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The map label for this gene is 153935549

Identifier: 153935549

GI number: 153935549

Start: 1178603

End: 1180111

Strand: Reverse

Name: 153935549

Synonym: CLC_1148

Alternate gene names: NA

Gene position: 1180111-1178603 (Counterclockwise)

Preceding gene: 153936087

Following gene: 153937156

Centisome position: 31.38

GC content: 29.03

Gene sequence:

>1509_bases
ATGGAAATAAAATTCTTAGGAGCAGCTTCTTGTGTAACAGGTTCCTGCCACTTATTAAAAATAAAAGATAAAAATATTCT
TTTAGACTGTGGTGCTTATCAAGGCAAAGACGATGAAGGAGATAGAAATTTTTCTTTTAAATTCGATATTAAAGATATAG
ATTGTGTAATACTCTCTCACGCTCATATAGATCACAGTGGACGAATTCCTTTTTTATATAAACTAGGCTATAGAGGAAAA
GTTATCTCTACTAAAGCTACTGCAGACCTATGCTCCATTATGCTTCCTGACAGCGGTCATATATTAGAATCAGAAGTTGA
ATGGAAAAACAGAAAAAGAATTCGTAGTGGTCTACCTCCTATAGAACCTTTATATAATTTAAAAACAGCTCAAATGAGTA
CATCCCTTTTTGAAGGTTACAATTACGATGAATATATAGAAATATTTTCTAATCTCAAAATAAGATTTTTAGATTCTGGT
CATCTCTTAGGCTCTGCTATAACTGAATTATATATAACTGAAAATGATAAAGAATTTAAAATTGTTTATTCTGGAGATCT
TGGCAATACAAATTTGCCTATACTAAAAGATCCTGTTCAAGTAGATTATGCAGATTATGTGCTAATGGAAACAACCTATG
GAAATAGACTTCATGATAACATAAATTCCCAATTAAAGCAATTGATTCATATCGTAAAGGATACCTTTAAAAGAAGAGGT
AATGTTATTATTCCTTCCTTTGCAGTGGGTAGAACTCAAGAAGTAATATACGCATTAAATAAATATGTGGAAAGTAATAT
ATTAAAAAATATCAAAGTCTACGTAGATAGCCCTTTAGCTTCAGAAGCTACTAAAATATTTAATGAATACACTACTGACT
TTGATGAAGATGCTCAAAAGTTATTAAAGGAAGGTGATAATCCTCTAGAATTTAATGGTCTTTACTTTACTAATTCTCCT
CAAGAATCTATGGAATTAAATAAAATAAAAACTGGTGCTATTATAATATCTGCTAGTGGAATGTGTGAAGCTGGTAGAAT
TCGTCATCATCTGAAACATAATCTTTGGAGAAAAGAATGTTCTATAGTATTTGTAGGTTATCAAGCCGAGGGAACTTTAG
GTCAAAAAATATTAAGCGGTGCTAAAAAAATAAAATTATTTGGTGAAGAGATTGCTGTAAATGCTGAAATATATAATCTA
CCATCATTATCTGGTCATGCTGACAAAAATGGCCTATTGAATTGGCTAGAAAATTTTAAAGAAAAACCTAAGGAAGTTAT
ATTGATCCATGGTGAAAAAGCTTCTAGAGATTATTTTAAAAATCTGTTAACTGAAAAAAACTATAATACCTTTTGTCCTA
ATATAGGTGATATATATTCAAGTGAATTTAAAGGTCAAAGAAAAAGTGTAGTTAAAAATAAAATAACTAATTTATTGAAT
TCCTTAGAGGATATAGACTCATTAAATAAAGAAGATTTATTAAACTTGATTAAAAAAGAAATATATTAA

Upstream 100 bases:

>100_bases
AATTATTTATATTATTTTTAAATACATATATATTTTTCAATAAAATAATATTAAAATATTCTTACAAGTATTAATTAATC
ATTAGAACAGGAGGGATCAT

Downstream 100 bases:

>100_bases
AAACAAAACCATTTTATCTATTAAATTTTAAAACTATCTATATATTAAAAAGAAAGAGGCTGTCTCAAAATAGATTTAAA
TTTGTTCTGAGATAGTCTCT

Product: metallo-beta-lactamase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 502; Mature: 502

Protein sequence:

>502_residues
MEIKFLGAASCVTGSCHLLKIKDKNILLDCGAYQGKDDEGDRNFSFKFDIKDIDCVILSHAHIDHSGRIPFLYKLGYRGK
VISTKATADLCSIMLPDSGHILESEVEWKNRKRIRSGLPPIEPLYNLKTAQMSTSLFEGYNYDEYIEIFSNLKIRFLDSG
HLLGSAITELYITENDKEFKIVYSGDLGNTNLPILKDPVQVDYADYVLMETTYGNRLHDNINSQLKQLIHIVKDTFKRRG
NVIIPSFAVGRTQEVIYALNKYVESNILKNIKVYVDSPLASEATKIFNEYTTDFDEDAQKLLKEGDNPLEFNGLYFTNSP
QESMELNKIKTGAIIISASGMCEAGRIRHHLKHNLWRKECSIVFVGYQAEGTLGQKILSGAKKIKLFGEEIAVNAEIYNL
PSLSGHADKNGLLNWLENFKEKPKEVILIHGEKASRDYFKNLLTEKNYNTFCPNIGDIYSSEFKGQRKSVVKNKITNLLN
SLEDIDSLNKEDLLNLIKKEIY

Sequences:

>Translated_502_residues
MEIKFLGAASCVTGSCHLLKIKDKNILLDCGAYQGKDDEGDRNFSFKFDIKDIDCVILSHAHIDHSGRIPFLYKLGYRGK
VISTKATADLCSIMLPDSGHILESEVEWKNRKRIRSGLPPIEPLYNLKTAQMSTSLFEGYNYDEYIEIFSNLKIRFLDSG
HLLGSAITELYITENDKEFKIVYSGDLGNTNLPILKDPVQVDYADYVLMETTYGNRLHDNINSQLKQLIHIVKDTFKRRG
NVIIPSFAVGRTQEVIYALNKYVESNILKNIKVYVDSPLASEATKIFNEYTTDFDEDAQKLLKEGDNPLEFNGLYFTNSP
QESMELNKIKTGAIIISASGMCEAGRIRHHLKHNLWRKECSIVFVGYQAEGTLGQKILSGAKKIKLFGEEIAVNAEIYNL
PSLSGHADKNGLLNWLENFKEKPKEVILIHGEKASRDYFKNLLTEKNYNTFCPNIGDIYSSEFKGQRKSVVKNKITNLLN
SLEDIDSLNKEDLLNLIKKEIY
>Mature_502_residues
MEIKFLGAASCVTGSCHLLKIKDKNILLDCGAYQGKDDEGDRNFSFKFDIKDIDCVILSHAHIDHSGRIPFLYKLGYRGK
VISTKATADLCSIMLPDSGHILESEVEWKNRKRIRSGLPPIEPLYNLKTAQMSTSLFEGYNYDEYIEIFSNLKIRFLDSG
HLLGSAITELYITENDKEFKIVYSGDLGNTNLPILKDPVQVDYADYVLMETTYGNRLHDNINSQLKQLIHIVKDTFKRRG
NVIIPSFAVGRTQEVIYALNKYVESNILKNIKVYVDSPLASEATKIFNEYTTDFDEDAQKLLKEGDNPLEFNGLYFTNSP
QESMELNKIKTGAIIISASGMCEAGRIRHHLKHNLWRKECSIVFVGYQAEGTLGQKILSGAKKIKLFGEEIAVNAEIYNL
PSLSGHADKNGLLNWLENFKEKPKEVILIHGEKASRDYFKNLLTEKNYNTFCPNIGDIYSSEFKGQRKSVVKNKITNLLN
SLEDIDSLNKEDLLNLIKKEIY

Specific function: Has endoribonuclease activity towards 23S and 16S rRNA (in vitro) [H]

COG id: COG1236

COG function: function code J; Predicted exonuclease of the beta-lactamase fold involved in RNA processing

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family [H]

Homologues:

Organism=Homo sapiens, GI33300633, Length=475, Percent_Identity=26.5263157894737, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI7706427, Length=445, Percent_Identity=26.0674157303371, Blast_Score=150, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI32564696, Length=476, Percent_Identity=27.9411764705882, Blast_Score=152, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI32566029, Length=440, Percent_Identity=27.2727272727273, Blast_Score=149, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6323307, Length=511, Percent_Identity=22.5048923679061, Blast_Score=130, Evalue=4e-31,
Organism=Drosophila melanogaster, GI21358523, Length=471, Percent_Identity=27.1762208067941, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24648013, Length=492, Percent_Identity=25.609756097561, Blast_Score=149, Evalue=6e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022712
- InterPro:   IPR001279
- InterPro:   IPR011108 [H]

Pfam domain/function: PF10996 Beta-Casp; PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 57002; Mature: 57002

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIKFLGAASCVTGSCHLLKIKDKNILLDCGAYQGKDDEGDRNFSFKFDIKDIDCVILSH
CEEEEEECCCCCCCCEEEEEEECCEEEEECCCCCCCCCCCCCCEEEEEECCCCEEEEEEE
AHIDHSGRIPFLYKLGYRGKVISTKATADLCSIMLPDSGHILESEVEWKNRKRIRSGLPP
EECCCCCCCCEEEEECCCCEEEECHHHHHHHHEECCCCCCEECCHHHHHHHHHHHHCCCC
IEPLYNLKTAQMSTSLFEGYNYDEYIEIFSNLKIRFLDSGHLLGSAITELYITENDKEFK
CCHHHCCHHHHHHHHHHCCCCHHHHHHHHHCCEEEEEECCCHHHHHHHEEEEECCCCEEE
IVYSGDLGNTNLPILKDPVQVDYADYVLMETTYGNRLHDNINSQLKQLIHIVKDTFKRRG
EEEECCCCCCCCCEECCCCEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCC
NVIIPSFAVGRTQEVIYALNKYVESNILKNIKVYVDSPLASEATKIFNEYTTDFDEDAQK
CEEEECCCCCCHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHCCCHHHHHHH
LLKEGDNPLEFNGLYFTNSPQESMELNKIKTGAIIISASGMCEAGRIRHHLKHNLWRKEC
HHHCCCCCEEECCEEEECCCHHHHHHHEEECCEEEEEECCCCCHHHHHHHHHHHHHHCCC
SIVFVGYQAEGTLGQKILSGAKKIKLFGEEIAVNAEIYNLPSLSGHADKNGLLNWLENFK
CEEEEEEECCCHHHHHHHCCHHHEEEECCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHH
EKPKEVILIHGEKASRDYFKNLLTEKNYNTFCPNIGDIYSSEFKGQRKSVVKNKITNLLN
CCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHH
SLEDIDSLNKEDLLNLIKKEIY
HHHHHHCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MEIKFLGAASCVTGSCHLLKIKDKNILLDCGAYQGKDDEGDRNFSFKFDIKDIDCVILSH
CEEEEEECCCCCCCCEEEEEEECCEEEEECCCCCCCCCCCCCCEEEEEECCCCEEEEEEE
AHIDHSGRIPFLYKLGYRGKVISTKATADLCSIMLPDSGHILESEVEWKNRKRIRSGLPP
EECCCCCCCCEEEEECCCCEEEECHHHHHHHHEECCCCCCEECCHHHHHHHHHHHHCCCC
IEPLYNLKTAQMSTSLFEGYNYDEYIEIFSNLKIRFLDSGHLLGSAITELYITENDKEFK
CCHHHCCHHHHHHHHHHCCCCHHHHHHHHHCCEEEEEECCCHHHHHHHEEEEECCCCEEE
IVYSGDLGNTNLPILKDPVQVDYADYVLMETTYGNRLHDNINSQLKQLIHIVKDTFKRRG
EEEECCCCCCCCCEECCCCEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCC
NVIIPSFAVGRTQEVIYALNKYVESNILKNIKVYVDSPLASEATKIFNEYTTDFDEDAQK
CEEEECCCCCCHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHCCCHHHHHHH
LLKEGDNPLEFNGLYFTNSPQESMELNKIKTGAIIISASGMCEAGRIRHHLKHNLWRKEC
HHHCCCCCEEECCEEEECCCHHHHHHHEEECCEEEEEECCCCCHHHHHHHHHHHHHHCCC
SIVFVGYQAEGTLGQKILSGAKKIKLFGEEIAVNAEIYNLPSLSGHADKNGLLNWLENFK
CEEEEEEECCCHHHHHHHCCHHHEEEECCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHH
EKPKEVILIHGEKASRDYFKNLLTEKNYNTFCPNIGDIYSSEFKGQRKSVVKNKITNLLN
CCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHH
SLEDIDSLNKEDLLNLIKKEIY
HHHHHHCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA