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The map label for this gene is fadN [H]

Identifier: 154244576

GI number: 154244576

Start: 698923

End: 701220

Strand: Reverse

Name: fadN [H]

Synonym: Xaut_0624

Alternate gene names: 154244576

Gene position: 701220-698923 (Counterclockwise)

Preceding gene: 154244577

Following gene: 154244575

Centisome position: 13.21

GC content: 69.93

Gene sequence:

>2298_bases
ATGGGCCAGATCCGCAAGACCGGCGTCATCGGCGCCGGCGTCATGGGATCGGGCATCGCCGCCCACCTCGCCAATGCCGG
GCTCGACGTGGTGCTGCTGGACGTGGAGGCGGCGACCGCCGCCGCGGCGGTGACAAAGCAGCTGAAGGCCGGCGGCTTCA
TGGATGCCGCCTTCGCCGAGCGGGTCGTCACCGGCTCGGTGAGCAGCGACATGCCGATGCTGTCCGACGCCGACCTGATC
ATCGAGGCGGTGGCGGAGCGGCTCGACGTGAAGCAGGGCCTCTATGGCCGCATCGAAGCGGTGCGCAAGCCGGGCTCCAT
CGTCAGTTCGAACACCTCCACCATCCCGCTGTCGGCGCTGGTGGAGGGCCTGCCAGAGGGCTTTGCCGCCGACTTCCTCG
TCACCCATTTCTTCAACCCGCCACGCACCATGCCCCTGCTGGAGCTGGTGGCGGGGCCCCGGACCCGGCCCGAGGCGCTG
GAAACAATCCGCGACTTCGGCGACCGAGTCCTCGGCAAGAGCGTGGTCGTTTGCCGCGATACGCCCGGCTTCATAGCCAA
CCGCGTCGGCAATTACTGGATGGCCGCCGCGGTAAACGAGGCCATCGCCCTGGGACTTGACGTGGAAGTGGCGGACGCAG
CCATCTCGAAGCCCTTCGGTATCCCGAAGACCGGTATTTTCGGGCTCATGGACCTGGTGGGGATCGACCTCATGTCGATG
GTGCTGCGCTCCCTGCACGACGCGCTGCCGCCGTCCGACCCCATGCAGGACTATCCCGTCGAGCCTGCGCTCCTCGCCCG
CATGGTCGGCGAGAAGCGCCTCGGCCGCAAAAGCGGCGCCGGCTTCGTCAAGCTCTCGGCCGATCGCAAGAGCCGGGAGG
TGACGGATCTCGTCACCGGCGCATATCGCCCGCAGAAGAAGGTGGAGAGCGACGCCCTCGACGCCGCCAAAGGCGACGCC
CGCGCGCTGATGCAGCATGACGGCGCCGCCGGGCGTTATGCCTCGGCGGTGATGGAAAAGGCGCTGGCCTATGCCGCCCG
CGTCACGCCCGAGATCGCCGACGGACCGGATGCGGTGGATACGGCCATGCGCGGCGGCTATGGCTGGGCGAAAGGGCCGT
TTGAGCTGATCGATCAGCTGGGGGCCGGCTGGCTTGTTGCGCGCCTTGAGAAACGCGGCGTTCCGGTGCCCGACTTTCTC
GCCAAAGCGGCGGCTGCGGGCGGCTTCTACGCCATCGAGAACGGCGCGCGCACCTGCCTGCTGCCAGACGGTACCCGCCG
CAAGGTCGCGCAGGCCGATGGGGTCATCACCCTGGCCGCGGTCCAGCTTGCCTCCAAGCCTGTCGAGGACTGGGGCACGG
CCCGGCTGTGGGATCTGGGCGACGGCATCGCCTGCTTCGAGATCCGCAGCAAGATGAATACCTTCGGCGCTCCCGTGCTG
GACGCGCTGGAGGCGACGCTGGCCCGCGTCCAGCAGAGCTTCAAGGGCCTCGTCATCGGCTCCGATGCGCCGCTGTTCAG
CGCCGGCGCGGACATCCGCGTGTTCCTTGAAACCGTGGAGACGAGTGGGCCTGCCGCCTTCGGCGCATCCATCGATCGCG
GCCACCGGTTGTTCAAGGCGGTGAAATATGCCCCCTTCCCGGTGGTGGGCGCGGCCGCGGGCCTCGCCTTCGGCGGCGGC
TGCGAGCTGCTGCTGCACTGCCGGGCCATCCAGGCCCATGCGGAACTGACCATCGGCCTCGTGGAGCCCCGCATCGGCGT
GGTGCCCGGCTGGGGCGGCTGCAAGGAGATGCTGCTACGTTTCGCCGAAGGCCATGCGAGCGCGAAGGGCCCGGTGGCAC
CGGCGCTCGCCGCCTTCGGCGTGATCGCGCCGGCAAAGGTCTCCAGCAGCGCGTTCGAGGCCCGCCGCCTCGGCTTTCTG
CGCCCCACCGATGGCATCACCATGAACCGCGACCGCCTGCTCGCCGATGCCAAGGCGAAAGCCCTTGCGCTGGCGGAGGA
TTACGCCCCGCCCGCCCCGCCGAGCCTCACCCTGTCCGGCCCCTCCGGCGCCTCGGCCCTGCGCAACGTGCTCGACACCG
AGGCCATGGCTGGCCGCCTCACCGCCCATGACCTTGTGGTGGGCGAGGCCCTCGCGAGCGTGCTTACCGGCGGCCCCGAT
GCCGATCCCGCCCGGCCGGTCGACGAGGACGCGGTGACGGCGCTGGAGCGCGCCGCCTTCATCGCCCTGCTTGGCGAGCC
GGCCACGCTGGAGCGCATCCGCCACATGCTCGCGACCGGCAAGCCCCTGCGCAACTGA

Upstream 100 bases:

>100_bases
AGGCGGCGCAGCTCCTGAAGCGCGACGGCGGGCGCTATGGCCTTGCCACCCAGTGTATCGGCGGCGGGCAGGGCATCGCC
CTCGTGCTGGAGGCCGCGTG

Downstream 100 bases:

>100_bases
TCTTCGACGCAAACCCATTTCGAGGCAAAACCCATGGCCACCTATACCGCGCCCGTCGACGACATCGGCTTCCTGCTGAC
GCGCGTTTTCGACTTCGATG

Product: NAD-binding 3-hydroxyacyl-CoA dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 765; Mature: 764

Protein sequence:

>765_residues
MGQIRKTGVIGAGVMGSGIAAHLANAGLDVVLLDVEAATAAAAVTKQLKAGGFMDAAFAERVVTGSVSSDMPMLSDADLI
IEAVAERLDVKQGLYGRIEAVRKPGSIVSSNTSTIPLSALVEGLPEGFAADFLVTHFFNPPRTMPLLELVAGPRTRPEAL
ETIRDFGDRVLGKSVVVCRDTPGFIANRVGNYWMAAAVNEAIALGLDVEVADAAISKPFGIPKTGIFGLMDLVGIDLMSM
VLRSLHDALPPSDPMQDYPVEPALLARMVGEKRLGRKSGAGFVKLSADRKSREVTDLVTGAYRPQKKVESDALDAAKGDA
RALMQHDGAAGRYASAVMEKALAYAARVTPEIADGPDAVDTAMRGGYGWAKGPFELIDQLGAGWLVARLEKRGVPVPDFL
AKAAAAGGFYAIENGARTCLLPDGTRRKVAQADGVITLAAVQLASKPVEDWGTARLWDLGDGIACFEIRSKMNTFGAPVL
DALEATLARVQQSFKGLVIGSDAPLFSAGADIRVFLETVETSGPAAFGASIDRGHRLFKAVKYAPFPVVGAAAGLAFGGG
CELLLHCRAIQAHAELTIGLVEPRIGVVPGWGGCKEMLLRFAEGHASAKGPVAPALAAFGVIAPAKVSSSAFEARRLGFL
RPTDGITMNRDRLLADAKAKALALAEDYAPPAPPSLTLSGPSGASALRNVLDTEAMAGRLTAHDLVVGEALASVLTGGPD
ADPARPVDEDAVTALERAAFIALLGEPATLERIRHMLATGKPLRN

Sequences:

>Translated_765_residues
MGQIRKTGVIGAGVMGSGIAAHLANAGLDVVLLDVEAATAAAAVTKQLKAGGFMDAAFAERVVTGSVSSDMPMLSDADLI
IEAVAERLDVKQGLYGRIEAVRKPGSIVSSNTSTIPLSALVEGLPEGFAADFLVTHFFNPPRTMPLLELVAGPRTRPEAL
ETIRDFGDRVLGKSVVVCRDTPGFIANRVGNYWMAAAVNEAIALGLDVEVADAAISKPFGIPKTGIFGLMDLVGIDLMSM
VLRSLHDALPPSDPMQDYPVEPALLARMVGEKRLGRKSGAGFVKLSADRKSREVTDLVTGAYRPQKKVESDALDAAKGDA
RALMQHDGAAGRYASAVMEKALAYAARVTPEIADGPDAVDTAMRGGYGWAKGPFELIDQLGAGWLVARLEKRGVPVPDFL
AKAAAAGGFYAIENGARTCLLPDGTRRKVAQADGVITLAAVQLASKPVEDWGTARLWDLGDGIACFEIRSKMNTFGAPVL
DALEATLARVQQSFKGLVIGSDAPLFSAGADIRVFLETVETSGPAAFGASIDRGHRLFKAVKYAPFPVVGAAAGLAFGGG
CELLLHCRAIQAHAELTIGLVEPRIGVVPGWGGCKEMLLRFAEGHASAKGPVAPALAAFGVIAPAKVSSSAFEARRLGFL
RPTDGITMNRDRLLADAKAKALALAEDYAPPAPPSLTLSGPSGASALRNVLDTEAMAGRLTAHDLVVGEALASVLTGGPD
ADPARPVDEDAVTALERAAFIALLGEPATLERIRHMLATGKPLRN
>Mature_764_residues
GQIRKTGVIGAGVMGSGIAAHLANAGLDVVLLDVEAATAAAAVTKQLKAGGFMDAAFAERVVTGSVSSDMPMLSDADLII
EAVAERLDVKQGLYGRIEAVRKPGSIVSSNTSTIPLSALVEGLPEGFAADFLVTHFFNPPRTMPLLELVAGPRTRPEALE
TIRDFGDRVLGKSVVVCRDTPGFIANRVGNYWMAAAVNEAIALGLDVEVADAAISKPFGIPKTGIFGLMDLVGIDLMSMV
LRSLHDALPPSDPMQDYPVEPALLARMVGEKRLGRKSGAGFVKLSADRKSREVTDLVTGAYRPQKKVESDALDAAKGDAR
ALMQHDGAAGRYASAVMEKALAYAARVTPEIADGPDAVDTAMRGGYGWAKGPFELIDQLGAGWLVARLEKRGVPVPDFLA
KAAAAGGFYAIENGARTCLLPDGTRRKVAQADGVITLAAVQLASKPVEDWGTARLWDLGDGIACFEIRSKMNTFGAPVLD
ALEATLARVQQSFKGLVIGSDAPLFSAGADIRVFLETVETSGPAAFGASIDRGHRLFKAVKYAPFPVVGAAAGLAFGGGC
ELLLHCRAIQAHAELTIGLVEPRIGVVPGWGGCKEMLLRFAEGHASAKGPVAPALAAFGVIAPAKVSSSAFEARRLGFLR
PTDGITMNRDRLLADAKAKALALAEDYAPPAPPSLTLSGPSGASALRNVLDTEAMAGRLTAHDLVVGEALASVLTGGPDA
DPARPVDEDAVTALERAAFIALLGEPATLERIRHMLATGKPLRN

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=299, Percent_Identity=31.1036789297659, Blast_Score=123, Evalue=7e-28,
Organism=Homo sapiens, GI296179427, Length=316, Percent_Identity=30.0632911392405, Blast_Score=120, Evalue=5e-27,
Organism=Homo sapiens, GI20127408, Length=411, Percent_Identity=28.4671532846715, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI68989263, Length=437, Percent_Identity=25.858123569794, Blast_Score=94, Evalue=6e-19,
Organism=Homo sapiens, GI261878539, Length=437, Percent_Identity=25.858123569794, Blast_Score=94, Evalue=6e-19,
Organism=Homo sapiens, GI115430219, Length=192, Percent_Identity=28.125, Blast_Score=70, Evalue=1e-11,
Organism=Escherichia coli, GI1787661, Length=460, Percent_Identity=29.5652173913043, Blast_Score=131, Evalue=2e-31,
Organism=Escherichia coli, GI1790281, Length=305, Percent_Identity=29.1803278688525, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI1788682, Length=335, Percent_Identity=29.8507462686567, Blast_Score=100, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17549919, Length=297, Percent_Identity=33.6700336700337, Blast_Score=142, Evalue=8e-34,
Organism=Caenorhabditis elegans, GI17553560, Length=300, Percent_Identity=33.6666666666667, Blast_Score=134, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17508953, Length=409, Percent_Identity=30.5623471882641, Blast_Score=115, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI17508951, Length=409, Percent_Identity=30.5623471882641, Blast_Score=115, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17558304, Length=429, Percent_Identity=29.3706293706294, Blast_Score=109, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI25144276, Length=320, Percent_Identity=31.875, Blast_Score=108, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71985923, Length=297, Percent_Identity=25.2525252525253, Blast_Score=99, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI17563036, Length=294, Percent_Identity=29.9319727891156, Blast_Score=97, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71985930, Length=302, Percent_Identity=24.8344370860927, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI19921000, Length=413, Percent_Identity=29.0556900726392, Blast_Score=110, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24583077, Length=413, Percent_Identity=29.0556900726392, Blast_Score=110, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24583079, Length=413, Percent_Identity=29.0556900726392, Blast_Score=110, Evalue=5e-24,
Organism=Drosophila melanogaster, GI45549573, Length=251, Percent_Identity=30.6772908366534, Blast_Score=107, Evalue=4e-23,
Organism=Drosophila melanogaster, GI20129993, Length=227, Percent_Identity=30.3964757709251, Blast_Score=84, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR001753
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N; PF00378 ECH [H]

EC number: =1.1.1.35 [H]

Molecular weight: Translated: 79805; Mature: 79674

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGQIRKTGVIGAGVMGSGIAAHLANAGLDVVLLDVEAATAAAAVTKQLKAGGFMDAAFAE
CCCCCCCCCEECCHHHCHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHCCCCHHHHHHH
RVVTGSVSSDMPMLSDADLIIEAVAERLDVKQGLYGRIEAVRKPGSIVSSNTSTIPLSAL
HHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCEECCCCCCCCHHHH
VEGLPEGFAADFLVTHFFNPPRTMPLLELVAGPRTRPEALETIRDFGDRVLGKSVVVCRD
HHHCCCHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCEEEEEC
TPGFIANRVGNYWMAAAVNEAIALGLDVEVADAAISKPFGIPKTGIFGLMDLVGIDLMSM
CCCHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
VLRSLHDALPPSDPMQDYPVEPALLARMVGEKRLGRKSGAGFVKLSADRKSREVTDLVTG
HHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHC
AYRPQKKVESDALDAAKGDARALMQHDGAAGRYASAVMEKALAYAARVTPEIADGPDAVD
CCCCHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
TAMRGGYGWAKGPFELIDQLGAGWLVARLEKRGVPVPDFLAKAAAAGGFYAIENGARTCL
HHHHCCCCCCCCHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHCCCEEEEECCCCEEE
LPDGTRRKVAQADGVITLAAVQLASKPVEDWGTARLWDLGDGIACFEIRSKMNTFGAPVL
CCCCCHHHHHHHCCEEEHHHHHHHCCCHHHCCCEEEEECCCCEEHHHHHHHHHHCCCHHH
DALEATLARVQQSFKGLVIGSDAPLFSAGADIRVFLETVETSGPAAFGASIDRGHRLFKA
HHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCEEHEEHHHCCCCCHHCCCHHHHHHHHHH
VKYAPFPVVGAAAGLAFGGGCELLLHCRAIQAHAELTIGLVEPRIGVVPGWGGCKEMLLR
HHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHEEEEEEECCCCEECCCCCCHHHHHHH
FAEGHASAKGPVAPALAAFGVIAPAKVSSSAFEARRLGFLRPTDGITMNRDRLLADAKAK
HHHCCCCCCCCCHHHHHHHHCCCCHHHCHHHHHHHHCCCCCCCCCCEECHHHHHHHHHHH
ALALAEDYAPPAPPSLTLSGPSGASALRNVLDTEAMAGRLTAHDLVVGEALASVLTGGPD
HHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCC
ADPARPVDEDAVTALERAAFIALLGEPATLERIRHMLATGKPLRN
CCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
GQIRKTGVIGAGVMGSGIAAHLANAGLDVVLLDVEAATAAAAVTKQLKAGGFMDAAFAE
CCCCCCCCEECCHHHCHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHCCCCHHHHHHH
RVVTGSVSSDMPMLSDADLIIEAVAERLDVKQGLYGRIEAVRKPGSIVSSNTSTIPLSAL
HHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCEECCCCCCCCHHHH
VEGLPEGFAADFLVTHFFNPPRTMPLLELVAGPRTRPEALETIRDFGDRVLGKSVVVCRD
HHHCCCHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCEEEEEC
TPGFIANRVGNYWMAAAVNEAIALGLDVEVADAAISKPFGIPKTGIFGLMDLVGIDLMSM
CCCHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
VLRSLHDALPPSDPMQDYPVEPALLARMVGEKRLGRKSGAGFVKLSADRKSREVTDLVTG
HHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHC
AYRPQKKVESDALDAAKGDARALMQHDGAAGRYASAVMEKALAYAARVTPEIADGPDAVD
CCCCHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
TAMRGGYGWAKGPFELIDQLGAGWLVARLEKRGVPVPDFLAKAAAAGGFYAIENGARTCL
HHHHCCCCCCCCHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHCCCEEEEECCCCEEE
LPDGTRRKVAQADGVITLAAVQLASKPVEDWGTARLWDLGDGIACFEIRSKMNTFGAPVL
CCCCCHHHHHHHCCEEEHHHHHHHCCCHHHCCCEEEEECCCCEEHHHHHHHHHHCCCHHH
DALEATLARVQQSFKGLVIGSDAPLFSAGADIRVFLETVETSGPAAFGASIDRGHRLFKA
HHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCEEHEEHHHCCCCCHHCCCHHHHHHHHHH
VKYAPFPVVGAAAGLAFGGGCELLLHCRAIQAHAELTIGLVEPRIGVVPGWGGCKEMLLR
HHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHEEEEEEECCCCEECCCCCCHHHHHHH
FAEGHASAKGPVAPALAAFGVIAPAKVSSSAFEARRLGFLRPTDGITMNRDRLLADAKAK
HHHCCCCCCCCCHHHHHHHHCCCCHHHCHHHHHHHHCCCCCCCCCCEECHHHHHHHHHHH
ALALAEDYAPPAPPSLTLSGPSGASALRNVLDTEAMAGRLTAHDLVVGEALASVLTGGPD
HHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCC
ADPARPVDEDAVTALERAAFIALLGEPATLERIRHMLATGKPLRN
CCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]