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The map label for this gene is pepQ [H]

Identifier: 154246243

GI number: 154246243

Start: 2566849

End: 2568750

Strand: Reverse

Name: pepQ [H]

Synonym: Xaut_2301

Alternate gene names: 154246243

Gene position: 2568750-2566849 (Counterclockwise)

Preceding gene: 154246244

Following gene: 154246242

Centisome position: 48.39

GC content: 70.5

Gene sequence:

>1902_bases
ATGGCTCTATGGTTGGCGCAATATTCTAATCCCCCAGCTCCGGCCGCCCCGCCCATGACCGTGCACCACAAGACCCCCCA
CGCCTTCAAGGCCGTGTTCCAGACCTTCGACGACCTCGCCGACAGCGCGGCCGGTCCTGCCCGGCTCGCCGCGCTGCGGG
CGGAACTCGCCCGGCTGAACGTGGACGGCTACGTGGTGCCGCGCGCCGACGCGCACCAGAACGAATATGTGCCGGCCTGC
GAGGAGCGCCTCGCCTTCCTCACCGGGTTCACCGGCTCGGCCGGCACGGTGATCGTGCTTGAAGACACCGCCGCCCTGTT
CGTGGACGGGCGCTACACCCTCCAGGCTCCCGCCCAGGTGGACACGGCGGCGTTCACAGTGGTGCCGCTGTCGCAGACCC
GGCCGGAGGCGTGGGTCGAGGCGAACCTCGCCCGTGGCGCGCGGCTGGCCTTCGATCCCTGGCGCACCACCATCGATGGC
CGCGACAGGCTGGCCAAGGCGGTGGGCGCGGCCGGCGGCATCCTCGTGCCGCTGGAGGCCGACCCCTTCACCGCCATCTG
GCCCGACCGGCCCGAGCCGCCCCGCGCGCCGGTGCGGCTGCTCGACCTCTCCGTGGCGGGCGAGGACACGGCGGCCAAAC
TCCTGCGCGTTCAGGAGAAGCTCACCGAAGCCAAGCTCGACGGAGCGCTGATCTCCGATCCCCACGGCGCGGCCTGGCTG
TTCAACATGCGCGGCGGCGACGTCGCCCACACGCCGCTGCCGCTGGCCTGGTGCATCGTGCCGCGCGAGGGACTGCCGGA
CCTCTTTCTCGAACCGCTCAAACTCTCCCATGAGGTGCGCGCGGCGCTGGCGGGGCACGCGCGCCTCCACGGAACCGGCG
ACCTCGACACCGTGCTCGCCGCCTTCGCCAAGGACCGCAAGGTCCGGCTGGACCAGGCCACGGCGCCGGTGCGGCTGGCC
GGCCTCATCGAGGCGGCAGGTGGCACCGTGGACAAGGGCGCCGACCCAATCGCCTTGCTGAAGGCGTCCAAGAACCCGGC
CGAGATCGCCGGCATGCGCGCCGCCCATGTGCGCGACGGCCTCGCCCTCGCCCGTTTCCTGGCGTGGTTCGACGCCGAGG
CGCCGAAGGGCCATCTCACCGAGATCGAGGCGGTGGAGGCACTGGAGACCTTCCGGCGCGGCACCGGCAATCTCACCGAC
GTTTCCTTCCCCACCATCGCCGGGGCGGGGGAGAACGGCGCCATCGTGCATTATCGCGTCACCCGCAAGACCAACCGGGC
CATCCATCCCGGCGAATTGTTCCTGCTGGATTCCGGCGCCCAATATCCGGACGGCACCACCGACATCACTCGCACCCTCG
CGGTGGGCACGCCCACGGCAGAGATGCGCCGCCACTACACGCTGGTGCTAAAGGGTCATCTGGCCCTGAGCCGGGCGGTG
TTTCCGCAAGGCATCACCGGGGCCCAGCTCGATCCGCTGGCGCGGCAATATCTGTGGGCGGCGGGACTGGATTTCGACCA
CGGCACCGGCCATGGCGTGGGCGCCGGCCTGTCGGTGCATGAAGGCCCGGCGCGCATTTCCCAGCTCGGGCACCTGGCTC
TGGCGGAGGGCATGATCCTCTCCAACGAGCCGGGCTATTACCGCACCGGGGCCTACGGCATCCGCATCGAGAACCTGATT
TTGGTGGAGCAGCGCACCGTGGAGGGCGGTGAGAAGCCCTGCCTCGGTTTCTCGACCCTCACCCTGGTGCCCTACGACCG
CCGTCTCATCGACCTCGGCCTGCTGGATGGCGCCGAGCGGGAGCAGGTGGACGCCTATCACGCGCTGGTGGCCGAAGCGC
TCGCCGGCGACCTTAACGAGGTGGAGCGGAACTGGCTGGCGCAGGCCACGGCACCGCTCTGA

Upstream 100 bases:

>100_bases
ATCGCAGGCACCCTTCTCCAGCAAGGGCGTTGCGCGAAATACCCACCGTCTGGAGGGGATGCCCCCCGTATGCCGCGAAA
CGGTACCCAATGCGCCTCAT

Downstream 100 bases:

>100_bases
CCACCCACGGGCGGGCGTCCGCTTCTGGCGCGCGCCTCAGGCCGGCATTCGCCATACTGCCACGGCATGACGCACACCCG
AGCGGAACCTCCGCCATCCG

Product: peptidase M24

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 633; Mature: 632

Protein sequence:

>633_residues
MALWLAQYSNPPAPAAPPMTVHHKTPHAFKAVFQTFDDLADSAAGPARLAALRAELARLNVDGYVVPRADAHQNEYVPAC
EERLAFLTGFTGSAGTVIVLEDTAALFVDGRYTLQAPAQVDTAAFTVVPLSQTRPEAWVEANLARGARLAFDPWRTTIDG
RDRLAKAVGAAGGILVPLEADPFTAIWPDRPEPPRAPVRLLDLSVAGEDTAAKLLRVQEKLTEAKLDGALISDPHGAAWL
FNMRGGDVAHTPLPLAWCIVPREGLPDLFLEPLKLSHEVRAALAGHARLHGTGDLDTVLAAFAKDRKVRLDQATAPVRLA
GLIEAAGGTVDKGADPIALLKASKNPAEIAGMRAAHVRDGLALARFLAWFDAEAPKGHLTEIEAVEALETFRRGTGNLTD
VSFPTIAGAGENGAIVHYRVTRKTNRAIHPGELFLLDSGAQYPDGTTDITRTLAVGTPTAEMRRHYTLVLKGHLALSRAV
FPQGITGAQLDPLARQYLWAAGLDFDHGTGHGVGAGLSVHEGPARISQLGHLALAEGMILSNEPGYYRTGAYGIRIENLI
LVEQRTVEGGEKPCLGFSTLTLVPYDRRLIDLGLLDGAEREQVDAYHALVAEALAGDLNEVERNWLAQATAPL

Sequences:

>Translated_633_residues
MALWLAQYSNPPAPAAPPMTVHHKTPHAFKAVFQTFDDLADSAAGPARLAALRAELARLNVDGYVVPRADAHQNEYVPAC
EERLAFLTGFTGSAGTVIVLEDTAALFVDGRYTLQAPAQVDTAAFTVVPLSQTRPEAWVEANLARGARLAFDPWRTTIDG
RDRLAKAVGAAGGILVPLEADPFTAIWPDRPEPPRAPVRLLDLSVAGEDTAAKLLRVQEKLTEAKLDGALISDPHGAAWL
FNMRGGDVAHTPLPLAWCIVPREGLPDLFLEPLKLSHEVRAALAGHARLHGTGDLDTVLAAFAKDRKVRLDQATAPVRLA
GLIEAAGGTVDKGADPIALLKASKNPAEIAGMRAAHVRDGLALARFLAWFDAEAPKGHLTEIEAVEALETFRRGTGNLTD
VSFPTIAGAGENGAIVHYRVTRKTNRAIHPGELFLLDSGAQYPDGTTDITRTLAVGTPTAEMRRHYTLVLKGHLALSRAV
FPQGITGAQLDPLARQYLWAAGLDFDHGTGHGVGAGLSVHEGPARISQLGHLALAEGMILSNEPGYYRTGAYGIRIENLI
LVEQRTVEGGEKPCLGFSTLTLVPYDRRLIDLGLLDGAEREQVDAYHALVAEALAGDLNEVERNWLAQATAPL
>Mature_632_residues
ALWLAQYSNPPAPAAPPMTVHHKTPHAFKAVFQTFDDLADSAAGPARLAALRAELARLNVDGYVVPRADAHQNEYVPACE
ERLAFLTGFTGSAGTVIVLEDTAALFVDGRYTLQAPAQVDTAAFTVVPLSQTRPEAWVEANLARGARLAFDPWRTTIDGR
DRLAKAVGAAGGILVPLEADPFTAIWPDRPEPPRAPVRLLDLSVAGEDTAAKLLRVQEKLTEAKLDGALISDPHGAAWLF
NMRGGDVAHTPLPLAWCIVPREGLPDLFLEPLKLSHEVRAALAGHARLHGTGDLDTVLAAFAKDRKVRLDQATAPVRLAG
LIEAAGGTVDKGADPIALLKASKNPAEIAGMRAAHVRDGLALARFLAWFDAEAPKGHLTEIEAVEALETFRRGTGNLTDV
SFPTIAGAGENGAIVHYRVTRKTNRAIHPGELFLLDSGAQYPDGTTDITRTLAVGTPTAEMRRHYTLVLKGHLALSRAVF
PQGITGAQLDPLARQYLWAAGLDFDHGTGHGVGAGLSVHEGPARISQLGHLALAEGMILSNEPGYYRTGAYGIRIENLIL
VEQRTVEGGEKPCLGFSTLTLVPYDRRLIDLGLLDGAEREQVDAYHALVAEALAGDLNEVERNWLAQATAPL

Specific function: Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Archaeal-type prolidase subfamily [H]

Homologues:

Organism=Homo sapiens, GI264681563, Length=616, Percent_Identity=38.3116883116883, Blast_Score=403, Evalue=1e-112,
Organism=Homo sapiens, GI264681565, Length=617, Percent_Identity=36.3047001620746, Blast_Score=368, Evalue=1e-102,
Organism=Homo sapiens, GI93141226, Length=603, Percent_Identity=34.4941956882255, Blast_Score=349, Evalue=5e-96,
Organism=Escherichia coli, GI1788728, Length=240, Percent_Identity=33.3333333333333, Blast_Score=96, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17509539, Length=594, Percent_Identity=35.3535353535354, Blast_Score=346, Evalue=3e-95,
Organism=Caenorhabditis elegans, GI25149105, Length=620, Percent_Identity=28.8709677419355, Blast_Score=251, Evalue=6e-67,
Organism=Saccharomyces cerevisiae, GI6322999, Length=652, Percent_Identity=33.1288343558282, Blast_Score=314, Evalue=3e-86,
Organism=Drosophila melanogaster, GI17137632, Length=605, Percent_Identity=34.2148760330578, Blast_Score=325, Evalue=8e-89,
Organism=Drosophila melanogaster, GI161078230, Length=643, Percent_Identity=26.4385692068429, Blast_Score=238, Evalue=7e-63,
Organism=Drosophila melanogaster, GI21357287, Length=643, Percent_Identity=26.4385692068429, Blast_Score=238, Evalue=7e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 67709; Mature: 67578

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALWLAQYSNPPAPAAPPMTVHHKTPHAFKAVFQTFDDLADSAAGPARLAALRAELARLN
CEEEEEECCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC
VDGYVVPRADAHQNEYVPACEERLAFLTGFTGSAGTVIVLEDTAALFVDGRYTLQAPAQV
CCCEEECCCCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEEECCEEEEECCEEEEECCCCC
DTAAFTVVPLSQTRPEAWVEANLARGARLAFDPWRTTIDGRDRLAKAVGAAGGILVPLEA
CCEEEEEEECCCCCCHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHCCCCCEEEEECC
DPFTAIWPDRPEPPRAPVRLLDLSVAGEDTAAKLLRVQEKLTEAKLDGALISDPHGAAWL
CCCEEECCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCEEECCCCCEEE
FNMRGGDVAHTPLPLAWCIVPREGLPDLFLEPLKLSHEVRAALAGHARLHGTGDLDTVLA
EECCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCEECCCCCHHHHHH
AFAKDRKVRLDQATAPVRLAGLIEAAGGTVDKGADPIALLKASKNPAEIAGMRAAHVRDG
HHHCCCEEEECCCCCCEEEEHHHHHCCCCCCCCCCCEEEEECCCCHHHHHCCHHHHHHHH
LALARFLAWFDAEAPKGHLTEIEAVEALETFRRGTGNLTDVSFPTIAGAGENGAIVHYRV
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCEEEEEE
TRKTNRAIHPGELFLLDSGAQYPDGTTDITRTLAVGTPTAEMRRHYTLVLKGHLALSRAV
ECCCCCCCCCCEEEEECCCCCCCCCCHHHHEEEEECCCHHHHHCEEEEEEECCHHHHHHH
FPQGITGAQLDPLARQYLWAAGLDFDHGTGHGVGAGLSVHEGPARISQLGHLALAEGMIL
CCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHCCEEE
SNEPGYYRTGAYGIRIENLILVEQRTVEGGEKPCLGFSTLTLVPYDRRLIDLGLLDGAER
ECCCCCEECCEEEEEEEEEEEEEEECCCCCCCCCCCEEEEEEECCCCEEEEEECCCCCCH
EQVDAYHALVAEALAGDLNEVERNWLAQATAPL
HHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
ALWLAQYSNPPAPAAPPMTVHHKTPHAFKAVFQTFDDLADSAAGPARLAALRAELARLN
EEEEEECCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC
VDGYVVPRADAHQNEYVPACEERLAFLTGFTGSAGTVIVLEDTAALFVDGRYTLQAPAQV
CCCEEECCCCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEEECCEEEEECCEEEEECCCCC
DTAAFTVVPLSQTRPEAWVEANLARGARLAFDPWRTTIDGRDRLAKAVGAAGGILVPLEA
CCEEEEEEECCCCCCHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHCCCCCEEEEECC
DPFTAIWPDRPEPPRAPVRLLDLSVAGEDTAAKLLRVQEKLTEAKLDGALISDPHGAAWL
CCCEEECCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCEEECCCCCEEE
FNMRGGDVAHTPLPLAWCIVPREGLPDLFLEPLKLSHEVRAALAGHARLHGTGDLDTVLA
EECCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCEECCCCCHHHHHH
AFAKDRKVRLDQATAPVRLAGLIEAAGGTVDKGADPIALLKASKNPAEIAGMRAAHVRDG
HHHCCCEEEECCCCCCEEEEHHHHHCCCCCCCCCCCEEEEECCCCHHHHHCCHHHHHHHH
LALARFLAWFDAEAPKGHLTEIEAVEALETFRRGTGNLTDVSFPTIAGAGENGAIVHYRV
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCEEEEEE
TRKTNRAIHPGELFLLDSGAQYPDGTTDITRTLAVGTPTAEMRRHYTLVLKGHLALSRAV
ECCCCCCCCCCEEEEECCCCCCCCCCHHHHEEEEECCCHHHHHCEEEEEEECCHHHHHHH
FPQGITGAQLDPLARQYLWAAGLDFDHGTGHGVGAGLSVHEGPARISQLGHLALAEGMIL
CCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHCCEEE
SNEPGYYRTGAYGIRIENLILVEQRTVEGGEKPCLGFSTLTLVPYDRRLIDLGLLDGAER
ECCCCCEECCEEEEEEEEEEEEEEECCCCCCCCCCCEEEEEEECCCCEEEEEECCCCCCH
EQVDAYHALVAEALAGDLNEVERNWLAQATAPL
HHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]