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The map label for this gene is dnaX [H]

Identifier: 154246111

GI number: 154246111

Start: 2427978

End: 2429846

Strand: Reverse

Name: dnaX [H]

Synonym: Xaut_2168

Alternate gene names: 154246111

Gene position: 2429846-2427978 (Counterclockwise)

Preceding gene: 154246112

Following gene: 154246110

Centisome position: 45.77

GC content: 70.41

Gene sequence:

>1869_bases
ATGAGCGAGGACACCCACGCGCACCAGGACGATGACGGGCCGAATCCGGGGCTAGGCCTCGACCTCGGCGCCCCGTCCGC
CCCCGCGCGTCCGGCTCCGCCCCCGGAGGCCCCCGCCGCCTATCGGGTGCTGGCACGCAAATACCGCCCGCAGAATTTCA
CGGACCTCATCGGCCAGGAGGCCATGGTCCGCACCCTGCGGAATGCCTTCTCCTCCGGGCGCATCGCGCAGGCCTATATC
CTCACCGGCGTGCGCGGCGTGGGCAAGACCACCACCGCGCGCATCCTCGCCCGCGCGCTGAACTACGAGCCAATGGATGG
CAGCGCCGGCGGGCCCAGCCTCGATCTCTCGGTCATGGGCAAGCAGTGCCGCGACATCATCGAATCCCGCCATGTGGACG
TGATGGAGATGGATGCGGCGTCCAATACCTCCATCAACGACATCCGCGAGATCATCGAGAGCGCCCGCTACCGCCCGGTG
ATGGCGCGCTACAAGGTCTACATCATCGACGAAGTGCACATGCTCTCCACGGCGGCCTTCAACGGCCTGTTGAAGACGCT
GGAAGAGCCGCCGGAGCATGTGAAGTTCATCTTCGCCACCACCGAGATCCGCAAGGTGCCGGTCACCGTGCTGTCGCGCT
GCCAGCGCTTCGACCTGCGGCGCGTGGAGGCCGGCGAGCTGGCGGCGCACCTCGCCGGCATCTGCGCCAAGGAAGGCGTC
ACCATCGAGCCGGAGGCGCTCGCCATCGTGGCGCGGGCGGCGGAAGGCTCGGTGCGCGACAGCCTCTCCCTGCTCGACCA
GGCCATCGCCCATGGCGGCGGCGCGGTGGGCGCGGAAGAGGTGCGGCGGCTGCTGGGCCTTGCCGACAAGGGCCGCGTCA
TCGACCTGTTCGAGGCGCTGATGAAGGGCGAGATGGCCCGCGCGCTCGCTGAATTCCGTGATCAGTATGATGCCGGCGCC
GATCCGGCGGTGATCCTCACGGATCTGGCCGAATTCACCCATCTGGTCACCCGCCTCAAGATCATGCCCGACGCGGCGCA
AGATGCAGCCCTCGTGGAAGCCGAACGGGTGCGCGGGTTGGAGATGGCGCAGGGCCTGTCCATGCGGGTGCTGGCGCGGG
CGTGGCAGATGCTCACCAAGGGCATCGGCGAGGTGCAGCAGGCTCCCAAGCCCGCCCAGGCGGCGGAAATGGCGCTGGTG
CGCCTCGGCTACGCCACCGATCTGCCCACCCCGGACGAAGCCCTGCGGCGCCTGAAAGGCCAGCCTGTTACCGACGCCCC
GGCTCCGCCCTCCGCCCCCTCTGGCGGCGGCGGTGGAGGCGGCGGCGGCGGTGCACGGCTGTCCCTCGCTCCCCGTCCCG
TCGAGGCCCGGCCGCAGATGCGGCCCGCGCCGGTGGCGGCCGTGGCGGCTCCGGCGGCGGGTCCCCGCCTCGCCAGCCTT
GCCGACGTGGCGCAGTACGTTGCTGCCAAGCGCGATCTGGCCCTGAAGCACGCGGTCGAGACATCGCTGCGTCCGGTGCA
TGTGGAGGAGGGCCGCATCGAGGTGGCGCTGGTACCCGGCGCTCCCGCCAGCGTCATTCAGGACCTCTCCCGCAAGCTCT
CGGACTGGACCGGCCGGCGCTGGCTGGTCTCCGTCTCCTCGCAGGCGGGCGGACCGACCTTGGCGGAGGAGAATGCGGCA
GTGAAGGCCGAGCGGGAGGAGGGCATCAAGGCCCATCCGCTGGTGGCCGCCGTGCTCGCCCGCTTCCCCGGCGCCGAGGT
GGTTGACGTGCGGACCCGCGAGGAAGCGCCCATCGACACCGAGGTGCTCGCCCCCTCGGAAGAAGACCTTTATGCCGGCC
CCGGGGCCGACGACGAACTCGAATATTGA

Upstream 100 bases:

>100_bases
TTTTGCCGGCCCGCCCATCGACGCGGGCGACCGCGATGCTATGTATGGGGCAGGTGCATCCTAGGGCAGGCACCCCCTGC
ACATCCCCAAAGGCAGCTTC

Downstream 100 bases:

>100_bases
TCGGTCCGCGCGGCGCCGAGCGCCGCCGCGCGCCATGACAGGGAGATGAAGTCCATGCGCGACCTGATGGGGATGATGAA
GCAGGCCAAGGAGCTTCAGG

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 622; Mature: 621

Protein sequence:

>622_residues
MSEDTHAHQDDDGPNPGLGLDLGAPSAPARPAPPPEAPAAYRVLARKYRPQNFTDLIGQEAMVRTLRNAFSSGRIAQAYI
LTGVRGVGKTTTARILARALNYEPMDGSAGGPSLDLSVMGKQCRDIIESRHVDVMEMDAASNTSINDIREIIESARYRPV
MARYKVYIIDEVHMLSTAAFNGLLKTLEEPPEHVKFIFATTEIRKVPVTVLSRCQRFDLRRVEAGELAAHLAGICAKEGV
TIEPEALAIVARAAEGSVRDSLSLLDQAIAHGGGAVGAEEVRRLLGLADKGRVIDLFEALMKGEMARALAEFRDQYDAGA
DPAVILTDLAEFTHLVTRLKIMPDAAQDAALVEAERVRGLEMAQGLSMRVLARAWQMLTKGIGEVQQAPKPAQAAEMALV
RLGYATDLPTPDEALRRLKGQPVTDAPAPPSAPSGGGGGGGGGGARLSLAPRPVEARPQMRPAPVAAVAAPAAGPRLASL
ADVAQYVAAKRDLALKHAVETSLRPVHVEEGRIEVALVPGAPASVIQDLSRKLSDWTGRRWLVSVSSQAGGPTLAEENAA
VKAEREEGIKAHPLVAAVLARFPGAEVVDVRTREEAPIDTEVLAPSEEDLYAGPGADDELEY

Sequences:

>Translated_622_residues
MSEDTHAHQDDDGPNPGLGLDLGAPSAPARPAPPPEAPAAYRVLARKYRPQNFTDLIGQEAMVRTLRNAFSSGRIAQAYI
LTGVRGVGKTTTARILARALNYEPMDGSAGGPSLDLSVMGKQCRDIIESRHVDVMEMDAASNTSINDIREIIESARYRPV
MARYKVYIIDEVHMLSTAAFNGLLKTLEEPPEHVKFIFATTEIRKVPVTVLSRCQRFDLRRVEAGELAAHLAGICAKEGV
TIEPEALAIVARAAEGSVRDSLSLLDQAIAHGGGAVGAEEVRRLLGLADKGRVIDLFEALMKGEMARALAEFRDQYDAGA
DPAVILTDLAEFTHLVTRLKIMPDAAQDAALVEAERVRGLEMAQGLSMRVLARAWQMLTKGIGEVQQAPKPAQAAEMALV
RLGYATDLPTPDEALRRLKGQPVTDAPAPPSAPSGGGGGGGGGGARLSLAPRPVEARPQMRPAPVAAVAAPAAGPRLASL
ADVAQYVAAKRDLALKHAVETSLRPVHVEEGRIEVALVPGAPASVIQDLSRKLSDWTGRRWLVSVSSQAGGPTLAEENAA
VKAEREEGIKAHPLVAAVLARFPGAEVVDVRTREEAPIDTEVLAPSEEDLYAGPGADDELEY
>Mature_621_residues
SEDTHAHQDDDGPNPGLGLDLGAPSAPARPAPPPEAPAAYRVLARKYRPQNFTDLIGQEAMVRTLRNAFSSGRIAQAYIL
TGVRGVGKTTTARILARALNYEPMDGSAGGPSLDLSVMGKQCRDIIESRHVDVMEMDAASNTSINDIREIIESARYRPVM
ARYKVYIIDEVHMLSTAAFNGLLKTLEEPPEHVKFIFATTEIRKVPVTVLSRCQRFDLRRVEAGELAAHLAGICAKEGVT
IEPEALAIVARAAEGSVRDSLSLLDQAIAHGGGAVGAEEVRRLLGLADKGRVIDLFEALMKGEMARALAEFRDQYDAGAD
PAVILTDLAEFTHLVTRLKIMPDAAQDAALVEAERVRGLEMAQGLSMRVLARAWQMLTKGIGEVQQAPKPAQAAEMALVR
LGYATDLPTPDEALRRLKGQPVTDAPAPPSAPSGGGGGGGGGGARLSLAPRPVEARPQMRPAPVAAVAAPAAGPRLASLA
DVAQYVAAKRDLALKHAVETSLRPVHVEEGRIEVALVPGAPASVIQDLSRKLSDWTGRRWLVSVSSQAGGPTLAEENAAV
KAEREEGIKAHPLVAAVLARFPGAEVVDVRTREEAPIDTEVLAPSEEDLYAGPGADDELEY

Specific function: The gamma chain seems to interact with the delta subunit to transfer the beta subunit on the DNA [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4506491, Length=283, Percent_Identity=23.321554770318, Blast_Score=73, Evalue=1e-12,
Organism=Homo sapiens, GI31881687, Length=283, Percent_Identity=23.321554770318, Blast_Score=73, Evalue=1e-12,
Organism=Homo sapiens, GI31563534, Length=261, Percent_Identity=25.2873563218391, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1786676, Length=386, Percent_Identity=40.9326424870466, Blast_Score=284, Evalue=2e-77,
Organism=Saccharomyces cerevisiae, GI6324478, Length=242, Percent_Identity=23.9669421487603, Blast_Score=73, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324039, Length=229, Percent_Identity=24.0174672489083, Blast_Score=71, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6322528, Length=305, Percent_Identity=21.3114754098361, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI18859927, Length=301, Percent_Identity=23.2558139534884, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI17647857, Length=260, Percent_Identity=25.3846153846154, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI19921076, Length=268, Percent_Identity=24.2537313432836, Blast_Score=70, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022001
- InterPro:   IPR022754
- InterPro:   IPR012763
- InterPro:   IPR021029 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3; PF12168 DNA_pol3_tau_4; PF12170 DNA_pol3_tau_5 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 66162; Mature: 66031

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEDTHAHQDDDGPNPGLGLDLGAPSAPARPAPPPEAPAAYRVLARKYRPQNFTDLIGQE
CCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHH
AMVRTLRNAFSSGRIAQAYILTGVRGVGKTTTARILARALNYEPMDGSAGGPSLDLSVMG
HHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
KQCRDIIESRHVDVMEMDAASNTSINDIREIIESARYRPVMARYKVYIIDEVHMLSTAAF
HHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHCCCCCHHHEEEEEEEHHHHHHHHHH
NGLLKTLEEPPEHVKFIFATTEIRKVPVTVLSRCQRFDLRRVEAGELAAHLAGICAKEGV
HHHHHHHHCCCCCEEEEEEEHHHHHCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCC
TIEPEALAIVARAAEGSVRDSLSLLDQAIAHGGGAVGAEEVRRLLGLADKGRVIDLFEAL
EECCHHHEEEEHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCHHHHHHHH
MKGEMARALAEFRDQYDAGADPAVILTDLAEFTHLVTRLKIMPDAAQDAALVEAERVRGL
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
EMAQGLSMRVLARAWQMLTKGIGEVQQAPKPAQAAEMALVRLGYATDLPTPDEALRRLKG
HHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHCC
QPVTDAPAPPSAPSGGGGGGGGGGARLSLAPRPVEARPQMRPAPVAAVAAPAAGPRLASL
CCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCHHHHCCCCCCCHHHHH
ADVAQYVAAKRDLALKHAVETSLRPVHVEEGRIEVALVPGAPASVIQDLSRKLSDWTGRR
HHHHHHHHHHHHHHHHHHHHHCCCCEEEECCEEEEEEECCCCHHHHHHHHHHHHHCCCCE
WLVSVSSQAGGPTLAEENAAVKAEREEGIKAHPLVAAVLARFPGAEVVDVRTREEAPIDT
EEEEECCCCCCCCCCCCCCCEECHHHCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCC
EVLAPSEEDLYAGPGADDELEY
CEECCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SEDTHAHQDDDGPNPGLGLDLGAPSAPARPAPPPEAPAAYRVLARKYRPQNFTDLIGQE
CCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHH
AMVRTLRNAFSSGRIAQAYILTGVRGVGKTTTARILARALNYEPMDGSAGGPSLDLSVMG
HHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
KQCRDIIESRHVDVMEMDAASNTSINDIREIIESARYRPVMARYKVYIIDEVHMLSTAAF
HHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHCCCCCHHHEEEEEEEHHHHHHHHHH
NGLLKTLEEPPEHVKFIFATTEIRKVPVTVLSRCQRFDLRRVEAGELAAHLAGICAKEGV
HHHHHHHHCCCCCEEEEEEEHHHHHCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCC
TIEPEALAIVARAAEGSVRDSLSLLDQAIAHGGGAVGAEEVRRLLGLADKGRVIDLFEAL
EECCHHHEEEEHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCHHHHHHHH
MKGEMARALAEFRDQYDAGADPAVILTDLAEFTHLVTRLKIMPDAAQDAALVEAERVRGL
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
EMAQGLSMRVLARAWQMLTKGIGEVQQAPKPAQAAEMALVRLGYATDLPTPDEALRRLKG
HHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHCC
QPVTDAPAPPSAPSGGGGGGGGGGARLSLAPRPVEARPQMRPAPVAAVAAPAAGPRLASL
CCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCHHHHCCCCCCCHHHHH
ADVAQYVAAKRDLALKHAVETSLRPVHVEEGRIEVALVPGAPASVIQDLSRKLSDWTGRR
HHHHHHHHHHHHHHHHHHHHHCCCCEEEECCEEEEEEECCCCHHHHHHHHHHHHHCCCCE
WLVSVSSQAGGPTLAEENAAVKAEREEGIKAHPLVAAVLARFPGAEVVDVRTREEAPIDT
EEEEECCCCCCCCCCCCCCCEECHHHCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCC
EVLAPSEEDLYAGPGADDELEY
CEECCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3534795; 3018672; 9278503; 2186364; 2187190; 2181440; 1575709 [H]