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The map label for this gene is uvrC [H]

Identifier: 154246286

GI number: 154246286

Start: 2618171

End: 2620510

Strand: Direct

Name: uvrC [H]

Synonym: Xaut_2344

Alternate gene names: 154246286

Gene position: 2618171-2620510 (Clockwise)

Preceding gene: 154246282

Following gene: 154246287

Centisome position: 49.32

GC content: 68.89

Gene sequence:

>2340_bases
ATGACCGGCAGACGCCCCATCGACCCGCCCGAGATCGCCTTTGCCCGAGACGATCAGGCCACCCCTGCGCCCGAATCCGA
CGAGATGGAGGCCGCGGACGAGGCCGACCTCCTTATTCTCGACGCCATCGACGCGCCGCCGCCCGGTGCCGAAAGCCTGG
CCAGCGGACGCGATGCCATCATCCGCGCGGTCAAGCATGCCCCGGCGGGCCCCGGCGTCTATCGCATGATCGCGGCGGAC
AGTTCCGTGCTCTATGTGGGCAAGGCCAAGAGCATCAGGAAGCGGGTGCTGAGCTACACGCGCCCGGTGGGTCACACCAA
CCGCATCGCGCGGATGATCGCCGCCACCGCGTCCATGGAGTTCGTCTCCACCCGCACCGAGCCGGAGGCCCTGCTGCTTG
AGGCCAACCTCATCAAGCAGCTGAAGCCGCGCTTCAACGTGCTGCTGCGGGACGACAAGTCCTTCCCCTATATCCTCATT
ACCGCCGATCACGTGGCGCCGCAGATCACCAAGCATCGCGGCGCGCGCAACAGGCCGGGGGATTATTACGGGCCGTTCGC
CAGCGTGTGGGCGGTGGACCGCACCATCAATGCGCTGGAGCGGGCCTTCCTTTTGCGCTCGTGCTCCGACAGCTATTACG
AGAACCGCACGCGCCCCTGCCTGCTCCACCAGATCAAGCGCTGCGCCGGTCCCTGCACCGGCGAGGTGAGCCACACCGAT
TATGCGGAGCTGGTGCGTGAGGCCCGCGCCTTCCTCTCCGGCCGCTCCCGCGCCGTGAAGGAAGAGCTGGCGCTGGAGAT
GGAGGCCGCGTCCCAGGAGCTGGAATTCGAGCGCGCCGCCCGCCTGCGCGATCGCCTCGCCGCGCTGTCCGCCGTGCAGG
GCTCGCAGGGCATCAACCCGAGGGGGGTGGAGGAGGCGGACGTGTTCGCCTGCCACCAGCAGGGTGGGGCTACCTGCGTG
GAGGTGTTCTTCTTCCGCACCGGCCAGAACTGGGGCAACCGGGCCTATTATCCCCGCGCCGACCGCTCCCTGTCGGAGGC
CGAGGTGCTGGGTGCCTTCCTTGCCCAATTCTATGAGGACAAGCCCTGCCCGCGCCTTATCCTGTTGTCCCATAAGGTGG
AGGAGCAGGCGCTCCTGGCCGAGGCCCTCTCGGAAAAGACCGGTCACCGCATCGAGATCGCGGCGCCCCAGCGCGGCGAG
AAGCGCGACCTCGTGGACCACGCGCTGCAGAACGCCCGCGAGGCCCTGGCCCGCACCCTGGCGGAAAGCGCCACCCAGAC
CAAGCTGCTGGAGGGCGTTGCAGCCACCTTCGGCCTCAAGGCCCCGCCCCAGCGCATTGAGGTCTATGACAATTCCCACA
TCATGGGCACCAATGCGGTGGGCGGCATGATCGTGGCGGGGCCGGAAGGCTTCCGCAAATCCCAGTACCGCAAGTTCAAC
ATCAAGTCGGCGGACATCGTGCCGGGCGACGATTTCGGCATGATGCGCGAGGTGCTGCGCCGCCGCTTCTCCCGGCTGCT
GAAGGAGGCGCCGCGCGACGGGGCGGGGGAGGGAGGGGACGTAGGTGGCGTCCAGGAGCTGGATGCAACGGGAGGGGACA
TCGGTCCCGCCAGCGAGGCCCAAAGCACTCAAGCCCCTTCGCCAGCCGTCATGCCCGGCCTTGAGCCGGGCATCCACGCC
GGGTCGATAGCCATGCGAGTGGAAGATAGCTCCCGGCCGCGGGGCGAGGATGGCCGGGACGAGCCCGGCCATGACGGCGA
TCTCTCGGGGGCAGTCGCGCCAACGCAGGTGGAAGCGACGCCCTTGATCGTCGAACCCGACACCCCACCCGATTCCGACC
CGGAGGAGGTGGACGCACTGCCGGACGCCACCGAAGCCTCGCCCTGGCCGGACCTCGTGCTCATCGACGGCGGCCTCGGC
CAGCTCAATGCGGCGCGCACGGTGCTGGACGAGCTGGGCATCACCGACGTGCCACTGGTGGGCATCGCCAAGGGCCTCGA
CCGCGAGGCGGGGCGCGAGCAGTTCTTCCTGCCCGGCCGCACCCCGTTCCGCATGGAGCCGCGCGACCCGGTGCTCTATT
TCATCCAGCGCCTGCGCGACGAGGCCCACCGCTTCGCCATCGGCTCCCATCGCGCCCGGAGGAAGAAGGACATCACCGAG
GCCGGGCTGCAGGCCATCGCCGGCGTCGGGCCCACGCGCAAGCGCGCGCTGCTGCGCCATTTCGGGACGCTCAAGGCCAT
CGAGCGGGCTTCGCTGGCCGATCTGGAGCAGGTGGCGGGCATCAACGCCGCCACCGCCAAGGCGGTGTATGATTATTTTC
ATGAGCGGCCGCCCGGCTGA

Upstream 100 bases:

>100_bases
CCGGGGTAGGTCGGGCGTTGGCGGTGTGGTTGAGCGGCAGTTAACGCCTTCGGCTCCGGCGGAGATTCCATCCGACGCCC
CGGCGCACTACATAGGCTCC

Downstream 100 bases:

>100_bases
GCGGCCTTGAGCGACGCCCTTTCGGACCCGGTCCAAGGCCTGGGCTTCGGTATCGCGGACCTGCTGGTTTTGCACGGAGG
CTTCCGCCTGCCGCCCGCGC

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 779; Mature: 778

Protein sequence:

>779_residues
MTGRRPIDPPEIAFARDDQATPAPESDEMEAADEADLLILDAIDAPPPGAESLASGRDAIIRAVKHAPAGPGVYRMIAAD
SSVLYVGKAKSIRKRVLSYTRPVGHTNRIARMIAATASMEFVSTRTEPEALLLEANLIKQLKPRFNVLLRDDKSFPYILI
TADHVAPQITKHRGARNRPGDYYGPFASVWAVDRTINALERAFLLRSCSDSYYENRTRPCLLHQIKRCAGPCTGEVSHTD
YAELVREARAFLSGRSRAVKEELALEMEAASQELEFERAARLRDRLAALSAVQGSQGINPRGVEEADVFACHQQGGATCV
EVFFFRTGQNWGNRAYYPRADRSLSEAEVLGAFLAQFYEDKPCPRLILLSHKVEEQALLAEALSEKTGHRIEIAAPQRGE
KRDLVDHALQNAREALARTLAESATQTKLLEGVAATFGLKAPPQRIEVYDNSHIMGTNAVGGMIVAGPEGFRKSQYRKFN
IKSADIVPGDDFGMMREVLRRRFSRLLKEAPRDGAGEGGDVGGVQELDATGGDIGPASEAQSTQAPSPAVMPGLEPGIHA
GSIAMRVEDSSRPRGEDGRDEPGHDGDLSGAVAPTQVEATPLIVEPDTPPDSDPEEVDALPDATEASPWPDLVLIDGGLG
QLNAARTVLDELGITDVPLVGIAKGLDREAGREQFFLPGRTPFRMEPRDPVLYFIQRLRDEAHRFAIGSHRARRKKDITE
AGLQAIAGVGPTRKRALLRHFGTLKAIERASLADLEQVAGINAATAKAVYDYFHERPPG

Sequences:

>Translated_779_residues
MTGRRPIDPPEIAFARDDQATPAPESDEMEAADEADLLILDAIDAPPPGAESLASGRDAIIRAVKHAPAGPGVYRMIAAD
SSVLYVGKAKSIRKRVLSYTRPVGHTNRIARMIAATASMEFVSTRTEPEALLLEANLIKQLKPRFNVLLRDDKSFPYILI
TADHVAPQITKHRGARNRPGDYYGPFASVWAVDRTINALERAFLLRSCSDSYYENRTRPCLLHQIKRCAGPCTGEVSHTD
YAELVREARAFLSGRSRAVKEELALEMEAASQELEFERAARLRDRLAALSAVQGSQGINPRGVEEADVFACHQQGGATCV
EVFFFRTGQNWGNRAYYPRADRSLSEAEVLGAFLAQFYEDKPCPRLILLSHKVEEQALLAEALSEKTGHRIEIAAPQRGE
KRDLVDHALQNAREALARTLAESATQTKLLEGVAATFGLKAPPQRIEVYDNSHIMGTNAVGGMIVAGPEGFRKSQYRKFN
IKSADIVPGDDFGMMREVLRRRFSRLLKEAPRDGAGEGGDVGGVQELDATGGDIGPASEAQSTQAPSPAVMPGLEPGIHA
GSIAMRVEDSSRPRGEDGRDEPGHDGDLSGAVAPTQVEATPLIVEPDTPPDSDPEEVDALPDATEASPWPDLVLIDGGLG
QLNAARTVLDELGITDVPLVGIAKGLDREAGREQFFLPGRTPFRMEPRDPVLYFIQRLRDEAHRFAIGSHRARRKKDITE
AGLQAIAGVGPTRKRALLRHFGTLKAIERASLADLEQVAGINAATAKAVYDYFHERPPG
>Mature_778_residues
TGRRPIDPPEIAFARDDQATPAPESDEMEAADEADLLILDAIDAPPPGAESLASGRDAIIRAVKHAPAGPGVYRMIAADS
SVLYVGKAKSIRKRVLSYTRPVGHTNRIARMIAATASMEFVSTRTEPEALLLEANLIKQLKPRFNVLLRDDKSFPYILIT
ADHVAPQITKHRGARNRPGDYYGPFASVWAVDRTINALERAFLLRSCSDSYYENRTRPCLLHQIKRCAGPCTGEVSHTDY
AELVREARAFLSGRSRAVKEELALEMEAASQELEFERAARLRDRLAALSAVQGSQGINPRGVEEADVFACHQQGGATCVE
VFFFRTGQNWGNRAYYPRADRSLSEAEVLGAFLAQFYEDKPCPRLILLSHKVEEQALLAEALSEKTGHRIEIAAPQRGEK
RDLVDHALQNAREALARTLAESATQTKLLEGVAATFGLKAPPQRIEVYDNSHIMGTNAVGGMIVAGPEGFRKSQYRKFNI
KSADIVPGDDFGMMREVLRRRFSRLLKEAPRDGAGEGGDVGGVQELDATGGDIGPASEAQSTQAPSPAVMPGLEPGIHAG
SIAMRVEDSSRPRGEDGRDEPGHDGDLSGAVAPTQVEATPLIVEPDTPPDSDPEEVDALPDATEASPWPDLVLIDGGLGQ
LNAARTVLDELGITDVPLVGIAKGLDREAGREQFFLPGRTPFRMEPRDPVLYFIQRLRDEAHRFAIGSHRARRKKDITEA
GLQAIAGVGPTRKRALLRHFGTLKAIERASLADLEQVAGINAATAKAVYDYFHERPPG

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=453, Percent_Identity=39.7350993377483, Blast_Score=332, Evalue=4e-92,
Organism=Escherichia coli, GI1788037, Length=183, Percent_Identity=31.6939890710383, Blast_Score=73, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 84830; Mature: 84699

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGRRPIDPPEIAFARDDQATPAPESDEMEAADEADLLILDAIDAPPPGAESLASGRDAI
CCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHCCHHHH
IRAVKHAPAGPGVYRMIAADSSVLYVGKAKSIRKRVLSYTRPVGHTNRIARMIAATASME
HHHHHHCCCCCCEEEEEECCCCEEEECCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
FVSTRTEPEALLLEANLIKQLKPRFNVLLRDDKSFPYILITADHVAPQITKHRGARNRPG
HHHCCCCCHHEEHHHHHHHHHCHHHCEEEECCCCCCEEEEECCHHHHHHHHHCCCCCCCC
DYYGPFASVWAVDRTINALERAFLLRSCSDSYYENRTRPCLLHQIKRCAGPCTGEVSHTD
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCH
YAELVREARAFLSGRSRAVKEELALEMEAASQELEFERAARLRDRLAALSAVQGSQGINP
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
RGVEEADVFACHQQGGATCVEVFFFRTGQNWGNRAYYPRADRSLSEAEVLGAFLAQFYED
CCCCHHHHHHHHCCCCCEEEHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCC
KPCPRLILLSHKVEEQALLAEALSEKTGHRIEIAAPQRGEKRDLVDHALQNAREALARTL
CCCCEEEEEHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
AESATQTKLLEGVAATFGLKAPPQRIEVYDNSHIMGTNAVGGMIVAGPEGFRKSQYRKFN
HHHHHHHHHHHHHHHHHCCCCCHHHEEEECCCEEEECCCCCCEEEECCCCHHHCCCEEEC
IKSADIVPGDDFGMMREVLRRRFSRLLKEAPRDGAGEGGDVGGVQELDATGGDIGPASEA
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCC
QSTQAPSPAVMPGLEPGIHAGSIAMRVEDSSRPRGEDGRDEPGHDGDLSGAVAPTQVEAT
CCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEECCC
PLIVEPDTPPDSDPEEVDALPDATEASPWPDLVLIDGGLGQLNAARTVLDELGITDVPLV
EEEECCCCCCCCCHHHHHCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCCHH
GIAKGLDREAGREQFFLPGRTPFRMEPRDPVLYFIQRLRDEAHRFAIGSHRARRKKDITE
HHHHCCCHHCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGLQAIAGVGPTRKRALLRHFGTLKAIERASLADLEQVAGINAATAKAVYDYFHERPPG
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TGRRPIDPPEIAFARDDQATPAPESDEMEAADEADLLILDAIDAPPPGAESLASGRDAI
CCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHCCHHHH
IRAVKHAPAGPGVYRMIAADSSVLYVGKAKSIRKRVLSYTRPVGHTNRIARMIAATASME
HHHHHHCCCCCCEEEEEECCCCEEEECCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
FVSTRTEPEALLLEANLIKQLKPRFNVLLRDDKSFPYILITADHVAPQITKHRGARNRPG
HHHCCCCCHHEEHHHHHHHHHCHHHCEEEECCCCCCEEEEECCHHHHHHHHHCCCCCCCC
DYYGPFASVWAVDRTINALERAFLLRSCSDSYYENRTRPCLLHQIKRCAGPCTGEVSHTD
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCH
YAELVREARAFLSGRSRAVKEELALEMEAASQELEFERAARLRDRLAALSAVQGSQGINP
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
RGVEEADVFACHQQGGATCVEVFFFRTGQNWGNRAYYPRADRSLSEAEVLGAFLAQFYED
CCCCHHHHHHHHCCCCCEEEHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCC
KPCPRLILLSHKVEEQALLAEALSEKTGHRIEIAAPQRGEKRDLVDHALQNAREALARTL
CCCCEEEEEHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
AESATQTKLLEGVAATFGLKAPPQRIEVYDNSHIMGTNAVGGMIVAGPEGFRKSQYRKFN
HHHHHHHHHHHHHHHHHCCCCCHHHEEEECCCEEEECCCCCCEEEECCCCHHHCCCEEEC
IKSADIVPGDDFGMMREVLRRRFSRLLKEAPRDGAGEGGDVGGVQELDATGGDIGPASEA
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCC
QSTQAPSPAVMPGLEPGIHAGSIAMRVEDSSRPRGEDGRDEPGHDGDLSGAVAPTQVEAT
CCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEECCC
PLIVEPDTPPDSDPEEVDALPDATEASPWPDLVLIDGGLGQLNAARTVLDELGITDVPLV
EEEECCCCCCCCCHHHHHCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCCHH
GIAKGLDREAGREQFFLPGRTPFRMEPRDPVLYFIQRLRDEAHRFAIGSHRARRKKDITE
HHHHCCCHHCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGLQAIAGVGPTRKRALLRHFGTLKAIERASLADLEQVAGINAATAKAVYDYFHERPPG
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA