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The map label for this gene is thrS [H]

Identifier: 153950233

GI number: 153950233

Start: 1980969

End: 1982897

Strand: Direct

Name: thrS [H]

Synonym: YpsIP31758_1712

Alternate gene names: 153950233

Gene position: 1980969-1982897 (Clockwise)

Preceding gene: 153950635

Following gene: 153948799

Centisome position: 41.94

GC content: 47.33

Gene sequence:

>1929_bases
ATGCCTGTTATTACCCTTCCTGATGGCAGTCAGCGTCATTATGACCATGCTGTTTCTGTCCTTGATGTTGCTCTTGATAT
CGGCCCTGGCTTAGCAAAAGCCTGCATTGCCGGTCGGGTGAATGGTGAGCTGGTGGATGCCAGTGATCTGATTGAGTCCG
ATGCTCAGTTGGCGATTATCACCGCCAAAGATGCTGAAGGTTTGGAGATTCTTCGCCATTCCTGCGCGCATTTGTTGGGA
CACGCTATCAAGCAACTCTGGCCAGATACCAAAATGGCTATTGGTCCAGTTATTGACAACGGTTTTTATTACGATGTTGA
TATCGAACATACTCTGACGCAGGAAGACTTGGCACTGCTGGAAAAGCGGATGCACGAGCTTGCCGATAAAGATTATGACG
TGATCAAGAAAAAAGTCAGTTGGCAAGAAGCCCGTGATACTTTTGCTGCTCGGGGCGAAGATTATAAAGTGGCTATTCTT
GATGAGAATATCAGTCGCGATGATCGTCCGGGCTTGTATCACCATGAAGAATACGTTGATATGTGCCGTGGTCCGCACGT
ACCGAATATGCGTTTCTGCCATCACTTTAAATTGCAGAAAACTTCCGGTGCTTATTGGCGTGGCGACAGCAAAAATAAAA
TGCTGCAACGTATCTATGGCACAGCTTGGGGTGATAAGAAGCAACTGAATGCTTATCTGCAACGCTTGGAAGAGGCGGCG
AAACGCGACCATCGTAAGATTGGTAAGCAACTCGATCTCTACCACATGCAGGAAGAAGCACCAGGCATGGTGTTCTGGCA
CAACGATGGTTGGACAATTTTCCGCGAATTGGAAACCTTTGTGCGTATGAAGCTCAAAGAGTACCAGTATCAGGAAGTGA
AAGGTCCATTTATGATGGATCGCGTACTGTGGGAAAAAACGGGGCATTGGGAAAACTACGCCGAGCATATGTTCACGACC
TCTTCGGAGAATCGTGAGTACTGCATTAAGCCAATGAACTGCCCCGGACACGTACAAATTTTCAATCAAGGATTGAAATC
TTACCGTGACCTGCCGCTGCGTATGGCTGAATTTGGTAGTTGCCACCGTAATGAACCTTCGGGCGCCCTACATGGCTTAA
TGCGTGTTCGTGGCTTTACTCAAGATGATGCCCATGTCTTCTGTACCGAAGAGCAAGTCCGTGATGAAGTAAACAGTTGC
ATCAAGATGGTGTACGACATGTACAGCACCTTTGGCTTCGAGAAGATTGTCGTCAAACTCTCTACCCGCCCTGAAAAGCG
TATTGGCAGTGATGAGTTATGGACACGTGCCGAAGACGATTTGGCTGCTGCGCTGACTGAAAATGGTATTCCGTTTGATT
ATCAGCCAGGCGAAGGGGCGTTCTATGGCCCGAAAATTGAATTTACCTTGCATGATTGTTTGGATCGTGCGTGGCAGTGT
GGTACCGTACAGCTCGATTTCTCATTACCGGGCCGCTTAAGTGCGTCTTACATCGGCGAAAACAATGATCGTCAGGTGCC
GGTAATGATTCACCGGGCAATTTTGGGTTCAATGGAGCGCTTCATCGGTATCTTAACCGAAGAATATGCGGGCTTTTTCC
CAACTTGGTTAGCTCCGGTACAAGTCGTGGTGATGAATATCACCGATAGCCAGTCTGATTATGTTCAGCAAGTAACCAAA
AAACTGCAAGATGCGGGTATTAGAGCAAAAGCAGACTTGAGAAATGAGAAGATTGGCTTTAAAATTCGTGAACATACGTT
GCGTCGGGTTCCATATATGTTGGTCTGTGGCGATAAAGAAGTCGAATCAGGCAAAATTGCCGTTCGTACTCGCCGCGGTA
AAGACTTAGGAAGTTTAGACGTCAACGTGGTCGTAGACCAGCTGCTAGCAGAAATTCGCAGCCGTAGTCTTCATCAACTG
GAGGAATAA

Upstream 100 bases:

>100_bases
ATGTGGGTTGAGTTGAGTACTTAACTTTTTGAAATCAAACAATAATTATGTCTTGCATGTGATCTGTCGTGAGGGTCACC
ACTGCAGATAAGGAATTAGA

Downstream 100 bases:

>100_bases
AGTATTAAAGGCGGAAAACGAGTTCAACCGGCGCGTCCTAATCGCATCAACAAAGAGATTCGCGCCACAGAAGTTCGCTT
AACAGGCGTCGATGGTGAAC

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS [H]

Number of amino acids: Translated: 642; Mature: 641

Protein sequence:

>642_residues
MPVITLPDGSQRHYDHAVSVLDVALDIGPGLAKACIAGRVNGELVDASDLIESDAQLAIITAKDAEGLEILRHSCAHLLG
HAIKQLWPDTKMAIGPVIDNGFYYDVDIEHTLTQEDLALLEKRMHELADKDYDVIKKKVSWQEARDTFAARGEDYKVAIL
DENISRDDRPGLYHHEEYVDMCRGPHVPNMRFCHHFKLQKTSGAYWRGDSKNKMLQRIYGTAWGDKKQLNAYLQRLEEAA
KRDHRKIGKQLDLYHMQEEAPGMVFWHNDGWTIFRELETFVRMKLKEYQYQEVKGPFMMDRVLWEKTGHWENYAEHMFTT
SSENREYCIKPMNCPGHVQIFNQGLKSYRDLPLRMAEFGSCHRNEPSGALHGLMRVRGFTQDDAHVFCTEEQVRDEVNSC
IKMVYDMYSTFGFEKIVVKLSTRPEKRIGSDELWTRAEDDLAAALTENGIPFDYQPGEGAFYGPKIEFTLHDCLDRAWQC
GTVQLDFSLPGRLSASYIGENNDRQVPVMIHRAILGSMERFIGILTEEYAGFFPTWLAPVQVVVMNITDSQSDYVQQVTK
KLQDAGIRAKADLRNEKIGFKIREHTLRRVPYMLVCGDKEVESGKIAVRTRRGKDLGSLDVNVVVDQLLAEIRSRSLHQL
EE

Sequences:

>Translated_642_residues
MPVITLPDGSQRHYDHAVSVLDVALDIGPGLAKACIAGRVNGELVDASDLIESDAQLAIITAKDAEGLEILRHSCAHLLG
HAIKQLWPDTKMAIGPVIDNGFYYDVDIEHTLTQEDLALLEKRMHELADKDYDVIKKKVSWQEARDTFAARGEDYKVAIL
DENISRDDRPGLYHHEEYVDMCRGPHVPNMRFCHHFKLQKTSGAYWRGDSKNKMLQRIYGTAWGDKKQLNAYLQRLEEAA
KRDHRKIGKQLDLYHMQEEAPGMVFWHNDGWTIFRELETFVRMKLKEYQYQEVKGPFMMDRVLWEKTGHWENYAEHMFTT
SSENREYCIKPMNCPGHVQIFNQGLKSYRDLPLRMAEFGSCHRNEPSGALHGLMRVRGFTQDDAHVFCTEEQVRDEVNSC
IKMVYDMYSTFGFEKIVVKLSTRPEKRIGSDELWTRAEDDLAAALTENGIPFDYQPGEGAFYGPKIEFTLHDCLDRAWQC
GTVQLDFSLPGRLSASYIGENNDRQVPVMIHRAILGSMERFIGILTEEYAGFFPTWLAPVQVVVMNITDSQSDYVQQVTK
KLQDAGIRAKADLRNEKIGFKIREHTLRRVPYMLVCGDKEVESGKIAVRTRRGKDLGSLDVNVVVDQLLAEIRSRSLHQL
EE
>Mature_641_residues
PVITLPDGSQRHYDHAVSVLDVALDIGPGLAKACIAGRVNGELVDASDLIESDAQLAIITAKDAEGLEILRHSCAHLLGH
AIKQLWPDTKMAIGPVIDNGFYYDVDIEHTLTQEDLALLEKRMHELADKDYDVIKKKVSWQEARDTFAARGEDYKVAILD
ENISRDDRPGLYHHEEYVDMCRGPHVPNMRFCHHFKLQKTSGAYWRGDSKNKMLQRIYGTAWGDKKQLNAYLQRLEEAAK
RDHRKIGKQLDLYHMQEEAPGMVFWHNDGWTIFRELETFVRMKLKEYQYQEVKGPFMMDRVLWEKTGHWENYAEHMFTTS
SENREYCIKPMNCPGHVQIFNQGLKSYRDLPLRMAEFGSCHRNEPSGALHGLMRVRGFTQDDAHVFCTEEQVRDEVNSCI
KMVYDMYSTFGFEKIVVKLSTRPEKRIGSDELWTRAEDDLAAALTENGIPFDYQPGEGAFYGPKIEFTLHDCLDRAWQCG
TVQLDFSLPGRLSASYIGENNDRQVPVMIHRAILGSMERFIGILTEEYAGFFPTWLAPVQVVVMNITDSQSDYVQQVTKK
LQDAGIRAKADLRNEKIGFKIREHTLRRVPYMLVCGDKEVESGKIAVRTRRGKDLGSLDVNVVVDQLLAEIRSRSLHQLE
E

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI38570111, Length=622, Percent_Identity=38.7459807073955, Blast_Score=454, Evalue=1e-127,
Organism=Homo sapiens, GI38202255, Length=643, Percent_Identity=38.7247278382582, Blast_Score=452, Evalue=1e-127,
Organism=Homo sapiens, GI20070344, Length=660, Percent_Identity=35, Blast_Score=388, Evalue=1e-108,
Organism=Escherichia coli, GI1788013, Length=642, Percent_Identity=88.3177570093458, Blast_Score=1214, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71984192, Length=634, Percent_Identity=38.01261829653, Blast_Score=453, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI71984184, Length=634, Percent_Identity=38.01261829653, Blast_Score=453, Evalue=1e-127,
Organism=Saccharomyces cerevisiae, GI6322112, Length=654, Percent_Identity=36.8501529051988, Blast_Score=437, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6322654, Length=398, Percent_Identity=38.1909547738693, Blast_Score=297, Evalue=4e-81,
Organism=Drosophila melanogaster, GI24583842, Length=628, Percent_Identity=40.4458598726115, Blast_Score=493, Evalue=1e-139,
Organism=Drosophila melanogaster, GI28574141, Length=628, Percent_Identity=40.4458598726115, Blast_Score=493, Evalue=1e-139,
Organism=Drosophila melanogaster, GI24583839, Length=628, Percent_Identity=40.4458598726115, Blast_Score=492, Evalue=1e-139,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD [H]

EC number: =6.1.1.3 [H]

Molecular weight: Translated: 73656; Mature: 73524

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVITLPDGSQRHYDHAVSVLDVALDIGPGLAKACIAGRVNGELVDASDLIESDAQLAII
CCEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCEECHHHHHCCCCCEEEE
TAKDAEGLEILRHSCAHLLGHAIKQLWPDTKMAIGPVIDNGFYYDVDIEHTLTQEDLALL
EECCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECCEECCCEEEEEECHHHCCHHHHHHH
EKRMHELADKDYDVIKKKVSWQEARDTFAARGEDYKVAILDENISRDDRPGLYHHEEYVD
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCHHHHH
MCRGPHVPNMRFCHHFKLQKTSGAYWRGDSKNKMLQRIYGTAWGDKKQLNAYLQRLEEAA
HHCCCCCCCCHHHHEEEEECCCCCEECCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
KRDHRKIGKQLDLYHMQEEAPGMVFWHNDGWTIFRELETFVRMKLKEYQYQEVKGPFMMD
HHHHHHHCCHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
RVLWEKTGHWENYAEHMFTTSSENREYCIKPMNCPGHVQIFNQGLKSYRDLPLRMAEFGS
HHHHHHCCCHHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHCC
CHRNEPSGALHGLMRVRGFTQDDAHVFCTEEQVRDEVNSCIKMVYDMYSTFGFEKIVVKL
CCCCCCCHHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEE
STRPEKRIGSDELWTRAEDDLAAALTENGIPFDYQPGEGAFYGPKIEFTLHDCLDRAWQC
CCCCHHCCCCHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCEECCEEEEEHHHHHHHHHCC
GTVQLDFSLPGRLSASYIGENNDRQVPVMIHRAILGSMERFIGILTEEYAGFFPTWLAPV
CEEEEECCCCCCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHE
QVVVMNITDSQSDYVQQVTKKLQDAGIRAKADLRNEKIGFKIREHTLRRVPYMLVCGDKE
EEEEEECCCCHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCHHHHHHHHCCEEEEECCCC
VESGKIAVRTRRGKDLGSLDVNVVVDQLLAEIRSRSLHQLEE
CCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PVITLPDGSQRHYDHAVSVLDVALDIGPGLAKACIAGRVNGELVDASDLIESDAQLAII
CEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCEECHHHHHCCCCCEEEE
TAKDAEGLEILRHSCAHLLGHAIKQLWPDTKMAIGPVIDNGFYYDVDIEHTLTQEDLALL
EECCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECCEECCCEEEEEECHHHCCHHHHHHH
EKRMHELADKDYDVIKKKVSWQEARDTFAARGEDYKVAILDENISRDDRPGLYHHEEYVD
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCHHHHH
MCRGPHVPNMRFCHHFKLQKTSGAYWRGDSKNKMLQRIYGTAWGDKKQLNAYLQRLEEAA
HHCCCCCCCCHHHHEEEEECCCCCEECCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
KRDHRKIGKQLDLYHMQEEAPGMVFWHNDGWTIFRELETFVRMKLKEYQYQEVKGPFMMD
HHHHHHHCCHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
RVLWEKTGHWENYAEHMFTTSSENREYCIKPMNCPGHVQIFNQGLKSYRDLPLRMAEFGS
HHHHHHCCCHHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHCC
CHRNEPSGALHGLMRVRGFTQDDAHVFCTEEQVRDEVNSCIKMVYDMYSTFGFEKIVVKL
CCCCCCCHHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEE
STRPEKRIGSDELWTRAEDDLAAALTENGIPFDYQPGEGAFYGPKIEFTLHDCLDRAWQC
CCCCHHCCCCHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCEECCEEEEEHHHHHHHHHCC
GTVQLDFSLPGRLSASYIGENNDRQVPVMIHRAILGSMERFIGILTEEYAGFFPTWLAPV
CEEEEECCCCCCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHE
QVVVMNITDSQSDYVQQVTKKLQDAGIRAKADLRNEKIGFKIREHTLRRVPYMLVCGDKE
EEEEEECCCCHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCHHHHHHHHCCEEEEECCCC
VESGKIAVRTRRGKDLGSLDVNVVVDQLLAEIRSRSLHQLEE
CCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA