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The map label for this gene is cyoE [H]

Identifier: 153949222

GI number: 153949222

Start: 3493842

End: 3494729

Strand: Direct

Name: cyoE [H]

Synonym: YpsIP31758_3102

Alternate gene names: 153949222

Gene position: 3493842-3494729 (Clockwise)

Preceding gene: 153949808

Following gene: 153948414

Centisome position: 73.97

GC content: 46.51

Gene sequence:

>888_bases
ATGATTAAGCAATACCTGCAAGTCACTAAGCCAGGAATTATTTTCGGTAATTTAATTTCTGTCATTGGGGGTTTTCTCCT
CGCTTCCAAGGGCGATATTGATTACCCCCTGTTTCTCTCCACCTTATTAGGTGTCTCGTTAGTTGTTGCCTCCGGGTGCG
TATTTAACAACTATATCGATCGAGATATCGATAAAATCATGGAGAGAACGAAGAATCGTGTCCTGGTCAAAGGGCTTATC
GATCCGAAGGTATCCCTGATTTATGCATCGGTACTGGGTATTGCTGGCATGCTGTTGCTCTACGTGGCAGCTAATGCATT
AGCAATGATGCTGGCTGTTATTGGTTTCGTTATCTATGTTGGGGTGTATAGCCTCTACATGAAACGTAAATCAGTCTACG
GCACCTTGATTGGCAGCTTGTCAGGCGCCGCTCCCCCCGTTATTGGTTACTGTGCCGTAACGGGGCAATTCGACACTGGC
GCACTGATCTTGTTGCTGATCTTCAGTCTGTGGCAAATGCCTCATTCCTATGCCATCGCCATCTTCCGCTTTAAGGATTA
TCAGGCCGCCAACATTCCGGTACTCCCGGTGATAAAAGGGATATCGGTCACCAAAAACCATATTACCCTTTATATTTTGG
CGTTTATGGTCGCAACCTTGATGCTGACATTAAGTGGCTATGCCGGTTATAAATATCTGGTTGTGGCTGCCGCGGTTAGC
GTCTGGTGGCTGGGTATGGCACTGCGCGGTTATAAGGCAACGAATGACAGCGTATGGGCGAGAAAACTCTTTGTCTTCTC
TATCATTGCCATTACGTCATTGAGCGTCATGATGTCAGTTGATTTCAATGTACACTCTTCGGCAGTACTCCTGACTTACG
CTGGATAG

Upstream 100 bases:

>100_bases
CTGTTCACCGCTATGATTATTGCAATCGTTGTAGTGGGCTCACTCTGGATTATGTACAACCTCAACATCAATATGATGGT
TGACTGAAGAGCTGCATGTG

Downstream 100 bases:

>100_bases
TCTTAGCGAAAATGATGAGAGTGAAATAAATCAAGTGGCTGGCAGGAATCGCTCTTGCCAGCCACTTTGTATTTGTTCCC
TGTTTTGTATTTGTACCCAG

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase [H]

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MIKQYLQVTKPGIIFGNLISVIGGFLLASKGDIDYPLFLSTLLGVSLVVASGCVFNNYIDRDIDKIMERTKNRVLVKGLI
DPKVSLIYASVLGIAGMLLLYVAANALAMMLAVIGFVIYVGVYSLYMKRKSVYGTLIGSLSGAAPPVIGYCAVTGQFDTG
ALILLLIFSLWQMPHSYAIAIFRFKDYQAANIPVLPVIKGISVTKNHITLYILAFMVATLMLTLSGYAGYKYLVVAAAVS
VWWLGMALRGYKATNDSVWARKLFVFSIIAITSLSVMMSVDFNVHSSAVLLTYAG

Sequences:

>Translated_295_residues
MIKQYLQVTKPGIIFGNLISVIGGFLLASKGDIDYPLFLSTLLGVSLVVASGCVFNNYIDRDIDKIMERTKNRVLVKGLI
DPKVSLIYASVLGIAGMLLLYVAANALAMMLAVIGFVIYVGVYSLYMKRKSVYGTLIGSLSGAAPPVIGYCAVTGQFDTG
ALILLLIFSLWQMPHSYAIAIFRFKDYQAANIPVLPVIKGISVTKNHITLYILAFMVATLMLTLSGYAGYKYLVVAAAVS
VWWLGMALRGYKATNDSVWARKLFVFSIIAITSLSVMMSVDFNVHSSAVLLTYAG
>Mature_295_residues
MIKQYLQVTKPGIIFGNLISVIGGFLLASKGDIDYPLFLSTLLGVSLVVASGCVFNNYIDRDIDKIMERTKNRVLVKGLI
DPKVSLIYASVLGIAGMLLLYVAANALAMMLAVIGFVIYVGVYSLYMKRKSVYGTLIGSLSGAAPPVIGYCAVTGQFDTG
ALILLLIFSLWQMPHSYAIAIFRFKDYQAANIPVLPVIKGISVTKNHITLYILAFMVATLMLTLSGYAGYKYLVVAAAVS
VWWLGMALRGYKATNDSVWARKLFVFSIIAITSLSVMMSVDFNVHSSAVLLTYAG

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group [H]

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI17921982, Length=168, Percent_Identity=35.1190476190476, Blast_Score=105, Evalue=3e-23,
Organism=Escherichia coli, GI1786631, Length=291, Percent_Identity=84.192439862543, Blast_Score=491, Evalue=1e-140,
Organism=Caenorhabditis elegans, GI71998235, Length=229, Percent_Identity=28.82096069869, Blast_Score=90, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6325085, Length=193, Percent_Identity=28.4974093264249, Blast_Score=83, Evalue=4e-17,
Organism=Drosophila melanogaster, GI19921064, Length=273, Percent_Identity=28.9377289377289, Blast_Score=112, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006369
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: 2.5.1.-

Molecular weight: Translated: 32048; Mature: 32048

Theoretical pI: Translated: 9.86; Mature: 9.86

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKQYLQVTKPGIIFGNLISVIGGFLLASKGDIDYPLFLSTLLGVSLVVASGCVFNNYID
CCHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHH
RDIDKIMERTKNRVLVKGLIDPKVSLIYASVLGIAGMLLLYVAANALAMMLAVIGFVIYV
HHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVYSLYMKRKSVYGTLIGSLSGAAPPVIGYCAVTGQFDTGALILLLIFSLWQMPHSYAIA
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHCCCHHEEE
IFRFKDYQAANIPVLPVIKGISVTKNHITLYILAFMVATLMLTLSGYAGYKYLVVAAAVS
EEEEECCCCCCCCHHHHHCCCEECHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
VWWLGMALRGYKATNDSVWARKLFVFSIIAITSLSVMMSVDFNVHSSAVLLTYAG
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCEEEEEECC
>Mature Secondary Structure
MIKQYLQVTKPGIIFGNLISVIGGFLLASKGDIDYPLFLSTLLGVSLVVASGCVFNNYID
CCHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHH
RDIDKIMERTKNRVLVKGLIDPKVSLIYASVLGIAGMLLLYVAANALAMMLAVIGFVIYV
HHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVYSLYMKRKSVYGTLIGSLSGAAPPVIGYCAVTGQFDTGALILLLIFSLWQMPHSYAIA
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHCCCHHEEE
IFRFKDYQAANIPVLPVIKGISVTKNHITLYILAFMVATLMLTLSGYAGYKYLVVAAAVS
EEEEECCCCCCCCHHHHHCCCEECHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
VWWLGMALRGYKATNDSVWARKLFVFSIIAITSLSVMMSVDFNVHSSAVLLTYAG
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA