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The map label for this gene is dxs [C]

Identifier: 154245984

GI number: 154245984

Start: 2299175

End: 2300167

Strand: Reverse

Name: dxs [C]

Synonym: Xaut_2041

Alternate gene names: 154245984

Gene position: 2300167-2299175 (Counterclockwise)

Preceding gene: 154245985

Following gene: 154245983

Centisome position: 43.33

GC content: 67.77

Gene sequence:

>993_bases
ATGAACCGGCCCCTTTCACCCAATTCCTGGCAATACCGCGAGCTGAACGCCAAGACCCCCGGCCTCAGCCACCTCTCCGA
CGCCCTGATCTCCCTGGTGGAGGCGGGAGAGCCGGTGGTGGCAGGCTCGGCGGACCTGCAATATTCCAACGGTCTCAATA
AGTTCGCCGCGCGCTATCCGGACCGCTACATCCAGTTCGGTATTTCCGAGCAGAACATGGTGACCGCCGCCGCCGGCCTC
GCCACCACCGGGCTCAAGCCCTATGTGGCGACGTTCGCCTCCTTCCTCGGGCTGTTGTGCTGCGAGCAGATCCGCATGGA
CGTGGCCTATTGCGCCCAGCCGGTGCGGCTCATCGGCCATCACACCGGCATCTCGCTGGGCTTCTACGGCACCTCCCACC
ACGCCACGGAAGACATCGCCACCATGCGGGCCATCGCCGACCTCACTGTGGTCTCGCCCGCCGACGGCCCGCAACTCGCG
GCCGCCATCAAGGCGTCGGCGGACTATCCCGAGCCCATCTATTTCCGCATCGGCCGGGGCCGCGAGCCGGACGTGTACCC
GCTCGACACCCCTTTCACCTTCGGCAAGGCCATCGAGCATCTGGTGGGCGAGGAGATCACCATCATCGCCTGCGGCATGA
CCGTGCATCCGGCGCTGGAGGCGGCACGGACGCTTAACGCGCAGGGCCATAGCGTGGGCGTCATCGACATGCCCACCGTC
AAGCCCCTCGACCGGGCCGCCATCCTTGCCGCCGCCGGGCGCTCGAAGGTGCTGATGAGCGTGGAGGAGCACAATGTGCT
GGGCGGCCTGGGCAGCGCCATCGCCGAGGTGTTGACTGACGAGGGCACCGGCGTGCGCCTGGTGCGCCACGGCATCCACG
ACGAATACAGCCTGATCGCGCCGCCCACCCACCTCTATGCCCATTACCGCCTCGACGCGGCGGGCATCGCCGAGGTGGCG
CGGGAGGCCATGGGGCTGCGCAAGGCGGCCTGA

Upstream 100 bases:

>100_bases
CGAACCCGGCTGGCACCTCGGCTATCTCGACCCCTCGGACGCCGCCCGCGCCGTCGAGGAAATCATGAACCGCACCATCT
GAGCCTAGGACACGCCTTTC

Downstream 100 bases:

>100_bases
TAGCGGCGCAAATCGAGAACGTGATCCCCGCGGCGCGGCCTGCGGGGACGACGCAGGGAGGACCAGAATGACCACCGCTG
AACAGCGCGCCCCTGAACCC

Product: transketolase central region

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MNRPLSPNSWQYRELNAKTPGLSHLSDALISLVEAGEPVVAGSADLQYSNGLNKFAARYPDRYIQFGISEQNMVTAAAGL
ATTGLKPYVATFASFLGLLCCEQIRMDVAYCAQPVRLIGHHTGISLGFYGTSHHATEDIATMRAIADLTVVSPADGPQLA
AAIKASADYPEPIYFRIGRGREPDVYPLDTPFTFGKAIEHLVGEEITIIACGMTVHPALEAARTLNAQGHSVGVIDMPTV
KPLDRAAILAAAGRSKVLMSVEEHNVLGGLGSAIAEVLTDEGTGVRLVRHGIHDEYSLIAPPTHLYAHYRLDAAGIAEVA
REAMGLRKAA

Sequences:

>Translated_330_residues
MNRPLSPNSWQYRELNAKTPGLSHLSDALISLVEAGEPVVAGSADLQYSNGLNKFAARYPDRYIQFGISEQNMVTAAAGL
ATTGLKPYVATFASFLGLLCCEQIRMDVAYCAQPVRLIGHHTGISLGFYGTSHHATEDIATMRAIADLTVVSPADGPQLA
AAIKASADYPEPIYFRIGRGREPDVYPLDTPFTFGKAIEHLVGEEITIIACGMTVHPALEAARTLNAQGHSVGVIDMPTV
KPLDRAAILAAAGRSKVLMSVEEHNVLGGLGSAIAEVLTDEGTGVRLVRHGIHDEYSLIAPPTHLYAHYRLDAAGIAEVA
REAMGLRKAA
>Mature_330_residues
MNRPLSPNSWQYRELNAKTPGLSHLSDALISLVEAGEPVVAGSADLQYSNGLNKFAARYPDRYIQFGISEQNMVTAAAGL
ATTGLKPYVATFASFLGLLCCEQIRMDVAYCAQPVRLIGHHTGISLGFYGTSHHATEDIATMRAIADLTVVSPADGPQLA
AAIKASADYPEPIYFRIGRGREPDVYPLDTPFTFGKAIEHLVGEEITIIACGMTVHPALEAARTLNAQGHSVGVIDMPTV
KPLDRAAILAAAGRSKVLMSVEEHNVLGGLGSAIAEVLTDEGTGVRLVRHGIHDEYSLIAPPTHLYAHYRLDAAGIAEVA
REAMGLRKAA

Specific function: Catalyzes The Acyloin Condensation Reaction Between C Atoms 2 And 3 Of Pyruvate And Glyceraldehyde 3-Phosphate To Yield 1-Deoxy-D-Xylulose-5-Phosphate (Dxp). [C]

COG id: COG3958

COG function: function code G; Transketolase, C-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=298, Percent_Identity=32.5503355704698, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI4507521, Length=298, Percent_Identity=32.5503355704698, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI133778974, Length=270, Percent_Identity=36.2962962962963, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI225637459, Length=256, Percent_Identity=33.984375, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI225637461, Length=256, Percent_Identity=33.984375, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI225637463, Length=256, Percent_Identity=33.984375, Blast_Score=130, Evalue=2e-30,
Organism=Escherichia coli, GI1786622, Length=295, Percent_Identity=30.5084745762712, Blast_Score=125, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17539652, Length=293, Percent_Identity=32.0819112627986, Blast_Score=125, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6325331, Length=244, Percent_Identity=27.4590163934426, Blast_Score=80, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6319593, Length=274, Percent_Identity=26.6423357664234, Blast_Score=73, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24645119, Length=304, Percent_Identity=31.5789473684211, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI45551847, Length=304, Percent_Identity=31.5789473684211, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI45550715, Length=304, Percent_Identity=31.5789473684211, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24666278, Length=276, Percent_Identity=30.7971014492754, Blast_Score=100, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 35210; Mature: 35210

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRPLSPNSWQYRELNAKTPGLSHLSDALISLVEAGEPVVAGSADLQYSNGLNKFAARYP
CCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCEEECCCCCCHHCCHHHHHHHCC
DRYIQFGISEQNMVTAAAGLATTGLKPYVATFASFLGLLCCEQIRMDVAYCAQPVRLIGH
CHHEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
HTGISLGFYGTSHHATEDIATMRAIADLTVVSPADGPQLAAAIKASADYPEPIYFRIGRG
CCCEEEEECCCCCCCHHHHHHHHHHHHEEEECCCCCHHHHHHHHCCCCCCCCEEEEECCC
REPDVYPLDTPFTFGKAIEHLVGEEITIIACGMTVHPALEAARTLNAQGHSVGVIDMPTV
CCCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCCCCCEEEEEECCCC
KPLDRAAILAAAGRSKVLMSVEEHNVLGGLGSAIAEVLTDEGTGVRLVRHGIHDEYSLIA
CCHHHHHHHHHCCCCEEEEEEHHCCHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCEEEC
PPTHLYAHYRLDAAGIAEVAREAMGLRKAA
CCHHEEEEEEECHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNRPLSPNSWQYRELNAKTPGLSHLSDALISLVEAGEPVVAGSADLQYSNGLNKFAARYP
CCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCEEECCCCCCHHCCHHHHHHHCC
DRYIQFGISEQNMVTAAAGLATTGLKPYVATFASFLGLLCCEQIRMDVAYCAQPVRLIGH
CHHEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
HTGISLGFYGTSHHATEDIATMRAIADLTVVSPADGPQLAAAIKASADYPEPIYFRIGRG
CCCEEEEECCCCCCCHHHHHHHHHHHHEEEECCCCCHHHHHHHHCCCCCCCCEEEEECCC
REPDVYPLDTPFTFGKAIEHLVGEEITIIACGMTVHPALEAARTLNAQGHSVGVIDMPTV
CCCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCCCCCEEEEEECCCC
KPLDRAAILAAAGRSKVLMSVEEHNVLGGLGSAIAEVLTDEGTGVRLVRHGIHDEYSLIA
CCHHHHHHHHHCCCCEEEEEEHHCCHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCEEEC
PPTHLYAHYRLDAAGIAEVAREAMGLRKAA
CCHHEEEEEEECHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]