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The map label for this gene is macA [H]

Identifier: 154244339

GI number: 154244339

Start: 396373

End: 397563

Strand: Reverse

Name: macA [H]

Synonym: Xaut_0382

Alternate gene names: 154244339

Gene position: 397563-396373 (Counterclockwise)

Preceding gene: 154244340

Following gene: 154244338

Centisome position: 7.49

GC content: 70.03

Gene sequence:

>1191_bases
GTGAAGCCGCAGCCCCTTCCCCCCGCCCTGGTCGAGACGGACTATTCCGCCGGCTGGCGCCGCCTCACCATCGCGCTCGC
CGTCGCCGTGGTGGCGGGACTGCTGCTCGGCTACTGGTATGTGGTGCCGCGCACCGCCGCCTGGCACCAGGTGCAGCCCC
GCCCCATGAGCCTTGAAATCAACGGGCCGGGCCTGCTCGACGCCATCAACCGCGTGGTGGTGACGAGCCGCATCCAGGGC
TTCCTCAAGTCCATCGAGGTGGACAAGAACGATGTGGTGAAGAAGGGCGAGGTGCTGGCGCGGCTGGAATCGGTGGACCT
CCAGAACCAGCTCGCCGCCGCCCAGGCGCAGGCCAGCGCCGCCGCCCTCGGCATCACCGGGAGCGAGAGTGAACGCGCCC
GCGCCAAGGCCGGCTTTGACCGGGCCAAGATCGAGTTCGAACGGCGCACCACCCTCGCCCGCACCAATGTCATCTCCCCC
GCCGAGCTGACCACCGCCGAATCCAACTTCCTGCAGGCCCAGGCGGAGATGGCCCGCGCCGACGCCGCCATAGAGCGCTC
GAAGGCGGAGCTGCTCGCCCAGGAGGCGAACGTGAAGGTGCTGGAGGCCCGCCTTGCCGATGCCACCATCACCTCACCGC
TCGACGGCGTGGTGATCTCGCGCGAGCGTAATCCCGGCGACCTGCTGTTGCCCGGCGCCAACCTGATGCAGGTGGTGGAG
CTATCCACCATCATCATATCCGCGCGCTTCGACGAATCCGCCCGCTCCTCCATCAGGCCGGGGCAGGCGGCGCGCATCCG
CTTCGCCTCCGATCCCACGCGGGTGTGGACCGGGCAGGTGCTGCGCCTGTCGCGGCAGGTGGACCAGGAGACCCGCGAGT
TCACCATCGACATCACCCTTGATGCCCTCCCCGAAAGCTGGGCCATCGGGCAGCGCGCCAATGTGGCGGTGGAAGCGCAA
TCCCCGGCGATGGCCATCGGCGTGCCGGAAACCTTCGTGACCCGCCGCGACGGGCGCGCCGGCGTCTGGCTGGCGCGGTC
GGGCCGGGCCACCTGGACCCCGGTGGCGCTCGGCTATACCAGCGGCACCAACATCGAGGTCTCGCGCGGCCTGAAGGCCG
GCGACGTGGTGCTGTCGCCGGTCGGCCGCTACTCTTTCGAGCCGGTCGACCTCGGGGAAGAGGTGCCCTGA

Upstream 100 bases:

>100_bases
GTGGCCTCCATCGTGGATACCGACGCGGAGGAGGAGACCGCGTGAGCAAGGCAGCCATCGCCCGCAGGGGCGGACGCCTT
CCGCCTGCGGAGGGGACACG

Downstream 100 bases:

>100_bases
CGCCAATGGGCGCAACTGGCGGCGGAGGCGCAGGCCCATGAACATCGCCCTCAAGGACATGCGGTTCTCGATGCTGCGCT
TCGCCCTCACGGCGGTGGGC

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MKPQPLPPALVETDYSAGWRRLTIALAVAVVAGLLLGYWYVVPRTAAWHQVQPRPMSLEINGPGLLDAINRVVVTSRIQG
FLKSIEVDKNDVVKKGEVLARLESVDLQNQLAAAQAQASAAALGITGSESERARAKAGFDRAKIEFERRTTLARTNVISP
AELTTAESNFLQAQAEMARADAAIERSKAELLAQEANVKVLEARLADATITSPLDGVVISRERNPGDLLLPGANLMQVVE
LSTIIISARFDESARSSIRPGQAARIRFASDPTRVWTGQVLRLSRQVDQETREFTIDITLDALPESWAIGQRANVAVEAQ
SPAMAIGVPETFVTRRDGRAGVWLARSGRATWTPVALGYTSGTNIEVSRGLKAGDVVLSPVGRYSFEPVDLGEEVP

Sequences:

>Translated_396_residues
MKPQPLPPALVETDYSAGWRRLTIALAVAVVAGLLLGYWYVVPRTAAWHQVQPRPMSLEINGPGLLDAINRVVVTSRIQG
FLKSIEVDKNDVVKKGEVLARLESVDLQNQLAAAQAQASAAALGITGSESERARAKAGFDRAKIEFERRTTLARTNVISP
AELTTAESNFLQAQAEMARADAAIERSKAELLAQEANVKVLEARLADATITSPLDGVVISRERNPGDLLLPGANLMQVVE
LSTIIISARFDESARSSIRPGQAARIRFASDPTRVWTGQVLRLSRQVDQETREFTIDITLDALPESWAIGQRANVAVEAQ
SPAMAIGVPETFVTRRDGRAGVWLARSGRATWTPVALGYTSGTNIEVSRGLKAGDVVLSPVGRYSFEPVDLGEEVP
>Mature_396_residues
MKPQPLPPALVETDYSAGWRRLTIALAVAVVAGLLLGYWYVVPRTAAWHQVQPRPMSLEINGPGLLDAINRVVVTSRIQG
FLKSIEVDKNDVVKKGEVLARLESVDLQNQLAAAQAQASAAALGITGSESERARAKAGFDRAKIEFERRTTLARTNVISP
AELTTAESNFLQAQAEMARADAAIERSKAELLAQEANVKVLEARLADATITSPLDGVVISRERNPGDLLLPGANLMQVVE
LSTIIISARFDESARSSIRPGQAARIRFASDPTRVWTGQVLRLSRQVDQETREFTIDITLDALPESWAIGQRANVAVEAQ
SPAMAIGVPETFVTRRDGRAGVWLARSGRATWTPVALGYTSGTNIEVSRGLKAGDVVLSPVGRYSFEPVDLGEEVP

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=381, Percent_Identity=25.4593175853018, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1787013, Length=251, Percent_Identity=27.0916334661355, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1789041, Length=234, Percent_Identity=26.4957264957265, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1788711, Length=211, Percent_Identity=24.1706161137441, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 42806; Mature: 42806

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPQPLPPALVETDYSAGWRRLTIALAVAVVAGLLLGYWYVVPRTAAWHQVQPRPMSLEI
CCCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEE
NGPGLLDAINRVVVTSRIQGFLKSIEVDKNDVVKKGEVLARLESVDLQNQLAAAQAQASA
CCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCC
AALGITGSESERARAKAGFDRAKIEFERRTTLARTNVISPAELTTAESNFLQAQAEMARA
EEEEECCCCCHHHHHHCCCCHHEEEEHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHHH
DAAIERSKAELLAQEANVKVLEARLADATITSPLDGVVISRERNPGDLLLPGANLMQVVE
HHHHHHHHHHHHHHHCCEEEEEEHHCCCEECCCCCCEEEECCCCCCCEEECCHHHHHHHH
LSTIIISARFDESARSSIRPGQAARIRFASDPTRVWTGQVLRLSRQVDQETREFTIDITL
HEEEEEEEECCHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEE
DALPESWAIGQRANVAVEAQSPAMAIGVPETFVTRRDGRAGVWLARSGRATWTPVALGYT
ECCCCCCCCCCCCCEEEEECCCEEEEECCHHHHCCCCCCCEEEEEECCCCEECEEEEEEC
SGTNIEVSRGLKAGDVVLSPVGRYSFEPVDLGEEVP
CCCCEEEECCCCCCCEEECCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKPQPLPPALVETDYSAGWRRLTIALAVAVVAGLLLGYWYVVPRTAAWHQVQPRPMSLEI
CCCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEE
NGPGLLDAINRVVVTSRIQGFLKSIEVDKNDVVKKGEVLARLESVDLQNQLAAAQAQASA
CCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCC
AALGITGSESERARAKAGFDRAKIEFERRTTLARTNVISPAELTTAESNFLQAQAEMARA
EEEEECCCCCHHHHHHCCCCHHEEEEHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHHH
DAAIERSKAELLAQEANVKVLEARLADATITSPLDGVVISRERNPGDLLLPGANLMQVVE
HHHHHHHHHHHHHHHCCEEEEEEHHCCCEECCCCCCEEEECCCCCCCEEECCHHHHHHHH
LSTIIISARFDESARSSIRPGQAARIRFASDPTRVWTGQVLRLSRQVDQETREFTIDITL
HEEEEEEEECCHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEE
DALPESWAIGQRANVAVEAQSPAMAIGVPETFVTRRDGRAGVWLARSGRATWTPVALGYT
ECCCCCCCCCCCCCEEEEECCCEEEEECCHHHHCCCCCCCEEEEEECCCCEECEEEEEEC
SGTNIEVSRGLKAGDVVLSPVGRYSFEPVDLGEEVP
CCCCEEEECCCCCCCEEECCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]