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The map label for this gene is ctpB [H]

Identifier: 152977393

GI number: 152977393

Start: 3774882

End: 3776318

Strand: Reverse

Name: ctpB [H]

Synonym: Bcer98_3721

Alternate gene names: 152977393

Gene position: 3776318-3774882 (Counterclockwise)

Preceding gene: 152977394

Following gene: 152977392

Centisome position: 92.4

GC content: 36.81

Gene sequence:

>1437_bases
TTGAAACGTAGAGTTGCGATTATTGGAATGATTGTTACATTTTTAATCGGTGCTGGTGGAATGTTTGCGGGTATGTATCT
GTTTGGTATTAACCCATCATATGTTGCACGAACAATAACAAACGATCGTGCTGGCACTACACAAGAGAACTTAGCAAAAA
TGAGTGAAGCGTATGCATTGATTCAGTCGAGTTATGTGGAAGACGTGAAAGATGACAAGCTTGTGGAGGGCGCGATACAA
GGAATGTTATCTACTCTGAAAGATCCTTATTCCACGTATATGGACCAAAAGACGGCAAAACAGTTTAACGAAGCTCTTGA
TCCCGAACTAGAAGGAATTGGAGCAGAAGTGAACAAAACAGATGACAAATTAATCATTGTTTCTCCAATTAAAGGGTCAC
CGGCAGAGAAAGCAGGTATGAAACCGAATGATGAAATTTTGTCAGTAGATGGAAAGAGTGTAAAAGGTTTATCGCGTGAA
GAGGCTGTGTTAAAGATTCGCGGTAAAAAAGGAACGACGGTTGCAATTGAAATTAAGCGTGCAGGAGTCACTGATCCAAT
CAAATTTGAAATTAAGCGTGATAAGATTCCGATTTTTACTGTATTTAGTTCCGTGAAGAAGGAAATGGACAAAAACATTG
GGTATATGCAAATTACTTCGTTCTCTGAAAAAACAGCGGAGGAATTTAAAGATCAATTAAAAGAGCTTGAAAAGAAAGAA
ATTACAGGATTGATAATCGATGTACGTGGTAATCCAGGTGGCTATTTAAAGAGTGTTGAAGATATTTTAGGATTAATCAT
GACCGATAAAAAGCCAATGTTGCAAGTAGAACAACGCAATGGTGAGAAAAAGAAATTCTATACTTCATTAAAAGAGAGAA
AACCGTATCCAATCTCGGTATTAATTGATAGTGGAAGTGCTTCTGCTTCGGAAATTTTAGCTGGTGCGTTAAAAGAAGGG
GAAGGATATAATTTAGTTGGTGAAAAGACATTTGGCAAAGGAACTGTGCAACAAGCTGTTCCATTTAAAGATGGTAGTAA
TATTAAATTAACGATGTTTAAATGGTTAACACCGAATGGCAATTGGATTCATAAAAAAGGGATTGCCCCAACCGTAGAGG
TGAAGCAACCAGATTATTATCATGCAACACCGATTCAAATTGAAAAGACACTTTCTTATAATTCAAATGATGTACAAGTA
AAACATGCGCAACAAATGTTGAAAAGTCTCGGATATGTGCCAGGTCGTGAAGATGGATATTTCAGCAAAGAAACAGAATC
AGCTGTTAAAGCGTTCCAAAATGCAAATCAGTTAGAAGCAACGGGAAAGCTTGATAAAAAAACAGCTGAAGCCATTCAAA
ATAAAATTATTGAAAAGATTCGCTCTGGTGAAAATGACTTGCAGCTACAAGCAGCATTAAAATTAATGGCGAAATAA

Upstream 100 bases:

>100_bases
GTACAAGCTTATCATATAGTAGAAATAGATAAAAGGCATCACACAATGTGTGATGCCTTTTGCTACACCACCTGTGTGTT
TTGGAAAGGGGAATTCCGCA

Downstream 100 bases:

>100_bases
GAAAAAACACAGGCAAAATGTGATGCCTGTGTTTTTTTATGCGTGTTAAACAAACGCTTGTTTAGTTGTGTTAATATAAA
AAGAAAGAATGATATAAATG

Product: carboxyl-terminal protease

Products: NA

Alternate protein names: C-terminal processing protease [H]

Number of amino acids: Translated: 478; Mature: 478

Protein sequence:

>478_residues
MKRRVAIIGMIVTFLIGAGGMFAGMYLFGINPSYVARTITNDRAGTTQENLAKMSEAYALIQSSYVEDVKDDKLVEGAIQ
GMLSTLKDPYSTYMDQKTAKQFNEALDPELEGIGAEVNKTDDKLIIVSPIKGSPAEKAGMKPNDEILSVDGKSVKGLSRE
EAVLKIRGKKGTTVAIEIKRAGVTDPIKFEIKRDKIPIFTVFSSVKKEMDKNIGYMQITSFSEKTAEEFKDQLKELEKKE
ITGLIIDVRGNPGGYLKSVEDILGLIMTDKKPMLQVEQRNGEKKKFYTSLKERKPYPISVLIDSGSASASEILAGALKEG
EGYNLVGEKTFGKGTVQQAVPFKDGSNIKLTMFKWLTPNGNWIHKKGIAPTVEVKQPDYYHATPIQIEKTLSYNSNDVQV
KHAQQMLKSLGYVPGREDGYFSKETESAVKAFQNANQLEATGKLDKKTAEAIQNKIIEKIRSGENDLQLQAALKLMAK

Sequences:

>Translated_478_residues
MKRRVAIIGMIVTFLIGAGGMFAGMYLFGINPSYVARTITNDRAGTTQENLAKMSEAYALIQSSYVEDVKDDKLVEGAIQ
GMLSTLKDPYSTYMDQKTAKQFNEALDPELEGIGAEVNKTDDKLIIVSPIKGSPAEKAGMKPNDEILSVDGKSVKGLSRE
EAVLKIRGKKGTTVAIEIKRAGVTDPIKFEIKRDKIPIFTVFSSVKKEMDKNIGYMQITSFSEKTAEEFKDQLKELEKKE
ITGLIIDVRGNPGGYLKSVEDILGLIMTDKKPMLQVEQRNGEKKKFYTSLKERKPYPISVLIDSGSASASEILAGALKEG
EGYNLVGEKTFGKGTVQQAVPFKDGSNIKLTMFKWLTPNGNWIHKKGIAPTVEVKQPDYYHATPIQIEKTLSYNSNDVQV
KHAQQMLKSLGYVPGREDGYFSKETESAVKAFQNANQLEATGKLDKKTAEAIQNKIIEKIRSGENDLQLQAALKLMAK
>Mature_478_residues
MKRRVAIIGMIVTFLIGAGGMFAGMYLFGINPSYVARTITNDRAGTTQENLAKMSEAYALIQSSYVEDVKDDKLVEGAIQ
GMLSTLKDPYSTYMDQKTAKQFNEALDPELEGIGAEVNKTDDKLIIVSPIKGSPAEKAGMKPNDEILSVDGKSVKGLSRE
EAVLKIRGKKGTTVAIEIKRAGVTDPIKFEIKRDKIPIFTVFSSVKKEMDKNIGYMQITSFSEKTAEEFKDQLKELEKKE
ITGLIIDVRGNPGGYLKSVEDILGLIMTDKKPMLQVEQRNGEKKKFYTSLKERKPYPISVLIDSGSASASEILAGALKEG
EGYNLVGEKTFGKGTVQQAVPFKDGSNIKLTMFKWLTPNGNWIHKKGIAPTVEVKQPDYYHATPIQIEKTLSYNSNDVQV
KHAQQMLKSLGYVPGREDGYFSKETESAVKAFQNANQLEATGKLDKKTAEAIQNKIIEKIRSGENDLQLQAALKLMAK

Specific function: Involved in the signal transduction pathway leading to the proteolytic activation of the mother cell transcription factor pro-sigma-K during sporulation. The signaling serine protease CtpB triggers pro-sigma-K processing by cleaving the regulatory protein

COG id: COG0793

COG function: function code M; Periplasmic protease

Gene ontology:

Cell location: Forespore intermembrane space. Note=Is expressed in both the mother cell and forespore compartments but that synthesis in the forespore is both necessary and sufficient for the proper timing of pro-sigma-K processing [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Escherichia coli, GI1788134, Length=315, Percent_Identity=32.6984126984127, Blast_Score=128, Evalue=9e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR005151
- InterPro:   IPR004447
- InterPro:   IPR002477 [H]

Pfam domain/function: PF00595 PDZ; PF03572 Peptidase_S41; PF01471 PG_binding_1 [H]

EC number: =3.4.21.102 [H]

Molecular weight: Translated: 52833; Mature: 52833

Theoretical pI: Translated: 9.59; Mature: 9.59

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRRVAIIGMIVTFLIGAGGMFAGMYLFGINPSYVARTITNDRAGTTQENLAKMSEAYAL
CCCHHHHHHHHHHHHHCCCHHHHHEEEECCCHHHHHEECCCCCCCCCHHHHHHHHHHHHH
IQSSYVEDVKDDKLVEGAIQGMLSTLKDPYSTYMDQKTAKQFNEALDPELEGIGAEVNKT
HHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCC
DDKLIIVSPIKGSPAEKAGMKPNDEILSVDGKSVKGLSREEAVLKIRGKKGTTVAIEIKR
CCCEEEEECCCCCCHHHCCCCCCCCEEEECCCCCCCCCCCCEEEEEECCCCCEEEEEEEE
AGVTDPIKFEIKRDKIPIFTVFSSVKKEMDKNIGYMQITSFSEKTAEEFKDQLKELEKKE
CCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHC
ITGLIIDVRGNPGGYLKSVEDILGLIMTDKKPMLQVEQRNGEKKKFYTSLKERKPYPISV
CCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCHHHHHCCCCCHHHHHHHHHHCCCCCEEE
LIDSGSASASEILAGALKEGEGYNLVGEKTFGKGTVQQAVPFKDGSNIKLTMFKWLTPNG
EEECCCCCHHHHHHHHHHCCCCCEEECCCCCCCCCHHHCCCCCCCCCEEEEEEEEECCCC
NWIHKKGIAPTVEVKQPDYYHATPIQIEKTLSYNSNDVQVKHAQQMLKSLGYVPGREDGY
CEEEECCCCCEEEECCCCCCCCCCEEEEEEECCCCCCEEHHHHHHHHHHCCCCCCCCCCC
FSKETESAVKAFQNANQLEATGKLDKKTAEAIQNKIIEKIRSGENDLQLQAALKLMAK
CCHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MKRRVAIIGMIVTFLIGAGGMFAGMYLFGINPSYVARTITNDRAGTTQENLAKMSEAYAL
CCCHHHHHHHHHHHHHCCCHHHHHEEEECCCHHHHHEECCCCCCCCCHHHHHHHHHHHHH
IQSSYVEDVKDDKLVEGAIQGMLSTLKDPYSTYMDQKTAKQFNEALDPELEGIGAEVNKT
HHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCC
DDKLIIVSPIKGSPAEKAGMKPNDEILSVDGKSVKGLSREEAVLKIRGKKGTTVAIEIKR
CCCEEEEECCCCCCHHHCCCCCCCCEEEECCCCCCCCCCCCEEEEEECCCCCEEEEEEEE
AGVTDPIKFEIKRDKIPIFTVFSSVKKEMDKNIGYMQITSFSEKTAEEFKDQLKELEKKE
CCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHC
ITGLIIDVRGNPGGYLKSVEDILGLIMTDKKPMLQVEQRNGEKKKFYTSLKERKPYPISV
CCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCHHHHHCCCCCHHHHHHHHHHCCCCCEEE
LIDSGSASASEILAGALKEGEGYNLVGEKTFGKGTVQQAVPFKDGSNIKLTMFKWLTPNG
EEECCCCCHHHHHHHHHHCCCCCEEECCCCCCCCCHHHCCCCCCCCCEEEEEEEEECCCC
NWIHKKGIAPTVEVKQPDYYHATPIQIEKTLSYNSNDVQVKHAQQMLKSLGYVPGREDGY
CEEEECCCCCEEEECCCCCCCCCCEEEEEEECCCCCCEEHHHHHHHHHHCCCCCCCCCCC
FSKETESAVKAFQNANQLEATGKLDKKTAEAIQNKIIEKIRSGENDLQLQAALKLMAK
CCHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9570401; 9384377 [H]