Click here to switch to the map view.

The map label for this gene is lrp [H]

Identifier: 152969478

GI number: 152969478

Start: 1031651

End: 1032145

Strand: Direct

Name: lrp [H]

Synonym: KPN_00921

Alternate gene names: 152969478

Gene position: 1031651-1032145 (Clockwise)

Preceding gene: 152969472

Following gene: 152969479

Centisome position: 19.41

GC content: 47.88

Gene sequence:

>495_bases
ATGGTAGATAGCAAGAAGCGCCCTGGCAAAGATCTCGACCGCATTGATCGTAACATCCTGAATGAATTGCAAAAAGATGG
GCGAATTTCTAACGTCGAGCTTTCTAAACGGGTGGGACTTTCTCCGACGCCTTGCCTTGAGCGTGTGCGTCGTCTTGAAA
GACAGGGTTTTATTCAGGGCTATACGGCGCTGCTCAACCCGCATTATCTGGATGCATCACTTCTGGTATTTGTTGAGATT
ACTCTGAATCGTGGCGCACCGGATGTGTTTGAGCAATTTAACGCCGCAGTGCAAAAACTTGAAGAAATTCAAGAGTGTCA
TCTGGTTTCCGGTGATTTCGACTATCTGTTGAAAACCCGTGTACCGGATATGTCAGCGTATCGTAAATTACTGGGCGAGA
CCTTGCTGCGCCTGCCGGGCGTTAACGACACCCGTACCTACGTGGTAATGGAAGAAGTCAAGCAAAGTAATCGTCTGGTT
ATTAAGACGCGCTAA

Upstream 100 bases:

>100_bases
GGGTTACCCAATGTCGTACGGGTGATAACAGGATGGGCTCTGGCAGTGAAGGCTCAGAGCCGGAACAGGAGTAGGGAAGG
AATACAGAGAGACAATAATA

Downstream 100 bases:

>100_bases
CACGGAACAGGTGCAAACTCGACGTAGTTTGATTACACTCCTGTTAATCCATACAGCAACAGTGCCGGGGAGACCCGGCG
CTGTTGTCCGTTTTAGCAGC

Product: leucine-responsive transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 164; Mature: 164

Protein sequence:

>164_residues
MVDSKKRPGKDLDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEI
TLNRGAPDVFEQFNAAVQKLEEIQECHLVSGDFDYLLKTRVPDMSAYRKLLGETLLRLPGVNDTRTYVVMEEVKQSNRLV
IKTR

Sequences:

>Translated_164_residues
MVDSKKRPGKDLDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEI
TLNRGAPDVFEQFNAAVQKLEEIQECHLVSGDFDYLLKTRVPDMSAYRKLLGETLLRLPGVNDTRTYVVMEEVKQSNRLV
IKTR
>Mature_164_residues
MVDSKKRPGKDLDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEI
TLNRGAPDVFEQFNAAVQKLEEIQECHLVSGDFDYLLKTRVPDMSAYRKLLGETLLRLPGVNDTRTYVVMEEVKQSNRLV
IKTR

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes [H]

COG id: COG1522

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=164, Percent_Identity=99.390243902439, Blast_Score=332, Evalue=7e-93,
Organism=Escherichia coli, GI87081742, Length=151, Percent_Identity=32.4503311258278, Blast_Score=95, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 18857; Mature: 18857

Theoretical pI: Translated: 9.10; Mature: 9.10

Prosite motif: PS00519 HTH_ASNC_1 ; PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDSKKRPGKDLDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQG
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHH
YTALLNPHYLDASLLVFVEITLNRGAPDVFEQFNAAVQKLEEIQECHLVSGDFDYLLKTR
HHHHHCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHC
VPDMSAYRKLLGETLLRLPGVNDTRTYVVMEEVKQSNRLVIKTR
CCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEEEEC
>Mature Secondary Structure
MVDSKKRPGKDLDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQG
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHH
YTALLNPHYLDASLLVFVEITLNRGAPDVFEQFNAAVQKLEEIQECHLVSGDFDYLLKTR
HHHHHCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHC
VPDMSAYRKLLGETLLRLPGVNDTRTYVVMEEVKQSNRLVIKTR
CCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]