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The map label for this gene is mutS2 [H]

Identifier: 152976937

GI number: 152976937

Start: 3304825

End: 3307185

Strand: Reverse

Name: mutS2 [H]

Synonym: Bcer98_3240

Alternate gene names: 152976937

Gene position: 3307185-3304825 (Counterclockwise)

Preceding gene: 152976938

Following gene: 152976936

Centisome position: 80.92

GC content: 40.32

Gene sequence:

>2361_bases
ATGTTAGAACGAACGTTGCGTGTATTAGAATATGACAAAGTAAAAGAACAGTTACTTGAGCATACAGCTTCTTCGCTTGG
CCGAGATAAAGTAAAGCGCCTTATGCCAAGCACAGATTTTGAAGAAATTGTGGAAATGCAAGATACAACTGATGAGGCGG
CGAAAGTGATCCGTTTAAAAGGACATGCACCACTCGGCGGGATTTTTGACATTCGATCGAATGTAAAGCGTGCAAAAATA
GGAAGTATGCTGAGCCCGCATGAATTACTGGATATCGCAAGTACGATGTATGGCAGCCGTCAAATGAAACGATTCATTGA
AGATATAGTTGATAATGGCGCTCAGCTTCCGATTTTAGAAACTCATGTTGCGCAAATTGTCTCTTTATATGATTTAGAAA
AGAAAATTACAGGCTGTATTGGAGATGGCGGCGAAGTACTCGATAGCGCCAGCGATAAATTGCGTGGTATTCGCAATCAA
ATTCGTACAGCGGAAAGTCGCATTCGTGAGAAGCTCGAAAATATGACGCGCTCTTCAAATGCGCAAAAGATGTTATCAGA
TGCCATTGTAACGATTCGTAACGATCGCTATGTAATTCCGGTTAAGCAGGAATATCGTGGCGTATATGGTGGCATTGTTC
ATGACCAATCTGCATCAGGACAAACGTTATTTATTGAACCGCAAGTCATCGTGGAACTGAATAACGCCCTGCAAGAAGCA
CGTGTGAAAGAGAAACAAGAAGTAGAACGTATTTTAATGATGCTTACGGAAGAAGTAGCAGCAGAAGCTGATATCGTACT
AGCAAATGTCGAAGTGATTGCGAATCTTGATTTTATCTTTGCGAAAGCTTTGTATGCGAAACGAATGAAAGCGACAAAAC
CGATTGTCAATAATGAGCGTTATATGGAGTTACGCCAAGCACGTCATCCGCTTATCGATCCAAAAGTGATTGTGCCAAAC
GATATTGTGCTTGGTAAAGACTTTACAACAATTGTCATTACAGGTCCGAACACAGGGGGGAAAACCGTTACGTTAAAGAC
GGTTGGAATATGCGTATTAATGGCACAGTCTGGTCTTCATATTCCCGTACAAGAGGAATCGGAAATATGCGTATTTAAAA
ATATTTTTGCTGATATCGGTGACGAGCAATCCATTGAACAAAGTTTAAGTACATTCTCTTCCCATATGGTTAATATTGTC
GATATTTTAGAGAAAGCTGACTTTGAAAGCTTAGTGCTATTTGATGAATTAGGTGCTGGAACAGACCCGCAAGAAGGGGC
AGCTCTTGCCATTTCTATCTTAGATGAAGTACATAATCGCGGTGCACGCGTTGTTGCAACAACGCACTATCCAGAATTGA
AAGCATATGGATATAATCGTAATCAAGTGATTAACGCAAGTGTGGAATTTGATGTGAATACATTGAGTCCAACTTACAAA
TTATTAATTGGTGTACCAGGACGTAGTAATGCTTTTGAAATTTCGAAGCGCCTTGGATTATCTGAACGCGTAATTAATCG
TGCTCGCAATCATATTAGTACAGATACAAATAAGATTGAAAATATGATTGCGAAATTAGAAGAAAGCCAAAAGAATGCAG
AACGTGATTGGAAAGAAGCAGAAGAGCTTCGTAAGCAGTCTGAAAAGCTTCATCGCGAATTGCAACGTCAAATTATTGAA
TTTAACGAAGAACGTGATGAACGATTATTAAAAGCGCAAAAAGAAGGGGAAGAAAAGGTCGAAGCTGCGAAGAAAGAAGC
AGAAGCGATTATTCGTGAACTTCGTCAATTGCGTAAAGCGCAGCTTGCCAATGTGAAAGATCATGAATTGATTGAAGCGA
AAAGTCGCCTAGAAGGGGCAGCGCCTGAGCTTGTGAAAAAGCAAAAAGTAAAAGTGAAAAATACAGCGCCAAAACAACAG
TTAAGACCAGGCGATGAAGTAAAAGTATTAACGTTTGGCCAAAAAGGTCAACTTCTAAAAAAAGTAAGTGATAGTGAGTG
GAACGTTCAAATTGGGATTCTGAAGATGAAAGTAAAAGAATCTGATATGGAATATATTAATACACCAAAGCAGCTTGAGA
AAAAAGCAGTTGCAACAGTAAAAGGACGGGACTACCATGTTTCTTTAGAACTGGATCTTCGCGGTGAACGTTTTGAAAAT
GCGATGATGCGTGTTGAAAAGTACTTAGATGATGCACAGCTCGCTAACTATCCACGTGTATCAATCATTCACGGTAAAGG
AACAGGAGCGCTTCGACAAGGTGTACAAGACTACTTGAAGAACCATCGCGGTGTGAAAAGTTTCCGCTACGGTGATATGG
GCGAGGGAGGCCTTGGCGTTACAGTTGTCGAATTAAAATAG

Upstream 100 bases:

>100_bases
AGGTTGGATTCAAAAAGATACTGTGATTAACACATGGGATATTGAACGTTTATTAGATTTTATTAAACGTAATAAGTAAC
ACAAGGGGGACAGGCAACTT

Downstream 100 bases:

>100_bases
CAAAAAGCCAAATAAAGGGGTAAACCGTTATGTTTATGGACAAACTTGCAAAAGTATTGTTAGCATGTTGCGGCATATTT
TTGGTGATTGGGGTTATTTA

Product: recombination and DNA strand exchange inhibitor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 786; Mature: 786

Protein sequence:

>786_residues
MLERTLRVLEYDKVKEQLLEHTASSLGRDKVKRLMPSTDFEEIVEMQDTTDEAAKVIRLKGHAPLGGIFDIRSNVKRAKI
GSMLSPHELLDIASTMYGSRQMKRFIEDIVDNGAQLPILETHVAQIVSLYDLEKKITGCIGDGGEVLDSASDKLRGIRNQ
IRTAESRIREKLENMTRSSNAQKMLSDAIVTIRNDRYVIPVKQEYRGVYGGIVHDQSASGQTLFIEPQVIVELNNALQEA
RVKEKQEVERILMMLTEEVAAEADIVLANVEVIANLDFIFAKALYAKRMKATKPIVNNERYMELRQARHPLIDPKVIVPN
DIVLGKDFTTIVITGPNTGGKTVTLKTVGICVLMAQSGLHIPVQEESEICVFKNIFADIGDEQSIEQSLSTFSSHMVNIV
DILEKADFESLVLFDELGAGTDPQEGAALAISILDEVHNRGARVVATTHYPELKAYGYNRNQVINASVEFDVNTLSPTYK
LLIGVPGRSNAFEISKRLGLSERVINRARNHISTDTNKIENMIAKLEESQKNAERDWKEAEELRKQSEKLHRELQRQIIE
FNEERDERLLKAQKEGEEKVEAAKKEAEAIIRELRQLRKAQLANVKDHELIEAKSRLEGAAPELVKKQKVKVKNTAPKQQ
LRPGDEVKVLTFGQKGQLLKKVSDSEWNVQIGILKMKVKESDMEYINTPKQLEKKAVATVKGRDYHVSLELDLRGERFEN
AMMRVEKYLDDAQLANYPRVSIIHGKGTGALRQGVQDYLKNHRGVKSFRYGDMGEGGLGVTVVELK

Sequences:

>Translated_786_residues
MLERTLRVLEYDKVKEQLLEHTASSLGRDKVKRLMPSTDFEEIVEMQDTTDEAAKVIRLKGHAPLGGIFDIRSNVKRAKI
GSMLSPHELLDIASTMYGSRQMKRFIEDIVDNGAQLPILETHVAQIVSLYDLEKKITGCIGDGGEVLDSASDKLRGIRNQ
IRTAESRIREKLENMTRSSNAQKMLSDAIVTIRNDRYVIPVKQEYRGVYGGIVHDQSASGQTLFIEPQVIVELNNALQEA
RVKEKQEVERILMMLTEEVAAEADIVLANVEVIANLDFIFAKALYAKRMKATKPIVNNERYMELRQARHPLIDPKVIVPN
DIVLGKDFTTIVITGPNTGGKTVTLKTVGICVLMAQSGLHIPVQEESEICVFKNIFADIGDEQSIEQSLSTFSSHMVNIV
DILEKADFESLVLFDELGAGTDPQEGAALAISILDEVHNRGARVVATTHYPELKAYGYNRNQVINASVEFDVNTLSPTYK
LLIGVPGRSNAFEISKRLGLSERVINRARNHISTDTNKIENMIAKLEESQKNAERDWKEAEELRKQSEKLHRELQRQIIE
FNEERDERLLKAQKEGEEKVEAAKKEAEAIIRELRQLRKAQLANVKDHELIEAKSRLEGAAPELVKKQKVKVKNTAPKQQ
LRPGDEVKVLTFGQKGQLLKKVSDSEWNVQIGILKMKVKESDMEYINTPKQLEKKAVATVKGRDYHVSLELDLRGERFEN
AMMRVEKYLDDAQLANYPRVSIIHGKGTGALRQGVQDYLKNHRGVKSFRYGDMGEGGLGVTVVELK
>Mature_786_residues
MLERTLRVLEYDKVKEQLLEHTASSLGRDKVKRLMPSTDFEEIVEMQDTTDEAAKVIRLKGHAPLGGIFDIRSNVKRAKI
GSMLSPHELLDIASTMYGSRQMKRFIEDIVDNGAQLPILETHVAQIVSLYDLEKKITGCIGDGGEVLDSASDKLRGIRNQ
IRTAESRIREKLENMTRSSNAQKMLSDAIVTIRNDRYVIPVKQEYRGVYGGIVHDQSASGQTLFIEPQVIVELNNALQEA
RVKEKQEVERILMMLTEEVAAEADIVLANVEVIANLDFIFAKALYAKRMKATKPIVNNERYMELRQARHPLIDPKVIVPN
DIVLGKDFTTIVITGPNTGGKTVTLKTVGICVLMAQSGLHIPVQEESEICVFKNIFADIGDEQSIEQSLSTFSSHMVNIV
DILEKADFESLVLFDELGAGTDPQEGAALAISILDEVHNRGARVVATTHYPELKAYGYNRNQVINASVEFDVNTLSPTYK
LLIGVPGRSNAFEISKRLGLSERVINRARNHISTDTNKIENMIAKLEESQKNAERDWKEAEELRKQSEKLHRELQRQIIE
FNEERDERLLKAQKEGEEKVEAAKKEAEAIIRELRQLRKAQLANVKDHELIEAKSRLEGAAPELVKKQKVKVKNTAPKQQ
LRPGDEVKVLTFGQKGQLLKKVSDSEWNVQIGILKMKVKESDMEYINTPKQLEKKAVATVKGRDYHVSLELDLRGERFEN
AMMRVEKYLDDAQLANYPRVSIIHGKGTGALRQGVQDYLKNHRGVKSFRYGDMGEGGLGVTVVELK

Specific function: This Protein Is Involved In The Repair Of Mismatches In DNA. It Is Possible That It Carries Out The Mismatch Recognition Step. This Protein Has A Weak Atpase Activity. [C]

COG id: COG1193

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Smr domain [H]

Homologues:

Organism=Homo sapiens, GI284813531, Length=589, Percent_Identity=25.2971137521222, Blast_Score=129, Evalue=8e-30,
Organism=Homo sapiens, GI4504191, Length=271, Percent_Identity=28.4132841328413, Blast_Score=104, Evalue=4e-22,
Organism=Homo sapiens, GI4557761, Length=194, Percent_Identity=32.9896907216495, Blast_Score=101, Evalue=3e-21,
Organism=Homo sapiens, GI26638666, Length=290, Percent_Identity=28.9655172413793, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI4505253, Length=290, Percent_Identity=28.9655172413793, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI36949366, Length=229, Percent_Identity=28.82096069869, Blast_Score=97, Evalue=5e-20,
Organism=Homo sapiens, GI26638664, Length=294, Percent_Identity=28.9115646258503, Blast_Score=94, Evalue=5e-19,
Organism=Homo sapiens, GI262231786, Length=218, Percent_Identity=31.1926605504587, Blast_Score=89, Evalue=1e-17,
Organism=Escherichia coli, GI1789089, Length=333, Percent_Identity=26.7267267267267, Blast_Score=100, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17508445, Length=360, Percent_Identity=27.7777777777778, Blast_Score=129, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI17534743, Length=370, Percent_Identity=25.1351351351351, Blast_Score=108, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17539736, Length=271, Percent_Identity=26.1992619926199, Blast_Score=87, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17508447, Length=278, Percent_Identity=25.8992805755396, Blast_Score=77, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6324482, Length=296, Percent_Identity=28.7162162162162, Blast_Score=105, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6319935, Length=248, Percent_Identity=30.241935483871, Blast_Score=104, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6321912, Length=319, Percent_Identity=25.0783699059561, Blast_Score=99, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6320302, Length=269, Percent_Identity=28.6245353159851, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6321109, Length=268, Percent_Identity=29.1044776119403, Blast_Score=91, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6320047, Length=298, Percent_Identity=24.496644295302, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24664545, Length=270, Percent_Identity=30.3703703703704, Blast_Score=117, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24584320, Length=280, Percent_Identity=28.2142857142857, Blast_Score=94, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005747
- InterPro:   IPR000432
- InterPro:   IPR007696
- InterPro:   IPR002625 [H]

Pfam domain/function: PF00488 MutS_V; PF01713 Smr [H]

EC number: NA

Molecular weight: Translated: 88518; Mature: 88518

Theoretical pI: Translated: 7.12; Mature: 7.12

Prosite motif: PS50828 SMR ; PS00486 DNA_MISMATCH_REPAIR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLERTLRVLEYDKVKEQLLEHTASSLGRDKVKRLMPSTDFEEIVEMQDTTDEAAKVIRLK
CCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCHHHHHHHHCCHHHHHHEEEEE
GHAPLGGIFDIRSNVKRAKIGSMLSPHELLDIASTMYGSRQMKRFIEDIVDNGAQLPILE
CCCCCCCHHHHHHCHHHHHHCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCHHH
THVAQIVSLYDLEKKITGCIGDGGEVLDSASDKLRGIRNQIRTAESRIREKLENMTRSSN
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
AQKMLSDAIVTIRNDRYVIPVKQEYRGVYGGIVHDQSASGQTLFIEPQVIVELNNALQEA
HHHHHHHHHEEEECCEEEEECHHHHCCHHCCEEECCCCCCCEEEECCHHHHHHHHHHHHH
RVKEKQEVERILMMLTEEVAAEADIVLANVEVIANLDFIFAKALYAKRMKATKPIVNNER
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
YMELRQARHPLIDPKVIVPNDIVLGKDFTTIVITGPNTGGKTVTLKTVGICVLMAQSGLH
HHHHHHHCCCCCCCEEECCCCEEECCCCEEEEEECCCCCCCEEEEEHHHHHHHHHCCCCC
IPVQEESEICVFKNIFADIGDEQSIEQSLSTFSSHMVNIVDILEKADFESLVLFDELGAG
CCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEHHCCCC
TDPQEGAALAISILDEVHNRGARVVATTHYPELKAYGYNRNQVINASVEFDVNTLSPTYK
CCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCHHCCCCCCCEEEEEEEEEEECCCCCEEE
LLIGVPGRSNAFEISKRLGLSERVINRARNHISTDTNKIENMIAKLEESQKNAERDWKEA
EEEECCCCCCHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
EELRKQSEKLHRELQRQIIEFNEERDERLLKAQKEGEEKVEAAKKEAEAIIRELRQLRKA
HHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
QLANVKDHELIEAKSRLEGAAPELVKKQKVKVKNTAPKQQLRPGDEVKVLTFGQKGQLLK
HHCCCCHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCHHHCCCCCCEEEEEECCCCHHHH
KVSDSEWNVQIGILKMKVKESDMEYINTPKQLEKKAVATVKGRDYHVSLELDLRGERFEN
HCCCCCCEEEEEEEEEEECCCCHHHCCCHHHHHHHHHHEECCCEEEEEEEEECCCHHHHH
AMMRVEKYLDDAQLANYPRVSIIHGKGTGALRQGVQDYLKNHRGVKSFRYGDMGEGGLGV
HHHHHHHHHCHHHHCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCE
TVVELK
EEEEEC
>Mature Secondary Structure
MLERTLRVLEYDKVKEQLLEHTASSLGRDKVKRLMPSTDFEEIVEMQDTTDEAAKVIRLK
CCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCHHHHHHHHCCHHHHHHEEEEE
GHAPLGGIFDIRSNVKRAKIGSMLSPHELLDIASTMYGSRQMKRFIEDIVDNGAQLPILE
CCCCCCCHHHHHHCHHHHHHCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCHHH
THVAQIVSLYDLEKKITGCIGDGGEVLDSASDKLRGIRNQIRTAESRIREKLENMTRSSN
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
AQKMLSDAIVTIRNDRYVIPVKQEYRGVYGGIVHDQSASGQTLFIEPQVIVELNNALQEA
HHHHHHHHHEEEECCEEEEECHHHHCCHHCCEEECCCCCCCEEEECCHHHHHHHHHHHHH
RVKEKQEVERILMMLTEEVAAEADIVLANVEVIANLDFIFAKALYAKRMKATKPIVNNER
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
YMELRQARHPLIDPKVIVPNDIVLGKDFTTIVITGPNTGGKTVTLKTVGICVLMAQSGLH
HHHHHHHCCCCCCCEEECCCCEEECCCCEEEEEECCCCCCCEEEEEHHHHHHHHHCCCCC
IPVQEESEICVFKNIFADIGDEQSIEQSLSTFSSHMVNIVDILEKADFESLVLFDELGAG
CCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEHHCCCC
TDPQEGAALAISILDEVHNRGARVVATTHYPELKAYGYNRNQVINASVEFDVNTLSPTYK
CCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCHHCCCCCCCEEEEEEEEEEECCCCCEEE
LLIGVPGRSNAFEISKRLGLSERVINRARNHISTDTNKIENMIAKLEESQKNAERDWKEA
EEEECCCCCCHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
EELRKQSEKLHRELQRQIIEFNEERDERLLKAQKEGEEKVEAAKKEAEAIIRELRQLRKA
HHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
QLANVKDHELIEAKSRLEGAAPELVKKQKVKVKNTAPKQQLRPGDEVKVLTFGQKGQLLK
HHCCCCHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCHHHCCCCCCEEEEEECCCCHHHH
KVSDSEWNVQIGILKMKVKESDMEYINTPKQLEKKAVATVKGRDYHVSLELDLRGERFEN
HCCCCCCEEEEEEEEEEECCCCHHHCCCHHHHHHHHHHEECCCEEEEEEEEECCCHHHHH
AMMRVEKYLDDAQLANYPRVSIIHGKGTGALRQGVQDYLKNHRGVKSFRYGDMGEGGLGV
HHHHHHHHHCHHHHCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCE
TVVELK
EEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA