Click here to switch to the map view.

The map label for this gene is atpA [H]

Identifier: 154246021

GI number: 154246021

Start: 2337863

End: 2339392

Strand: Direct

Name: atpA [H]

Synonym: Xaut_2078

Alternate gene names: 154246021

Gene position: 2337863-2339392 (Clockwise)

Preceding gene: 154246020

Following gene: 154246022

Centisome position: 44.04

GC content: 65.82

Gene sequence:

>1530_bases
ATGGACATTCGAGCCGCTGAAATCACCGCCATCCTCAAGGAGCAGATCCAGAACTTCGGCCAGGAGGCCGAGGTTTCCGA
GGTGGGTCAGGTTCTCTCCGTCGGTGACGGCATTGCCCGCGTCTACGGCCTCGACAATGTCCAGGCCGGTGAGATGGTCG
AGTTCGAGAATGGCACGCGCGGCATGGCGCTGAACCTCGAAATCGACAACGTCGGCATCGTGATCTTCGGCTCGGACCGC
GAGATCAAGGAAGGCCAGACCGTCAAGCGCACCCGCGCCATCGTGGACGCTCCGGTGGGCAAGGGCCTGCTCGGCCGCGT
CGTGGACGCCCTCGGCAACCCGATCGATGGCAAGGGCCCGATCGTATATACCGAGCGCCGCCGCGTCGACGTGAAGGCGC
CGGGCATCATCCCGCGCAAGTCGGTGCATGAGCCCATGCAGACCGGCCTCAAGGCCATCGACGCGCTGATCCCCATCGGC
CGCGGCCAGCGCGAGCTGATCATCGGCGACCGCCAGACCGGCAAGACCGCCGTGGCGCTCGACTCGATCCTCAACCAGAA
GCCCATCAACCAGGGCACGGACGAGAAGGCCAAGCTCTACTGCGTGTACGTCGCGGTGGGCCAGAAGCGTTCCACCGTCG
CGCAGTTCGTGAAGGTGCTGGAAGAGCAGGGCGCGCTGGAATACTCCATCGTGGTCGCCGCCACCGCCTCGGACGCGGCC
CCCATGCAGTTCCTGGCGCCGTTCACCGGCACCGCCATGGGCGAGTATTTCCGTGACAACGGCATGCACGCCCTGATCAT
CCACGACGACCTGTCCAAGCAGGCCGTGGCCTATCGCCAGATGTCGCTGCTGCTGCGCCGCCCGCCGGGCCGCGAGGCCT
ATCCCGGCGACGTGTTCTACCTGCACTCCCGCCTGCTGGAGCGCGCCGCGAAGCTGAACGATTCGCTGGGCGCCGGCTCC
CTCACCGCGCTGCCGGTGATCGAGACCCAGGCCAACGACGTGTCGGCCTACATCCCGACCAACGTGATCTCCATCACCGA
CGGTCAGATCTTCCTTGAGTCCGACCTGTTCTACCAGGGCATCCGCCCGGCGGTGAACGTCGGCCTGTCGGTGTCGCGCG
TGGGCTCCTCGGCCCAGATCAAGGCGATGAAGCAGGTGGCGGGCAAGATCAAGGGCGAGCTCGCCCAGTATCGTGAGCTT
GCCGCCTTCGCCCAGTTCGGCTCGGACCTCGACGCTTCGACCCAGAAGCTGCTCAACCGTGGCGCCCGCCTCACCGAGCT
GCTGAAGCAGAGCCAGTTCTCGCCCCTCAAGGTCGAGGAGCAGGTGGCGGTGATCTTCGCCGGCACCAACGGCTACCTCG
ACCCGCTGCCGGTCTCCAAGGTGCGTGAGTTCGAGCAGGGTCTCCTGCTTGCCCTGCGCTCCCAGCATCCGGAGATCCTG
GAAGCCATCCGCTCGTCCAAGGAGATTTCCAAGGACACCACGGAGAAGCTGACGAAGGCCCTCGACGCCTTCGCCAAGAG
CTTTGCCTGA

Upstream 100 bases:

>100_bases
TCCTCGGTGGTCTCATCGTGAAGCTCGGCTCCCGCATGGTCGATGCCTCTCTCAAGACCAAACTCAATTCTATCCGGCAT
GCGATGAAAGAGGTCCGCTG

Downstream 100 bases:

>100_bases
GCGGCGCCTGTTCCTCGAACCTGACGGACGGGCACCATGGCGAGCCTGAAAGACCTAAGGAACCGCATCGCCTCGGTGAA
GGCGACGCAGAAGATCACCA

Product: F0F1 ATP synthase subunit alpha

Products: NA

Alternate protein names: ATP synthase F1 sector subunit alpha; F-ATPase subunit alpha [H]

Number of amino acids: Translated: 509; Mature: 509

Protein sequence:

>509_residues
MDIRAAEITAILKEQIQNFGQEAEVSEVGQVLSVGDGIARVYGLDNVQAGEMVEFENGTRGMALNLEIDNVGIVIFGSDR
EIKEGQTVKRTRAIVDAPVGKGLLGRVVDALGNPIDGKGPIVYTERRRVDVKAPGIIPRKSVHEPMQTGLKAIDALIPIG
RGQRELIIGDRQTGKTAVALDSILNQKPINQGTDEKAKLYCVYVAVGQKRSTVAQFVKVLEEQGALEYSIVVAATASDAA
PMQFLAPFTGTAMGEYFRDNGMHALIIHDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLNDSLGAGS
LTALPVIETQANDVSAYIPTNVISITDGQIFLESDLFYQGIRPAVNVGLSVSRVGSSAQIKAMKQVAGKIKGELAQYREL
AAFAQFGSDLDASTQKLLNRGARLTELLKQSQFSPLKVEEQVAVIFAGTNGYLDPLPVSKVREFEQGLLLALRSQHPEIL
EAIRSSKEISKDTTEKLTKALDAFAKSFA

Sequences:

>Translated_509_residues
MDIRAAEITAILKEQIQNFGQEAEVSEVGQVLSVGDGIARVYGLDNVQAGEMVEFENGTRGMALNLEIDNVGIVIFGSDR
EIKEGQTVKRTRAIVDAPVGKGLLGRVVDALGNPIDGKGPIVYTERRRVDVKAPGIIPRKSVHEPMQTGLKAIDALIPIG
RGQRELIIGDRQTGKTAVALDSILNQKPINQGTDEKAKLYCVYVAVGQKRSTVAQFVKVLEEQGALEYSIVVAATASDAA
PMQFLAPFTGTAMGEYFRDNGMHALIIHDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLNDSLGAGS
LTALPVIETQANDVSAYIPTNVISITDGQIFLESDLFYQGIRPAVNVGLSVSRVGSSAQIKAMKQVAGKIKGELAQYREL
AAFAQFGSDLDASTQKLLNRGARLTELLKQSQFSPLKVEEQVAVIFAGTNGYLDPLPVSKVREFEQGLLLALRSQHPEIL
EAIRSSKEISKDTTEKLTKALDAFAKSFA
>Mature_509_residues
MDIRAAEITAILKEQIQNFGQEAEVSEVGQVLSVGDGIARVYGLDNVQAGEMVEFENGTRGMALNLEIDNVGIVIFGSDR
EIKEGQTVKRTRAIVDAPVGKGLLGRVVDALGNPIDGKGPIVYTERRRVDVKAPGIIPRKSVHEPMQTGLKAIDALIPIG
RGQRELIIGDRQTGKTAVALDSILNQKPINQGTDEKAKLYCVYVAVGQKRSTVAQFVKVLEEQGALEYSIVVAATASDAA
PMQFLAPFTGTAMGEYFRDNGMHALIIHDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLNDSLGAGS
LTALPVIETQANDVSAYIPTNVISITDGQIFLESDLFYQGIRPAVNVGLSVSRVGSSAQIKAMKQVAGKIKGELAQYREL
AAFAQFGSDLDASTQKLLNRGARLTELLKQSQFSPLKVEEQVAVIFAGTNGYLDPLPVSKVREFEQGLLLALRSQHPEIL
EAIRSSKEISKDTTEKLTKALDAFAKSFA

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit [H]

COG id: COG0056

COG function: function code C; F0F1-type ATP synthase, alpha subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family [H]

Homologues:

Organism=Homo sapiens, GI50345984, Length=503, Percent_Identity=71.1729622266402, Blast_Score=739, Evalue=0.0,
Organism=Homo sapiens, GI4757810, Length=503, Percent_Identity=71.1729622266402, Blast_Score=739, Evalue=0.0,
Organism=Homo sapiens, GI19913428, Length=299, Percent_Identity=28.0936454849498, Blast_Score=109, Evalue=6e-24,
Organism=Homo sapiens, GI19913426, Length=338, Percent_Identity=28.1065088757396, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI32189394, Length=405, Percent_Identity=26.4197530864197, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI19913424, Length=322, Percent_Identity=24.8447204968944, Blast_Score=67, Evalue=6e-11,
Organism=Escherichia coli, GI1790172, Length=515, Percent_Identity=54.3689320388349, Blast_Score=556, Evalue=1e-159,
Organism=Escherichia coli, GI1790170, Length=423, Percent_Identity=25.7683215130024, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1788251, Length=343, Percent_Identity=27.4052478134111, Blast_Score=107, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71988063, Length=503, Percent_Identity=70.7753479125249, Blast_Score=736, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71988080, Length=503, Percent_Identity=70.7753479125249, Blast_Score=734, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71988074, Length=503, Percent_Identity=65.6063618290258, Blast_Score=669, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17510931, Length=298, Percent_Identity=29.8657718120805, Blast_Score=115, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI17570191, Length=294, Percent_Identity=29.9319727891156, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71988068, Length=76, Percent_Identity=55.2631578947368, Blast_Score=96, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI25144756, Length=377, Percent_Identity=25.1989389920424, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17509265, Length=50, Percent_Identity=70, Blast_Score=81, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6319370, Length=502, Percent_Identity=70.7171314741036, Blast_Score=738, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319603, Length=341, Percent_Identity=29.9120234604106, Blast_Score=121, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6322581, Length=378, Percent_Identity=26.1904761904762, Blast_Score=98, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24658560, Length=505, Percent_Identity=68.9108910891089, Blast_Score=722, Evalue=0.0,
Organism=Drosophila melanogaster, GI281361666, Length=304, Percent_Identity=29.6052631578947, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24646341, Length=304, Percent_Identity=29.6052631578947, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI17136796, Length=304, Percent_Identity=29.6052631578947, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24638766, Length=381, Percent_Identity=26.246719160105, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI28574560, Length=419, Percent_Identity=26.491646778043, Blast_Score=89, Evalue=5e-18,

Paralogues:

None

Copy number: 9,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR005294
- InterPro:   IPR017458
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100 [H]

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N [H]

EC number: =3.6.3.14 [H]

Molecular weight: Translated: 55191; Mature: 55191

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIRAAEITAILKEQIQNFGQEAEVSEVGQVLSVGDGIARVYGLDNVQAGEMVEFENGTR
CCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHCCCCCCCCCEEEECCCCC
GMALNLEIDNVGIVIFGSDREIKEGQTVKRTRAIVDAPVGKGLLGRVVDALGNPIDGKGP
CEEEEEEECCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCC
IVYTERRRVDVKAPGIIPRKSVHEPMQTGLKAIDALIPIGRGQRELIIGDRQTGKTAVAL
EEEECCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHH
DSILNQKPINQGTDEKAKLYCVYVAVGQKRSTVAQFVKVLEEQGALEYSIVVAATASDAA
HHHHCCCCCCCCCCCCEEEEEEEEEECCCHHHHHHHHHHHHHCCCEEEEEEEEEECCCCC
PMQFLAPFTGTAMGEYFRDNGMHALIIHDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFY
CHHHHCCCCHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHH
LHSRLLERAAKLNDSLGAGSLTALPVIETQANDVSAYIPTNVISITDGQIFLESDLFYQG
HHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCEEEECCCCEEEEECCEEEEECCHHHHC
IRPAVNVGLSVSRVGSSAQIKAMKQVAGKIKGELAQYRELAAFAQFGSDLDASTQKLLNR
CCHHHHCCEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHC
GARLTELLKQSQFSPLKVEEQVAVIFAGTNGYLDPLPVSKVREFEQGLLLALRSQHPEIL
CHHHHHHHHHCCCCCCEECCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHH
EAIRSSKEISKDTTEKLTKALDAFAKSFA
HHHHHHHHHCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDIRAAEITAILKEQIQNFGQEAEVSEVGQVLSVGDGIARVYGLDNVQAGEMVEFENGTR
CCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHCCCCCCCCCEEEECCCCC
GMALNLEIDNVGIVIFGSDREIKEGQTVKRTRAIVDAPVGKGLLGRVVDALGNPIDGKGP
CEEEEEEECCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCC
IVYTERRRVDVKAPGIIPRKSVHEPMQTGLKAIDALIPIGRGQRELIIGDRQTGKTAVAL
EEEECCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHH
DSILNQKPINQGTDEKAKLYCVYVAVGQKRSTVAQFVKVLEEQGALEYSIVVAATASDAA
HHHHCCCCCCCCCCCCEEEEEEEEEECCCHHHHHHHHHHHHHCCCEEEEEEEEEECCCCC
PMQFLAPFTGTAMGEYFRDNGMHALIIHDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFY
CHHHHCCCCHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHH
LHSRLLERAAKLNDSLGAGSLTALPVIETQANDVSAYIPTNVISITDGQIFLESDLFYQG
HHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCEEEECCCCEEEEECCEEEEECCHHHHC
IRPAVNVGLSVSRVGSSAQIKAMKQVAGKIKGELAQYRELAAFAQFGSDLDASTQKLLNR
CCHHHHCCEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHC
GARLTELLKQSQFSPLKVEEQVAVIFAGTNGYLDPLPVSKVREFEQGLLLALRSQHPEIL
CHHHHHHHHHCCCCCCEECCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHH
EAIRSSKEISKDTTEKLTKALDAFAKSFA
HHHHHHHHHCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA