATGCCAAGCGCATGGCGAAGGACGTGGAAGC
GGCGGTGACGGCGGTCGCCGCCGAGCATGGCGGCCTCTCGGCGGAGGCCGCGGCCCGCTTCGTGGCCGACCTGAAGACCG
CCGGCCGCTACCAGGCCGACGTGTACTGA

Upstream 100 bases:

>100_bases
GCTGGCGGAGGTGGCATGACGCCCAACCAGCCGGGCCGCACTGCGGCCTGACGCTCGATTTCGCGCCCAAGGCGCGCCAC
CCGACACCGAGACCACAGCC

Downstream 100 bases:

>100_bases
CCCCCGAAACGCCTCAGGCAGGATCGGCCCCCCATGAACGCGCCTCTCGCCTCGCCCCCCTCGGTGAAGACCACCTGCCC
CTATTGCGGCGTCGGCTGCG

Product: sulfite reductase

Products: NA

Alternate protein names: SiR-FP [H]

Number of amino acids: Translated: 542; Mature: 541

Protein sequence:

>542_residues
MSLQTRIPVVPVLPDSAPFTGEQRAWLNGFFAAILSADQVSAPTALSAGDAAALMPGMPVPAAAPEDDGAPWHDPAMPLA
ERMALAEGRALPRRMMAAMAQQDCGQCGYVCETYAKALADGAESKLNLCAPGGKETLRMLKQLAEETSAPAAKPAATPAA
AVSYAHEPHAPAPLGTRENPGEVTFLGRTRLNKDGSEKETWHIEFDLAGSGIDYVAGDSFGVFPVNDPDLVAAVLAALHA
PPDFPIADKTLGEVLSREVCLKSAPDALFTLISYITGGDRKAKARALASGADPDGDAATLDVLAALEKFPGIRPDPEALV
ECLEPLQPRLYSISSSPTATPGKLTLTVDAVRYEQTGRTRLGVASTFLGGRIAPGTRMKAYIQKAHGFALPADLSKDVIM
VGPGTGIAPFRSFLHERLATKAPGRNWLFFGHQKRDTDFFYEDELNGLQACGTLTRLDTAWSRDGAAKVYVQDKIRAAGP
ELWAWLQAGAHFYICGDAKRMAKDVEAAVTAVAAEHGGLSAEAAARFVADLKTAGRYQADVY

Sequences:

>Translated_542_residues
MSLQTRIPVVPVLPDSAPFTGEQRAWLNGFFAAILSADQVSAPTALSAGDAAALMPGMPVPAAAPEDDGAPWHDPAMPLA
ERMALAEGRALPRRMMAAMAQQDCGQCGYVCETYAKALADGAESKLNLCAPGGKETLRMLKQLAEETSAPAAKPAATPAA
AVSYAHEPHAPAPLGTRENPGEVTFLGRTRLNKDGSEKETWHIEFDLAGSGIDYVAGDSFGVFPVNDPDLVAAVLAALHA
PPDFPIADKTLGEVLSREVCLKSAPDALFTLISYITGGDRKAKARALASGADPDGDAATLDVLAALEKFPGIRPDPEALV
ECLEPLQPRLYSISSSPTATPGKLTLTVDAVRYEQTGRTRLGVASTFLGGRIAPGTRMKAYIQKAHGFALPADLSKDVIM
VGPGTGIAPFRSFLHERLATKAPGRNWLFFGHQKRDTDFFYEDELNGLQACGTLTRLDTAWSRDGAAKVYVQDKIRAAGP
ELWAWLQAGAHFYICGDAKRMAKDVEAAVTAVAAEHGGLSAEAAARFVADLKTAGRYQADVY
>Mature_541_residues
SLQTRIPVVPVLPDSAPFTGEQRAWLNGFFAAILSADQVSAPTALSAGDAAALMPGMPVPAAAPEDDGAPWHDPAMPLAE
RMALAEGRALPRRMMAAMAQQDCGQCGYVCETYAKALADGAESKLNLCAPGGKETLRMLKQLAEETSAPAAKPAATPAAA
VSYAHEPHAPAPLGTRENPGEVTFLGRTRLNKDGSEKETWHIEFDLAGSGIDYVAGDSFGVFPVNDPDLVAAVLAALHAP
PDFPIADKTLGEVLSREVCLKSAPDALFTLISYITGGDRKAKARALASGADPDGDAATLDVLAALEKFPGIRPDPEALVE
CLEPLQPRLYSISSSPTATPGKLTLTVDAVRYEQTGRTRLGVASTFLGGRIAPGTRMKAYIQKAHGFALPADLSKDVIMV
GPGTGIAPFRSFLHERLATKAPGRNWLFFGHQKRDTDFFYEDELNGLQACGTLTRLDTAWSRDGAAKVYVQDKIRAAGPE
LWAWLQAGAHFYICGDAKRMAKDVEAAVTAVAAEHGGLSAEAAARFVADLKTAGRYQADVY

Specific function: Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow f

COG id: COG0369

COG function: function code P; Sulfite reductase, alpha subunit (flavoprotein)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 flavodoxin-like domain [H]

Homologues:

Organism=Homo sapiens, GI127139033, Length=448, Percent_Identity=30.5803571428571, Blast_Score=195, Evalue=1e-49,
Organism=Homo sapiens, GI24041029, Length=392, Percent_Identity=32.1428571428571, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI169790958, Length=418, Percent_Identity=30.3827751196172, Blast_Score=155, Evalue=9e-38,
Organism=Homo sapiens, GI169790956, Length=418, Percent_Identity=30.3827751196172, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI7657393, Length=407, Percent_Identity=30.2211302211302, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI221316705, Length=416, Percent_Identity=29.5673076923077, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI10835173, Length=401, Percent_Identity=32.1695760598504, Blast_Score=146, Evalue=5e-35,
Organism=Homo sapiens, GI221316709, Length=407, Percent_Identity=29.97542997543, Blast_Score=145, Evalue=8e-35,
Organism=Homo sapiens, GI40254422, Length=404, Percent_Identity=30.9405940594059, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI221316707, Length=364, Percent_Identity=28.8461538461538, Blast_Score=115, Evalue=9e-26,
Organism=Escherichia coli, GI1789123, Length=407, Percent_Identity=40.04914004914, Blast_Score=281, Evalue=6e-77,
Organism=Caenorhabditis elegans, GI17554134, Length=405, Percent_Identity=32.5925925925926, Blast_Score=194, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI17566446, Length=379, Percent_Identity=28.4960422163588, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17531441, Length=253, Percent_Identity=31.2252964426877, Blast_Score=95, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6321143, Length=379, Percent_Identity=28.4960422163588, Blast_Score=138, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6321832, Length=412, Percent_Identity=26.6990291262136, Blast_Score=133, Evalue=7e-32,
Organism=Saccharomyces cerevisiae, GI6325305, Length=407, Percent_Identity=24.3243243243243, Blast_Score=97, Evalue=8e-21,
Organism=Drosophila melanogaster, GI24582192, Length=450, Percent_Identity=32.4444444444444, Blast_Score=195, Evalue=8e-50,
Organism=Drosophila melanogaster, GI17137192, Length=450, Percent_Identity=32.4444444444444, Blast_Score=194, Evalue=9e-50,
Organism=Drosophila melanogaster, GI78706872, Length=380, Percent_Identity=32.1052631578947, Blast_Score=158, Evalue=7e-39,
Organism=Drosophila melanogaster, GI24583543, Length=380, Percent_Identity=32.1052631578947, Blast_Score=158, Evalue=9e-39,
Organism=Drosophila melanogaster, GI78706876, Length=380, Percent_Identity=32.1052631578947, Blast_Score=158, Evalue=9e-39,
Organism=Drosophila melanogaster, GI24660907, Length=232, Percent_Identity=31.4655172413793, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24660903, Length=232, Percent_Identity=31.4655172413793, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24647438, Length=372, Percent_Identity=23.1182795698925, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010199
- InterPro:   IPR003097
- InterPro:   IPR017927
- InterPro:   IPR001094
- InterPro:   IPR008254
- InterPro:   IPR001709
- InterPro:   IPR023173
- InterPro:   IPR001433
- InterPro:   IPR017938 [H]

Pfam domain/function: PF00667 FAD_binding_1; PF00258 Flavodoxin_1; PF00175 NAD_binding_1 [H]

EC number: =1.8.1.2 [H]

Molecular weight: Translated: 57368; Mature: 57236

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLQTRIPVVPVLPDSAPFTGEQRAWLNGFFAAILSADQVSAPTALSAGDAAALMPGMPV
CCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCCC
PAAAPEDDGAPWHDPAMPLAERMALAEGRALPRRMMAAMAQQDCGQCGYVCETYAKALAD
CCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHC
GAESKLNLCAPGGKETLRMLKQLAEETSAPAAKPAATPAAAVSYAHEPHAPAPLGTRENP
CCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCC
GEVTFLGRTRLNKDGSEKETWHIEFDLAGSGIDYVAGDSFGVFPVNDPDLVAAVLAALHA
CCEEEEECCCCCCCCCCCCEEEEEEEECCCCCCEECCCCEEEECCCCHHHHHHHHHHHCC
PPDFPIADKTLGEVLSREVCLKSAPDALFTLISYITGGDRKAKARALASGADPDGDAATL
CCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCHHHH
DVLAALEKFPGIRPDPEALVECLEPLQPRLYSISSSPTATPGKLTLTVDAVRYEQTGRTR
HHHHHHHHCCCCCCCHHHHHHHHHHHCHHHEECCCCCCCCCCEEEEEEEEEEECCCCCCH
LGVASTFLGGRIAPGTRMKAYIQKAHGFALPADLSKDVIMVGPGTGIAPFRSFLHERLAT
HHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHH
KAPGRNWLFFGHQKRDTDFFYEDELNGLQACGTLTRLDTAWSRDGAAKVYVQDKIRAAGP
CCCCCCEEEECCCCCCCCCEEHHHCCHHHHHHHHHHHHHHHCCCCCEEEEEECHHHHCCH
ELWAWLQAGAHFYICGDAKRMAKDVEAAVTAVAAEHGGLSAEAAARFVADLKTAGRYQAD
HHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEECC
VY
CC
>Mature Secondary Structure 
SLQTRIPVVPVLPDSAPFTGEQRAWLNGFFAAILSADQVSAPTALSAGDAAALMPGMPV
CCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCCC
PAAAPEDDGAPWHDPAMPLAERMALAEGRALPRRMMAAMAQQDCGQCGYVCETYAKALAD
CCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHC
GAESKLNLCAPGGKETLRMLKQLAEETSAPAAKPAATPAAAVSYAHEPHAPAPLGTRENP
CCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCC
GEVTFLGRTRLNKDGSEKETWHIEFDLAGSGIDYVAGDSFGVFPVNDPDLVAAVLAALHA
CCEEEEECCCCCCCCCCCCEEEEEEEECCCCCCEECCCCEEEECCCCHHHHHHHHHHHCC
PPDFPIADKTLGEVLSREVCLKSAPDALFTLISYITGGDRKAKARALASGADPDGDAATL
CCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCHHHH
DVLAALEKFPGIRPDPEALVECLEPLQPRLYSISSSPTATPGKLTLTVDAVRYEQTGRTR
HHHHHHHHCCCCCCCHHHHHHHHHHHCHHHEECCCCCCCCCCEEEEEEEEEEECCCCCCH
LGVASTFLGGRIAPGTRMKAYIQKAHGFALPADLSKDVIMVGPGTGIAPFRSFLHERLAT
HHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHH
KAPGRNWLFFGHQKRDTDFFYEDELNGLQACGTLTRLDTAWSRDGAAKVYVQDKIRAAGP
CCCCCCEEEECCCCCCCCCEEHHHCCHHHHHHHHHHHHHHHCCCCCEEEEEECHHHHCCH
ELWAWLQAGAHFYICGDAKRMAKDVEAAVTAVAAEHGGLSAEAAARFVADLKTAGRYQAD
HHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEECC
VY
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA