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The map label for this gene is ndk

Identifier: 154246270

GI number: 154246270

Start: 2601846

End: 2602268

Strand: Reverse

Name: ndk

Synonym: Xaut_2328

Alternate gene names: 154246270

Gene position: 2602268-2601846 (Counterclockwise)

Preceding gene: 154246271

Following gene: 154246269

Centisome position: 49.02

GC content: 65.72

Gene sequence:

>423_bases
ATGGCGATCGAGCGCACCTTCTCGATCATCAAGCCCGACGCCACGCGTCGGAACCTCACCGGCGCCGTGAATGCCGTCAT
CGAGACGGCCGGCCTGCGGATCGTCGCCCAGAAGCGCATCCTGATGACCAAGGCCCAGGCCGAGACCTTCTACGCCGTGC
ACAGCGCGCGTCCCTTCTTCGGCGACCTCGTGTCCTTCATGACCTCCGGCCCGGTGGTGGTGCAGGTCCTCGAAGCCGAG
AACGCCGTCGCCAAGTATCGCGAAGTGATGGGCGCCACCAACCCGGCCAATGCGGCCGAGGGCACCATCCGCAAGCTGCT
CGCCGAGTCCATCGAGGCCAATTCCGCCCACGGTTCCGACAGCGTCGAGAACGCCGCGGTGGAAATCGCCCAGTTCTTCT
CCGGCAACGAAATCGTCGGCTGA

Upstream 100 bases:

>100_bases
AGCCCTTCCCTTGCCCCTTCAGGCTCCGGCTGCTAAGAGCCGCGCCATCCGCGGACACTGCGGCATCCCATCCCACCAGC
AACAGACAGGACGGTCCCCC

Downstream 100 bases:

>100_bases
GCGGGGAAATCCCGGCGATGCACCCGCATCTCCGGGCCCTCGCTTGCGGCGGTAACAGGCTCGGATGCCGCAGCGCGCCA
ACGAATGATGCGCTGCGTCA

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase [H]

Number of amino acids: Translated: 140; Mature: 139

Protein sequence:

>140_residues
MAIERTFSIIKPDATRRNLTGAVNAVIETAGLRIVAQKRILMTKAQAETFYAVHSARPFFGDLVSFMTSGPVVVQVLEAE
NAVAKYREVMGATNPANAAEGTIRKLLAESIEANSAHGSDSVENAAVEIAQFFSGNEIVG

Sequences:

>Translated_140_residues
MAIERTFSIIKPDATRRNLTGAVNAVIETAGLRIVAQKRILMTKAQAETFYAVHSARPFFGDLVSFMTSGPVVVQVLEAE
NAVAKYREVMGATNPANAAEGTIRKLLAESIEANSAHGSDSVENAAVEIAQFFSGNEIVG
>Mature_139_residues
AIERTFSIIKPDATRRNLTGAVNAVIETAGLRIVAQKRILMTKAQAETFYAVHSARPFFGDLVSFMTSGPVVVQVLEAEN
AVAKYREVMGATNPANAAEGTIRKLLAESIEANSAHGSDSVENAAVEIAQFFSGNEIVG

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate [H]

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family [H]

Homologues:

Organism=Homo sapiens, GI37693993, Length=138, Percent_Identity=42.0289855072464, Blast_Score=110, Evalue=3e-25,
Organism=Homo sapiens, GI66392203, Length=137, Percent_Identity=41.6058394160584, Blast_Score=108, Evalue=1e-24,
Organism=Homo sapiens, GI66392227, Length=137, Percent_Identity=41.6058394160584, Blast_Score=108, Evalue=1e-24,
Organism=Homo sapiens, GI66392205, Length=137, Percent_Identity=41.6058394160584, Blast_Score=108, Evalue=1e-24,
Organism=Homo sapiens, GI4505409, Length=137, Percent_Identity=41.6058394160584, Blast_Score=108, Evalue=1e-24,
Organism=Homo sapiens, GI66392192, Length=137, Percent_Identity=41.6058394160584, Blast_Score=108, Evalue=1e-24,
Organism=Homo sapiens, GI38045913, Length=137, Percent_Identity=41.6058394160584, Blast_Score=106, Evalue=6e-24,
Organism=Homo sapiens, GI4557797, Length=137, Percent_Identity=41.6058394160584, Blast_Score=106, Evalue=7e-24,
Organism=Homo sapiens, GI4826862, Length=136, Percent_Identity=38.2352941176471, Blast_Score=92, Evalue=2e-19,
Organism=Homo sapiens, GI7019465, Length=133, Percent_Identity=33.0827067669173, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI37574614, Length=133, Percent_Identity=33.0827067669173, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI5031951, Length=136, Percent_Identity=36.7647058823529, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI4505413, Length=135, Percent_Identity=28.1481481481481, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI148839372, Length=138, Percent_Identity=28.2608695652174, Blast_Score=66, Evalue=9e-12,
Organism=Escherichia coli, GI1788866, Length=139, Percent_Identity=56.8345323741007, Blast_Score=160, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI17506807, Length=135, Percent_Identity=42.2222222222222, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6322783, Length=136, Percent_Identity=40.4411764705882, Blast_Score=110, Evalue=5e-26,
Organism=Drosophila melanogaster, GI45549037, Length=136, Percent_Identity=45.5882352941176, Blast_Score=119, Evalue=8e-28,
Organism=Drosophila melanogaster, GI18860097, Length=134, Percent_Identity=33.5820895522388, Blast_Score=78, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001564
- InterPro:   IPR023005 [H]

Pfam domain/function: PF00334 NDK [H]

EC number: =2.7.4.6 [H]

Molecular weight: Translated: 14926; Mature: 14795

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: PS00469 NDP_KINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIERTFSIIKPDATRRNLTGAVNAVIETAGLRIVAQKRILMTKAQAETFYAVHSARPFF
CCCCCCHHHCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
GDLVSFMTSGPVVVQVLEAENAVAKYREVMGATNPANAAEGTIRKLLAESIEANSAHGSD
HHHHHHHCCCCCEEEEHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCC
SVENAAVEIAQFFSGNEIVG
HHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
AIERTFSIIKPDATRRNLTGAVNAVIETAGLRIVAQKRILMTKAQAETFYAVHSARPFF
CCCCCHHHCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
GDLVSFMTSGPVVVQVLEAENAVAKYREVMGATNPANAAEGTIRKLLAESIEANSAHGSD
HHHHHHHCCCCCEEEEHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCC
SVENAAVEIAQFFSGNEIVG
HHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA